Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis

Developmental Cell

Volumn 2, Issue 6, 2002, Pages 745-756

  Sobko, Alex ^a   Ma, Hui ^a   Firtel, Richard A ^a  

^a SECTION OF CELL AND DEVELOPMENTAL BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; LIGASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; UBIQUITIN; UBIQUITIN E3; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL AGGREGATION; CELL NUCLEUS; CHEMICAL MODIFICATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOSOL; DICTYOSTELIUM; ENZYME ACTIVATION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SUMOYLATION; UBIQUITINATION;

DICTYOSTELIUM;

EID: 0036080376     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00186-7     Document Type: Article

References (29)

1. Fluorescence microscopy in three dimensions
2. New clue at the nuclear pore: RanBP2 is an E3 enzyme for SUMO1
3. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
4. Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1
5. SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increase Mdm2 ability to ubiquitinate p53
6. PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis
7. A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation
8. Signaling pathways controlling cell polarity and chemotaxis
9. SUMO-1 modification of IκBα inhibits NF-κB activation
10. Cytoplasmic localization of mitogen-activated protein kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal
11. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
12. Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum
13. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
14. Sp-Ring for SUMO. New functions bloom for a ubiquitin-like protein
15. Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins
16. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
17. The Dictyostelium MAP kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase
18. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
19. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
20. SUMO-nonclassical ubiquitin
21. SUMO, ubiquitin's mysterious cousin
22. High-copy-number transformants and co-transformation in Dictyostelium
23. A cell's sense of direction
24. The nucleoporin RanBP2 has SUMO1 E3 ligase activity
25. Leukocytes navigate by compass: Roles of PI3K-γ and its lipid products
26. The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification
27. Computer-assisted characterization of the behavioral defects of cytoskeletal mutants of Dictyostelium discoideum
28. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κB activation