Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

Molecular Cell

Volumn 2, Issue 5, 1998, Pages 571-580

  Zhou, Pengbo ^a   Howley, Peter M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A MATING FACTOR; A-MATING FACTOR; ANAPHASE PROMOTING COMPLEX; ANAPHASE-PROMOTING COMPLEX; CARRIER PROTEIN; CDC4 PROTEIN, S CEREVISIAE; CDC53 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; CLN2 PROTEIN, YEAST; CULLIN; CYCLIN DEPENDENT KINASE 1; CYCLINE; CYSTEINE PROTEINASE; F BOX PROTEIN; FUNGAL PROTEIN; GRR1 PROTEIN, S CEREVISIAE; HYBRID PROTEIN; HYDROXYUREA; LIGASE; LIPOPROTEIN; MULTIENZYME COMPLEX; NOCODAZOLE; PROTEASOME; S PHASE KINASE ASSOCIATED PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL CYCLE; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HALF LIFE TIME; METABOLISM; MUTATION; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; SERODIAGNOSIS;

CARRIER PROTEINS; CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE; CELL CYCLE PROTEINS; CULLIN PROTEINS; CYCLINS; CYSTEINE ENDOPEPTIDASES; F-BOX PROTEINS; FUNGAL PROTEINS; HALF-LIFE; HYDROXYUREA; LIGASES; LIPOPROTEINS; MULTIENZYME COMPLEXES; MUTATION; NOCODAZOLE; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; S-PHASE KINASE-ASSOCIATED PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 0032215237     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80156-2     Document Type: Article

References (42)

1. Bachmair, A., Finley, D., and Varshavsky, A. (1986). In vivo half-life of a protein is a function of its amino-terminal residue. Science 234, 179-186.
2. Bai, C., Richman, R., and Elledge, S.J. (1994). Human cyclin F. EMBO J. 13, 6087-6098.
3. Bal, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W., and Elledge, S.J. (1996). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
4. Barral, Y., Jentsch, S., and Mann, C. (1995). G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9, 399-409.
5. Deshaies, R.J. (1997). Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast. Curr. Opin. Genet. Dev. 7, 7-16. Erratum: Curr. Opin. Genet. Dev. 7(3), 1997.
6. Deshaies, R.J., Chau, V., and Kirschner, M. (1995). Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14, 303-312.
7. Dieffenbach, C., Dveksler, W., and Gabriela, S. (1995). PCR Primer, a Laboratory Manual (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
8. Drury, L.S., Perkins, G., and Diffley, J.F. (1997). The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16, 5966-5976.
9. Ellison, M.J., and Hochstrasser, M. (1991). Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function. J. Biol. Chem. 266, 21150-21157.
10. Feldman, R.M., Correll, C.C., Kaplan, K.B., and Deshaies, R.J. (1997). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230.
11. Gari, E., Piedrafita, L., Aldea, M., and Herrero, E. (1997). A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae. Yeast 13, 837-848.
12. Goebl, M.G., Goetsch, L., and Byers, B. (1994). The Ubc3 (Cdc34) ubiquitin-conjugating enzyme is ubiquitinated and phosphorylated in vivo. Mol. Cell. Biol. 14, 3022-3029.
13. Harlow, E., and Lane, D. (1988). Antibodies: A Laboratory Manual (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
14. Henchoz, S., Chi, Y., Catarin, B., Herskowitz, I., Deshaies, R.J., and Peter, M. (1997). Phosphorylation-and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev. 11, 3046-3060.
15. Hilt, W., Enenkel, C., Gruhler, A., Singer, T., and Wolf, D.H. (1993). The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress-and ubiquitin-dependent proteolysis. J. Biol. Chem. 268, 3479-3486.
16. Hochstrasser, M. (1996). Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439.
17. Hubbard, E.J., Wu, G., Kitajewski, J., and Greenwald, I. (1997). sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11, 3182-3193.
18. Jallepalli, P. V., and Kelly, T. J. (1996). Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev. 10, 541-552.
19. Jiang, J., and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
20. Johnson, S.L. (1991). Structure and function analysis of the yeast CDC4 gene product. PhD thesis. University of Washington, Seattle, Washington.
21. Kaplan, K.B., Hyman, A.A., and Sorger, P.K. (1997). Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91, 491-500.
22. King, R.W., Deshaies, R.J., Peters, J.M., and Kirschner, M.W. (1996). How proteolysis drives the cell cycle. Science 274, 1652-1659.
23. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W., and Hedgecock, E.M. (1996). cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839.
24. Kominami, K., and Toda, T. (1997). Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev. 11, 1548-1560.
25. Kornitzer, D., Raboy, B., Kulka, R.G., and Fink, G.R. (1994). Regulated degradation of the transcription factor Gcn4. EMBO J. 13, 6021-6030.
26. Li, F.N., and Johnston, M. (1997). Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629-5638.
27. Lisztwan, J., Marti, A., Sutterlüty, H., Gstaiger, M., Wirbelauer, C., and Krek, W. (1998). Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17, 368-383.
28. Margottin, F., Bour, S.P., Durand, H., Selig, L., Benichou, S., Richard, V., Thomas, D., Strebel, K., and Benarous, R. (1998). A novel human WD protein, h-βTrCP, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-Box motif. Mol. Cell 1, 565-574.
29. Mathias, N., Johnson, S.L., Winey, M., Adams, A.E., Goetsch, L., Pringle, J.R., Byers, B., and Goebl, M.G. (1996). Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mol. Cell. Biol. 16, 6634-6643.
30. Mathias, N., Steussy, C.N., and Goebl, M.G. (1998). An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae. J. Biol. Chem. 273, 4040-4045.
31. McKinney, J.D., Chang, F., Heintz, N., and Cross, F.R. (1993). Negative regulation of FAR1 at the start of the yeast cell cycle. Genes Dev. 7, 833-843.
32. Mumberg, D., Muller, R., and Funk, M. (1994). Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22, 5767-5768.
33. Patton, E.E., Willems, A.R., Sa, D., Kuras, L., Thomas, D., Craig, K.L., and Tyers, M. (1998). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692-705.
34. Piatti, S., Bohm, T., Cocker, J.H., Diffley, J.F., and Nasmyth, K. (1996). Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10, 1516-1531.
35. Salama, S.R., Hendricks, K.B., and Thorner, J. (1994). G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol. 14, 7953-7966.
36. Schneider, B.L., Yang, Q.H., and Futcher, A.B. (1996). Linkage of replication to start by the Cdk inhibitor Sic1. Science 272, 560-562.
37. Schwob, E., Bohm, T., Mendenhall, M.D., and Nasmyth, K. (1994). The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244. Erratum: Cell 84(1), 1996.
38. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J., and Harper, J.W. (1997). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
39. Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G., and Deshaies, R.J. (1997). Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455-460.
40. Visintin, R., Prinz, S., and Amon, A. (1997). CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460-463.
41. Willems, A.R., Lanker, S., Patton, E.E., Craig, K.L., Nason, T.F., Mathias, N., Kobayashi, R., Wittenberg, C., and Tyers, M. (1996). Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86, 453-463.
42. Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915-925.