Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

Nature Neuroscience

Volumn 6, Issue 3, 2003, Pages 231-242

  Ehlers, Michael D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; UBIQUITIN;

ANIMAL TISSUE; ARTICLE; BRAIN; CHEMICAL COMPOSITION; CONJUGATION; CONTROLLED STUDY; HIPPOCAMPUS; MAMMAL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION; SYNAPSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYSTEINE ENDOPEPTIDASES; HIPPOCAMPUS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTIC TRANSMISSION; UBIQUITIN;

EID: 0037374587     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1013     Document Type: Article

References (50)

1. Yuste, R. & Bonhoeffer, T. Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu. Rev. Neurosci. 24, 1071-1089 (2001).
2. Luscher, C., Nicoll, R.A., Malenka, R.C. & Muller, D. Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat. Neurosci. 3, 545-550 (2000).
3. Husi, H., Ward, M.A., Choudhary, J.S., Blackstock, W.P. & Grant, S.G. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat. Neurosci. 3, 661-669 (2000).
4. Sheng, M. & Kim, M.J. Postsynaptic signaling and plasticity mechanisms. Science 298, 776-780 (2002).
5. Murthy, V.N., Schikorski, T., Stevens, C.F. & Zhu, Y. Inactivity produces increases in neurotransmitter release and synapse size. Neuron 32, 673-682 (2001).
6. Geinisman, Y., deToledo-Morrell, L. & Morrell, F. Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities. Brain Res. 566, 77-88 (1991).
7. Toni, N., Buchs, P.A., Nikonenko, I., Bron, C.R. & Muller, D. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402, 421-425 (1999).
8. Okabe, S., Kim, H.D., Miwa, A., Kuriu, T. & Okado, H. Continual remodeling of postsynaptic density and its regulation by synaptic activity. Nat. Neurosci. 2, 804-811 (1999).
9. Marrs, G.S., Green, S.H. & Dailey, M.E. Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nat. Neurosci. 4, 1006-1013 (2001).
10. Meyer, T. & Shen, K. In and out of the postsynaptic region: signaling proteins on the move. Trends Cell Biol. 10, 238-244 (2000).
11. Turrigiano, G.G. & Nelson, S.B. Hebb and homeostasis in neuronal plasticity. Curr. Opin. Neurobiol. 10, 358-364 (2000).
12. Rao, A. & Craig, A.M. Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons. Neuron 19, 801-812 (1997).
13. O'Brien, R.J. et al. Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 21, 1067-1078 (1998).
14. Malinow, R. & Malenka, R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103-126 (2002).
15. Thiagarajan, T.C., Piedras-Renteria, E.S. & Tsien, R.W. alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36, 1103-1114 (2002).
16. West, A.E. et al. Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci. USA 98, 11024-11031 (2001).
17. Steward, O. & Schuman, E.M. Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci. 24, 299-325 (2001).
18. Adams, J.P. & Sweatt, J.D. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu. Rev. Pharmacol. Toxicol. 42, 135-163 (2002).
19. Glickman, M.H. & Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82, 373-428 (2002).
20. Hicke, L. Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell. Biol. 2, 195-201 (2001).
21. Hegde, A.N. et al. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115-126 (1997).
22. Jiang, Y.H. et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21, 799-811 (1998).
23. DiAntonio, A. et al. Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412, 449-452 (2001).
24. Wilson, S.M. et al. Synaptic defects in ataxia mice result from a mutation in Usp 14, encoding a ubiquitin-specific protease. Nat. Genet. 7, 7 (2002).
25. Murphey, R. & Godenschwege, T. New roles for ubiquitin in the assembly and function of neuronal circuits. Neuron 36, 5 (2002).
26. Hegde, A.N. & DiAntonio, A. Ubiquitin and the synapse. Nat. Rev. Neurosci. 3, 854-861 (2002).
27. Burbea, M., Dreier, L., Dittman, J.S., Grunwald, M.E. & Kaplan, J.M. Ubiquitin and AP 180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C elegans. Neuron 35, 107-120 (2002).
28. Chapman, A.P., Smith, S.J., Rider, C.C. & Beesley, P.W. Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities. Neurosci. Lett. 168, 238-242 (1994).
29. Cho, K.O., Hunt, C.A. & Kennedy, M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs - large tumor suppressor protein. Neuron 9, 929-942 (1992).
30. Watt, A.J., van Rossum, M.C., MacLeod, K.M., Nelson, S.B. & Turrigiano, G.G. Activity co-regulates quantal AMPA and NMDA currents at neocortical synapses. Neuron 26, 659-670 (2000).
31. Ehlers, M.D. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 28, 511-525 (2000).
32. Boeckers, T.M., Bockmann, J., Kreutz, M.R. & Gundelfinger, E.D. ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J. Neurochem. 81, 903-910 (2002).
33. Liao, D., Zhang, X., O'Brien, R., Ehlers, M.D. & Huganir, R.L. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat. Neurosci. 2, 37-43 (1999).
34. Turrigiano, G.G., Leslie, K.R., Desai, N.S., Rutherford, L.C. & Nelson, S.B. Activity-dependent scaling of quantal amplitude in neocortical neurons. Nature 391, 892-896 (1998).
35. Deveraux, Q., Ustrell, V., Pickart, C. & Rechsteiner, M. A 26 S protease subunit that binds ubiquitin conjugates. J. Biol. Chem. 269, 7059-7061 (1994).
36. Michel, J.J. & Scott, J.D. AKAP mediated signal transduction. Annu. Rev. Pharmacol. Toxicol. 42, 235-257 (2002).
37. Lonze, B.E. & Ginty, D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623 (2002).
38. Lu, W. et al. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29, 243-254 (2001).
39. Hardingham, G.E., Arnold, F.J. & Bading, H. A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat. Neurosci. 4, 565-566 (2001).
40. Hardingham, G.E., Fukunaga, Y. & Bading, H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405-414 (2002).
41. Tovar, K.R. & Westbrook, G.L. Mobile NMDA receptors at hippocampal synapses. Neuron 34, 255-264 (2002).
42. Sala, C., Rudolph-Correia, S. & Sheng, M. Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response elementbinding protein (CREB) in hippocampal neurons. J. Neurosci. 20, 3529-3536 (2000).
43. Akaaboune, M., Culican, S.M., Turney, S.G. & Lichtman, J.W. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science 286, 503-507 (1999).
44. Chain, D.G. et al. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22, 147-156 (1999).
45. Campbell, D.S. & Holt, C.E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32, 1013-1026 (2001).
46. Luscher, C. et al. Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24, 649-658 (1999).
47. Fong, D.K., Rao, A., Crump, F.T. & Craig, A.M. Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II. J. Neurosci. 22, 2153-2164 (2002).
48. Minichiello, L. et al. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 36, 121 (2002).
49. Wu, G.Y., Deisseroth, K. & Tsien, R.W. Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat. Neurosci. 4, 151-158 (2001).
50. Mammen, A.L., Huganir, R.L. & O'Brien, R.J. Redistribution and stabilization of cell surface glutamate receptors during synapse formation. J. Neurosci. 17, 7351-7358 (1997).