Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 586-592

  Weaver D J , Jr ^a   Liu, B ^a   Tisch, R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN FC FRAGMENT; INSULIN; INTERLEUKIN 4; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; VACCINATION;

EID: 0035399816     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.586     Document Type: Article

References (53)

1. Antigen-specific immunotherapy: Is it a real possibility to combat T-cell-mediated autoimmunity?
2. Antigen-based immunotherapy for autoimmune disease: From animal models to humans?
3. Systemic antigen treatment of T cell-mediated autoimmune diseases
4. High-dose soluble antigen: Peripheral T cell proliferation or apoptosis
5. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. III. A role for anergy/deletion
6. Oral tolerance: Mechanisms and therapeutic applications
7. Redirecting Th1 and Th2 responses in autoimmune diseases
8. + T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway
9. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
10. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic autoantigens
11. Antigen-specific therapy for autoimmune disease
12. The effect of antigen dose in a T cell receptor α/β-transgenic model
13. + T cell population to the T helper 2 cell pathway
14. Revisiting tolerance induced by autoantigen in incomplete Freund's adjuvant
15. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
16. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
17. Attenuation of inducible Th2 immunity with autoimmune progression
18. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
19. Endogenous myelin basic protein inactivates the high avidity T cell repertoire
20. CD8 T cell ignorance or tolerance to islet cell antigens depends on antigen dose
21. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen
22. DNA vaccines
23. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell costimulation
24. Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
25. DNA immunization to prevent autoimmune diabetes
26. Intramuscular injection of plasmid DNA encoding intracellular or secreted glutamic acid decarboxylase causes decreased insulitis in the nonobese diabetic mouse
27. Biolistic-mediated interleukin 4 gene transfer prevents the onset of type 1 diabetes
28. TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
29. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
30. Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination
31. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
32. Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes
33. Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin dependent diabetes
34. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B(9-23)
35. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription
36. Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys
37. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
38. Detection of cell surface molecules, secreted products of single cells and cellular proliferation by enzyme immunoassay
39. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
40. Ontogeny of T cell tolerance to peripherally expressed antigens
41. Identification of a MHC class I-restricted autoantigen in type I diabetes by screening an organ-specific cDNA library
42. 9-23 T cell receptor AV1353 T cell clones of the NOD mouse
43. Determination of tissue distribution of an intramuscular plasmid vaccine using PCR and in situ DNA hybridization
44. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
45. Cytokines induce the development of functionally heterogeneous T helper cell subsets
46. + T cell responses: The alternative approaches
47. Evidence of positive cross-regulation on Th1 and Th2 and antigen presenting cells: Effects on Th1 induced by IL-4 and IL-12
48. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration
49. Modulation of the immunogenicity of antigenic determinants by their flanking residues
50. B-lymphocytes are critical antigen presenting cells for the initiation of T cell mediated autoimmune diabetes in NOD mice
51. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice
52. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
53. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants