메뉴 건너뛰기




Volumn 36, Issue 1, 2006, Pages 216-223

IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin

Author keywords

Diabetes; IFN ; IL 17; IL 23

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INSULIN; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 23; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 30944455075     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535325     Document Type: Article
Times cited : (72)

References (47)
  • 1
    • 0019981647 scopus 로고
    • Streptozotocin: A review of its pharmacology, efficacy, and toxicity
    • Weiss, R. B., Streptozotocin: a review of its pharmacology, efficacy, and toxicity. Cancer Treat. Rep. 1982. 66: 427-438.
    • (1982) Cancer Treat. Rep. , vol.66 , pp. 427-438
    • Weiss, R.B.1
  • 2
    • 0033842759 scopus 로고    scopus 로고
    • Zinc sulfate induces metallothionein in pancreatic islet of mice and protects against diabetes induced by multiple low doses of streptozotocin
    • Ohly, P., Dohle, C., Abel, J., Seissler, J. and Gleichmann, H., Zinc sulfate induces metallothionein in pancreatic islet of mice and protects against diabetes induced by multiple low doses of streptozotocin. Diabetologia 2000. 43: 1020-1030.
    • (2000) Diabetologia , vol.43 , pp. 1020-1030
    • Ohly, P.1    Dohle, C.2    Abel, J.3    Seissler, J.4    Gleichmann, H.5
  • 3
    • 2442680510 scopus 로고    scopus 로고
    • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin
    • Friesen, N. T. E., Buchau, A. S., Schott-Ohly, P., Lgssiar, A. and Gleichmann, H., Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. Diabetologia 2004. 47: 676-685.
    • (2004) Diabetologia , vol.47 , pp. 676-685
    • Friesen, N.T.E.1    Buchau, A.S.2    Schott-Ohly, P.3    Lgssiar, A.4    Gleichmann, H.5
  • 4
    • 0036700969 scopus 로고    scopus 로고
    • Streptozotocin upregulates GAD67 expression in MIN6N8a mouse beta cells
    • Chol, S. E., Noh, H. L, Kim, H. M., Yoon, J. W. and Kang, Y., Streptozotocin upregulates GAD67 expression in MIN6N8a mouse beta cells. J. Autommun. 2002. 19: 1-8.
    • (2002) J. Autommun. , vol.19 , pp. 1-8
    • Chol, S.E.1    Noh, H.L.2    Kim, H.M.3    Yoon, J.W.4    Kang, Y.5
  • 5
    • 0035985085 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expression glutamic acid decarboxylase
    • Jun, H. S., Chung, H. Y., Han, J., Kim, A., Yoo, S. S., Sherwin, R. S. and Yoon, J. W., Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expression glutamic acid decarboxylase. Diabetologia 2002. 45: 668-676.
    • (2002) Diabetologia , vol.45 , pp. 668-676
    • Jun, H.S.1    Chung, H.Y.2    Han, J.3    Kim, A.4    Yoo, S.S.5    Sherwin, R.S.6    Yoon, J.W.7
  • 7
    • 0027953701 scopus 로고
    • Autommune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin
    • Elias, D., Prigozin, H., Polak, N., Rapoport, M., Lohse, A. W. and Cohen, I. R., Autommune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin. Diabetes 1994. 43: 992-998.
    • (1994) Diabetes , vol.43 , pp. 992-998
    • Elias, D.1    Prigozin, H.2    Polak, N.3    Rapoport, M.4    Lohse, A.W.5    Cohen, I.R.6
  • 8
    • 0242492516 scopus 로고    scopus 로고
    • Lack of the mediators of innate immunity attenuates the development of autoimmune diabetes in mice
    • Lukic, M. L., Mensah-Brown, E., Wei, X., Shahin, A., Liew, F. Y., Lack of the mediators of innate immunity attenuates the development of autoimmune diabetes in mice. J. Autoimmun. 2003. 21: 239-246.
    • (2003) J. Autoimmun. , vol.21 , pp. 239-246
    • Lukic, M.L.1    Mensah-Brown, E.2    Wei, X.3    Shahin, A.4    Liew, F.Y.5
  • 9
    • 0036251665 scopus 로고    scopus 로고
    • Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes
    • Mensah-Brown, E. P., Stosic-Grujicic, S., Maksimovic, D., Jasima, A., Shahin, A. and Lukic, M. L., Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes. Mol. Immunol. 2002. 38: 941-946.
    • (2002) Mol. Immunol. , vol.38 , pp. 941-946
    • Mensah-Brown, E.P.1    Stosic-Grujicic, S.2    Maksimovic, D.3    Jasima, A.4    Shahin, A.5    Lukic, M.L.6
  • 10
    • 0035110543 scopus 로고    scopus 로고
    • Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production
    • Stosic-Grujicic, S., Maksimovic, D., Badovinac, V., Samardzic, T., Trajkovic, V., Lukic, M. L. and Mostarica-Stojkovic, M., Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production. J. Autoimmun. 2001. 16: 47-58.
    • (2001) J. Autoimmun. , vol.16 , pp. 47-58
    • Stosic-Grujicic, S.1    Maksimovic, D.2    Badovinac, V.3    Samardzic, T.4    Trajkovic, V.5    Lukic, M.L.6    Mostarica-Stojkovic, M.7
  • 11
    • 0041820127 scopus 로고    scopus 로고
    • Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes
    • Lamhamedi-Cherradi, S. E., Zheng, S., Tisch, R. M. and Chen, Y. H., Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes 2003. 52: 2274-2278.
    • (2003) Diabetes , vol.52 , pp. 2274-2278
    • Lamhamedi-Cherradi, S.E.1    Zheng, S.2    Tisch, R.M.3    Chen, Y.H.4
  • 12
    • 0042977338 scopus 로고    scopus 로고
    • Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct
    • Nicoletti, F., Di Marco, R., Papaccio, G., Conget, I, Gomis, R., Bernadini, R., Sims, JE. et al., Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct. Eur. J. Immunol. 2003. 33: 2278-2286.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2278-2286
    • Nicoletti, F.1    Di Marco, R.2    Papaccio, G.3    Conget, I.4    Gomis, R.5    Bernadini, R.6    Sims, J.E.7
  • 13
    • 0035865053 scopus 로고    scopus 로고
    • Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent
    • Pechhold, K., Patterson, N. B., Blum, C., Fleischacker, C. L., Boehm, B. O. and Harlan, D. M., Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. J. Immunol. 2001. 166: 2531-2539.
    • (2001) J. Immunol. , vol.166 , pp. 2531-2539
    • Pechhold, K.1    Patterson, N.B.2    Blum, C.3    Fleischacker, C.L.4    Boehm, B.O.5    Harlan, D.M.6
  • 14
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
    • Trinchieri, G., Pflanz, S. and Kastelein, R. A., The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003. 19: 641-644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 15
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri, G., Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003. 3: 133-146.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 16
    • 16244363083 scopus 로고    scopus 로고
    • Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations
    • Sonobe, Y., Yawata, I., Kawanokuchi, J., Takeuchi, H., Mizuno, T. and Suzumura, A., Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Brain Res. 2005. 1040: 202-207.
    • (2005) Brain Res. , vol.1040 , pp. 202-207
    • Sonobe, Y.1    Yawata, I.2    Kawanokuchi, J.3    Takeuchi, H.4    Mizuno, T.5    Suzumura, A.6
  • 17
    • 10244260369 scopus 로고    scopus 로고
    • Immune cells, pancrease development, regeneration and type 1 diabetes
    • Homo-Delarche, F. and Drexhage, H. A., Immune cells, pancrease development, regeneration and type 1 diabetes. Trends Immunol. 2004. 25: 222-229.
    • (2004) Trends Immunol. , vol.25 , pp. 222-229
    • Homo-Delarche, F.1    Drexhage, H.A.2
  • 18
    • 0025104170 scopus 로고
    • Essential contribution of macrophages to islet cell destruction in vivo and in vitro
    • Kolb, H., Burkart, V., Appels, B., Hanenberg, H., Kantwerk-Funke, G., Kiesel, U. et al., Essential contribution of macrophages to islet cell destruction in vivo and in vitro. J. Autoimmun. 1990 Suppl. 1: 117-120.
    • (1990) J. Autoimmun. , Issue.SUPPL. 1 , pp. 117-120
    • Kolb, H.1    Burkart, V.2    Appels, B.3    Hanenberg, H.4    Kantwerk-Funke, G.5    Kiesel, U.6
  • 19
    • 0031686176 scopus 로고    scopus 로고
    • Effector mechanisms in low-dose streptozotocin-induced diabetes
    • Lukic, M. L., Stosic-Grujicic, S., and Shahin, A., Effector mechanisms in low-dose streptozotocin-induced diabetes. Dev. Immunol. 1998. 6: 119-128.
    • (1998) Dev. Immunol. , vol.6 , pp. 119-128
    • Lukic, M.L.1    Stosic-Grujicic, S.2    Shahin, A.3
  • 20
    • 4644287379 scopus 로고    scopus 로고
    • Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expression CD154 on the pancreatic β-cells
    • Haase, C., Skak, K., Michelsen, B. K. and Markholst, H., Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expression CD154 on the pancreatic β-cells. Diabetes 2004. 53: 2588-2595.
    • (2004) Diabetes , vol.53 , pp. 2588-2595
    • Haase, C.1    Skak, K.2    Michelsen, B.K.3    Markholst, H.4
  • 21
    • 2942692039 scopus 로고    scopus 로고
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 1467-1477.
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Oslon, K.3    Toy, P.4    Steinman, R.M.5
  • 22
    • 0029957071 scopus 로고    scopus 로고
    • Inteferon-gamma confers resistance to experimental allergic encephalomyelitis
    • Krakowski, M: and Owens, T., Inteferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 1996. 26: 1641-1646.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 23
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6    Lucian, L.7
  • 28
    • 0025944353 scopus 로고
    • Inhibition of nitric oxide generation affects the induction of diabetes by streptozotocin in mice
    • Lukic, M. L., Stosic-Grujucic, S., Ostojic, N., Chan, W. L. and Liew, F. Y., Inhibition of nitric oxide generation affects the induction of diabetes by streptozotocin in mice. Biochem. Biophys. Res. Commun. 1991. 178: 913-920.
    • (1991) Biochem. Biophys. Res. Commun. , vol.178 , pp. 913-920
    • Lukic, M.L.1    Stosic-Grujucic, S.2    Ostojic, N.3    Chan, W.L.4    Liew, F.Y.5
  • 29
    • 0036251665 scopus 로고    scopus 로고
    • Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes
    • Mensah-Brown, E. P., Stosic-Grujicic, S., Maksimovic, D., Jasima, A., Shahin, A. and Lukic, M. L., Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes. Mol. Immunol. 2002. 38: 941-946.
    • (2002) Mol. Immunol. , vol.38 , pp. 941-946
    • Mensah-Brown, E.P.1    Stosic-Grujicic, S.2    Maksimovic, D.3    Jasima, A.4    Shahin, A.5    Lukic, M.L.6
  • 30
    • 0036068246 scopus 로고    scopus 로고
    • Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production
    • Thomas, H. E., Darwiche, R., Corbett, J. A. and Kay, T. W., Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. Diabetes 2002. 51: 311-316.
    • (2002) Diabetes , vol.51 , pp. 311-316
    • Thomas, H.E.1    Darwiche, R.2    Corbett, J.A.3    Kay, T.W.4
  • 31
    • 0141483042 scopus 로고    scopus 로고
    • Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction
    • Kato, Y., Miura, Y., Yamamoto, N., Ozaki, N. and Oiso, Y., Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction. Diabetologia 2003. 46: 1228-1233.
    • (2003) Diabetologia , vol.46 , pp. 1228-1233
    • Kato, Y.1    Miura, Y.2    Yamamoto, N.3    Ozaki, N.4    Oiso, Y.5
  • 32
    • 0027164671 scopus 로고
    • Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
    • Kleemann, R., Rothe, H., Kolb-Bachofen, V., Xie, Q. W., Nathan, C., Martin, S. and Kolb, H., Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett. 1993. 328: 9-12.
    • (1993) FEBS Lett. , vol.328 , pp. 9-12
    • Kleemann, R.1    Rothe, H.2    Kolb-Bachofen, V.3    Xie, Q.W.4    Nathan, C.5    Martin, S.6    Kolb, H.7
  • 33
    • 0037514387 scopus 로고    scopus 로고
    • IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ
    • Trembleau, S., Penna, G., Gregori, S., Giarratana, N. and Adorini, L., IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ. Immunology 2003. 170: 5491-5501.
    • (2003) Immunology , vol.170 , pp. 5491-5501
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Giarratana, N.4    Adorini, L.5
  • 34
    • 14744284737 scopus 로고    scopus 로고
    • IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naïve T cells in human
    • Eijnden, S. V., Goriely, S., De Wit, D., Willems, F. and Goldman, M., IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naïve T cells in human. Eur. J. Immunol. 2005, 35: 469-475.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 469-475
    • Eijnden, S.V.1    Goriely, S.2    De Wit, D.3    Willems, F.4    Goldman, M.5
  • 35
    • 85069333115 scopus 로고    scopus 로고
    • Role of IL-23 in experimental autoimmune encephalomyelitis: A paradoxical effect
    • (Abstract 247. 5)
    • Gran, B., Touil, T., Chu, N., Yonghai, L., Zhang, G. X. and Rostami, A. M., Role of IL-23 in experimental autoimmune encephalomyelitis: a paradoxical effect. FASEB J. 2005. 19: A 326 (Abstract 247. 5).
    • (2005) FASEB J. , vol.19
    • Gran, B.1    Touil, T.2    Chu, N.3    Yonghai, L.4    Zhang, G.X.5    Rostami, A.M.6
  • 36
    • 13244290058 scopus 로고    scopus 로고
    • IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together
    • Bettelli, E. and Kuchroo, V. K., IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J. Exp. Med. 2005. 201: 169-171.
    • (2005) J. Exp. Med. , vol.201 , pp. 169-171
    • Bettelli, E.1    Kuchroo, V.K.2
  • 37
    • 0032055597 scopus 로고    scopus 로고
    • IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages
    • Jovanovic, D,V., Di Battista, J. A., Marterl-Pelletier, J., Jolicoeur, F.C., He, Y., Zhang, M., Mineau, F. et al., IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J. Immunol. 1998. 160: 3513-3521.
    • (1998) J. Immunol. , vol.160 , pp. 3513-3521
    • Jovanovic, D.V.1    Di Battista, J.A.2    Marterl-Pelletier, J.3    Jolicoeur, F.C.4    He, Y.5    Zhang, M.6    Mineau, F.7
  • 38
    • 0036888372 scopus 로고    scopus 로고
    • Cytokines: Promoters and dampeners of autoimmunity
    • Hill, N. and Sarvetnick, N., Cytokines: promoters and dampeners of autoimmunity. Curr. Opin. Immunol. 2002. 14: 791-797.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 791-797
    • Hill, N.1    Sarvetnick, N.2
  • 39
    • 0035004613 scopus 로고    scopus 로고
    • Dual role of interferon-gamma signaling pathway in sensitivity of pancreatic beta cells to immune destruction
    • Gysemans, C. A., Pavlovic, D., Bouillon, R., Eizirik, D. L. and Mathieu, C., Dual role of interferon-gamma signaling pathway in sensitivity of pancreatic beta cells to immune destruction. Diabetologia 2001. 44: 567-574.
    • (2001) Diabetologia , vol.44 , pp. 567-574
    • Gysemans, C.A.1    Pavlovic, D.2    Bouillon, R.3    Eizirik, D.L.4    Mathieu, C.5
  • 40
    • 26644460214 scopus 로고    scopus 로고
    • Toll-like receptor 3 and STAT-1 contribute for dsRNA+IFN-γ-induced apoptosis in primary pancreatic β-cells
    • Rasschaert, J., Ladrière, L., Irbain, M., Dogusan, Z., Katabua, B., Sata, S., Akira, S. et al., Toll-like receptor 3 and STAT-1 contribute for dsRNA+IFN-γ-induced apoptosis in primary pancreatic β-cells. J. Biol. Chem. 2005. 280: 33984-33991.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33984-33991
    • Rasschaert, J.1    Ladrière, L.2    Irbain, M.3    Dogusan, Z.4    Katabua, B.5    Sata, S.6    Akira, S.7
  • 41
    • 23644437526 scopus 로고    scopus 로고
    • Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β cells
    • Gysemans, C. A., Ladriere, L., Callewaert, H., Rasschaert, J., Flamez, D., Levy, D.E., Matthys, P. et al., Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β cells. Diabetes 2005. 54: 2396-2403.
    • (2005) Diabetes , vol.54 , pp. 2396-2403
    • Gysemans, C.A.1    Ladriere, L.2    Callewaert, H.3    Rasschaert, J.4    Flamez, D.5    Levy, D.E.6    Matthys, P.7
  • 42
    • 1642554789 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase activation by interleukin-17
    • Miljkovic, D. and Trajkovic, V., Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev. 2004, 15: 21-32.
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 21-32
    • Miljkovic, D.1    Trajkovic, V.2
  • 43
    • 0036785194 scopus 로고    scopus 로고
    • Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro
    • Van Bezooijen, R. L., Van Der Wee-Pals, L., Papapoulos, S. E. and Lowik, C. W., Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann. Rheum. Dis. 2002. 61: 870-876.
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 870-876
    • Van Bezooijen, R.L.1    Van Der Wee-Pals, L.2    Papapoulos, S.E.3    Lowik, C.W.4
  • 44
    • 14944354879 scopus 로고    scopus 로고
    • Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1
    • Koenders, M. I., Lubberts, E., Oppers-Walgreen, B., van den Bersselaar, L., Helsen, M. M., Kolls, J. K., Joosten, L. A. et al., Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1. Arthritis Rheum. 2005. 52: 975-983.
    • (2005) Arthritis Rheum. , vol.52 , pp. 975-983
    • Koenders, M.I.1    Lubberts, E.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Helsen, M.M.5    Kolls, J.K.6    Joosten, L.A.7
  • 46
    • 0014042613 scopus 로고
    • Method of isolation of intact islets of Langerhans from the rat pancreas
    • Lacy, P. E. and Kostianovsky, M., Method of isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967. 16: 35-39.
    • (1967) Diabetes , vol.16 , pp. 35-39
    • Lacy, P.E.1    Kostianovsky, M.2
  • 47
    • 0016209124 scopus 로고
    • The preparation of, and studies on, free cell suspensions from mouse pancreatic islets
    • Lernmark, A., The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia 1974. 10: 431-438.
    • (1974) Diabetologia , vol.10 , pp. 431-438
    • Lernmark, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.