Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Journal of Biological Chemistry

Volumn 275, Issue 12, 2000, Pages 8945-8951

  Fang, Shengyun ^a   Jensen, Jane P ^a   Ludwig, Robert L ^b   Vousden, Karen H ^b   Weissman, Allan M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIVALENT CATION; PROTEASOME; PROTEIN MDM2; PROTEIN P53; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; ZINC;

ANIMAL CELL; ARTICLE; CHELATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

ALKYLATION; AMINO ACID SEQUENCE; CHELATING AGENTS; CONSENSUS SEQUENCE; CYSTEINE ENDOPEPTIDASES; LIGASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS; ZINC; ZINC FINGERS;

ANIMALIA; EUKARYOTA;

EID: 0034708458     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.12.8945     Document Type: Article

References (76)

1. Giaccia, A. J., and Kastan, M. B. (1998) Genes Dev. 12, 2973-2983
2. Gottlieb, T. M., and Oren, M. (1998) Semin. Cancer Biol. 8, 359-368
3. Bates, S., and Vousden, K. H. (1999) Cell. Mol. Life Sci. 55, 28-37
4. Prives, C. (1998) Cell 95, 5-8
5. Ashcroft, M., and Vousden, K. H. (1999) Oncogene, 18, 7637-7643
6. Kubbutat, M. H., and Vousden, K. H. (1998) Mol. Med. Today 4, 250-256
7. Kubbutat, M. H., Jones, S. N., and Vousden, K. H. (1997) Nature 387, 299-303
8. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997) Nature 387, 296-299
9. Shieh, S. Y., Taya, Y., and Prives, C. (1999) EMBO J. 18, 1815-1823
10. Unger, T., Juven-Gershon, T., Moallem, E., Berger, M., Vogt Sionov, R., Lozano, G., Oren, M., and Haupt, Y. (1999) EMBO J. 18, 1805-1814
11. Jamal, S., and Ziff, E. B. (1995) Oncogene 10, 2095-2101
12. Meek, D. W., Campbell, L. E., Jardine, L. J., Knippschild, U., McKendrick, L., and Milne, D. M. (1997) Biochem. Soc. Trans. 25, 416-419
13. Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. (1997) Cell 91, 325-334
14. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. (1998) Science 281, 1677-1679
15. Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., and Levine, A. J. (1998) EMBO J. 17, 554-564
16. Tao, W., and Levine, A. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3077-3080
17. Tao, W., and Levine, A. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6937-6941
18. Lain, S., Midgley, C., Sparks, A., Lane, E. B., and Lane, D. P. (1999) Exp. Cell Res. 248, 457-472
19. Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., and Bar-Sagi, D. (1999) Nat. Cell Biol. 1, 22-26
20. Zhang, Y., and Xiong, Y. (1999) Mol. Cell 3, 579-591
21. Sherr, C. J. (1998) Genes Dev. 12, 2984-2991
22. Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., and Roussel, M. F. (1998) Genes Dev. 12, 2424-2433
23. Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., and Vousden, K. H. (1998) Nature 395, 124-125
24. Palmero, I., Pantoja, C., and Serrano, M. (1998) Nature 395, 125-126
25. de Stanchina, E., McCurrach, M. E., Zindy, F., Shieh, S. Y., Ferbeyre, G., Samuelson, A. V., Prives, C., Roussel, M. F., Sherr, C. J., and Lowe, S. W. (1998) Genes Dev. 12, 2434-2442
26. Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z. X., Kumar, S., Howley, P. M., and Livingston, D. M. (1998) Mol. Cell 2, 405-415
27. Hsieh, J. K., Chan, F. S., O'Connor, D. J., Mittnacht, S., Zhong, S., and Lu, X. (1999) Mol. Cell 3, 181-193
28. Sionov, R. V., Moallem, E., Berger, M., Kazaz, A., Gerlitz, O., Ben-Neriah, Y., Oren, M., and Haupt, Y. (1999) J. Biol. Chem. 274, 8371-8374
29. Honda, R., Tanaka, H., and Yasuda, H. (1997) FEBS Lett. 420, 25-27
30. Honda, R., and Yasuda, H. (1999) EMBO J. 18, 22-27
31. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
32. Huibregtse, J. M., Scheffner, M., Beaudenon, S., and Howley, P. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2563-2567
33. Lai, Z., Freedman, D. A., Levine, A. J., and McLendon, G. L. (1998) Biochemistry 37, 7005-7015
34. Kubbutat, M. H., Ludwig, R. L., Levine, A. J., and Vousden, K. H. (1999) Cell Growth Differ. 10, 87-92
35. Mishra, L., Tully, R. E., Monga, S. P., Yu, P., Cai, T., Makalowski, W., Mezey, E., Pavan, W. J., and Mishra, B. (1997) Oncogene 15, 2361-2368
36. Jensen, J. P., Bates, P. W., Yang, M., Vierstra, R. D., and Weissman, A. M. (1995) J. Biol. Chem. 270, 30408-30414
37. Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., and Weissman, A. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11364-11369
38. Scheffner, M., Huibregtse, J. M., and Howley, P. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8797-8801
39. Shumaker, D. K., Vann, L. R., Goldberg, M. W., Allen, T. D., and Wilson, K. L. (1998) Cell Calcium 23, 151-164
40. Boddy, M. N., Freemont, P. S., and Borden, K. L. (1994) Trends Biochem. Sci. 19, 198-199
41. Tyers, M., and Willems, A. R. (1999) Science 284, 601, 603-604
42. Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Moreland, R. J., Iliopoulos, O., Lane, W. S., Kaelin, W. G. J., Elledge, S. J., Conaway, R. C., Harper, J. W., and Conaway, J. W. (1999) Science 284, 657-661
43. Ohta, T., Michel, J. J., Schottelius, A. J., and Xiong, Y. (1999) Mol. Cell 3, 535-541
44. Tan, P., Fuchs, S. Y., Chen, A., Wu, K., Gomez, C., Ronai, Z., and Pan, Z. Q. (1999) Mol. Cell 3, 527-533
45. Seol, J. H., Feldman, R. M., Zachariae, W., Shevchenko, A., Correll, C. C., Lyapina, S., Chi, Y., Galova, M., Claypool, J., Sandmeyer, S., Nasmyth, K., and Deshaies, R. J. (1999) Genes Dev. 13, 1614-1626
46. Lisztwan, J., Imbert, G., Wirbelauer, C., Gstaiger, M., and Krek, W. (1999) Genes Dev. 13, 1822-1833
47. Waterman, H., Levkowitz, G., Alroy, I., and Yarden, Y. (1999) J. Biol. Chem. 274, 22151-22154
48. Borden, K. L., and Freemont, P. S. (1996) Curr. Opin. Struct. Biol. 6, 395-401
49. Saurin, A. J., Borden, K. L., Boddy, M. N., and Freemont, P. S. (1996) Trends Biochem. Sci. 21, 208-214
50. Borden, K. L., Boddy, M. N., Lally, J., O'Reilly, N. J., Martin, S., Howe, K., Solomon, E., and Freemont, P. S. (1995) EMBO J. 14, 1532-1541
51. Kubbutat, M. H., Ludwig, R. L., Ashcroft, M., and Vousden, K. H. (1998) Mol. Cell. Biol. 18, 5690-5698
52. Kwon, Y. T., Reiss, Y., Fried, V. A., Hershko, A., Yoon, J. K., Gonda, D. K., Sangan, P., Copeland, N. G., Jenkins, N. A., and Varshavsky, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7898-7903
53. Zachariae, W., Shevchenko, A., Andrews, P. D., Ciosk, R., Galova, M., Stark, M. J., Mann, M., and Nasmyth, K. (1998) Science 279, 1216-1219
54. Joazeiro, C. A., Wing, S. S., Huang, H., Leverson, J. D., Hunter, T., and Liu, Y. C. (1999) Science 286, 309-312
55. Li, S., Li, Y., Carthew, R. W., and Lai, Z. C. (1997) Cell 90, 469-478
56. Tang, A. H., Neufeld, T. P., Kwan, E., and Rubin, G. M. (1997) Cell 90, 459-467
57. Zhang, J., Guenther, M. G., Carthew, R. W., and Lazar, M. A. (1998) Genes Dev. 12, 1775-1780
58. Hu, G., Zhang, S., Vidal, M., Baer, J. L., Xu, T., and Fearon, E. R. (1997) Genes Dev. 11, 2701-2714
59. Hu, G., and Fearon, E. R. (1999) Mol. Cell. Biol. 19, 724-732
60. Everett, R. D., Freemont, P., Saitoh, H., Dasso, M., Orr, A., Kathoria, M., and Parkinson, J. (1998) J. Virol. 72, 6581-6591
61. Everett, R. D., Earnshaw, W. C., Findlay, J., and Lomonte, P. (1999) EMBO J. 18, 1526-1538
62. Parkinson, J., Lees-Miller, S. P., and Everett, R. D. (1999) J. Virol. 73, 650-657
63. Hampton, R. Y., Gardner, R. G., and Rine, J. (1996) Mol. Biol. Cell 7, 2029-2044
64. Bordallo, J., and Wolf, D. H. (1999) FEBS Lett. 448, 244-248
65. Bailly, V., Lauder, S., Prakash, S., and Prakash, L. (1997) J. Biol. Chem. 272, 23360-23365
66. Roehm, P. C., and Berg, J. M. (1997) Biochemistry 36, 10240-10245
67. Zeng, X., Chen, L., Jost, C. A., Maya, R., Keller, D., Wang, X., Kaelin, W. G. J., Oren, M., Chen, J., and Lu, H. (1999) Mol. Cell. Biol. 19, 3257-3266
68. Dobbelstein, M., Wienzek, S., Konig, C., and Roth, J. (1999) Oncogene 18, 2101-2106
69. Balint, E., Bates, S., and Vousden, K. H. (1999) Oncogene 18, 3923-3929
70. Duprez, E., Saurin, A. J., Desterro, J. M., Lallemand-Breitenbach, V., Howe, K., Boddy, M. N., Solomon, E., de The, H., Hay, R. T., and Freemont, P. S. (1999) J. Cell Sci. 112, 381-393
71. Meza, J. E., Brzovic, P. S., King, M. C., and Klevit, R. E. (1999) J. Biol. Chem. 274, 5659-5665
72. Tanimura, S., Ohtsuka, S., Mitsui, K., Shirouzu, K., Yoshimura, A., and Ohtsubo, M. (1999) FEBS Lett. 447, 5-9
73. Torii, K. U., Stoop-Myer, C. D., Okamoto, H., Coleman, J. E., Matsui, M., and Deng, X. W. (1999) J. Biol. Chem. 274, 27674-27681
74. Kutateladze, T. G., Kenyon, D., Ogburn, K. D., Watson, W. T., Beer, T. D., Emr, S. D., Burd, C. G., and Overduin, M. (1999) Mol. Cell 3, 805-811
75. Freedman, D. A., Wu, L., and Levine, A. J. (1999) Cell. Mol. Life Sci. 55, 96-107
76. Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., and Bradley, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15608-15612