Infection of intact human islets by a lentiviral vector

Gene Therapy

Volumn 6, Issue 9, 1999, Pages 1545-1551

  Giannoukakis, N ^a   Mi, Z ^a   Gambotto, A ^a   Eramo, A ^c   Ricordi, C ^b   Trucco, M ^c   Robbins, P D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Adenovirus; Diabetes; Islets; Lentivirus

Indexed keywords

GLUCOSE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; VIRUS VECTOR;

ADENOVIRUS; ADENOVIRUS 5; APOPTOSIS; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GRAFT REJECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; LENTIVIRINAE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RETROVIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRIDAE; APOPTOSIS; BETA-GALACTOSIDASE; CELLS, CULTURED; DEFECTIVE VIRUSES; FLOW CYTOMETRY; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLUCOSE; GREEN FLUORESCENT PROTEINS; HIV-1; HUMANS; INSULIN; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; ISLETS OF LANGERHANS; LUMINESCENT PROTEINS; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS;

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 5; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0032855209     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300996     Document Type: Article

References (42)

1. Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 1994; 15: 516-542.
2. Eisenbarth GS. Molecular aspects of the etiology of type I diabetes mellitus. J Diabetes Comp 1993; 7: 142-150.
3. Lacy PE. The intraislet macrophage and type I diabetes. Mt Sinai J Med 1994; 61: 170-174.
4. Arnush M et al. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 1998; 160: 2684-2691.
5. Arnush M et al. IL-1 produced and released endogenously within human islets inhibits beta cell function. J Clin Invest 1998; 102: 516-526.
6. Stassi G et al. Nitric oxide primes pancreatic beta cells for Fasmediated destruction in insulin-dependent diabetes mellitus. J Exp Med 1997; 186: 1193-1200.
7. Yamada K et al. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 1996; 39: 1306-1312.
8. Sandberg JO, Eizirik DL, Sandler S. IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice. Clin Exp Immunol 1997; 108: 314-317.
9. Chao SH et al. Interleukin-10 (IL-10) prevents primary nonfunction in allogeneic islet transplantation. Transplant Proc 1995; 27: 602-604.
10. Rabinovitch A et al. Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts. Transplantation 1997; 64: 1525-1531.
11. Deng S et al. IL-10 and TGF-beta gene transfer to rodent islets: effect on xenogeneic islet graft survival in naive and B cell-deficient mice. Transplant Proc 1997; 29: 2207-2208.
12. Lenschow DJ et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig (see comments). Science 1992; 257: 789-792.
13. Levisetti MG et al. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol 1997; 159: 5187-5191.
14. Roy-Chaudhury P et al. CTLA4Ig attenuates accelerated rejection (presensitization) in the mouse islet allograft model. Transplantation 1997; 64: 172-175.
15. Steurer W et al. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. J Immunol 1995; 155: 1165-1174.
16. Tran HM et al. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment. J Immunol 1997; 159: 2232-2239.
17. Balasa B et al. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol 1997; 159: 4620-4627.
18. Markees TG et al. Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation. Transplant Proc 1996; 28: 814-815.
19. Csete ME et al. Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation 1995; 59: 263-268.
20. Csete ME et al. Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function. Transplant Proc 1994; 26: 756-757.
21. Benhamou PY et al. Decreased alloreactivity to human islets secreting recombinant viral interleukin 10. Transplantation 1996; 62: 1306-1312.
22. Gainer AL et al. Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival. Transplantation 1997; 63: 1017-1021.
23. Gainer AL et al. Prolongation of allograft survival of transfected islets expressing human CTLA4-Ig, human soluble Fas ligand or a combination of the two. Transplant Proc 1998; 30: 534.
24. Guo Z et al. Effect of gene gun-mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection. Transplant Proc 1998; 30: 589.
25. Weber M et al. Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function. J Surg Res 1997; 69: 23-32.
26. Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926-932.
27. Zufferey R et al. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997; 15: 871-875.
28. Naldini L et al. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 1996; 93: 11382-11388.
29. Blomer U et al. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol 1997; 71: 6641-6649.
30. Miyoshi H et al. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA 1997; 94: 10319-10323.
31. Nielsen DA et al. Sorting of pancreatic islet cell subpopulations by light scattering using a fluorescence-activated cell sorter. Diabetes 1982; 31: 299-306.
32. Corbett JA et al. Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone. Autoimmunity 1993; 15: 145-153.
33. Corbett JA, McDaniel ML. Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. Biochem J 1994; 299: 719-724.
34. Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181: 559-568.
35. Ju Q et al. Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector. Diabetologia 1998; 41: 736-739.
36. Peakman M et al. Development of techniques for obtaining monodispersed human islet cells. Transplantation 1994; 57: 384-393.
37. Deng S et al. Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival. Transplant Proc 1997; 29: 770.
38. Corbett JA et al. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci USA 1993; 90: 1731-1735.
39. Stassi G et al. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro. Transplant Proc 1995; 27: 3271-3275.
40. Hardy S et al. Construction of adenovirus vectors through cre-lox recombination. J Virol 1997; 71: 1842-1849.
41. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 1996; 70: 7498-7509.
42. Linetsky E et al. Improved human islet isolation using a new enzyme blend, liberase. Diabetes 1997; 46: 1120-1123.