Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor β chain to late endocytic compartments

Molecular Biology of the Cell

Volumn 12, Issue 5, 2001, Pages 1293-1301

  Rocca, A ^a   Lamaze, C ^a   Subtil, A ^a   Dautry Varsat, A ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR BETA; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL GROWTH; CELL SURFACE; CHIMERA; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; ENZYME MECHANISM; HUMAN; HUMAN CELL; LYSOSOME; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR INTRINSIC ACTIVITY; THERMOSTABILITY;

EID: 0034768447     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.5.1293     Document Type: Article

References (44)

1. Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking
2. Structural design and molecular evolution of a cytokine receptor superfamily
3. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
4. The ubiquitin-proteasome pathway: On protein death and cell life
5. A 26 S protease subunit that binds ubiquitin conjugates
6. Down regulation of high affinity interleukin 2 receptors in a human tumor T cell line: IL2 increases the rate of surface receptor decay
7. Receptor mediated endocytosis of interleukin 2 in a human tumor T cell line: Degradation of interleukin 2 and evidence for the absence of recycling of interleukin 2 receptors
8. Autocrine growth stimulation of a human T-cell lymphoma line by IL2
9. Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein
10. Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor
11. Cyclosporin A inhibits the interleukin 2 receptor a chain gene transcription but not its cell surface expression: The α chain stability can explain this discrepancy
12. Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β and γ chains
13. The ubiquitm system
14. Gettin'down with ubiquitin: Turning off cell-surface receptors, transporters and channels
15. Degradation of the met tyrosine kinase receptor by the ubiquitin-proteasome pathway
16. A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1
17. The Gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway
18. Proteasome inhibitors: Valuable new tools for cell biologists
19. Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles
20. Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae
21. Monoubiquitination is sufficient to signal internalization of the maltose transporter in Saccharomyces cerevisiae
22. The IL2 receptor complex: Its structure, function, and target genes
23. Degradation process of ligand-stimulated platelet-derived growth factor β-receptor involves ubiquitin-proteasome proteolytic pathway
24. Endocytosis
25. A di-leucine signal in the ubiquitin moiety
26. Ubiquitination of the PEST-like endocytosis signal of the yeast a-factor
27. Monoubiquitin carries a novel internalization signal that is appended to activated receptors
28. Regulation of stability and function of the epithelial Na-channel (ENaC) by ubiquitination
29. The ubiquitin-proteasome system and endocytosis
30. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor
31. An α-helical signal in the cytosolic domain of the interleukin 2 receptor β chain mediates sorting towards degradation after endocytosis
32. Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited
33. Molecular characterization of the signal responsible for the targeting of the IL2 receptor β chain toward intracellular degradation
34. The interleukin 2 receptor γ chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID
35. A function for monoubiquitination in the internalization of a G protein-coupled receptor
36. Interleukin 2 high-affinity receptors expression requires two distinct binding proteins
37. Recognition of the polyubiquitin proteolytic signal
38. Endocytosis and degradation of the growth hormone receptor are proteasome-dependent
39. Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor γ chain
40. Regulating protein degradation by ubiquitination
41. Only high affinity receptors for interleukin 2 mediate internalization of ligand
42. The endocytic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis
43. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes
44. DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes