Molecular basis for HLA-DQ associations with IDDM

Diabetes

Volumn 47, Issue 8, 1998, Pages 1177-1184

  Nepom, Gerald T ^a,b   Kwok, William W ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ALLELE; AUTOIMMUNE DISEASE; DISEASE PREDISPOSITION; GENE AMPLIFICATION; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS;

EID: 0031847984     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.8.1177     Document Type: Review

References (38)

1. Marrack P, Lo D, Brinster R, Palmiter R, Burkly L, Flavell RH, Kappler J: The effect of thymus environment on T-cell development and tolerance. Cell 53:627-634, 1988
2. Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ, Perlmutter RM: Positive and negative selection invoke distinct signaling pathways. J Exp Med 184:9-18, 1996
3. Benoist C, Mathis D: Positive selection of the T-cell repertoire: where and when does it occur? Cell 58:1027-1033, 1989
4. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR: T-cell receptor antagonist peptides induce positive selection. Cell 76:17-27, 1994
5. Choi Y, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J: Interaction of Staphylococcus aureus toxin "superantigens" with human T-cells. Proc Natl Acad Sci U S A 86:8941-8945, 1989
6. Conrad B, Weidmann E, Trucco G, Rudert WA, Behboo R, Ricordi C, Rodriquez-Rilo H, Finegold D, Trucco M: Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 371:351-355, 1995
7. Katz JD, Wang B, Haskins K, Benoist C, Mathis D: Following a diabetogenic T-cell from genesis through pathogenesis. Cell 74:1089-1100, 1993
8. Andre I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D: Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A 93:2260-2263, 19979
9. Kim DT, Rothbard JB, Bloom DD, Fathman CG: Quantitative analysis of T-cell activation: role of TCR/ligand density and TCR affinity. J Immunol 156:2737-2742, 1996
10. Murray JS, Pfeiffer C, Madri J, Bottomly K: Major histocompatibiltiy complex (MHC) control of CD4 T-cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur J Immunol 22:559-565, 1992
11. Constant S, Pfeiffer C, Woodard A, Pasqualini T. Bottomly K: Extent of T-cell receptor ligation can determine the functional differentiation of naive CD4+ T-cells. J Exp Med 182:1591-1596, 1995
12. McCulloch DK, Klaff LJ, Kahn SE, Schoenfeld SL, Greenbaum CJ, Mauseth RS, Benson EA, Nepom GT, Shewey L, Palmer JP: Nonprogression of subclinical β-cell dysfunction among first-degree relatives of IDDM patients: 5-years follow-up of the Seattle Family Study. Diabetes 39:549-556, 1990
13. Wicker LS, Miller BJ, Chai A, Terada M, Mullen Y: Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells: transfer of diabetes and insulitis to non-diabetic (NODxB10) F1 mice with bone marrow cells from NOD mice. J Exp Med 167:1801-1810, 1988
14. Nepom GT: Immunogenetics and IDDM. Diabetes Rev 1:93-103, 1993
15. Caillat-Zucman S, Djilali-Saiah I, Timsit J, Bonifacio E, Sepe V, Collins P, Bottazzo GF, Maclaren N, Delamaire M, Martin S, Yamamoto AM, McWeeney S, Valdez AM, Babron MC, Thorsby E, Clerget-Darpoux F, Thomson G, Bach JF, participating centers: Insulin dependent diabetes mellitus (IDDM): 12th International Histocompatibility Workshop Study. In HLA Genetic Diversity of HLA: Functional and Medical implication: Proceedings of the 12th International Histocompatibility Workshop and Conference. Charron D, Ed. Paris, EDK, 1997, p. 389-398
16. Nepom GT, Erlich H: MHC class II molecules and autoimmunity. Ann Rev Immunol 9:493-525, 1991
17. Sheehy MJ, Scharf SJ, Rowe JR, Neme de Gimenez MH, Meske LM, Erlich HA, Nepom BS: A diabetes-susceptible HLA haplotype is best denned by a combination of HLA-DR and -DQ alleles. J Clin Invest 83:830-835, 1989
18. Kwok WW, Domeier ME, Raymond FC, Byers P, Nepom GT: Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol 156:2171-2177, 1996
19. Nepom BS, Nepom GT, Coleman M, Kwok WW: Critical contribution of β chain residue 57 in peptide binding ability of both HLA DR and DQ molecules. Proc Natl Acad Sci U S A 93:7202-7206, 1996
20. Kwok WW, Domeier ME, Johnson ML, Nepom GT, Koelle DM: HLA-DQB1 codon 57 is critical for peptide binding and recognition. J Exp Med 183:1253-1258, 1996
21. Buckner J, Kwok WW, Nepom B, Nepom GT: Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions. J Immunol 157:4940-4945, 1996
22. g7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156:450-458, 1996
23. Ridgway WM, Fasso M, Lanctot A, Garvey C, Fathman CG: Breaking self-tolerance in nonobese diabetic mice. J Exp Med 183:1657-1662, 1996
24. Kronenberg M: Self-tolerance and autoimmunity. Cell 65:537-542, 1991
25. Liu GY, Fairchild PJ, Smith RM, Prowle JR, Kioussis D, Wraith DC: Low avidity recognition of self-antigen by T-cells permits escape from central tolerance. Immunity 3:407-415, 1995
26. Fairchild PJ, Wildgoose R, Atherton E, Webb S, Wraith DC: An autoantigenic T-cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Int Immunol 5:1151-1158, 1993
27. Ignatowicz L, Rees W, Pacholczyk R, Ignatowicz H. Kushnir E, Kappler J, Marrack P: T-cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity 7:179-186, 1997
28. Dyrberg T: Molecular mimicry between virus proteins and autoantigens in autoimmunity. In The Molecular Biology of Autoimmune Disease. Demaine AG, Banga J-P, McGregor AM, Eds. Berlin, Springer, 1990, p. 181-191
29. Nepom BS, Schwarz D, Palmer JP, Nepom GT: Transcomplementation of HLA genes in IDDM: HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes. Diabetes 36:114-117, 1987
30. Tait BD, Harrison LC, Drummond BP, Stewart V, Varney MD, Honeyman MC: HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol 42:116-122, 1995
31. Valitutti S, Lanzavecchia A: Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition (Review). Immunol Today 18:299-304, 1997
32. Nepom GT: A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes 39:1153-1157, 1990
33. Baisch JM, Weeks T, Giles T, Hoover M, Stastny P, Capra JD: Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 322:1836-1841, 1990
34. Lernmark A, Barmeier H, Dube S, Hagopian W, Karlsen A, Wassmuth R: Autoimmunity of diabetes. Endocrinol Metab Clin 20:589-617, 1991
35. Erlich HA, Zeidler A, Chang J, Shaw S, Raffel LJ, Klitz W, Beshkov Y, Costin G, Pressman S, Bugawan T, Rotter JI: HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat Genet 3:358-364, 1993
36. Schmidt D, Verdaguer J, Averill N, Santamaria P: A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186:1050-1075, 1997
37. Gianani R, Verge CF, Moromisato-Gianani RI, Yu L, Zhang YJ, Pugliese A, Eisenbarth GS: Limited loss of tolerance to islet autoantigens in ICA+ first degree relatives of patients with type I diabetes expressing the HLA dqb 1*0602 allele. J Autoimmun 9:423-425, 1996
38. Uchigata Y, Tokunaga K, Nepom G, Bannai M, Kuwata S, Dozio N, Benson EA, Ronningen KS, Spinas GA, Tadokoro K, Hirata Y, Juji T, Omori Y: Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome. Diabetes 44:1227-1232, 1995