Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

Journal of Cell Biology

Volumn 150, Issue 4, 2000, Pages 905-911

  Confalonieri, Stefano ^a,c   Salcini, Anna Elisabetta ^a   Puri, Claudia ^b   Tacchetti, Carlo ^b   Fiore, Pier Paolo Di ^a,c  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Endocytosis; Epidermal growth factor receptor; Eps15; Phosphotyrosine; Transferrin receptor

Indexed keywords

BINDING PROTEIN; CELL MEMBRANE PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; MEMBRANE RECEPTOR; PHOSPHOPEPTIDE; PHOSPHOTYROSINE; TRANSFERRIN RECEPTOR;

ARTICLE; BINDING SITE; ENDOCYTOSIS; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM-BINDING PROTEINS; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; COS CELLS; ENDOCYTOSIS; LIGANDS; MICE; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TRANSFERRIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TYROSINE;

EID: 0034698787     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.4.905     Document Type: Article

References (32)

1. The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2
2. AP-2/Eps15 interaction is required for receptor-mediated endocytosis
3. Inhibition of clathrin-coated pit assembly by an Eps15 mutant
4. Eps15 and eps15R are essential components of the endocytic pathway
5. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
6. Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors
7. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis
8. Eps15, a novel tyrosine kinase substrate, exhibits transforming activity
9. Resolution of multiple endosomal compartments associated with the internalization of epidermal growth factor and transferrin
10. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes
11. Mapping of the molecular determinants involved in the interaction between eps15 and AP-2
12. Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions
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15. The structural era of endocytosis
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24. The EH network
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28. Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization
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