CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation

Cell

Volumn 95, Issue 2, 1998, Pages 211-223

  Bartsch, Dusan ^b   Casadio, Andrea ^b   Karl, Kevin A ^a,b   Serodio, Paulo ^b   Kandel, Eric R ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL; APLYSIA; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FACILITATION; GENE EXPRESSION; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATOR GENE; REPRESSOR GENE; SENSORY NERVE CELL; SEQUENCE HOMOLOGY; SYNAPSE;

EID: 0032538271     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81752-3     Document Type: Article

References (34)

1. Alberini, C.M., Ghirardi, M., Metz, R., and Kandel, E.R. (1994). C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell 76, 1099-1114.
2. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1993). Current Protocols in Molecular Biology (New York: John Wiley and Sons, Inc.).
3. Bailey, C.H., and Chen, M. (1983). Morphological basis of long-term habituation and sensitization in Aplysia. Science 220, 91-93.
4. Bailey, C.H., Bartsch, D., and Kandel, E.R. (1996). Toward a molecular definition of long-term memory storage. Proc. Natl. Acad. Sci. USA 93, 13445-13452.
5. Bartsch, D., Ghirardi, M., Skehel, P.A., Karl, K.A., Herder, S.P., Chen, M., Bailey, C.H., and Kandel, E.R. (1995). Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell 83, 979-992.
6. 2+ - and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-1214.
7. Bliss, T.V., and Collingridge, G.L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
8. Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., and Silva, A.J. (1994). Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79, 59-68.
9. Dash, P.K., Hochner, B., and Kandel, E.R. (1990). Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345, 718-721.
10. Deisseroth, K., Bito, H., and Tsien, R.W. (1996). Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16, 89-101.
11. Fiol, C.J., Williams, J.S., Chou, C.H., Wang, Q.M., Roach, P.J., and Andrisani, O.M. (1994). A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J. Biol. Chem. 269, 32187-32193.
12. Foulkes, N.S., Borrelli, E., and Sassone-Corsi, P. (1991). CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64, 739-749.
13. Galliot, B., Welschof, M., Schuckert, O., Hoffmeister, S., and Schaller, H. (1995). The cAMP response element binding protein is involved in hydra regeneration. Dev. Suppl. 121, 1205-1216.
14. Gonzalez, G.A., Yamamoto, K.K., Fischer, W.H., Karr, D., Menzel, P., Biggs, W., 3rd, Vale, W.W., and Montminy, M.R. (1989). A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337, 749-752.
15. Habener, J.F., Miller, C.P., and Vallejo, M. (1995). cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator. Vitam. Horm. 51, 1-57.
16. Harlow, E., and Lane, D.P. (1988). Antibodies, First Edition (Cold Spring Harbor: Cold Spring Harbor Laboratory Press).
17. Hermanson, O., Gustavsson, J., Stralfors, P., and Blomqvist, A. (1996). Cytoplasmic CREB alpha-like antigens in specific regions of the rat brain. Biochem. Biophys. Res. Commun. 225, 256-262.
18. Hummler, E., Cole, T.J., Blendy, J.A., Ganss, R., Aguzzi, A., Schmid, W., Beermann, F., and Schutz, G. (1994). Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc. Natl. Acad. Sci. USA 91, 5647-5651.
19. Kaang, B.K., Kandel, E.R., and Grant, S.G. (1993). Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron 10, 427-435.
20. Kozak, M. (1986a). Bifunctional messenger RNAs in eukaryotes. Cell 47, 481-483.
21. Kozak, M. (1986b). Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44, 283-292.
22. Martin, K.C., Michael, D., Rose, J.C., Barad, M., Casadio, A., Zhu, H., and Kandel, E.R. (1997). MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron 18, 899-912.
23. Molina, C.A., Foulkes, N.S., Lalli, E., and Sassone-Corsi, P. (1993). Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response represser. Cell 75, 875-886.
24. Montarolo, P.G., Goelet, P., Castellucci, V.F., Morgan, J., Kandel, E.R., and Schacher, S. (1986). A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science 234, 1249-1254.
25. Nguyen, P.V., Abel, T., and Kandel, E.R. (1994). Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265, 1104-1107.
26. Nibuya, M., Nestler, E.J., and Duman, R.S. (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 16, 2365-2372.
27. Ruppert, S., Cole, T.J., Boshart, M., Schmid, E., and Schutz, G. (1992). Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J. 11, 1503-1512.
28. Sun, P., Enslen, H., Myung, P.S., and Maurer, R.A. (1994). Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 8, 2527-2539.
29. Waeber, G., Meyer, T.E., LeSieur, M., Hermann, H.L., Gerard, N., and Habener, J.F. (1991). Developmental stage-specific expression of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol. Endocrinol. 5, 1418-1430.
30. Walker, W.H., Girardet, C., and Habener, J.F. (1996). Alternative exon splicing controls a translational switch from activator to represser isoforms of transcription factor CREB during spermatogenesis. J. Biol. Chem. 271, 20145-21050.
31. Widnell, K.L., Self, D.W., Lane, S.B., Russell, D.S., Vaidya, V.A., Miserendino, M.J., Rubin, C.S., Duman, R.S., and Nestler, E.J. (1996). Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J. Pharmacol. Exp. Ther. 276, 306-315.
32. Yin, J.C., Wallach, J.S., Del Vecchio, M., Wilder, E.L., Zhou, H., Quinn, W.G., and Tully, T. (1994). Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49-58.
33. Yin, J.C., Del Vecchio, M., Zhou, H., and Tully, T. (1995a). CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81, 107-115.
34. Yin, J.C., Wallach, J.S., Wilder, E.L., Klingensmith, J., Dang, D., Perrimon, N., Zhou, H., Tully, T., and Quinn, W.G. (1995b). A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol. Cell. Biol. 15, 5123-5130.