Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity

Progress in Neurobiology

Volumn 73, Issue 5, 2004, Pages 311-357

  Hegde, Ashok N ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ADENOSINE TRIPHOSPHATASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID DERIVATIVE; APC; BETA 2 ADRENERGIC RECEPTOR; BINDING PROTEIN; CARRIER PROTEIN; CELL ADHESION MOLECULE; CYCLIC AMP; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; HYDROLASE; NEUROTRANSMITTER; PROTEASOME; PROTEIN DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR; UBIQUITIN; VASOPRESSIN RECEPTOR;

ALLELE; ALLOSTERISM; ALPHA HELIX; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; BRAIN MATURATION; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONJUGATION; CRYSTAL STRUCTURE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EUKARYOTE; GENE MUTATION; GENETIC CODE; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HUMAN; HUNTINGTON CHOREA; LYSOSOME; MICROMORPHOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; NERVE CELL PLASTICITY; NEUROBIOLOGY; NEUROMODULATION; NONHUMAN; PARKINSON DISEASE; PHYSARUM POLYCEPHALUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REACTION ANALYSIS; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPATIAL AUTOCORRELATION ANALYSIS; SYNAPSE; TRANSCRIPTION INITIATION;

ANIMALS; HUMANS; NEURONAL PLASTICITY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DENATURATION; SYNAPSES; UBIQUITIN;

EID: 4143112402     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2004.05.005     Document Type: Review

References (362)

1. + channel (H1) by the ubiquitin-protein ligase Nedd4 FEBS Lett. 466 2000 377 380
2. + channel by Nedd4 in Liddle's syndrome J. Clin. Invest. 103 1999 667 673
3. A.Y. Amerik, and M. Hochstrasser Analysis of the deubiquitinating enzymes of the yeast S. cerevisiae Biol. Chem. 9-10 2000 981 992
4. L. Aravind, and E.V. Koonin The U box is a modified RING finger: a common domain in ubiquitination Curr. Biol. 10 2000 R132 134
5. L. Aravind, and C.P. Ponting Homologues of 26S proteasome subunits are regulators of transcription and translation Protein Sci. 7 1998 1250 1254
6. A.K. Azad, T. Tani, N. Shiki, S. Tsuneyoshi, S. Urushiyama, and Y. Ohshima Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe Mol. Biol. Cell 8 1997 825 841
7. M. Babst, D.J. Katzmann, W.B. Snyder, B. Wendland, and S.D. Emr Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body Dev. Cell 3 2002 283 289
8. M. Babst, D.J. Katzmann, E.J. Estepa-Sabal, T. Meerloo, and S.D. Emr ESCRT-III: an endosome-associated heterooligomeric protein complex required for mvb sorting Dev. Cell 3 2002 271 282
9. I. Bach, and H.P. Ostendorff Orchestrating nuclear functions: ubiquitin sets the rhythm Trends Biochem. Sci. 28 2003 189 195
10. C.H. Bailey, and M. Chen Morphological basis of long-term habituation and sensitization in Aplysia Science 220 1983 91 93
11. C.H. Bailey, and M. Chen Morphological aspects of synaptic plasticity in Aplysia. An anatomical substrate for long-term memory Ann. N.Y. Acad. Sci. 627 1991 181 196
12. C.H. Bailey, M. Chen, F. Keller, and E.R. Kandel Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia Science 256 1992 645 649
13. C.H. Bailey, and E.R. Kandel Structural changes accompanying memory storage Annu. Rev. Physiol. 55 1993 397 426
14. C.H. Bailey, P. Montarolo, M. Chen, E.R. Kandel, and S. Schacher Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia Neuron 9 1992 749 758
15. R.T. Baker, and P.G. Board The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily Nucleic Acids Res. 15 1987 443 463
16. R.T. Baker, and P.G. Board The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes Nucleic Acids Res. 19 1991 1035 1040
17. A. Barco, J.M. Alarcon, and E.R. Kandel Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture Cell 108 2002 689 703
18. D. Bartsch, A. Casadio, K.A. Karl, P. Serodio, and E.R. Kandel CREB-1 encodes a nuclear activator, a repressor and a cytoplasmic modulator that together constitute a regulatory unit critical for long-term facilitation in Aplysia Cell 95 1998 1 13
19. N.W. Bays, R.G. Gardner, L.P. Seelig, C.A.P. Joazeiro, and R.Y. Hampton Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation Nature Cell Biol. 3 2001 24 29
20. F.K. Bedford, J.T. Kittler, E. Muller, P. Thomas, J.M. Uren, D. Merlo, W. Wisden, A. Triller, T.G. Smart, and S.J. Moss GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1 Nat. Neurosci. 4 2001 908 916
21. P. Beer-Romero, S. Glass, and M. Rolfe Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells Oncogene 14 1997 595 602
22. N.F. Bence, R.M. Sampat, and R.R. Kopito Impairment of the ubiquitin system by protein aggregation Science 292 2001 1552 1555
23. B. Bercovich, I. Stancovski, A. Mayer, N. Blumenfeld, A. Laszlo, A.L. Schwatz, and A. Ciechanover Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70 J. Biol. Chem. 272 1997 9002 9010
24. V. Bernier-Villamor, D.A. Sampson, M.J. Matunis, and C.D. Lima Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1 Cell 108 2002 345 356
25. T. Biederer, C. Volkwein, and T. Sommer Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway EMBO J. 15 1996 2069 2076
26. T. Biederer, C. Volkwein, and T. Sommer Role of Cue1p in ubiquitination and degradation at the ER surface Science 278 1997 1806 1809
27. Bingol, B.N., Patrick, G.N., Weld, H., Schuman, E.M., 2003. A potential role for ubiquitin-mediated degradation in AMPA receptor recycling and synaptic plasticity. Soc. Neurosci. Abstr. Program No. 230.09.
28. M. Bochtler, M. Ditzel, M. Groll, C. Hartmann, and R. Huber The proteasome Annu. Rev. Biophys. Biomol. Struct. 28 1999 295 317
29. J. Bock, and K. Braun Filial imprinting in domestic chicks is associated with spine pruning in the associative area, dorsocaudal neostriatum Eur. J. Neurosci. 11 1999 2566 2570
30. V. Bonifati, P. Rizzu, M.J. van Baren, O. Schaap, G.J. Breedveld, E. Krieger, M.C. Dekker, F. Squitieri, P. Ibanez, M. Joosse, J.W. van Dongen, N. Vanacore, J.C. van Swieten, A. Brice, G. Meco, C.M. van Duijn, B.A. Oostra, and P. Heutink Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism Science 299 2003 256 259
31. A. Borodovsky, B.M. Kessler, R. Casagrande, H.S. Overkleeft, K.D. Wilkinson, and H.L. Ploegh A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 EMBO J. 20 2001 5187 5196
32. R. Bourtchuladze, B. Frenguelli, J. Blendy, D. Cioffi, G. Shutz, and A.J. Silva Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein Cell 79 1994 59 68
33. O. Bozdagi, W. Shan, H. Tanaka, D.L. Benson, and G.W. Huntley Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation Neuron 28 2000 245 259
34. T.R. Brummelkamp, S.M. Nijman, A.M. Dirac, and R. Bernards Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB Nature 424 2003 797 801
35. P.A. Buchs, and D. Muller Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses Proc. Natl. Acad. Sci. U.S.A. 93 1996 8040 8045
36. M. Burbea, L. Dreier, J.S. Dittman, M.E. Grunwald, and J.M. Kaplan Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans Neuron 35 2002 107 120
37. C. Buttner, S. Sadtler, A. Leyendecker, B. Laube, N. Griffon, H. Betz, and G. Schmalzing Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors J. Biol. Chem. 276 2001 42978 42985
38. P. Calabresi, M. Napolitano, D. Centonze, G.A. Marfia, P. Gubellini, M.A. Teule, N. Berretta, G. Bernardi, L. Frati, M. Tolu, and A. Gilino Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory Eur. J. Neurosci. 12 2000 1002 1012
39. D.S. Campbell, and C.E. Holt Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation Neuron 32 2001 1013 1026
40. R. Carbone, S. Fre, G. Iannolo, F. Belleudi, P. Mancini, P.G. Pelicci, M.R. Torrisi, and P.P. Di Fiore eps15 and eps15R are essential components of the endocytic pathway Cancer Res. 57 1997 5498 5504
41. A. Casadio, K.C. Martin, M. Giustetto, H. Zhu, M. Chen, D. Bartsch, C.H. Bailey, and E.R. Kandel A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis Cell 99 1999 221 237
42. D. Centonze, M. Napolitano, E. Saulle, P. Gubellini, B. Picconi, A. Martorana, A. Pisani, A. Gulino, G. Bernardi, and P. Calabresi Tissue plasminogen activator is required for corticostriatal long-term potentiation Eur. J. Neurosci. 16 2002 713 721
43. D. Chain, A.N. Hegde, N. Yamamoto, B. Liu-Marsh, and J.H. Schwartz Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia J. Neurosci. 15 1995 7592 7603
44. D.G. Chain, A. Casadio, S. Schacher, A.N. Hegde, M. Valbrun, Y. Yamamoto, A.L. Goldberg, D. Bartsch, E.R. Kandel, and J.H. Schwartz Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia Neuron 22 1999 1 10
45. C. Chen, and S. Tonegawa Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain Annu. Rev. Neurosci. 20 1997 157 184
46. H. Chen, S. Fre, V.I. Slepnev, M.R. Capua, K. Takei, M.H. Butler, P.P. Di Fiore, and P. De Camilli Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis Nature 394 1998 793 797
47. K. Chaturvedi, P. Bandari, N. Chinen, and R.D. Howells Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptors J. Biol. Chem. 276 2001 12345 12355
48. L. Chen, and N.G. Davis Ubiquitin-independent entry into the yeast recycling pathway Traffic 3 2002 110 123
49. L.S. Chin, J.P. Vavalle, and L. Li Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation J. Biol. Chem. 277 2002 35071 35079
50. A. Ciechanover, and P. Brundin The ubiquitin proteasome system in neurodegenerative diseases. Sometimes the chicken, sometimes the egg Neuron 40 2003 427 446
51. A. Ciechanover, J.A. DiGiuseppe, B. Bercovich, A. Orian, J.D. Richter, A.L. Schwartz, and G.M. Brodeur Degradation of nuelar oncoproteins by the ubiquitin sytem in vitro Proc. Natl. Acad. Sci. U.S.A. 88 1991 139 143
52. M. Colledge, E.M. Snyder, R.A. Crozier, J.A. Soderling, Y. Jin, L.K. Langeberg, H. Lu, M.F. Bear, and J.D. Scott Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression Neuron 40 2003 595 607
53. S. Confalonieri, A.E. Salcini, C. Puri, C. Tacchetti, and P.P. Di Fiore Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis J. Cell Biol. 150 2000 905 912
54. M.R. Cookson Pathways to Parkinsonism Neuron 37 2003 7 10
55. G.A. Cope, G.S. Suh, L. Aravind, S.E. Schwarz, S.L. Zipursky, E.V. Koonin, and R.J. Deshaies Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 Science 298 2002 608 611
56. O. Coux, K. Tanaka, and A.L. Goldberg Structure and functions of the 20 S and 26 S proteasome Annu. Rev. Biochem. 65 1996 801 847
57. F. Crick Memory and molecular turnover Nature 312 1984 101
58. A. D'Andrea, and D. Pellman Deubiquitinating enzymes: a new class of biological regulators Crit. Rev. Biochem. Mol. Biol. 33 1998 332 337
59. P.K. Dash, B. Hochner, and E.R. Kandel Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation Nature 345 1990 718 721
60. G.W. Davis, C.M. Schuster, and C.S. Goodman Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity Neuron 17 1996 669 679
61. A. Davy, P. Bello, N. Thierry-Mieg, P. Vagilo, J. Hitti, L. Doucette-Stamm, D. Thierry-leg, J. Reboul, S. Boulton, A.J.M. Walhout, O. Coux, and M. Vidal A protein-protein map of the C. elegans 26S proteasome EMBO Rep. 2 2001 821 828
62. S.P. Dawson, J.E. Arnold, N.J. Mayer, S.E. Reynolds, M.A. Billett, C. Gordon, L. Colleaux, P.M. Kloetzel, K. Tanaka, and R.J. Mayer Developmental changes of the 26S proteasome in abdominal intersegmental muscles of Manduca sexta during programmed cell death J. Biol. Chem. 270 1995 1850 1858
63. + channel cell surface expression EMBO J. 20 2001 7052 7059
64. J. Demand, S. Alberti, C. Patterson, and J. Hohfeld Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling Curr. Biol. 11 2001 1569 1577
65. G.N. DeMartino, C.R. Moomaw, O.P. Zagnitko, R.J. Proske, C.P. Ma, S.J. Afendis, J.C. Swaffield, and C.A. Slaughter PA700, an ATP-dependent activator of the 20S proteasome, is an ATPase containing multiple members of a nucleotide binding protein family J. Biol. Chem. 269 1994 20878 20884
66. L. Deng, C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z.J. Chen Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain Cell 103 2000 351 361
67. J.B. Denny, J. Polan-Curtain, A. Ghuman, M.J. Wayner, and D.L. Armstrong Calpain inhibitors block long-term potentiation Brain Res. 534 1990 317 320
68. N.L. Desmond, and W.B. Levy Changes in the numerical density of synaptic contacts with long-term potentiation in the hippocampal dentate gyrus J. Comp. Neurol. 253 1986 466 475
69. N.L. Desmond, and W.B. Levy Changes in the postsynaptic density with long-term potentiation in the dentate gyrus J. Comp. Neurol. 253 1986 476 482
70. M. de Virgilio, H. Weninger, and N.E. Ivessa Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome J. Biol. Chem. 273 1998 9734 9743
71. A. DiAntonio, A.P. Haghighi, S.L. Portman, J.D. Lee, A.M. Amaranto, and C.S. Goodman Ubiquitination-dependent mechanisms regulate synaptic growth and function Nature 412 2001 449 452
72. Q. Ding, J.J. Lewis, K.M. Strum, E. Dimayuga, A.J. Bruce-Keller, J.C. Dunn, and J.N. Keller Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival J. Biol. Chem. 277 2002 13935 13942
73. G.A. Dittmar, C.R. Wilkinson, P.T. Jedrzejewski, and D. Finley Role of a ubiquitin-like modification in polarized morphogenesis Science 295 2002 2442 2446
74. W. Dubiel, K. Ferrell, and M. Rechsteiner Subunits of the regulatory complex of the 26S proteasome Mol. Biol. Rep. 21 1995 27 34
75. J. Dubnau, A.S. Chiang, L. Grady, J. Barditch, S. Gossweiler, J. McNeil, P. Smith, F. Buldoc, R. Scott, U. Certa, C. Broger, and T. Tully The staufen/pumilio pathway is involved in Drosophila long-term memory Curr. Biol. 13 2003 286 296
76. J.R. Dyer, F. Manseau, V.F. Castellucci, and W.S. Sossin Serotonin persistently activates the extracellular signal-related kinase in sensory neurons of Aplysia independently of cAMP or protein kinase C Neuroscience 116 2003 13 17
77. M.D. Ehlers Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system Nat. Neurosci. 6 2003 231 242
78. S. Fang, J.P. Jensen, R.L. Ludwig, K.H. Vousden, and A.M. Weissman Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 J. Biol. Chem. 275 2000 8945 8951
79. G. Fenteany, R.F. Standaert, W.S. Lane, S. Choi, E.J. Corey, and S.L. Schreiber Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin Science 268 1995 726 731
80. A. Ferdous, F. Gonzalez, L. Sun, T. Kodadek, and S.A. Johnston The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II Mol. Cell 7 2001 981 991
81. D. Finley, and V. Chau Ubiquitination Annu. Rev. Cell Biol. 7 1991 25 69
82. D. Finley, K. Tanaka, C. Mann, H. Feldmann, M. Hochstrasser, R. Vierstra, S. Johnston, R. Hampton, J. Haber, P. Silver, L. Frontali, P. Thorsness, A. Varshavsky, B. Byers, D. Wolf, S. Jentsch, T. Sommer, W. Baumeister, A. Goldberg, V. Fried, D. Rubin, M. Glickman, and A. Toh-e Unified nomenclature for subunits of the S. cerevisiae proteasome regulatory particle Trends Biochem. Sci. 23 1998 244 245
83. A.G. Foley, B.P. Hartz, H.C. Gallagher, L.C. Ronn, V. Berezin, E. Bock, and C.M. Regan A synthetic peptide ligand of neural cell adhesion molecule (NCAM) IgI domain prevents NCAM internalization and disrupts passive avoidance learning J. Neurochem. 74 2000 2607 2613
84. U. Frey, and R.G. Morris Synaptic tagging and long-term potentiation Nature 385 1997 533 536
85. T. Foroud, E. Siemers, D. Kleindorfer, D.J. Bill, M.E. Hodes, J.A. Norton, P.M. Conneally, and J.C. Christian Cognitive scores in carriers of Huntington's disease gene compared to noncarriers Ann. Neurol. 37 1995 657 664
86. U. Frey, and R.G. Morris Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation Trends Neurosci. 21 1998 181 188
87. U. Frey, and R.G. Morris Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP Neuropharmacology 37 1998 545 552
88. H.Y. Fu, N. Reis, Y. Lee, M.H. Glickman, and R. Vierstra Subunit interaction maps for the regulatory particle of the 26s proteasome and the cop9 signalosome reveal a conserved core structure EMBO J. 20 2001 7096 7107
89. Y. Fujita, G. Krause, M. Scheffner, D. Zechner, H.E. Leddy, J. Behrens, T. Sommer, and W. Birchmeier Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex Nat. Cell Biol. 4 2002 222 231
90. Y. Fukazawa, Y. Saitoh, F. Ozawa, Y. Ohta, K. Mizuno, and K. Inokuchi Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo Neuron 38 2003 447 460
91. J.M. Galan, and M. Peter Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism Proc. Natl. Acad. Sci. U.S.A. 96 1999 9124 9129
92. M.S. Gelman, E.S. Kannegaard, and R.R. Kopito A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator J. Biol. Chem. 277 2002 11709 11714
93. C. Gieffers, B.H. Peters, E.R. Kramer, C.G. Dotti, and J.M. Peters Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons Proc. Natl. Acad. Sci. U.S.A. 96 1999 11317 11322
94. M. Giustetto, A.N. Hegde, K. Si, A. Casadio, K. Inokuchi, W. Pei, E.R. Kandel, and J.H. Schwartz Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse Proc. Natl. Acad. Sci. U.S.A. 100 2003 13680 13685
95. M.H. Glickman, and A. Ciechanover The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol. Rev. 82 2002 373 428
96. M.H. Glickman, D.M. Rubin, O. Coux, I. Wefes, G. Pfeifer, Z. Cjeka, W. Baumeister, V.A. Fried, and D. Finley A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9/Signalosome and eIF3 Cell 94 1998 615 623
97. M.H. Glickman, D.M. Rubin, V.A. Fried, and D. Finley The regulatory particle of the S. cerevisiae proteasome Mol. Cell. Biol. 18 1998 3149 3162
98. A. Globus, and A. Scheibel The effect of visual deprivation on cortical neurons: a Golgi study Exp. Neurol. 19 1967 331 345
99. Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Bhatnagar, A., Meloni, E.G., Wu, N., Ackerson, L.C., Klapstein, G.J., Gajendiran, M., Roth, B.L., Chesselet, M.F., Maidment, N.T., Levine, M.S., Shen, J., 2003. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. (Epub ahead of print).
100. C. Gorbea, D. Taillandier, and M. Rechsteiner Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7 J. Biol. Chem. 275 2000 875 882
101. S.M. Greenberg, V.F. Castellucci, H. Bayley, and J.H. Schwartz A molecular mechanism for long-term sensitization in Aplysia Nature 329 1987 62 65
102. M. Groll, L. Ditzel, J. Lowe, D. Stock, M. Bochtler, H.D. Bartunik, and R. Huber Structure of 20S proteasome from yeast at a 2.4 Angstrom resolution Nature 386 1997 463 471
103. J. Grutzendler, N. Kasthuri, and W.B. Gan Long-term dendritic spine stability in the adult cortex Nature 420 2002 812 816
104. J.F. Habener, C.P. Miller, and M. Vallejo cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator Vitamins Hormones 51 1995 1 57
105. T. Hadari, J.V. Warms, I.A. Rose, and A. Hershko A ubiquitin-C-terminal isopeptidase that acts on polyubiquitin chains: role in protein degradation J. Biol. Chem. 267 1992 719 727
106. K. Haglund, S. Sigismund, S. Polo, I. Szymkiewicz, P.P. Di Fiore, and I. Dikic Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation Nat. Cell Biol. 5 2003 461 466
107. P.M. Handley, M. Mueckler, N.R. Siegel, A. Ciechanover, and A.L. Schwartz Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme, E1 Proc. Natl. Acad. Sci. U.S.A. 88 1991 258 262
108. K.L. Hari, K.R. Cook, and G.H. Karpen The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family Genes Dev. 15 2001 1334 1348
109. M. Hart, J.P. Concordet, I. Lassot, I. Albert, R. del los Santos, H. Durand, C. Perret, B. Rubinfeld, F. Margottin, R. Benarous, and P. Polakis The F-box protein beta-TrCP associates with phosphorylated betaβ-catenin and regulates its activity in the cell Curr. Biol. 9 1999 207 210
110. R. Hartmann-Petersen, K. Tanaka, and K.B. Hendil Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking Arch. Biochem. Biophys. 386 2001 89 94
111. S. Hatakeyama, M. Yada, M. Matsumoto, N. Ishida, and K-I. Nakayama U-box proteins as a new family of ubiquitin-protein ligases J. Biol. Chem. 276 2001 33111 33120
112. H.P. Hauser, M. Bardroff, G. Pyrowolakis, and S. Jentsch A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors J. Cell. Biol. 141 1998 1415 1422
113. A.N. Hegde, and A. DiAntonio Ubiquitin and the synapse Nat. Rev. Neurosci. 3 2002 854 861
114. A.N. Hegde, A.L. Goldberg, and J.H. Schwartz Regulatory subunits of the cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity Proc. Natl. Acad. Sci. U.S.A. 90 1993 7436 7440
115. A.N. Hegde, K. Inokuchi, W. Pei, A. Casadio, M. Ghirardi, D.G. Chain, K.C. Martin, E.R. Kandel, and J.H. Schwartz Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia Cell 89 1997 115 126
116. A.N. Hegde, B.M. Broome, M. Qiang, and J.H. Schwartz Structure and expression of the Aplysia polyubiquitin gene Brain Res. Mol. Brain Res. 76 2000 424 428
117. S.B. Helliwell, S. Losko, and C.A. Kaiser Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease J. Cell. Biol. 153 2001 649 662
118. A. Hengstermann, L.K. Linares, A. Ciechanover, N.J. Whitaker, and M. Scheffner Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells Proc. Natl. Acad. Sci. U.S.A. 98 2001 1218 1223
119. A. Hershko, and A. Ciechanover The ubiquitin system for protein degradation Annu. Rev. Biochem. 61 1992 761 807
120. A. Hershko, and A. Ciechanover The ubiquitin-proteasome pathway Annu. Rev. Biochem. 67 1998 425 479
121. S. Hietanen, S. Lain, E. Krausz, C. Blattner, and D.P. Lane Activation of p53 in cervical carcinoma cells by small molecules Proc. Natl. Acad. Sci. U.S.A. 97 2000 8501 8506
122. M.M. Hiller, A. Finger, M. Schweiger, and D.H. Wolf ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway Science 273 1996 1725 1728
123. 2/M Mol. Cell. Biol. 14 1994 3158 3165
124. M. Hochstrasser There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation Genes Dev. 12 1998 901 907
125. M. Hochstrasser Evolution and function of ubiquitin-like protein-conjugating systems Nature Cell Biol. 2 2000 E153 E157
126. H. Hoelzl, B. Kapelari, J. Kellermann, E. Seemuller, M. Sumegi, A. Udvardy, O. Medalia, J. Sperling, S. Muller, A. Engel, and W. Baumeister The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme J. Cell. Biol. 150 2000 119 130
127. K. Hofmann, and P. Bucher The PCI domain: a common theme in three multi-protein complexes Trends Biochem. Sci. 23 1998 204 205
128. R.M. Hofmann, and C.M. Pickart Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair Cell 96 1999 645 653
129. K. Hofmann, and L. Falquet A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal degradation systems Trends Biochem. Sci. 26 2001 347 350
130. R. Honda, and H. Yasuda Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 EMBO J. 18 1999 22 27
131. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
132. J.M. Huibregtse, M. Scheffner, and P.M. Howley Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53 Mol. Cell. Biol. 13 1993 775 784
133. J.M. Huibregtse, M. Scheffner, S. Beaudenon, and P.M. Howley A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase Proc. Natl. Acad. Sci. U.S.A. 92 1995 2563 2567
134. D.P. Huynh, D.R. Scoles, D. Nguyen, and S.M. Pulst The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI Hum. Mol. Genet. 12 2003 2587 2597
135. W.W. Hwang, S. Venkatasubrahmanyam, A.G. Ianculescu, A. Tong, C. Boone, and H.D. Madhani A conserved RING finger protein required for histone H2B monoubiquitination and cell size control Mol. Cell 11 2003 261 266
136. P.K. Jackson, A.G. Eldridge, E. Freed, L. Frustenthal, J.Y. Hsu, B.K. Kaiser, and J.D.R. Reimann The lore of the RINGS: substrate recognition and catalysis by ubiquitin ligases Trends Cell Biol. 10 2000 429 439
137. N.R. Jana, E.A. Zemskov, G. Wang, and N. Nukina Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release Hum. Mol. Genet. 10 2001 1049 1059
138. E. Jarosch, C. Taxis, C. Volkwein, J. Bordallo, D. Finley, D.H. Wolf, and T. Sommer Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48 Nat. Cell Biol. 4 2002 134 139
139. T.J. Jensen, M.A. Loo, S. Pind, D.B. Williams, A.L. Goldberg, and J.R. Riordan Multiple proteolytic systems, including the proteasome, contribute to CFTR processing Cell 83 1995 129 135
140. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
141. C. Jiang, and E.M. Schuman Regulation and function of local protein synthesis in neuronal dendrites Trends Biochem. Sci. 27 2002 506 513
142. J. Jiang, C.A. Ballinger, Y. Wu, Q. Dai, D.M. Cyr, J. Hohfeld, and C. Patterson CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation J. Biol. Chem. 276 2001 42938 42944
143. Y.H. Jiang, D. Armstrong, U. Albrecht, C.M. Atkins, J.L. Noebels, G. Eichele, J.D. Sweatt, and A.L. Beaudet Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation Neuron 21 1998 799 811
144. C.A. Joazeiro, and A.M. Weissman RING finger proteins: mediators of ubiquitin ligase activity Cell 102 2000 549 552
145. J. Kaminska, B. Gajewska, A.K. Hopper, and T. Zoladek Rsp5p, a new link between the actin cytoskeleton and endocytosis in the yeast Saccharomyces cerevisiae Mol. Cell. Biol. 22 2002 6946 6948
146. E.R. Kandel Cellular insights into behavior and learning Harvey Lect. 73 1979 19 92
147. E.R. Kandel The molecular biology of memory storage: a dialogue between genes and synapses Science 294 2001 1030 1038
148. M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-κB activity Annu. Rev. Immunol. 18 2000 621 663
149. D.J. Katzmann, M. Babust, and S.D. Emr Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I Cell 106 2001 145 155
150. G. Kauselmann, M. Weiler, P. Wulff, S. Jessberger, U. Konietzko, J. Scafidi, U. Staubli, J. Bereiter-Hahn, K. Strebhardt, and D. Kuhl The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity EMBO J. 18 1999 5528 5539
151. H. Kawahara, and H. Yokosawa Cell cycle-dependent change of proteasome distribution during embryonic development of the ascidian Halocynthia roretzi Dev. Biol. 151 1992 27 33
152. H. Kawahara, and H. Yokosawa Intra cellular calcium mobilization regulates the activity of 26 S proteasome during the metaphase-anaphase transition in the ascidian meiotic cell cycle Dev. Biol. 166 1994 623 633
153. S. Keck, R. Nitsch, T. Grune, and O. Ullrich Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease J. Neurochem. 85 2003 115 122
154. J.N. Keller, K.B. Hanni, and W.R. Markesbery Impaired proteasome function in Alzheimer's disease J. Neurochem. 75 2000 436 439
155. A. Khan, A.M. Pepio, and W.S. Sossin Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes J. Neurosci. 21 2001 382 391
156. C.H. Kim, and J.E. Lisman A role of actin filament in synaptic transmission and long-term potentiation J. Neurosci. 19 1999 4314 4324
157. S.A. Kirov, and K.M. Harris Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated Nat. Neurosci. 2 1999 878 883
158. T. Kishino, M. Lalande, and J. Wagstaff UBE3a/E6-AP mutations cause Angelman syndrome Nat. Genet. 15 1997 70 73
159. T. Kitada, S. Asakawa, N. Hattori, H. Matsumine, Y. Yamamura, S. Minoshima, M. Yokochi, Y. Mizuno, and N. Shimizu Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 392 1998 605 608
160. M. Koegl, T. Hoppe, S. Schlenker, H.D. Ulrich, T.U. Mayer, and S. Jentsch A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly Cell 96 1999 635 644
161. D. Kornitzer, and A. Ciechanover Modes of regulation of ubiquitin-mediated protein degradation J. Cell. Physiol. 182 2000 1 11
162. S. Kotani, S. Tugendreich, M. Fujii, P.M. Jorgensen, N. Watanabe, C. Hoog, P. Hieter, and K. Todokoro PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression Mol. Cell 1 1998 371 380
163. A. Kovalenko, C. Chable-Bessia, G. Cantarella, A. Israel, D. Wallach, and G. Courtois The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination Nature 424 2003 801 805
164. S. Lahav-Baratz, V. Sudakin, J.V. Ruderman, and A. Hershko Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase Proc. Natl. Acad. Sci. U.S.A. 92 1995 9303 9307
165. Y.A. Lam, G.N. DeMartino, C.M. Pickart, and R.E. Cohen Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes J. Biol. Chem. 272 1997 28438 28446
166. G. Laroia, R. Cuesta, G. Brewer, and R.J. Schneider Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Science 284 1999 499 502
167. G. Laroia, B. Sarkar, and R.J. Schneider Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs Proc. Natl. Acad. Sci. U.S.A. 99 2002 1842 1846
168. C.N. Larsen, B.A. Krantz, and K.D. Wilkinson Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases Biochemistry 37 1998 3358 3368
169. D.S. Leggett, J. Hanna, A. Borodovsky, B. Crosas, M. Schmidt, R.T. Baker, T. Walz, H. Ploegh, and D. Finley Multiple associated proteins regulate proteasome structure and function Mol. Cell 10 2002 495 507
170. E. Leroy, R. Boyer, G. Auburger, B. Leube, G. Ulm, E. Mezey, G. Harta, M.J. Brownstein, S. Jonnalagada, T. Chernova, A. Dehejia, C. Lavedan, T. Gasser,
171. K.W. Lange, B.J. Sahakian, N.P. Quinn, C.D. Marsden, and T.W. Robbins Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia J. Neurol. Neurosurg. Psychiatr. 58 1995 598 606
172. A.D. Lawrence, B.J. Sahakian, J.R. Hodges, A.E. Rosser, K.W. Lange, and T.W. Robbins Executive and mnemonic functions in early Huntington's disease Brain 119 Pt. 5 1996 1633 1645
173. A.D. Lawrence, J.R. Hodges, A.E. Rosser, A. Kershaw, C. Ffrench-Constant, D.C. Rubinsztein, T.W. Robbins, and B.J. Sahakian Evidence for specific cognitive deficits in preclinical Huntington's disease Brain 121 Pt. 7 1998 1329 1341
174. J.A. Lee, C.S. Lim, S.H. Lee, H. Kim, N. Nukina, and B.K. Kaang Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons J. Neurochem. 85 2003 160 169
175. G. Levkowitz, H. Waterman, E. Zamir, Z. Kam, S. Oved, W.Y. Landon, L. Beguinot, B. Geiger, and Y. Yarden c-Cbl regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor Genes Dev. 12 1998 3663 3674
176. G. Levkowitz, H. Waterman, S.A. Ettenberg, M. Katz, A.Y. Tsygankov, I. Alroy, S. Lavi, K. Iwai, Y. Reiss, A. Ciechanover, S. Lipkowitz, and Y. Yarden Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Mol. Cell 4 1999 1029 1040
177. X. Li, Y. Yang, and J.D. Ashwell TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 Nature 416 2002 345 349
178. D. Liakopoulos, G. Doenges, K. Matuschewski, and S. Jentsch A novel protein modification pathway related to the ubiquitin system EMBO J. 17 1998 2208 2214
179. H.H. Lim, P.Y. Goh, and U. Surana Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast Curr. Biol. 8 1998 231 234
180. H. Lin, A. Keriel, C.R. Morales, N. Bedard, Q. Zhao, P. Hingamp, S. Lefrancois, L. Combaret, and S.S. Wing Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures Mol. Cell. Biol. 20 2000 6568 6578
181. H. Lin, L. Yin, J. Reid, K.D. Wilkinson, and S.S. Wing Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity J. Biol. Chem. 276 2001 20357 20363
182. J. Liu, and J.H. Schwartz The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons Brain Res. 959 2003 68 76
183. J. Lowe, D. Stock, B. Jap, P. Zwickl, W. Baumeister, and R. Huber Crystal structure of the 20S proteasome from the archeon T. acidophilum at 3.4 Angstrom resolution Science 268 1995 533 539
184. X. Long, and L.C. Griffith Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster J. Biol. Chem. 275 2000 40765 40776
185. M. Lopez-Salon, M. Alonso, M.R. Vianna, H. Viola, T. Mello e Souza, I. Izquierdo, J.M. Pasquini, and J.H. Medina The ubiquitin-proteasome cascade is required for mammalian long-term memory formation Eur. J. Neurosci. 14 2001 1820 1826
186. K.L. Lorick, J.P. Jensen, S. Fang, A.M. Ong, S. Hatakeyama, and A.M. Weissman RING finger mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination Proc. Natl. Acad. Sci. U.S.A. 96 1999 11364 11369
187. J. Lotharius, and P. Brundin Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein Nat. Rev. Neurosci. 3 2002 932 942
188. M. Lowndes, and M.G. Stewart Dendritic spine density in the lobus parolfactorius of the domestic chick is increased 24 h after one-trial passive avoidance training. Brain Res. 654 1994 129 136
189. B. Luscher, and C.A. Keller Ubiquitination, proteasomes and GABA(A) receptors Nat. Cell Biol. 3 2001 E232 E233
190. G. Lynch, and M. Baudry The biochemistry of memory: a new and specific hypothesis Science 224 1984 1057 1063
191. R. Madani, S. Hulo, N. Toni, H. Madani, T. Steimer, D. Muller, and J.D. Vassalli Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice EMBO J. 18 1999 3007 3012
192. M. Maletic-Savatic, R. Malinow, and K. Svoboda Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity Science 283 1999 1923 1927
193. F. Margottin, S.P. Bour, H. Durand, L. Selig, S. Benichou, V. Richard, D. Thomas, K. Strebel, and R. Benarous A novel human WD protein, human β-TrCP, that interacts with HIV-1 Vpu, connects CD4 to the ER degradation pathway through an F-box motif Mol. Cell 1 1998 565 574
194. M.D. Marmor, and Y. Yarden Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases Oncogene 23 2004 2057 2070
195. K.C. Martin, A. Casadio, H. Zhu, E. Yaping, J.C. Rose, M. Chen, C.H. Bailey, and E.R. Kandel Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage Cell 91 1997 927 938
196. K.C. Martin, and K.S. Kosik Synaptic tagging - who's it? Nat Rev. Neurosci. 3 2002 813 820
197. Martin, N.P., Lefkowitz, R.J., Shenoy, S.K., 2003. Regulation of V2 vasopressin receptor degradation by agonist promoted Ubiquitination. J. Biol. Chem. (Epub ahead of print).
198. E. Martin-Aparicio, A. Yamamoto, F. Hernandez, R. Hen, J. Avila, and J.J. Lucas Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease J. Neurosci. 21 2001 8772 8781
199. G.G. Mason, R.Z. Murray, D. Pappin, and A.J. Rivett Phosphorylation of ATPase subunits of the 26S proteasome FEBS Lett. 430 1998 269 274
200. L.D. Mastrandrea, J. You, E.G. Niles, and C.M. Pickart E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains J. Biol. Chem. 274 1999 27299 27306
201. T. Matsuura, J.S. Sutcliffe, P. Fang, R.J. Galjaard, Y.H. Jiang, C.S. Benton, J.M. Rommens, and A.L. Beaudet De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome Nat. Genet. 15 1997 74 77
202. J.A. Maupin-Furlow, H.L. Wilson, S.J. Kaczowka, and M.S. Ou Proteasomes in the archaea: from structure to function Front Biosci. 5 2000 D837 D865
203. V. Maytal-Kivity, N. Reis, K. Hofmann, and M.H. Glickman MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function BMC Biochem. 3 2002 28
204. A. Mayer, N.R. Siegel, A.L. Schwartz, and A. Ciechanover Degradation of proteins with acetylated amino termini by the ubiquitin system Science 244 1989 1480 1483
205. M. Mayford, A. Barzilai, F. Keller, S. Schacher, and E.R. Kandel Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia Science 256 1992 638 644
206. B.D. McCabe, S. Hom, H. Aberle, R.D. Fetter, G. Marques, T.E. Haerry, H. Wan, M.B. O'Connor, C.S. Goodman, and A.P. Haghighi Highwire regulates presynaptic BMP signaling essential for synaptic growth Neuron 41 2004 891 905
207. McClellan, A.J., Frydman, J., 2001. Molecular chaperones and the art of recognizing a lost cause. Nat. Cell Biol. 3, E1-E3.
208. A.A. McCracken, and J.L. Brodsky Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD) Bioessays. 25 2003 868 877
209. S.L. McCutchen-Maloney, K. Matsuda, N. Shimbara, D.D. Binns, K. Tanaka, C.A. Slaughter, G.N. DeMartino, and D.P. de Kleijn cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome J. Biol. Chem. 275 2000 18557 18565
210. P.H. McDonald, C.W. Chow, W.E. Miller, S.A. Laporte, M.E. Field, F.T. Lin, R.J. Davis, and R.J. Lefkowitz Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Science 290 2000 1574 1577
211. J.P. McGrath, S. Jentsch, and A. Varshavsky UBAl: an essential yeast gene encoding ubiquitin-activating enzyme EMBO J. 10 1991 227 236
212. G.C. Meacham, C. Patterson, Z. Wenyue, J.M. Younger, and D.M. Cyr The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation Nat. Cell Biol. 3 2001 100 105
213. N. Meiri, T. Masos, K. Rosenblum, R. Miskin, and Y. Dudai Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning Proc. Natl. Acad. Sci. U.S.A. 91 1994 3196 3200
214. R. Mendez, D. Barnard, and J.D. Richter Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction EMBO J. 21 2002 1833 1844
215. F.A. Middleton, K. Mirnics, J.N. Pierri, D.A. Lewis, and P. Levitt Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J. Neurosci. 22 2002 2718 2729
216. J. Miller, A.D. McLachlan, and A. Klug Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes EMBO J. 4 1985 1609 1614
217. N. Mizushima, T. Noda, T. Yoshimori, Y. Tanaka, T. Ishii, M.D. George, D.J. Klionsky, M. Ohsumi, and Y. Ohsumi A protein conjugation system essential for autophagy Nature 395 1998 395 398
218. C. Mladek, K. Guger, and M.T. Hauser Identification and characterization of the ARIADNE gene family in Arabidopsis. A group of putative E3 ligases Plant Physiol. 131 2003 27 40
219. E. Mohr, P. Brouwers, J.J. Claus, U.M. Mann, P. Fedio, and T.N. Chase Visuospatial cognition in Huntington's disease Mov. Disord. 6 1991 127 132
220. S. Mori, C.H. Heldin, and L. Claesson-Welsh Ligand-induced polyubiquitination of the platelet-derived growth factor β-receptor J. Biol. Chem. 267 1992 6429 6434
221. M.C. Morris, P. Kaiser, S. Rudyak, C. Baskerville, M.H. Watson, and S.I. Reed Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast Nature 424 2003 1009 1013
222. A.J. Morton, R.L. Faull, and J.M. Edwardson Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease. Brain Res. Bull. 56 2001 111 117
223. Y. Mosesson, K. Shtiegman, M. Katz, Y. Zwang, G. Vereb, J. Szollosi, and Y. Yarden Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation J. Biol. Chem. 278 2003 21323 21326
224. M.G. Muralidhar, and J.B. Thomas The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes Neuron 11 1993 253 266
225. K.P. Murphy, R.J. Carter, L.A. Lione, L. Mangiarini, A. Mahal, G.P. Bates, S.B. Dunnett, and A.J. Morton Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation J. Neurosci. 20 2000 5115 5123
226. A.M. Musti, M. Treier, and D. Bohmann Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases Science 275 1997 400 402
227. A. Myat, P. Henry, V. McCabe, L. Flintoft, D. Rotin, and G. Tear Drosophila Nedd4, a ubiquitin ligase, is recruited by commissureless to control cell surface levels of the roundabout receptor Neuron 35 2002 447 459
228. M. Nakamura, and Y. Tanigawa Ubiquitin-like polypeptide conjugates to acceptor proteins in concanavalin A- and interferon gamma-stimulated T-cells Biochem. J. 330 1998 683 688
229. H. Nakazawa, and T.H. Murphy Activation of nuclear calcium dynamics by synaptic stimulation in cultured cortical neurons J. Neurochem. 73 1999 1075 1083
230. P. Nash, X. Tang, S. Orlicky, Q. Chen, F.B. Gertler, M.D. Mendenhall, F. Sicheri, T. Pawson, and M. Tyers Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication Nature 414 2001 514 521
231. Z. Nawaz, D.M. Lonard, A.P. Dennis, C.L. Smith, and B.W. O'Malley Proteasome-dependent degradation of the human estrogen receptor Proc. Natl. Acad. Sci. U.S.A. 96 1999 1858 1862
232. M. Nishizawa, K. Okazaki, N. Furuno, N. Watanabe, and N. Sagata The "second-codon rule" and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes EMBO J. 11 1992 2433 2446
233. M. Nishizawa, N. Furuno, K. Okazaki, H. Tanaka, Y. Ogawa, and N. Sagata Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos EMBO J. 12 1993 4021 4027
234. C.E. Oh, R. McMahon, S. Benzer, and M.A. Tanouye bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog J. Neurosci. 14 1994 3166 3179
235. M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, W.J. Chazin, and K.L. Gould Structural insights into the U-box, a domain associated with multi-ubiquitination Nat. Struct. Biol. 10 2003 250 255
236. C.E. Oldham, R.P. Mohney, S.L. Miller, R.N. Hanes, and J.P. O'Bryan The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination Curr. Biol. 12 2002 1112 1116
237. D.D. O'Leary, A.R. Bicknese, J.A. De Carlos, C.D. Heffner, S.E. Koester, L.J. Kutka, and T. Terashima Target selection by cortical axons: alternative mechanisms to establish axonal connections in the developing brain Cold Spring Harb. Symp. Quant. Biol. 55 1990 453 468
238. D.D. O'Leary, and S.E. Koester Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex Neuron 991 1993 10 1006
239. C.U. Onyike, A.H. Lin, and T.W. Abrams Persistence of the interaction of calmodulin with adenylyl cyclase: implications for integration of transient calcium stimuli J. Neurochem. 71 1998 1298 1306
240. A.M. Page, and P. Hieter The anaphase-promoting complex: new substrates and regulators Annu. Rev. Biochem. 68 1999 583 609
241. D.T. Pak, and M. Sheng Targeted protein degradation and synapse remodeling by an inducible protein kinase Science 302 2003 1368 1373
242. D.T. Pak, S. Yang, S. Rudolph-Correia, E. Kim, and M. Sheng Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP Neuron. 31 2001 289 303
243. F.R. Papa, and M. Hochstrasser The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the tre-2 oncogene Nature 366 1993 313 319
244. M. Papa, M.C. Bundman, V. Greenberger, and M. Segal Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons J. Neurosci. 15 1995 1 11
245. J. Parnavelas, A. Globus, and P. Kaups Continuous illumination from birth affects spine density of neurons in the visual cortex of the rat Exp. Neurol. 40 1973 742 747
246. G.N. Patrick, P. Zhou, Y.T. Kwon, P.M. Howley, and L.H. Tsai p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway J. Biol. Chem. 273 1998 24057 24064
247. G.N. Patrick, B. Bingol, H.A. Weld, and E.M. Schuman Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs Curr. Biol. 13 2003 2073 2081
248. C. Patterson A new gun in town: the U box is a ubiquitin ligase domain Sci STKE 116 2002 PE4
249. J.M. Peters, R.W. King, C. Hoog, and M.W. Kirschner Identification of BIME as a subunit of the anaphase-promoting complex Science 274 1996 1199 1201
250. A. Pichler, A. Gast, J.S. Seeler, A. Dejean, and F. Melchior The nucleoporin RanBP2 has SUMO1 E3 ligase activity Cell 108 2002 109 120
251. S.M. Plafker, and I.G. Macara Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2 EMBO J. 19 2000 5502 5513
252. C.M. Pickart, and I.A. Rose Functional heterogeneity of ubiquitin carrier proteins J. Biol. Chem. 260 1985 1573 1581
253. M. Pilon, R. Schekman, and K. Romisch Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation EMBO J. 16 1997 4540 4548
254. R.K. Plemper, S. Bohmler, J. Bordallo, T. Sommer, and D.H. Wolf Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation Nature 388 1997 891 895
255. R.K. Plemper, and D.H. Wolf Retrograde protein translocation: ERADication of secretory proteins in health and disease Trends Biochem. Sci. 24 1999 266 270
256. S. Polo, S. Sigismund, M. Faretta, M. Guidi, M.R. Capua, G. Bossi, H. Chen, P. De Camilli, and P.P. Di Fiore A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins Nature 416 2002 451 455
257. M.H. Polymeropoulos Genetics of Parkinson's disease Ann. NY Acad. Sci. 920 2000 28 32
258. J. Pomerantz, N. Schreiber-Agus, N.J. Liegeois, A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H.W. Lee, C. Cordon-Cardo, and R.A. DePinho The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 Cell 92 1998 713 723
259. V.I. Popov, L.S. Bocharova, and A.G. Bragin Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation Neuroscience 48 1992 45 51
260. R. Puertollano, and J.S. Bonifacino Interactions of GGA3 with the ubiquitin sorting machinery Nat. Cell Biol. 6 2004 244 251
261. Z. Qian, M.E. Gilbert, M.A. Colicos, E.R. Kandel, and D. Kuhl Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation Nature 361 1993 453 457
262. M. Rechsteiner, L. Hoffman, and W. Dubiel The multicatalytic and 26S proteases J. Biol. Chem. 268 1993 6065 6068
263. C.G. Reverte, M.D. Ahearn, and L.E. Hake CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome Dev. Biol. 231 2001 447 458
264. C. Richmond, C. Gorbea, and M. Rechsteiner Specific interactions between ATPase subunits of the 26S proteasome J. Biol. Chem. 272 1997 13403 13411
265. K. Robzyk, J. Recht, and M.A. Osley Rad6-dependent ubiquitination of histone H2B in yeast Science 287 2000 501 504
266. A. Rocca, C. Lamaze, A. Subtil, and A. Dautry-Varsat Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments. Mol. Biol. Cell 12 2001 1293 1301
267. M.S. Rodriguez, C. Gwizdek, R. Haguenauer-Tsapis, and C. Dargemont The HECT ubiquitin ligase Rsp5p is required for proper nuclear export of mRNA in Saccharomyces cerevisiae Traffic 4 2003 566 575
268. J.A. Rosenthal, H. Chen, V.I. Slepnev, L. Pellegrini, A.E. Salcini, P.P. Di Fiore, and P. De Camilli The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module J. Biol. Chem. 274 1999 33959 33965
269. S. Ross, J.L. Best, L.I. Zon, and G. Gill SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization Mol. Cell 10 2002 831 842
270. D. Rotin Regulation of the epithelial sodium channel (ENaC) by accessory proteins Curr. Opin. Nephrol. Hypertens. 9 2000 529 534
271. E. Sakata, Y. Yamaguchi, E. Kurimoto, J. Kikuchi, S. Yokoyama, S. Yamada, H. Kawahara, H. Yokosawa, N. Hattori, Y. Mizuno, K. Tanaka, and K. Kato Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain EMBO Rep. 4 2003 301 306
272. A.E. Salcini, H. Chen, G. Iannolo, P. De Camilli, and P.P. Di Fiore Epidermal growth factor pathway substrate 15, Eps15 Int. J. Biochem. Cell Biol. 31 1999 805 809
273. S.E. Salghetti, M. Muratani, H. Wijnen, B. Futcher, and W.P. Tansey Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis Proc. Natl. Acad. Sci. U.S.A. 97 2000 3118 3123
274. S.E. Salghetti, A.A. Caudy, J.G. Chenoweth, and W.P. Tansey Regulation of transcriptional activation domain function by ubiquitin Science 293 2001 1651 1653
275. A. Sapetschnig, G. Rischitor, H. Braun, A. Doll, M. Schergaut, F. Melchior, and G. Suske Transcription factor Sp3 is silenced through SUMO modification by PIAS1 EMBO J. 21 2002 5206 5215
276. P. Sassone-Corsi Transcription factors responsive to cAMP Annu. Rev. Cell Dev. Biol. 11 1995 355 377
277. K. Saigoh, Y.L. Wang, J.G. Suh, T. Yamanishi, Y. Sakai, H. Kiyosawa, T. Harada, N. Ichihara, S. Wakana, T. Kikuchi, and K. Wada Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice Nat. Genet. 23 1999 47 51
278. K. Satoh, H. Sasajima, K.I. Nyoumura, H. Yokosawa, and H. Sawada Assembly of the 26S proteasome is regulated by phosphorylation of the p45/Rpt6 ATPase subunit Biochemistry 40 2001 314 319
279. A.J. Saurin, K.L.B. Borden, M.N. Boddy, and P.S. Freemont Does this have a familiar RING? Trends Biochem. Sci. 21 1996 208 214
280. S. Schacher, and P.G. Montarolo Target-dependent structural changes in sensory neurons of Aplysia accompany long-term heterosynaptic inhibition Neuron 6 1991 679 690
281. E.M. Schuman Neurotrophin regulation of synaptic transmission Curr. Opin. Neurobiol. 9 1999 105 109
282. C.M. Schuster, G.W. Davis, R.D. Fetter, and C.S. Goodman Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity Neuron 17 1996 655 667
283. Schwartz, J.H., 2003. Ubiquitination, protein turnover, and long-term synaptic plasticity. Sci STKE. 26.
284. D.C. Schwartz, and M. Hochstrasser A superfamily of protein tags: ubiquitin. SUMO and related modifiers Trends Biochem. Sci. 28 2003 321 328
285. M.A. Schwarzschild, R.L. Cole, and S.E. Hyman Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons J. Neurosci. 17 1997 3455 3466
286. 1 to S transition in S. cerevisiae Cell 79 1994 233 244
287. P.M. Scott, P.S. Bilodeau, O. Zhdankina, S.C. Winistorfer, M.J. Hauglund, M.M. Allaman, W.R. Kearney, A.D. Robertson, A.L. Boman, and R.C. Piper GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network Nat. Cell Biol. 6 2004 252 259
288. D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
289. P.F. Shelbourne, N. Killeen, R.F. Hevner, H.M. Johnston, L. Tecott, M. Lewandoski, M. Ennis, L. Ramirez, Z. Li, C. Iannicola, D.R. Littman, and R.M. Myers A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice Hum. Mol. Genet. 8 1999 763 774
290. S.K. Shenoy, and R.J. Lefkowitz Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination J. Biol. Chem. 278 2003 14498 14506
291. S.K. Shenoy, P.H. McDonald, T.A. Kohout, and R.J. Lefkowitz Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin Science 294 2001 1307 1313
292. C.S. Shi, and J.H. Kehrl Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2) J. Biol. Chem. 278 2003 15429 15434
293. H. Shimura, N. Hattori, S.I. Kubo, Y. Mizuno, S. Asakawa, S. Minoshima, N. Shimizu, T.C. Iwai, K. Tanaka, and T. Suzuki Familial Parkinson disease gene product, Parkin, is a ubiquitin-protein ligase Nat. Genet. 25 2000 302 305
294. H. Shimura, M.G. Schlossmacher, N. Hattori, M.P. Frosch, A. Trockenbacher, R. Schneider, Y. Mizuno, K.S. Kosik, and D.J. Selkoe Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease Science 293 2001 263 269
295. M. Shirayama, W. Zachariae, R. Ciosk, and K. Nasmyth The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae EMBO J. 17 1998 1336 1349
296. A. Sobko, H. Ma, and R.A. Firtel Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis Dev. Cell 2 2002 745 756
297. T. Sommer, and S. Jentsch A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum Nature 365 1993 176 179
298. W.S. Sossin Mechanisms for the generation of synapse specificity in long-term memory: the implications of a requirement for transcription Trends Neurosci. 19 1996 215 218
299. P. Soubeyran, K. Kowanetz, I. Szymkiewicz, W.Y. Langdon, and I. Dikic Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors Nature 416 2002 183 187
300. S.D. Speese, N. Trotta, C.K. Rodesch, B. Aravamudan, and K. Broadie The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy Curr. Biol. 13 2003 899 910
301. K. Stade, F. Vogel, I. Schwienhorst, B. Meusser, C. Volkwein, B. Nentwig, R.J. Dohmen, and T. Sommer A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast J. Biol. Chem. 277 2002 49554 49561
302. B.B. Stanfield, and D.D. O'Leary The transient corticospinal projection from the occipital cortex during the postnatal development of the rat J. Comp. Neurol. 238 1985 236 248
303. E.N. Star, D.J. Kwiatkowski, and V.N. Murthy Rapid turnover of actin in dendritic spines and its regulation by activity Nat. Neurosci. 5 2002 239 246
304. + channel (ENaC) by ubiquitination EMBO J. 16 1997 6325 6336
305. A.G. Stephen, J.S. Trausch-Azar, A. Ciechanover, and A.L. Schwartz The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner J. Biol. Chem. 271 1996 15608 15614
306. F.J. Stott, S. Bates, M.C. James, B.B. McConnell, M. Starborg, S. Brookes, I. Palmero, K. Ryan, E. Hara, K.H. Vousden, and G. Peters The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2 EMBO J. 17 1998 5001 5014
307. S. Swaminathan, A.Y. Amerik, and M. Hochstrasser The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast Mol. Biol. Cell 10 1999 2583 2594
308. J. Swindle, J. Ajioka, H. Eisen, B. Sanwal, C. Jacquemot, Z. Browder, and G. Buck The genomic organization and transcription of the ubiquitin genes of Trypanosoma cruzi EMBO J. 7 1988 1121 1127
309. K. Takayanagi, S. Dawson, S.E. Reynolds, and R.J. Mayer Specific developmental changes in the regulatory subunits of the 26 S proteasome in intersegmental muscles preceding eclosion in Maduca sexta Biochem. Biophys. Res. Commun. 228 1996 517 523
310. N. Tamura, F. Lottspeich, W. Baumeister, and T. Tamura The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation Cell 95 1998 637 648
311. H. Tanaka, W. Shan, G.R. Phillips, K. Arndt, O. Bozdagi, L. Shapiro, G.W. Huntley, D.L. Benson, and D.R. Colman Molecular modification of N-cadherin in response to synaptic activity Neuron 25 2000 93 107
312. J. Terrell, S.C. Shih, R. Dunn, and L. Hicke A function for monoubiquitination in the internalization of a G protein-coupled receptor Mol. Cell 1 1998 193 202
313. J.S. Thrower, L. Hoffman, M. Rechsteiner, and C.M. Pickart Recognition of the polyubiquitin proteolytic signal EMBO J. 19 2000 94 102
314. T. Tokumoto Nature and role of proteasome in fish oocytes Int. Rev. Cytol. 186 1999 261 294
315. J.T. Trachtenberg, B.E. Chen, G.W. Knott, G. Feng, J.R. Sanes, E. Welker, and K. Svoboda Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex Nature 20 2002 788 794
316. M. Traidej, L. Chen, D. Yu, S. Agrawal, and J. Chen The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells Antisense. Nucleic Acid Drug Dev. 10 2000 17 27
317. E. Trompouki, E. Hatzivassiliou, T. Tsichritzis, H. Farmer, A. Ashworth, and G. Mosialos CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members Nature 424 2003 793 796
318. C.T. Turner, F. Du, and A. Varshavsky Peptides accelerate their uptake by activating ubiquitin-dependent proteolytic pathway Nature 405 2000 579 583
319. M. Tyers, and A.R. Willems One RING to rule a superfamily of E3 ubiquitin ligases Science 284 1999 901 904
320. S.C. Upadhya, and A.N. Hegde A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins Trends Biochem. Sci. 28 2003 280 283
321. Upadhya, S.C., Smith, T.K., Bonsignore, C., Schacher, S., Hegde, A.N., 2002. Induction of a nuclear proteasome regulator critical for long-term memory. Soc. Neurosci. Abstr. 28, Program No. 413.4.
322. Upadhya, S.C., Smith, T.K., Denton, Z.W., Hegde, A.N., 2003. Differential nuclear and synaptic expression of proteasome subunits: relevance to synapse-specific plasticity. Soc. Neurosci. Abstr. 29, Program No. 230.4.
323. Upadhya S.C., Smith T.K., Hegde, A.N., 2004. Ubiquitin-Proteasome- Mediated CREB Repressor Degradation during Induction of Long-Term Facilitation, J. Neurochem., in press.
324. T. Utsugi, A. Hirata, Y. Sekiguchi, T. Sasaki, A. Toh-e, and Y. Kikuchi Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures Gene 234 1999 285 295
325. F. Valverde Apical dendritic spines of the visual cortex and light deprivation in the mouse Exp. Brain Res. 3 1967 337 352
326. F. Valverde Rate and extent of recovery from dark rearing in the visual cortex of the mouse Brain Res. 33 1971 1 11
327. P. van Kerkhof, R. Govers, C.M. Alves dos Santos, and G.J. Strous Endocytosis and degradation of the growth hormone receptor are proteasome-dependent J. Biol. Chem. 275 2000 1575 1580
328. P. van Kerkhof, C.M. Alves dos Santos, M. Sachse, J. Klumperman, G. Bu, and G.J. Strous Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins Mol. Biol. Cell 12 2001 2556 2566
329. F.W. Van Leeuwen, D.P. de Kleijn, H.H. van den Hurk, A. Neubauer, M.A. Sonnemans, J.A. Sluijs, S. Koycu, R.D.J. Ramdjielal, A. Salehi, G.J.M. Martens, F.G. Grosveld, J. Peter, H. Burbach, and E.M. Hol Frameshift mutants of β-amyloid precursor protein and ubiquitin-B in Alzheimer's and Down's patients Science 279 1998 242 247
330. 1 Cdk required for its degradation and entry into S phase Science 278 1997 455 460
331. A. Vecchione, A. Marchese, P. Henry, D. Rotin, and A. Morrione The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor Mol. Cell. Biol. 23 2003 3363 3372
332. R. Verma, S. Chen, R. Feldman, D. Schieltz, J. Yates, J. Dohmen, and R.J. Deshaies Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes Mol. Biol. Cell 11 2000 3425 3439
333. R. Visintin, S. Prinz, and A. Amon CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis Science 278 1997 460 463
334. N. von der Lehr, S. Johansson, S. Wu, F. Bahram, A. Castell, C. Cetinkaya, P. Hydbring, I. Weidung, K. Nakayama, K.I. Nakayama, O. Soderberg, T.K. Kerppola, and L.G. Larsson The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription Mol. Cell 11 2003 1189 1200
335. D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, M.S. Wolfe, M.J. Rowan, and D.J. Selkoe Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535 539
336. H.I. Wan, A. DiAntonio, R.D. Fetter, K. Bergstrom, R. Strauss, and C.S. Goodman Highwire regulates synaptic growth in Drosophila Nature 26 2000 313 329
337. C. Wang, L. Deng, M. Hong, G.R. Akkaraju, I.J. Inoue, and Z.J. Chen Tak1 is a ubiquitin-dependent kinase of MKK and IKK Nature 412 2001 346 351
338. R.J. Watts, E.D. Hoopfer, and L. Luo Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system Neuron 38 2003 871 885
339. E.D. Werner, J.L. Brodsky, and A.A. McCracken Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate Proc. Natl. Acad. Sci. U.S.A. 93 1996 13797 13801
340. T.C. Wheeler, L.S. Chin, Y. Li, F.L. Roudabush, and L. Li Regulation of synaptophysin degradation by mammalian homologues of seven in absentia J. Biol. Chem. 277 2002 10273 10282
341. K.D. Wilkinson Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome Semin. Cell Dev. Biol. 11 2000 141 148
342. K.D. Wilkinson, S. Deshpande, and C.N. Larsen Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases Biochem. Soc. Trans. 20 1992 631 637
343. K.D. Wilkinson, V.L. Tashayev, L.B. O'Connor, C.N. Larsen, E. Kasperek, and C.M. Pickart Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T Biochemistry 34 1995 14535 14546
344. C.L. Ward, S. Omura, and R.R. Kopito Degradation of CFTR by the ubiquitin-proteasome pathway Cell 83 1995 121 127
345. E.J. Wiertz, D. Tortorella, M. Bogyo, J. Yu, W. Mothes, T.R. Jones, T.A. Rapoport, and H.L. Ploegh Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction Nature 384 1996 432 438
346. S.M. Wilson, B. Bhattacharyya, R.A. Rachel, V. Coppola, L. Tessarollo, D.B. Householder, C.F. Fletcher, R.J. Miller, N.G. Copeland, and N.A. Jenkins Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease Nat. Genet. 32 2002 420 425
347. S.S. Wing Deubiquitinating enzymes - the importance of driving in reverse along the ubiquitin-proteasome pathway Int. J. Biochem. Cell Biol. 35 2003 590 605
348. E.S. Wong, C.W. Fong, J. Lim, P. Yusoff, B.C. Low, W.Y. Langdon, and G.R. Guy Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling EMBO J. 21 2002 4796 4808
349. A. Wood, N.J. Krogan, J. Dover, J. Schneider, J. Heidt, M.A. Boateng, K. Dean, A. Golshani, Y. Zhang, J.F. Greenblatt, M. Johnston, and A. Shilatifard Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter Mol. Cell 11 2003 267 274
350. H. Yamada, K. Kumada, and M. Yanagida Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast J. Cell Sci. 110 1997 1793 1804
351. Y. Yamamoto, A.N. Hegde, D.G. Chain, and J.H. Schwartz Activation and degradation of the transcription factor C/EBP during long-term facilitation in Aplysia J. Neurochem. 73 1999 2415 2423
352. H. Yamano, J. Gannon, and T. Hunt The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe EMBO J. 15 1996 5268 5279
353. Y. Yang, K. Fruh, K. Ahn, and P.A. Peterson In vivo assembly of the proteasomal complexes, implications for antigen processing J. Biol. Chem. 270 1995 27687 27694
354. T. Yao, and R.E. Cohen Giant proteases: beyond the proteasome Curr. Biol. 9 1999 R551 553
355. A. Yaron, A. Hatzubai, M. Davis, I. Lavon, S. Amit, A.M. Manning, J.S. Andersen, M. Mann, F. Mercurio, and Y. Ben-Neriah Identification of the receptor component of the IkB-ubiquitin ligase Nature 396 1998 590 594
356. J.C. Yin, J.S. Wallach, M. Del Vecchio, E.L. Wilder, H. Zhou, W.G. Quinn, and T. Tully Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila Cell 79 1994 49 58
357. H. Yu, J.M. Peters, R.W. King, A.M. Page, P. Hieter, and M.W. Kirschner Identification of a cullin homology region in a subunit of the anaphase-promoting complex Science 279 1998 1219 1222
358. A. Yu, and T.R. Malek The proteasome regulates receptor-mediated endocytosis of interleukin-2 J. Biol. Chem. 276 2001 381 385
359. D.M. Zaiss, S. Standera, H. Holzhutter, P. Kloetzel, and A.J. Sijts The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes FEBS Lett. 457 1999 333 338
360. Y. Zhang, J. Gao, K.K. Chung, H. Huang, V.L. Dawson, and T.M. Dawson Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 Proc. Natl. Acad. Sci. U.S.A. 97 2000 13354 13359
361. Y. Zhao, A.N. Hegde, and K.C. Martin The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengthening Curr. Biol. 13 2003 887 898
362. P. Zhou, and P.M. Howley Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases Mol. Cell 2 1998 571 580