A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Nature Immunology

Volumn 6, Issue 11, 2005, Pages 1133-1141

  Park, Heon ^a   Li, Zhaoxia ^a   Yang, Xuexian O ^b   Chang, Seon Hee ^b   Nurieva, Roza ^b   Wang, Yi Hong ^b   Wang, Ying ^a   Hood, Leroy ^c   Zhu, Zhou ^d   Tian, Qiang ^c   Dong, Chen ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD28 ANTIGEN; CD4 ANTIGEN; CHEMOKINE; CHEMOKINE CCL20; CHEMOKINE CCL22; CHEMOKINE CX3CL1; COLLAGENASE 3; CXCL1 CHEMOKINE; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GELATINASE B; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; STROMELYSIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; BRAIN REGION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; IMMUNOPATHOGENESIS; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION; LUNG ALVEOLUS EPITHELIUM; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENE;

ANIMALS; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CHEMOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-17; LUNG; MICE; MICE, TRANSGENIC; MUTATION; PNEUMONIA; RATS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 27544465354     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1261     Document Type: Article

References (38)

1. Mosmann, T.R. & Coffman, R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
2. Lenschow, D.J., Walunas, T.L. & Bluestone, J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258 (1996).
3. Dong, C. & Nurieva, R.I. Regulation of immune and autoimmune responses by ICOS. J. Autoimmun. 21, 255-260 (2003).
4. Szabo, S.J., Sullivan, B.M., Peng, S.L. & Glimcher, L.H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713-758 (2003).
5. Trinchieri, G., Pflanz, S. & Kastelein, R.A. The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses. Immunity 19, 641-644 (2003).
6. + T-cell subsets in autoimmunity. Immunity 16, 755-758 (2002).
7. Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
8. Murphy, C.A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmume inflammation. J. Exp. Med. 198, 1951-1957 (2003).
9. Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14, 1693-1711 (2000).
10. Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
11. Ho, I.C., Hodge, M.R., Rooney, J.W. & Glimcher, L.H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85, 973-983 (1996).
12. Kim, J.I., Ho, I.C., Grusby, M.J. & Glimcher, L.H. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10, 745-751 (1999).
13. Aggarwal, S. & Gurney, A.L. IL-17: Prototype member of an emerging cytokine family. J. Leukoc. Biol. 71, 1-8 (2002).
14. Moseley, T.A., Haudenschild, D.R., Rose, L. & Reddi, A.H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14, 155-174 (2003).
15. Kolls, J.K. & Linden, A. Interleulkin-17 family members and inflammation. Immunity 21, 467-476 (2004).
16. Schwandner, R., Yamaguchi, K. & Cao, Z. Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J. Exp. Med. 191, 1233-1240 (2000).
17. Ye, P. et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194, 519-527 (2001).
18. Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387 (2002).
19. Nakae, S., Nambu, A., Sudo, K. & Iwakura, Y. Suppression of immune iInduction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171, 6173-6177 (2003).
20. Bush, K.A., Farmer, K.M., Walker, J.S. & Kirkham, B.W. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 46, 802-805 (2002).
21. Yao, Z. et al. Human IL-17: A novel cytokine derived from T cells. J. Immunol. 155, 5483-5486 (1995).
22. Aggarwal, S., Ghilardi, N., Xie, M.H., De Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910-1914 (2003).
23. Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
24. + effector and memory T cell generation. Nat. Immunol. 4, 835-842 (2003).
25. + T cells: Evidence for two distinct pathways for promoter activation. Eur. J. Immunol. 29, 548-555 (1999).
26. Prasad, D.V., Richards, S., Mai, X.M. & Dong, C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18, 863-873 (2003).
27. Ruddy, MJ et al. Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members. J. Biol. Chem. 279, 2559-2567 (2004).
28. Sun, M. et al. Characterization of mouse and human B7-H3 genes. J. Immunol. 168, 6294-6297 (2002).
29. Ransohoff, R.M. The chemokine system in neuroinflammation: An update. J. Infect. Dis. 186, S152-S156 (2002).
30. Huang, D., Wang, J., Kivisakk, P., Rollins, B.J. & Ransohoff, R.M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 Immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193, 713-726 (2001).
31. Vignola, A.M. et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 158, 1945-1950 (1998).
32. Beeh, K.M., Beier, J., Kornmann, O. & Buhl, R. Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects. Respir. Med. 97, 634-639 (2003).
33. Infante-Duarte, C., Horton, H.F., Byrne, M.C. & Kamradt, T. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 165, 6107-6115 (2000).
34. Linden, A. Role of interleukin-17 and the neutrophil in asthma. Int. Arch. Allergy Immunol. 126, 179-184 (2001).
35. Stark, M.A. et al. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22, 285-294 (2005).
36. Zhu, Z. et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103, 779-788 (1999).
37. Ideker, T., Thorsson, V., Siegel, A.F. & Hood, L.E. Testing for differentially-expressed genes by maximum-likelihood analysis of microarray data. J. Comput. Biol. 7, 805-817 (2000).
38. Dong, C. et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97-102 (2001).