Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

Molecular Cell

Volumn 11, Issue 1, 2003, Pages 267-274

  Wood, Adam ^a   Krogan, Nevan J ^b   Dover, Jim ^c   Schneider, Jessica ^a   Heidt, Jonathan ^a   Boateng, Marry Ann ^a   Dean, Kimberly ^a   Golshani, Ashkan ^a   Zhang, Yi ^d   Greenblatt, Jack F ^b   Johnston, Mark ^c   Shilatifard, Ali ^a,e  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e SAINT LOUIS UNIVERSITY CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2B; HISTONE H3; LIGASE; LYSINE; PROTEIN;

ARTICLE; CATALYST; CHROMATIN; ENZYME SUBSTRATE; FUNGAL STRAIN; GENE EXPRESSION; GENE SILENCING; IMMUNOPRECIPITATION; METHYLATION; NONHUMAN; PROMOTER REGION; TELOMERE;

EID: 0037248944     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00802-X     Document Type: Article

References (34)

1. Bailly V., Lamb J., Sung P., Prakash S., Prakash L. Specific complex formation between yeast RAD6 and RAD18 proteins. a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites Genes Dev. 8:1994;811-820.
2. Briggs S.D., Xiao T., Sun Z.-W., Caldwell J.A., Shabanowitz J., Hunt D.F., Allis C.D., Strahl B.D. Gene silencing. trans-histone regulatory pathway in chromatin Nature. 418:2002;498.
3. Conaway R.C., Brower C.S., Conway J.W. Emerging roles of ubiquitin in transcription regulation. Science. 296:2002;1254-1258.
4. Dover J., Schneider J., Boateng M.A., Wood A., Dean K., Johnston M., Shilatifard A.J. Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. Biol. Chem. 277:2002;28368-28371.
5. He C.H., Masson J.Y., Ramotar D. A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene. Can. J. Microbiol. 42:1996;1263-1266.
6. Heude M., Chanet R., Fabre F. Regulation of the Saccharomyces cerevisiae Srs2 helicase during the mitotic cell cycle, meiosis and after irradiation. Mol. Gen. Genet. 248:1995;59-68.
7. Hishida T., Ohno T., Iwasaki H., Shinagawa H. Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway. EMBO J. 21:2002;2019-2029.
8. Hochstrasser M. All in the ubiquitin family. Science. 289:2000;563-564.
9. Huang H., Kahana A., Gottschling D.E., Prakash L., Liebman S.W. The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:1997;6693-6699.
10. Jentsch S., McGrath J.P., Varshavsky A. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature. 329:1987;131-134.
11. Kamura T., Conrad M.N., Yan Q., Conaway R.C., Conaway J.W. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev. 13:1999;2928-2933.
12. Kang X.L., Yadao F., Gietz R.D., Kunz B.A. Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C→T.A transversions as well as transposition of the Ty element. implications for the control of spontaneous mutation Genetics. 130:1992;285-294.
13. Koken M., Reynolds P., Bootsma D., Hoeijmakers J., Prakash S., Prakash L. Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6. Proc. Natl. Acad. Sci. USA. 88:1991;3832-3836.
14. Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A. COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression. J. Biol. Chem. 277:2002;10753-10755. a.
15. Krogan N.J., Kim M., Ahn S.H., Zhong G., Kobor M.S., Cagney G., Emili A., Shilatifard A., Buratowski S., Greenblatt J.F. RNA polymerase II elongation factors of Saccharomyces cerevisiae. a targeted proteomics approach Mol. Cell. Biol. 22:2002;6979-6992. b.
16. Kupiec M., Simchen G. Regulation of the RAD6 gene of Saccharomyces cerevisiae in the mitotic cell cycle and in meiosis. Mol. Gen. Genet. 203:1986;538-543.
17. Lu Z., Xu S., Joazeiro C., Cobb M.H., Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell. 9:2002;945-956.
18. Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P., Johnston M., Greenblatt J.F., Shilatifard A. Compass. a complex of proteins associated with a trithorax-related set domain protein Proc. Natl. Acad. Sci. USA. 98:2001;12902-12907.
19. Nagy P.L., Griesenbeck J., Kornberg R.D., Cleary M.L. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc. Natl. Acad. Sci. USA. 99:2002;90-94.
20. Ng H.H., Feng Q., Wang H., Erdjument-Bromage H., Tempst P., Zhang Y., Struhl K. Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 16:2002;1518-1527. a.
21. Ng H.H., Xu R.M., Zhang Y., Struhl K. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J. Biol. Chem. 277:2002;34655-34657. b.
22. Nislow C., Ray E., Pillus L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Cell. 8:1997;2421-2436.
23. Oyen M.E., Gunilla M.B., Ronne H. Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast. 18:2001;163-172.
24. Ramotar D., Masson J.Y. Saccharomyces cerevisiae DNA repair processes. an update Mol. Cell. Biochem. 158:1996;65-75.
25. Robzyk K., Recht L., Osley M.A. Rad6-dependent ubiquitination of histone H2B in yeast. Science. 287:2000;501-504.
26. Roguev A., Schaft D., Shevchenko A., Pijnappel W.W., Wilm M., Aasland R., Stewart A.F. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20:2001;7137-7148.
27. Sun Z.W., Allis C.D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature. 418:2002;104-108.
28. Swanson R., Locher M., Hochstrasser M. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation. Genes Dev. 15:2001;2660-2674.
29. Ulrich H.D. The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway. Nucleic Acids Res. 29:2001;3487-3494.
30. Ulrich H.D., Jentsch S. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J. 19:2000;3388-3397.
31. Urnov F.D., Wolffe A.P. Chromatin remodeling and transcriptional activation. the cast (in order of appearance) Oncogene. 20:2001;2991-3006.
32. van Leeuwen F., Gafken P.R., Gottschling D.E. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell. 109:2002;745-756.
33. Wolffe A.P. Transcriptional regulation in the context of chromatin structure. Essays Biochem. 37:2001;45-57.
34. Workman J.L., Kingston R.E. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu. Rev. Biochem. 67:1998;545-579.