Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4627-4636

  Schmidt, Dennis ^a   Amrani, Abdelaziz ^a   Verdaguer, Joan ^a   Bou, Sonny ^a   Santamaria, Pere ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SUPERANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CELL PROTECTION; COMPLEX FORMATION; DIABETOGENESIS; EPITHELIUM CELL; GENE DELETION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; THYMOCYTE;

EID: 0033561541     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Vyse, T. J., and J. A. Todd. 1996. Genetic analysis of autoimmune disease. Cell 85:311.
2. Tisch, R., and H. O. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell 85:291.
3. Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.
4. Acha-Orbea, H., and H.O. McDevitt. 1987. The first external domain of the non-obese diabetic mouse class II I-Aβ chain is unique. Proc. Natl. Acad. Sci. USA 84:2435.
5. g7 molecules from non-obese diabetic mice are poor peptide binders. J. Immunol. 156:450.
6. Wicker, L., J. Todd, and L. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
7. Zinkernagel, R. M., and P. Doherty. 1975. H-2 compatibility requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus: different cytotoxic T-cell specificities are associated with structures from H-2K or H-2D. J. Exp. Med. 141:1427.
8. Kappler, J. W., and P. Marrack. 1976. Helper T-cells recognize antigen and macrophage surface components simultaneously. Nature 262:797.
9. Bevan, M. J. 1977. In a radiation chimera host H-2 antigens determine the immune responsiveness of donor cytotoxic cells. Nature 169:417.
10. Zinkemagel, R. M., G. N. Callahan, A. Althage, S. Cooper, P. A. Klein, and J. Klein. 1978. On the thymus in the differentiation of "H-2 self recognition" by T-cells: evidence for dual recognition? J. Exp. Med. 147:882.
11. Lo, D., and J. Sprent. 1986. Identity of cells that imprint H-2 restricted T cell specificity in the thymus. Nature 319:672.
12. Nikolic-Zugic, J., and M. Bevan. 1990. Role of self peptides in positively selecting the T-cell repertoire. Nature 344:65.
13. Anderson, G., E. J. Jenkinson, N. C. Moore, and J. J. Owen. 1993. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362:70.
14. Ashton-Rickardt, P. G., A. Bandiera, J. R. Delaney, L. Van Kaer, H. P. Pircher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T-cell selection in the thymus. Cell 76:651.
15. Hogquist, K. A., C. S. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T-cell receptor antagonist peptides induce positive selection. Cell 76:17.
16. Sebzda, E., V. A. Wallace, J. Mayer, R. S. M. Yeung, T. W. Mak, and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
17. Kappler, J. W., N. Roehm, and P. Marrack, P. 1987. T-cell tolerance by clonal elimination in the thymus. Cell 49:273.
18. + thymocytes. Nature 333:742.
19. a-encoded antigens. Nature 332:40.
20. Sha, W., C. Nelson, R. Newberry, D. Kranz, J. Russell, and D. Loh. 1988. Positive and negative selection of an antigen receptor on T-cells in transgenic mice. Nature 336:73.
21. + T cells. Immunity 7:209.
22. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383:81.
23. k NOD transgenic mice. Int. Immunol. 1:210.
24. Reich, E. P., R. S. Sherwin, O. Kanagawa, and C. A. Janeway, Jr. 1989. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 341:326.
25. Lund, T., L. O'Reilly, P. Hutchings, O. Kanagawa, E. Simpson, R. Gravely, P. Chandler, P., J. Dyson, J. K. Picard. A. K. Edwards, et al. 1990. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-Aβ chain or normal I-Eα-chain. Nature 345:727.
26. Ridgway, W. M., M. Fasso, A. Lanctot, C. Garvey, and C. G. Fathman. 1996. Breaking self-tolerance in nonobese diabetic mice. J. Exp. Med. 183:1657.
27. Buckner, J., W. W. Kwok, B. B. Nepom, and G. T. Nepom. 1996. Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions. J. Immunol. 157:4940.
28. Schmidt, D., J. Verdaguer, N. Averill, and P. Santamaria. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 7:1059.
29. Serreze, D. V., and E. H. Leiter. 1991. Development of diabetogenic T-cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hematopoietic origin, but not on thymic epithelium. J. Immunol. 147:1222.
30. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
31. lo thymocytes in vivo. Science 250: 1720.
32. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
33. Pawlowski, T. J., M. D. Singleton, D. Y. Loh, R. Berg, and U. D. Staerz. 1996. Permissive recognition during positive selection. Eur. J. Immunol. 26:851.
34. Benoist, C., and D. Mathis. 1997. Positive selection of T cells: fastidious or promiscuous? Curr. Opin. Immunol. 9:245.
35. Brabb, T., E. S. Huseby, T. M. Morgan, D. B. Sant'Angelo, J. Kirchner, A. G. Fair, and J. Goverman. 1997. Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions. Eur. J. Immunol. 27:136.
36. d resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo. Immunity 7:233.
37. + thymocyte selection by a single MHC class II/peptide ligand in vivo affected by its expression level in thymus. Immunity 6:401.
38. + T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7:197.
39. Nakano, N., R. Rooke, C. Benoist, and D. Mathis. 1997. Positive selection of T cells induced by viral delivery of neo-peptides to the thymus. Science 275:678.
40. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
41. o/o mice. Immunity 7:187.
42. Verdaguer, J., D. Schmidt, A. Amrani, B. Anderson, N. Averill, and P. Santamaria. 1997. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J. Exp. Med. 186:1663.
43. Martin, W. D., G. G. Hicks, S. K. Mendiratta, H. I. Leva, H. E. Ruley, and L. Van Kaer. 1996. H-2 M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84: 543.
44. + T-cells expressing identical endogenous TCRa chains. J. Immunol. 157:4726.
45. Coligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. H. Shevack, and W. Strober. 1995. Current Protocols in Immunology. John Wiley and Sons, New York.
46. Miyazaki, T., P. Wolf, S. Tourne, C. Waltzinger, A. Dierich, N. Barois, H. Ploegh, C. Benoist, and D. Mathis. 1996. Mice lacking H-2 M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84:531.
47. Fung-Leung, W.-P., C. D. Surh, M. Lijedahl, J. Pang, D. Leturcq, P. A. Peterson, S. R. Webb, and L. Karlsson. 1996. Antigen presentation and T cell development in H-2 M-deficient mice. Science 271:1278.
48. Schumacher, T. N., and H. L. Ploegh. 1994. Are MHC-bound peptides a nuisance for positive selection? Immunity 1:721.
49. Smith, P. A., A. Brunmark, M. R. Jackson, and T. A. Potter. 1997. Peptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL). J. Exp. Med. 185:1023.
50. Vessey, S. J. R., D. H. Barouch, S. N. McAdam, L. G. Tussey, M. A. Davenport, C. A. O'Callaghan, J. I. Bell, A. J. McMichael, and B. K. Jakobsen. 1997. Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide. Eur. J. Immunol. 27:879.
51. Ohashi, P. S. 1996. T cell selection and autoimmunity: flexibility and tuning. Curr. Opin. Immunol. 8:808.
52. Pircher, H., U. H. Rohrer, D. Moskophidis, R. M. Zinkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351:482.
53. Kaye, J., and C. A. Janeway, Jr. 1984. The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia, J. Exp. Med 159:1397.
54. Hanson, M. S., M. Cetkovic-Cvrlje, V. K. Ramiya, M. A. Atkinson, N. K. Maclaren, B. Singh, J. F. Elliott, D. V. Serreze, and E. H. Leiter. 1996. Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine levels of diabetes resistance and indicate mechanism of protection. J. Immunol. 157:1279.
55. Lühder, F., J. Katz, C. Benoist, and D. Mathis. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J. Exp. Med. 187:379.