Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

Nature Cell Biology

Volumn 5, Issue 5, 2003, Pages 461-466

  Haglund, Kaisa ^a   Sigismund, Sara ^b   Polo, Simona ^b   Szymkiewicz, Iwona ^a   Di Fiore, Pier Paolo ^b,c   Dikic, Ivan ^a,d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYUBIQUITIN; PROTEASOME; TYROSINE KINASE RECEPTOR; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MEMBRANE; CHIMERA; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYSOSOME; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; ENDOCYTOSIS; EUKARYOTIC CELLS; HELA CELLS; HUMANS; LYSOSOMES; MICE; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; UBIQUITIN;

ANIMALIA;

EID: 0038394715     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb983     Document Type: Article

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