메뉴 건너뛰기




Volumn 28, Issue 5, 2007, Pages 648-676

Oxidative stress: A bridge between Down's syndrome and Alzheimer's disease

Author keywords

Antioxidant therapy; Biomarkers; Central nervous system; Down's syndrome; Oxidative stress; Periphery

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BIOLOGICAL MARKER; CAROTENOID; CYANOCOBALAMIN; DONEPEZIL; ESTROGEN; FLAVONOID; FOLIC ACID; GINKGO BILOBA EXTRACT; LEVACECARNINE; MELATONIN; NONSTEROID ANTIINFLAMMATORY AGENT; PIRACETAM; POLYPHENOL; PRASTERONE; PROTEIN; PYRIDOXINE; RIBOFLAVIN; RIVASTIGMINE; SELEGILINE; SUPEROXIDE DISMUTASE; THIOCTIC ACID; UNINDEXED DRUG; VITAMIN; VITAMIN B GROUP;

EID: 33847349325     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.03.008     Document Type: Review
Times cited : (113)

References (384)
  • 1
    • 0025077481 scopus 로고
    • Redox regulation of fos and jun DNA-binding activity in vitro
    • Abate C., Patel L., Rauscher III F.J., and Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science 249 4973 (1990) 1157-1161
    • (1990) Science , vol.249 , Issue.4973 , pp. 1157-1161
    • Abate, C.1    Patel, L.2    Rauscher III, F.J.3    Curran, T.4
  • 2
    • 0032734510 scopus 로고    scopus 로고
    • DNA strand breaks in Alzheimer's disease
    • Adamec E., Vonsattel J.P., and Nixon R.A. DNA strand breaks in Alzheimer's disease. Brain Res 849 1-2 (1999) 67-77
    • (1999) Brain Res , vol.849 , Issue.1-2 , pp. 67-77
    • Adamec, E.1    Vonsattel, J.P.2    Nixon, R.A.3
  • 3
    • 0029147825 scopus 로고
    • No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease
    • Ahlskog J.E., Uitti R.J., Low P.A., Tyce G.M., Nickander K.K., Petersen R.C., et al. No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease. Mov Disord 10 5 (1995) 566-573
    • (1995) Mov Disord , vol.10 , Issue.5 , pp. 566-573
    • Ahlskog, J.E.1    Uitti, R.J.2    Low, P.A.3    Tyce, G.M.4    Nickander, K.K.5    Petersen, R.C.6
  • 4
    • 13244270042 scopus 로고    scopus 로고
    • Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment
    • Ahmed N., Ahmed U., Thornalley P.J., Hager K., Fleischer G., and Munch G. Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment. J Neurochem 92 2 (2005) 255-263
    • (2005) J Neurochem , vol.92 , Issue.2 , pp. 255-263
    • Ahmed, N.1    Ahmed, U.2    Thornalley, P.J.3    Hager, K.4    Fleischer, G.5    Munch, G.6
  • 5
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study
    • Aisen P.S., Davis K.L., Berg J.D., Schafer K., Campbell K., Thomas R.G., et al. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54 3 (2000) 588-593
    • (2000) Neurology , vol.54 , Issue.3 , pp. 588-593
    • Aisen, P.S.1    Davis, K.L.2    Berg, J.D.3    Schafer, K.4    Campbell, K.5    Thomas, R.G.6
  • 6
    • 0037046179 scopus 로고    scopus 로고
    • Randomized pilot study of nimesulide treatment in Alzheimer's disease
    • Aisen P.S., Schmeidler J., and Pasinetti G.M. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 58 7 (2002) 1050-1054
    • (2002) Neurology , vol.58 , Issue.7 , pp. 1050-1054
    • Aisen, P.S.1    Schmeidler, J.2    Pasinetti, G.M.3
  • 7
    • 0034024347 scopus 로고    scopus 로고
    • Oxidative modification of creatine kinase BB in Alzheimer's disease brain
    • Aksenov M., Aksenova M., Butterfield D.A., and Markesbery W.R. Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J Neurochem 74 6 (2000) 2520-2527
    • (2000) J Neurochem , vol.74 , Issue.6 , pp. 2520-2527
    • Aksenov, M.1    Aksenova, M.2    Butterfield, D.A.3    Markesbery, W.R.4
  • 9
    • 0030657456 scopus 로고    scopus 로고
    • Oxidative modification of glutamine synthetase by amyloid β peptide
    • Aksenov M.Y., Aksenova M.V., Carney J.M., and Butterfield D.A. Oxidative modification of glutamine synthetase by amyloid β peptide. Free Radic Res 27 3 (1997) 267-281
    • (1997) Free Radic Res , vol.27 , Issue.3 , pp. 267-281
    • Aksenov, M.Y.1    Aksenova, M.V.2    Carney, J.M.3    Butterfield, D.A.4
  • 10
    • 3142514196 scopus 로고    scopus 로고
    • Oxidative stress in neurodegeneration: cause or consequence?
    • Andersen J.K. Oxidative stress in neurodegeneration: cause or consequence?. Nat Med 10 Suppl (2004) S18-S25
    • (2004) Nat Med , vol.10 , Issue.SUPPL
    • Andersen, J.K.1
  • 11
    • 0034622238 scopus 로고    scopus 로고
    • Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
    • Anderson A.J., Stoltzner S., Lai F., Su J., and Nixon R.A. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiol Aging 21 4 (2000) 511-524
    • (2000) Neurobiol Aging , vol.21 , Issue.4 , pp. 511-524
    • Anderson, A.J.1    Stoltzner, S.2    Lai, F.3    Su, J.4    Nixon, R.A.5
  • 12
    • 27844592673 scopus 로고    scopus 로고
    • Can herbs provide a new generation of drugs for treating Alzheimer's disease?
    • Anekonda T.S., and Reddy P.H. Can herbs provide a new generation of drugs for treating Alzheimer's disease?. Brain Res Brain Res Rev 50 2 (2005) 361-376
    • (2005) Brain Res Brain Res Rev , vol.50 , Issue.2 , pp. 361-376
    • Anekonda, T.S.1    Reddy, P.H.2
  • 13
    • 0034101420 scopus 로고    scopus 로고
    • Nutritional supplementation in Down syndrome: theoretical considerations and current status
    • Ani C., Grantham-McGregor S., and Muller D. Nutritional supplementation in Down syndrome: theoretical considerations and current status. Dev Med Child Neurol 42 3 (2000) 207-213
    • (2000) Dev Med Child Neurol , vol.42 , Issue.3 , pp. 207-213
    • Ani, C.1    Grantham-McGregor, S.2    Muller, D.3
  • 14
    • 0022480830 scopus 로고
    • Increased glutathione peroxidase activity in erythrocytes in patients with Alzheimer's disease/senile dementia of Alzheimer's type
    • Anneren G., Gardner A., and Lundin T. Increased glutathione peroxidase activity in erythrocytes in patients with Alzheimer's disease/senile dementia of Alzheimer's type. Acta Neurol Scand 73 6 (1986) 586-589
    • (1986) Acta Neurol Scand , vol.73 , Issue.6 , pp. 586-589
    • Anneren, G.1    Gardner, A.2    Lundin, T.3
  • 15
    • 0024817022 scopus 로고
    • Increased plasma and erythrocyte selenium concentrations but decreased erythrocyte glutathione peroxidase activity after selenium supplementation in children with Down syndrome
    • Anneren G., Gebre-Medhin M., and Gustavson K.H. Increased plasma and erythrocyte selenium concentrations but decreased erythrocyte glutathione peroxidase activity after selenium supplementation in children with Down syndrome. Acta Paediatr Scand 78 6 (1989) 879-884
    • (1989) Acta Paediatr Scand , vol.78 , Issue.6 , pp. 879-884
    • Anneren, G.1    Gebre-Medhin, M.2    Gustavson, K.H.3
  • 16
    • 0023112696 scopus 로고
    • Lipid peroxidation and superoxide dismutase-1 and glutathione peroxidase activities in trisomy 16 fetal mice and human trisomy 21 fibroblasts
    • Anneren K.G., and Epstein C.J. Lipid peroxidation and superoxide dismutase-1 and glutathione peroxidase activities in trisomy 16 fetal mice and human trisomy 21 fibroblasts. Pediatr Res 21 1 (1987) 88-92
    • (1987) Pediatr Res , vol.21 , Issue.1 , pp. 88-92
    • Anneren, K.G.1    Epstein, C.J.2
  • 17
    • 0025041205 scopus 로고
    • Selenium therapy in Down syndrome (DS): a theory and a clinical trial
    • Antila E., Nordberg U.R., Syvaoja E.L., and Westermarck T. Selenium therapy in Down syndrome (DS): a theory and a clinical trial. Adv Exp Med Biol 264 (1990) 183-186
    • (1990) Adv Exp Med Biol , vol.264 , pp. 183-186
    • Antila, E.1    Nordberg, U.R.2    Syvaoja, E.L.3    Westermarck, T.4
  • 18
    • 0344823703 scopus 로고    scopus 로고
    • Neuroprotection by bioactive components in medicinal and food plant extracts
    • Aruoma O.I., Bahorun T., and Jen L.S. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutat Res 544 2-3 (2003) 203-215
    • (2003) Mutat Res , vol.544 , Issue.2-3 , pp. 203-215
    • Aruoma, O.I.1    Bahorun, T.2    Jen, L.S.3
  • 19
    • 0024393445 scopus 로고
    • Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene
    • Asahara H., Wistort P.M., Bank J.F., Bakerian R.H., and Cunningham R.P. Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene. Biochemistry 28 10 (1989) 4444-4449
    • (1989) Biochemistry , vol.28 , Issue.10 , pp. 4444-4449
    • Asahara, H.1    Wistort, P.M.2    Bank, J.F.3    Bakerian, R.H.4    Cunningham, R.P.5
  • 20
    • 0033003028 scopus 로고    scopus 로고
    • Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study
    • Asthana S., Craft S., Baker L.D., Raskind M.A., Birnbaum R.S., Lofgreen C.P., et al. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology 24 6 (1999) 657-677
    • (1999) Psychoneuroendocrinology , vol.24 , Issue.6 , pp. 657-677
    • Asthana, S.1    Craft, S.2    Baker, L.D.3    Raskind, M.A.4    Birnbaum, R.S.5    Lofgreen, C.P.6
  • 21
    • 29144460127 scopus 로고    scopus 로고
    • A folate-dependent metabolite in amniotic fluid from pregnancies with normal or trisomy 21 chromosomes
    • Baggot P.J., Eliseo A.J., Kalamarides J.A., and Shoemaker J.D. A folate-dependent metabolite in amniotic fluid from pregnancies with normal or trisomy 21 chromosomes. Fetal Diagn Ther 21 1 (2006) 148-152
    • (2006) Fetal Diagn Ther , vol.21 , Issue.1 , pp. 148-152
    • Baggot, P.J.1    Eliseo, A.J.2    Kalamarides, J.A.3    Shoemaker, J.D.4
  • 22
    • 0035226664 scopus 로고    scopus 로고
    • Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease
    • Balcz B., Kirchner L., Cairns N., Fountoulakis M., and Lubec G. Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. J Neural Transmemb 61 Suppl (2001) 193-201
    • (2001) J Neural Transmemb , vol.61 , Issue.SUPPL , pp. 193-201
    • Balcz, B.1    Kirchner, L.2    Cairns, N.3    Fountoulakis, M.4    Lubec, G.5
  • 23
    • 0031899264 scopus 로고    scopus 로고
    • Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging
    • Baldereschi M., Di Carlo A., Lepore V., Bracco L., Maggi S., Grigoletto F., et al. Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Neurology 50 4 (1998) 996-1002
    • (1998) Neurology , vol.50 , Issue.4 , pp. 996-1002
    • Baldereschi, M.1    Di Carlo, A.2    Lepore, V.3    Bracco, L.4    Maggi, S.5    Grigoletto, F.6
  • 24
    • 0035949667 scopus 로고    scopus 로고
    • Neural roles for heme oxygenase: contrasts to nitric oxide synthase
    • Baranano D.E., and Snyder S.H. Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc Natl Acad Sci USA 98 20 (2001) 10996-11002
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.20 , pp. 10996-11002
    • Baranano, D.E.1    Snyder, S.H.2
  • 25
    • 0022470541 scopus 로고
    • Radioresistant DNA synthesis in cells of patients showing increased chromosomal sensitivity to ionizing radiation
    • Barenfeld L.S., Pleskach N.M., Bildin V.N., Prokofjeva V.V., and Mikhelson V.M. Radioresistant DNA synthesis in cells of patients showing increased chromosomal sensitivity to ionizing radiation. Mutat Res 165 3 (1986) 159-164
    • (1986) Mutat Res , vol.165 , Issue.3 , pp. 159-164
    • Barenfeld, L.S.1    Pleskach, N.M.2    Bildin, V.N.3    Prokofjeva, V.V.4    Mikhelson, V.M.5
  • 26
    • 4644275696 scopus 로고    scopus 로고
    • Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
    • Baum L., and Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis 6 4 (2004) 367-377
    • (2004) J Alzheimers Dis , vol.6 , Issue.4 , pp. 367-377
    • Baum, L.1    Ng, A.2
  • 27
    • 0030903206 scopus 로고    scopus 로고
    • Neuroprotection against oxidative stress by estrogens: structure-activity relationship
    • Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J., et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51 4 (1997) 535-541
    • (1997) Mol Pharmacol , vol.51 , Issue.4 , pp. 535-541
    • Behl, C.1    Skutella, T.2    Lezoualc'h, F.3    Post, A.4    Widmann, M.5    Newton, C.J.6
  • 28
    • 0028971169 scopus 로고
    • 17-β Estradiol protects neurons from oxidative stress-induced cell death in vitro
    • Behl C., Widmann M., Trapp T., and Holsboer F. 17-β Estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216 2 (1995) 473-482
    • (1995) Biochem Biophys Res Commun , vol.216 , Issue.2 , pp. 473-482
    • Behl, C.1    Widmann, M.2    Trapp, T.3    Holsboer, F.4
  • 30
    • 0029145084 scopus 로고
    • Are reactive oxygen species involved in Alzheimer's disease?
    • Benzi G., and Moretti A. Are reactive oxygen species involved in Alzheimer's disease?. Neurobiol Aging 16 4 (1995) 661-674
    • (1995) Neurobiol Aging , vol.16 , Issue.4 , pp. 661-674
    • Benzi, G.1    Moretti, A.2
  • 31
    • 0030747490 scopus 로고    scopus 로고
    • Determination of malonaldehyde in Alzheimer's disease: a comparative study of high-performance liquid chromatography and thiobarbituric acid test
    • Bermejo P., Gomez-Serranillos P., Santos J., Pastor E., Gil P., and Martin-Aragon S. Determination of malonaldehyde in Alzheimer's disease: a comparative study of high-performance liquid chromatography and thiobarbituric acid test. Gerontology 43 4 (1997) 218-222
    • (1997) Gerontology , vol.43 , Issue.4 , pp. 218-222
    • Bermejo, P.1    Gomez-Serranillos, P.2    Santos, J.3    Pastor, E.4    Gil, P.5    Martin-Aragon, S.6
  • 32
    • 0038681645 scopus 로고    scopus 로고
    • Effects of acetyl-l-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors
    • Bianchetti A., Rozzini R., and Trabucchi M. Effects of acetyl-l-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Curr Med Res Opin 19 4 (2003) 350-353
    • (2003) Curr Med Res Opin , vol.19 , Issue.4 , pp. 350-353
    • Bianchetti, A.1    Rozzini, R.2    Trabucchi, M.3
  • 33
    • 0024410048 scopus 로고
    • The effects of multivitamins and minerals on children with Down syndrome
    • Bidder R.T., Gray P., Newcombe R.G., Evans B.K., and Hughes M. The effects of multivitamins and minerals on children with Down syndrome. Dev Med Child Neurol 31 4 (1989) 532-537
    • (1989) Dev Med Child Neurol , vol.31 , Issue.4 , pp. 532-537
    • Bidder, R.T.1    Gray, P.2    Newcombe, R.G.3    Evans, B.K.4    Hughes, M.5
  • 36
    • 0026533905 scopus 로고
    • Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization
    • Boiteux S., Gajewski E., Laval J., and Dizdaroglu M. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31 1 (1992) 106-110
    • (1992) Biochemistry , vol.31 , Issue.1 , pp. 106-110
    • Boiteux, S.1    Gajewski, E.2    Laval, J.3    Dizdaroglu, M.4
  • 37
    • 28544444991 scopus 로고    scopus 로고
    • Vitamin C and Vitamin E for Alzheimer's disease
    • Boothby L.A., and Doering P.L. Vitamin C and Vitamin E for Alzheimer's disease. Ann Pharmacother 39 12 (2005) 2073-2079
    • (2005) Ann Pharmacother , vol.39 , Issue.12 , pp. 2073-2079
    • Boothby, L.A.1    Doering, P.L.2
  • 38
    • 0034914927 scopus 로고    scopus 로고
    • Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients
    • Bourdel-Marchasson I., Delmas-Beauvieux M.C., Peuchant E., Richard-Harston S., Decamps A., Reignier B., et al. Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. Age Ageing 30 3 (2001) 235-241
    • (2001) Age Ageing , vol.30 , Issue.3 , pp. 235-241
    • Bourdel-Marchasson, I.1    Delmas-Beauvieux, M.C.2    Peuchant, E.3    Richard-Harston, S.4    Decamps, A.5    Reignier, B.6
  • 39
    • 16444379174 scopus 로고    scopus 로고
    • Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Aβ(1-42)-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
    • Boyd-Kimball D., Sultana R., Abdul H.M., and Butterfield D.A. Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Aβ(1-42)-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J Neurosci Res 79 5 (2005) 700-706
    • (2005) J Neurosci Res , vol.79 , Issue.5 , pp. 700-706
    • Boyd-Kimball, D.1    Sultana, R.2    Abdul, H.M.3    Butterfield, D.A.4
  • 41
    • 84907115618 scopus 로고
    • Oxidative stress in trisomy 21. A possible role in cataractogenesis
    • Bras A., Monteiro C., and Rueff J. Oxidative stress in trisomy 21. A possible role in cataractogenesis. Ophthalmic Paediatr Genet 10 4 (1989) 271-277
    • (1989) Ophthalmic Paediatr Genet , vol.10 , Issue.4 , pp. 271-277
    • Bras, A.1    Monteiro, C.2    Rueff, J.3
  • 42
    • 0029160270 scopus 로고
    • Delayed onset of Alzheimer's disease with non-steroidal anti-inflammatory and histamine H2 blocking drugs
    • Breitner J.C., Welsh K.A., Helms M.J., Gaskell P.C., Gau B.A., Roses A.D., et al. Delayed onset of Alzheimer's disease with non-steroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiol Aging 16 4 (1995) 523-530
    • (1995) Neurobiol Aging , vol.16 , Issue.4 , pp. 523-530
    • Breitner, J.C.1    Welsh, K.A.2    Helms, M.J.3    Gaskell, P.C.4    Gau, B.A.5    Roses, A.D.6
  • 43
    • 0021485455 scopus 로고
    • Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Down's syndrome fetal brain
    • Brooksbank B.W., and Balazs R. Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Down's syndrome fetal brain. Brain Res 318 1 (1984) 37-44
    • (1984) Brain Res , vol.318 , Issue.1 , pp. 37-44
    • Brooksbank, B.W.1    Balazs, R.2
  • 44
    • 0037213976 scopus 로고    scopus 로고
    • Oxidative stress-mediated DHEA formation in Alzheimer's disease pathology
    • Brown R.C., Han Z., Cascio C., and Papadopoulos V. Oxidative stress-mediated DHEA formation in Alzheimer's disease pathology. Neurobiol Aging 24 1 (2003) 57-65
    • (2003) Neurobiol Aging , vol.24 , Issue.1 , pp. 57-65
    • Brown, R.C.1    Han, Z.2    Cascio, C.3    Papadopoulos, V.4
  • 45
    • 0033461154 scopus 로고    scopus 로고
    • Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome
    • Brugge K., Nichols S., Saitoh T., and Trauner D. Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome. Biol Psychiatry 46 12 (1999) 1682-1689
    • (1999) Biol Psychiatry , vol.46 , Issue.12 , pp. 1682-1689
    • Brugge, K.1    Nichols, S.2    Saitoh, T.3    Trauner, D.4
  • 46
    • 0027156173 scopus 로고
    • Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients
    • Buckland P., Tidmarsh S., Spurlock G., Kaiser F., Yates M., O'Mahony G., et al. Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients. Brain Res Mol Brain Res 18 4 (1993) 316-320
    • (1993) Brain Res Mol Brain Res , vol.18 , Issue.4 , pp. 316-320
    • Buckland, P.1    Tidmarsh, S.2    Spurlock, G.3    Kaiser, F.4    Yates, M.5    O'Mahony, G.6
  • 47
    • 0027443398 scopus 로고
    • l-Deprenyl in the treatment of mild dementia of the Alzheimer type: results of a 15-month trial
    • Burke W.J., Roccaforte W.H., Wengel S.P., Bayer B.L., Ranno A.E., and Willcockson N.K. l-Deprenyl in the treatment of mild dementia of the Alzheimer type: results of a 15-month trial. J Am Geriatr Soc 41 11 (1993) 1219-1225
    • (1993) J Am Geriatr Soc , vol.41 , Issue.11 , pp. 1219-1225
    • Burke, W.J.1    Roccaforte, W.H.2    Wengel, S.P.3    Bayer, B.L.4    Ranno, A.E.5    Willcockson, N.K.6
  • 48
    • 0037186074 scopus 로고    scopus 로고
    • Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome
    • Busciglio J., Pelsman A., Wong C., Pigino G., Yuan M., Mori H., et al. Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33 5 (2002) 677-688
    • (2002) Neuron , vol.33 , Issue.5 , pp. 677-688
    • Busciglio, J.1    Pelsman, A.2    Wong, C.3    Pigino, G.4    Yuan, M.5    Mori, H.6
  • 49
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio J., and Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378 6559 (1995) 776-779
    • (1995) Nature , vol.378 , Issue.6559 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 50
    • 12144286106 scopus 로고    scopus 로고
    • Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis
    • Bush A., and Beail N. Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis. Am J Ment Retard 109 2 (2004) 83-97
    • (2004) Am J Ment Retard , vol.109 , Issue.2 , pp. 83-97
    • Bush, A.1    Beail, N.2
  • 52
    • 0030928406 scopus 로고    scopus 로고
    • Beta-amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease
    • Butterfield D.A. Beta-amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chem Res Toxicol 10 5 (1997) 495-506
    • (1997) Chem Res Toxicol , vol.10 , Issue.5 , pp. 495-506
    • Butterfield, D.A.1
  • 53
    • 0141767139 scopus 로고    scopus 로고
    • Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration
    • Butterfield D.A., Boyd-Kimball D., and Castegna A. Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration. J Neurochem 86 6 (2003) 1313-1327
    • (2003) J Neurochem , vol.86 , Issue.6 , pp. 1313-1327
    • Butterfield, D.A.1    Boyd-Kimball, D.2    Castegna, A.3
  • 54
    • 1842519391 scopus 로고    scopus 로고
    • Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide
    • Butterfield D.A., and Bush A.I. Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide. Neurobiol Aging 25 5 (2004) 563-568
    • (2004) Neurobiol Aging , vol.25 , Issue.5 , pp. 563-568
    • Butterfield, D.A.1    Bush, A.I.2
  • 55
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • Butterfield D.A., Castegna A., Lauderback C.M., and Drake J. Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 23 5 (2002) 655-664
    • (2002) Neurobiol Aging , vol.23 , Issue.5 , pp. 655-664
    • Butterfield, D.A.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 56
    • 0030921729 scopus 로고    scopus 로고
    • Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease
    • Butterfield D.A., Hensley K., Cole P., Subramaniam R., Aksenov M., Aksenova M., et al. Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease. J Neurochem 68 6 (1997) 2451-2457
    • (1997) J Neurochem , vol.68 , Issue.6 , pp. 2451-2457
    • Butterfield, D.A.1    Hensley, K.2    Cole, P.3    Subramaniam, R.4    Aksenov, M.5    Aksenova, M.6
  • 57
    • 0031029393 scopus 로고    scopus 로고
    • Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone
    • Butterfield D.A., Howard B.J., Yatin S., Allen K.L., and Carney J.M. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci USA 94 2 (1997) 674-678
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.2 , pp. 674-678
    • Butterfield, D.A.1    Howard, B.J.2    Yatin, S.3    Allen, K.L.4    Carney, J.M.5
  • 58
    • 0035880007 scopus 로고    scopus 로고
    • Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins
    • Butterfield D.A., and Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech Ageing Dev 122 9 (2001) 945-962
    • (2001) Mech Ageing Dev , vol.122 , Issue.9 , pp. 945-962
    • Butterfield, D.A.1    Kanski, J.2
  • 59
    • 0036591849 scopus 로고    scopus 로고
    • Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress
    • Butterfield D.A., and Lauderback C.M. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 32 11 (2002) 1050-1060
    • (2002) Free Radic Biol Med , vol.32 , Issue.11 , pp. 1050-1060
    • Butterfield, D.A.1    Lauderback, C.M.2
  • 60
    • 4043119110 scopus 로고    scopus 로고
    • Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes
    • Calabrese V., Boyd-Kimball D., Scapagnini G., and Butterfield D.A. Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes. In Vivo 18 3 (2004) 245-267
    • (2004) In Vivo , vol.18 , Issue.3 , pp. 245-267
    • Calabrese, V.1    Boyd-Kimball, D.2    Scapagnini, G.3    Butterfield, D.A.4
  • 61
    • 14144255699 scopus 로고    scopus 로고
    • Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2
    • Calabrese V., Ravagna A., Colombrita C., Scapagnini G., Guagliano E., Calvani M., et al. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2. J Neurosci Res 79 4 (2005) 509-521
    • (2005) J Neurosci Res , vol.79 , Issue.4 , pp. 509-521
    • Calabrese, V.1    Ravagna, A.2    Colombrita, C.3    Scapagnini, G.4    Guagliano, E.5    Calvani, M.6
  • 62
    • 1842525777 scopus 로고    scopus 로고
    • Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state
    • Calabrese V., Scapagnini G., Ravagna A., Colombrita C., Spadaro F., Butterfield D.A., et al. Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech Ageing Dev 125 4 (2004) 325-335
    • (2004) Mech Ageing Dev , vol.125 , Issue.4 , pp. 325-335
    • Calabrese, V.1    Scapagnini, G.2    Ravagna, A.3    Colombrita, C.4    Spadaro, F.5    Butterfield, D.A.6
  • 63
    • 4544327666 scopus 로고    scopus 로고
    • Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance
    • Calabrese V., Stella A.M., Butterfield D.A., and Scapagnini G. Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance. Antioxid Redox Signal 6 5 (2004) 895-913
    • (2004) Antioxid Redox Signal , vol.6 , Issue.5 , pp. 895-913
    • Calabrese, V.1    Stella, A.M.2    Butterfield, D.A.3    Scapagnini, G.4
  • 64
    • 30544442097 scopus 로고    scopus 로고
    • Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes
    • Calabrese V., Stella A.M., Calvani M., and Butterfield D.A. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J Nutr Biochem 17 2 (2006) 73-88
    • (2006) J Nutr Biochem , vol.17 , Issue.2 , pp. 73-88
    • Calabrese, V.1    Stella, A.M.2    Calvani, M.3    Butterfield, D.A.4
  • 65
    • 0034727901 scopus 로고    scopus 로고
    • The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons
    • Camandola S., Poli G., and Mattson M.P. The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. Brain Res Mol Brain Res 85 1-2 (2000) 53-60
    • (2000) Brain Res Mol Brain Res , vol.85 , Issue.1-2 , pp. 53-60
    • Camandola, S.1    Poli, G.2    Mattson, M.P.3
  • 66
    • 17144429616 scopus 로고    scopus 로고
    • The use of dehydroepiandrosterone therapy in clinical practice
    • Cameron D.R., and Braunstein G.D. The use of dehydroepiandrosterone therapy in clinical practice. Treat Endocrinol 4 2 (2005) 95-114
    • (2005) Treat Endocrinol , vol.4 , Issue.2 , pp. 95-114
    • Cameron, D.R.1    Braunstein, G.D.2
  • 67
    • 0034762806 scopus 로고    scopus 로고
    • Down syndrome: advances in molecular biology and the neurosciences
    • Capone G.T. Down syndrome: advances in molecular biology and the neurosciences. J Dev Behav Pediatr 22 1 (2001) 40-59
    • (2001) J Dev Behav Pediatr , vol.22 , Issue.1 , pp. 40-59
    • Capone, G.T.1
  • 69
    • 0037101889 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I. Creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1
    • Castegna A., Aksenov M., Aksenova M., Thongboonkerd V., Klein J.B., Pierce W.M., et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I. Creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic Biol Med 33 4 (2002) 562-571
    • (2002) Free Radic Biol Med , vol.33 , Issue.4 , pp. 562-571
    • Castegna, A.1    Aksenov, M.2    Aksenova, M.3    Thongboonkerd, V.4    Klein, J.B.5    Pierce, W.M.6
  • 70
    • 0036733145 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II. Dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
    • Castegna A., Aksenov M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II. Dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem 82 6 (2002) 1524-1532
    • (2002) J Neurochem , vol.82 , Issue.6 , pp. 1524-1532
    • Castegna, A.1    Aksenov, M.2    Thongboonkerd, V.3    Klein, J.B.4    Pierce, W.M.5    Booze, R.6
  • 71
    • 4444323845 scopus 로고    scopus 로고
    • Platelets provide human tissue to unravel pathogenic mechanisms of Alzheimer disease
    • Cattabeni F., Colciaghi F., and Di Luca M. Platelets provide human tissue to unravel pathogenic mechanisms of Alzheimer disease. Prog Neuropsychopharmacol Biol Psychiatry 28 5 (2004) 763-770
    • (2004) Prog Neuropsychopharmacol Biol Psychiatry , vol.28 , Issue.5 , pp. 763-770
    • Cattabeni, F.1    Colciaghi, F.2    Di Luca, M.3
  • 72
    • 0029871412 scopus 로고    scopus 로고
    • Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type-place of the extracellular glutathione peroxidase
    • Ceballos-Picot I., Merad-Boudia M., Nicole A., Thevenin M., Hellier G., Legrain S., et al. Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type-place of the extracellular glutathione peroxidase. Free Radic Biol Med 20 4 (1996) 579-587
    • (1996) Free Radic Biol Med , vol.20 , Issue.4 , pp. 579-587
    • Ceballos-Picot, I.1    Merad-Boudia, M.2    Nicole, A.3    Thevenin, M.4    Hellier, G.5    Legrain, S.6
  • 73
    • 0037111170 scopus 로고    scopus 로고
    • Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients
    • Cecchi C., Fiorillo C., Sorbi S., Latorraca S., Nacmias B., Bagnoli S., et al. Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic Biol Med 33 10 (2002) 1372-1379
    • (2002) Free Radic Biol Med , vol.33 , Issue.10 , pp. 1372-1379
    • Cecchi, C.1    Fiorillo, C.2    Sorbi, S.3    Latorraca, S.4    Nacmias, B.5    Bagnoli, S.6
  • 74
    • 20444462454 scopus 로고    scopus 로고
    • RAGE and amyloid β interactions: atomic force microscopy and molecular modeling
    • Chaney M.O., Stine W.B., Kokjohn T.A., Kuo Y.M., Esh C., Rahman A., et al. RAGE and amyloid β interactions: atomic force microscopy and molecular modeling. Biochim Biophys Acta 1741 1-2 (2005) 199-205
    • (2005) Biochim Biophys Acta , vol.1741 , Issue.1-2 , pp. 199-205
    • Chaney, M.O.1    Stine, W.B.2    Kokjohn, T.A.3    Kuo, Y.M.4    Esh, C.5    Rahman, A.6
  • 75
    • 0042268004 scopus 로고    scopus 로고
    • Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part IV)
    • Cheon M.S., Shim K.S., Kim S.H., Hara A., and Lubec G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part IV). Amino Acids 25 1 (2003) 41-47
    • (2003) Amino Acids , vol.25 , Issue.1 , pp. 41-47
    • Cheon, M.S.1    Shim, K.S.2    Kim, S.H.3    Hara, A.4    Lubec, G.5
  • 76
    • 20044368432 scopus 로고    scopus 로고
    • Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
    • Cherubini A., Martin A., Andres-Lacueva C., Di Iorio A., Lamponi M., Mecocci P., et al. Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiol Aging 26 7 (2005) 987-994
    • (2005) Neurobiol Aging , vol.26 , Issue.7 , pp. 987-994
    • Cherubini, A.1    Martin, A.2    Andres-Lacueva, C.3    Di Iorio, A.4    Lamponi, M.5    Mecocci, P.6
  • 77
    • 0033398932 scopus 로고    scopus 로고
    • Neuroprotective properties of nitric oxide
    • Chiueh C.C. Neuroprotective properties of nitric oxide. Ann NY Acad Sci 890 (1999) 301-311
    • (1999) Ann NY Acad Sci , vol.890 , pp. 301-311
    • Chiueh, C.C.1
  • 79
    • 15744398884 scopus 로고    scopus 로고
    • Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases
    • Choi J., Rees H.D., Weintraub S.T., Levey A.I., Chin L.S., and Li L. Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem 280 12 (2005) 11648-11655
    • (2005) J Biol Chem , vol.280 , Issue.12 , pp. 11648-11655
    • Choi, J.1    Rees, H.D.2    Weintraub, S.T.3    Levey, A.I.4    Chin, L.S.5    Li, L.6
  • 80
    • 0033954991 scopus 로고    scopus 로고
    • Oxidative stress and Alzheimer disease
    • Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr 71 2 (2000) 621S-629S
    • (2000) Am J Clin Nutr , vol.71 , Issue.2
    • Christen, Y.1
  • 81
    • 0038009864 scopus 로고    scopus 로고
    • Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia
    • Clarke R., Harrison G., and Richards S. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med 254 1 (2003) 67-75
    • (2003) J Intern Med , vol.254 , Issue.1 , pp. 67-75
    • Clarke, R.1    Harrison, G.2    Richards, S.3
  • 82
  • 83
    • 0033103644 scopus 로고    scopus 로고
    • Oxidative DNA damage, antioxidants, and cancer
    • Collins A.R. Oxidative DNA damage, antioxidants, and cancer. Bioessays 21 3 (1999) 238-246
    • (1999) Bioessays , vol.21 , Issue.3 , pp. 238-246
    • Collins, A.R.1
  • 84
    • 0041846404 scopus 로고    scopus 로고
    • Quantitative assessment of DNA fragmentation and β-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease
    • Colurso G.J., Nilson J.E., and Vervoort L.G. Quantitative assessment of DNA fragmentation and β-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease. Life Sci 73 14 (2003) 1795-1803
    • (2003) Life Sci , vol.73 , Issue.14 , pp. 1795-1803
    • Colurso, G.J.1    Nilson, J.E.2    Vervoort, L.G.3
  • 87
    • 0024379688 scopus 로고
    • Catalase and glutathione peroxidase activity in cells with trisomy 21
    • Crosti N., Bajer J., Gentile M., Resta G., and Serra A. Catalase and glutathione peroxidase activity in cells with trisomy 21. Clin Genet 36 2 (1989) 107-116
    • (1989) Clin Genet , vol.36 , Issue.2 , pp. 107-116
    • Crosti, N.1    Bajer, J.2    Gentile, M.3    Resta, G.4    Serra, A.5
  • 88
    • 0030874738 scopus 로고    scopus 로고
    • Plaques and tangles: searching for primary events in a forest of data
    • Cummings B.J. Plaques and tangles: searching for primary events in a forest of data. Neurobiol Aging 18 4 (1997) 358-362
    • (1997) Neurobiol Aging , vol.18 , Issue.4 , pp. 358-362
    • Cummings, B.J.1
  • 89
    • 0042591268 scopus 로고    scopus 로고
    • Is DNA repair compromised in Alzheimer's disease?
    • Davydov V., Hansen L.A., and Shackelford D.A. Is DNA repair compromised in Alzheimer's disease?. Neurobiol Aging 24 7 (2003) 953-968
    • (2003) Neurobiol Aging , vol.24 , Issue.7 , pp. 953-968
    • Davydov, V.1    Hansen, L.A.2    Shackelford, D.A.3
  • 90
    • 0031795484 scopus 로고    scopus 로고
    • Nitric oxide in neurodegeneration
    • Dawson V.L., and Dawson T.M. Nitric oxide in neurodegeneration. Prog Brain Res 118 (1998) 215-229
    • (1998) Prog Brain Res , vol.118 , pp. 215-229
    • Dawson, V.L.1    Dawson, T.M.2
  • 91
    • 0028288688 scopus 로고
    • Effect of the chronic treatment with l-acetylcarnitine in Down's syndrome
    • De Falco F.A., D'Angelo E., Grimaldi G., Scafuro F., Sachez F., and Caruso G. Effect of the chronic treatment with l-acetylcarnitine in Down's syndrome. Clin Ter 144 2 (1994) 123-127
    • (1994) Clin Ter , vol.144 , Issue.2 , pp. 123-127
    • De Falco, F.A.1    D'Angelo, E.2    Grimaldi, G.3    Scafuro, F.4    Sachez, F.5    Caruso, G.6
  • 92
    • 0029553764 scopus 로고
    • Cu/Zn-superoxide dismutase and glutathione peroxidase during aging
    • de Haan J.B., Cristiano F., Iannello R.C., and Kola I. Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem Mol Biol Int 35 6 (1995) 1281-1297
    • (1995) Biochem Mol Biol Int , vol.35 , Issue.6 , pp. 1281-1297
    • de Haan, J.B.1    Cristiano, F.2    Iannello, R.C.3    Kola, I.4
  • 93
    • 0033903441 scopus 로고    scopus 로고
    • Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
    • de la Monte S.M., Luong T., Neely T.R., Robinson D., and Wands J.R. Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 80 8 (2000) 1323-1335
    • (2000) Lab Invest , vol.80 , Issue.8 , pp. 1323-1335
    • de la Monte, S.M.1    Luong, T.2    Neely, T.R.3    Robinson, D.4    Wands, J.R.5
  • 94
    • 13644251549 scopus 로고    scopus 로고
    • Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients
    • de las C.N., Munoz U., Hermida O.G., and Martin-Requero A. Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients. Neurobiol Aging 26 5 (2005) 615-624
    • (2005) Neurobiol Aging , vol.26 , Issue.5 , pp. 615-624
    • de las, C.N.1    Munoz, U.2    Hermida, O.G.3    Martin-Requero, A.4
  • 95
    • 0037076799 scopus 로고    scopus 로고
    • Platelet phagocytosis and processing of β-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis
    • De Meyer G.R., De Cleen D.M., Cooper S., Knaapen M.W., Jans D.M., Martinet W., et al. Platelet phagocytosis and processing of β-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis. Circ Res 90 11 (2002) 1197-1204
    • (2002) Circ Res , vol.90 , Issue.11 , pp. 1197-1204
    • De Meyer, G.R.1    De Cleen, D.M.2    Cooper, S.3    Knaapen, M.W.4    Jans, D.M.5    Martinet, W.6
  • 96
    • 0042169046 scopus 로고    scopus 로고
    • Ginkgo biloba extracts and cancer: a research area in its infancy
    • DeFeudis F.V., Papadopoulos V., and Drieu K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol 17 4 (2003) 405-417
    • (2003) Fundam Clin Pharmacol , vol.17 , Issue.4 , pp. 405-417
    • DeFeudis, F.V.1    Papadopoulos, V.2    Drieu, K.3
  • 98
    • 0031721665 scopus 로고    scopus 로고
    • Differential level of platelet amyloid β precursor protein isoforms: an early marker for Alzheimer disease
    • Di Luca M., Pastorino L., Bianchetti A., Perez J., Vignolo L.A., Lenzi G.L., et al. Differential level of platelet amyloid β precursor protein isoforms: an early marker for Alzheimer disease. Arch Neurol 55 9 (1998) 1195-1200
    • (1998) Arch Neurol , vol.55 , Issue.9 , pp. 1195-1200
    • Di Luca, M.1    Pastorino, L.2    Bianchetti, A.3    Perez, J.4    Vignolo, L.A.5    Lenzi, G.L.6
  • 99
    • 0029819924 scopus 로고    scopus 로고
    • Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome
    • Di Luca M., Pastorino L., Cattabeni F., Zanardi R., Scarone S., Racagni G., et al. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome. Arch Neurol 53 11 (1996) 1162-1166
    • (1996) Arch Neurol , vol.53 , Issue.11 , pp. 1162-1166
    • Di Luca, M.1    Pastorino, L.2    Cattabeni, F.3    Zanardi, R.4    Scarone, S.5    Racagni, G.6
  • 100
    • 0026737695 scopus 로고
    • Oxidative damage to DNA in mammalian chromatin
    • Dizdaroglu M. Oxidative damage to DNA in mammalian chromatin. Mutat Res 275 3-6 (1992) 331-342
    • (1992) Mutat Res , vol.275 , Issue.3-6 , pp. 331-342
    • Dizdaroglu, M.1
  • 101
    • 4944220507 scopus 로고    scopus 로고
    • Ginkgo biloba in Down syndrome
    • Donfrancesco R., and Dell'uomo A. Ginkgo biloba in Down syndrome. Phytomedicine 11 6 (2004) 469
    • (2004) Phytomedicine , vol.11 , Issue.6 , pp. 469
    • Donfrancesco, R.1    Dell'uomo, A.2
  • 102
    • 0035826771 scopus 로고    scopus 로고
    • Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Doody R.S., Stevens J.C., Beck C., Dubinsky R.M., Kaye J.A., Gwyther L., et al. Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56 9 (2001) 1154-1166
    • (2001) Neurology , vol.56 , Issue.9 , pp. 1154-1166
    • Doody, R.S.1    Stevens, J.C.2    Beck, C.3    Dubinsky, R.M.4    Kaye, J.A.5    Gwyther, L.6
  • 103
    • 0037097270 scopus 로고    scopus 로고
    • Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress
    • Drake J., Kanski J., Varadarajan S., Tsoras M., and Butterfield D.A. Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress. J Neurosci Res 68 6 (2002) 776-784
    • (2002) J Neurosci Res , vol.68 , Issue.6 , pp. 776-784
    • Drake, J.1    Kanski, J.2    Varadarajan, S.3    Tsoras, M.4    Butterfield, D.A.5
  • 104
    • 0442307849 scopus 로고    scopus 로고
    • 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease
    • Drake J., Petroze R., Castegna A., Ding Q., Keller J.N., Markesbery W.R., et al. 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease. Neurosci Lett 356 3 (2004) 155-158
    • (2004) Neurosci Lett , vol.356 , Issue.3 , pp. 155-158
    • Drake, J.1    Petroze, R.2    Castegna, A.3    Ding, Q.4    Keller, J.N.5    Markesbery, W.R.6
  • 105
    • 0031753652 scopus 로고    scopus 로고
    • Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome
    • Druzhyna N., Nair R.G., LeDoux S.P., and Wilson G.L. Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome. Mutat Res 409 2 (1998) 81-89
    • (1998) Mutat Res , vol.409 , Issue.2 , pp. 81-89
    • Druzhyna, N.1    Nair, R.G.2    LeDoux, S.P.3    Wilson, G.L.4
  • 106
    • 0000920292 scopus 로고    scopus 로고
    • Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease
    • Du Y.S., Zhu H., Fu J., Yan S.F., Roher A., Tourtellotte W.W., et al. Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA 94 10 (1997) 5296-5301
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.10 , pp. 5296-5301
    • Du, Y.S.1    Zhu, H.2    Fu, J.3    Yan, S.F.4    Roher, A.5    Tourtellotte, W.W.6
  • 107
    • 4344665176 scopus 로고    scopus 로고
    • A critical evaluation of the relationship between serum Vitamin B, folate and total homocysteine with cognitive impairment in the elderly
    • Ellinson M., Thomas J., and Patterson A. A critical evaluation of the relationship between serum Vitamin B, folate and total homocysteine with cognitive impairment in the elderly. J Hum Nutr Diet 17 4 (2004) 371-383
    • (2004) J Hum Nutr Diet , vol.17 , Issue.4 , pp. 371-383
    • Ellinson, M.1    Thomas, J.2    Patterson, A.3
  • 110
    • 0035232356 scopus 로고    scopus 로고
    • Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis
    • Engidawork E., Balic N., Juranville J.F., Fountoulakis M., Dierssen M., and Lubec G. Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis. J Neural Transm 61 Suppl (2001) 149-162
    • (2001) J Neural Transm , vol.61 , Issue.SUPPL , pp. 149-162
    • Engidawork, E.1    Balic, N.2    Juranville, J.F.3    Fountoulakis, M.4    Dierssen, M.5    Lubec, G.6
  • 111
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
    • Etminan M., Gill S., and Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 327 7407 (2003) 128-132
    • (2003) BMJ , vol.327 , Issue.7407 , pp. 128-132
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 112
    • 0037342554 scopus 로고    scopus 로고
    • The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
    • Farr S.A., Poon H.F., Dogrukol-Ak D., Drake J., Banks W.A., Eyerman E., et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem 84 5 (2003) 1173-1183
    • (2003) J Neurochem , vol.84 , Issue.5 , pp. 1173-1183
    • Farr, S.A.1    Poon, H.F.2    Dogrukol-Ak, D.3    Drake, J.4    Banks, W.A.5    Eyerman, E.6
  • 113
    • 4344568620 scopus 로고    scopus 로고
    • Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease
    • Feng Z., Chang Y., Cheng Y., Zhang B.L., Qu Z.W., Qin C., et al. Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease. J Pineal Res 37 2 (2004) 129-136
    • (2004) J Pineal Res , vol.37 , Issue.2 , pp. 129-136
    • Feng, Z.1    Chang, Y.2    Cheng, Y.3    Zhang, B.L.4    Qu, Z.W.5    Qin, C.6
  • 114
    • 0032999243 scopus 로고    scopus 로고
    • Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group
    • Filip V., and Kolibas E. Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group. J Psychiatry Neurosci 24 3 (1999) 234-243
    • (1999) J Psychiatry Neurosci , vol.24 , Issue.3 , pp. 234-243
    • Filip, V.1    Kolibas, E.2
  • 115
  • 116
    • 16544380413 scopus 로고    scopus 로고
    • Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms
    • Fillon-Emery N., Chango A., Mircher C., Barbe F., Blehaut H., Herbeth B., et al. Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms. Am J Clin Nutr 80 6 (2004) 1551-1557
    • (2004) Am J Clin Nutr , vol.80 , Issue.6 , pp. 1551-1557
    • Fillon-Emery, N.1    Chango, A.2    Mircher, C.3    Barbe, F.4    Blehaut, H.5    Herbeth, B.6
  • 119
    • 0030273697 scopus 로고    scopus 로고
    • Non-steroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a population-based cohort study
    • Fourrier A., Letenneur L., Begaud B., and Dartigues J.F. Non-steroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a population-based cohort study. J Clin Epidemiol 49 10 (1996) 1201
    • (1996) J Clin Epidemiol , vol.49 , Issue.10 , pp. 1201
    • Fourrier, A.1    Letenneur, L.2    Begaud, B.3    Dartigues, J.F.4
  • 120
    • 0031943163 scopus 로고    scopus 로고
    • l-Deprenyl in Alzheimer's disease: cognitive and behavioral effects
    • Freedman M., Rewilak D., Xerri T., Cohen S., Gordon A.S., Shandling M., et al. l-Deprenyl in Alzheimer's disease: cognitive and behavioral effects. Neurology 50 3 (1998) 660-668
    • (1998) Neurology , vol.50 , Issue.3 , pp. 660-668
    • Freedman, M.1    Rewilak, D.2    Xerri, T.3    Cohen, S.4    Gordon, A.S.5    Shandling, M.6
  • 121
    • 0031754202 scopus 로고    scopus 로고
    • Increased nuclear DNA oxidation in the brain in Alzheimer's disease
    • Gabbita S.P., Lovell M.A., and Markesbery W.R. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 71 5 (1998) 2034-2040
    • (1998) J Neurochem , vol.71 , Issue.5 , pp. 2034-2040
    • Gabbita, S.P.1    Lovell, M.A.2    Markesbery, W.R.3
  • 122
    • 0027946643 scopus 로고
    • Nootropics: pharmacological properties and therapeutic use
    • Gabryel B., and Trzeciak H.I. Nootropics: pharmacological properties and therapeutic use. Pol J Pharmacol 46 5 (1994) 383-394
    • (1994) Pol J Pharmacol , vol.46 , Issue.5 , pp. 383-394
    • Gabryel, B.1    Trzeciak, H.I.2
  • 123
    • 0023950507 scopus 로고
    • Effects of bleomycin on Down's syndrome lymphocytes in culture
    • Gadhia P., Gadhia M., and Zankl H. Effects of bleomycin on Down's syndrome lymphocytes in culture. Mutat Res 207 3-4 (1988) 153-158
    • (1988) Mutat Res , vol.207 , Issue.3-4 , pp. 153-158
    • Gadhia, P.1    Gadhia, M.2    Zankl, H.3
  • 124
    • 0026087552 scopus 로고
    • Adriamycin-induced sister chromatid exchange and chromosomal aberrations in Down's syndrome lymphocytes
    • Gadhia P., Gadhia M., and Zankl H. Adriamycin-induced sister chromatid exchange and chromosomal aberrations in Down's syndrome lymphocytes. Mutagenesis 6 1 (1991) 31-33
    • (1991) Mutagenesis , vol.6 , Issue.1 , pp. 31-33
    • Gadhia, P.1    Gadhia, M.2    Zankl, H.3
  • 125
    • 0030000652 scopus 로고    scopus 로고
    • Cognitive impairment and mortality in a cohort of elderly people
    • Gale C.R., Martyn C.N., and Cooper C. Cognitive impairment and mortality in a cohort of elderly people. BMJ 312 7031 (1996) 608-611
    • (1996) BMJ , vol.312 , Issue.7031 , pp. 608-611
    • Gale, C.R.1    Martyn, C.N.2    Cooper, C.3
  • 126
    • 0034096319 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study
    • Ganguli M., Chandra V., Kamboh M.I., Johnston J.M., Dodge H.H., Thelma B.K., et al. Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study. Arch Neurol 57 6 (2000) 824-830
    • (2000) Arch Neurol , vol.57 , Issue.6 , pp. 824-830
    • Ganguli, M.1    Chandra, V.2    Kamboh, M.I.3    Johnston, J.M.4    Dodge, H.H.5    Thelma, B.K.6
  • 127
    • 5644250686 scopus 로고    scopus 로고
    • Homocysteine and cognitive function in elderly people
    • Garcia A., and Zanibbi K. Homocysteine and cognitive function in elderly people. CMAJ 171 8 (2004) 897-904
    • (2004) CMAJ , vol.171 , Issue.8 , pp. 897-904
    • Garcia, A.1    Zanibbi, K.2
  • 128
    • 21644471827 scopus 로고    scopus 로고
    • Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients
    • Genedani S., Rasio G., Cortelli P., Antonelli F., Guidolin D., Galantucci M., et al. Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients. Neurotox Res 6 4 (2004) 327-332
    • (2004) Neurotox Res , vol.6 , Issue.4 , pp. 327-332
    • Genedani, S.1    Rasio, G.2    Cortelli, P.3    Antonelli, F.4    Guidolin, D.5    Galantucci, M.6
  • 129
    • 0028607581 scopus 로고
    • Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging
    • Gibbs R.B. Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging. Ann NY Acad Sci 743 (1994) 165-196
    • (1994) Ann NY Acad Sci , vol.743 , pp. 165-196
    • Gibbs, R.B.1
  • 130
    • 0028920708 scopus 로고
    • Protective effect of fruits and vegetables on development of stroke in men
    • Gillman M.W., Cupples L.A., Gagnon D., Posner B.M., Ellison R.C., Castelli W.P., et al. Protective effect of fruits and vegetables on development of stroke in men. JAMA 273 14 (1995) 1113-1117
    • (1995) JAMA , vol.273 , Issue.14 , pp. 1113-1117
    • Gillman, M.W.1    Cupples, L.A.2    Gagnon, D.3    Posner, B.M.4    Ellison, R.C.5    Castelli, W.P.6
  • 131
    • 1942520335 scopus 로고    scopus 로고
    • N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease
    • Girones X., Guimera A., Cruz-Sanchez C.Z., Ortega A., Sasaki N., Makita Z., et al. N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease. Free Radic Biol Med 36 10 (2004) 1241-1247
    • (2004) Free Radic Biol Med , vol.36 , Issue.10 , pp. 1241-1247
    • Girones, X.1    Guimera, A.2    Cruz-Sanchez, C.Z.3    Ortega, A.4    Sasaki, N.5    Makita, Z.6
  • 132
    • 0029902166 scopus 로고    scopus 로고
    • Evidence of neuronal oxidative damage in Alzheimer's disease
    • Good P.F., Werner P., Hsu A., Olanow C.W., and Perl D.P. Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149 1 (1996) 21-28
    • (1996) Am J Pathol , vol.149 , Issue.1 , pp. 21-28
    • Good, P.F.1    Werner, P.2    Hsu, A.3    Olanow, C.W.4    Perl, D.P.5
  • 133
    • 10244263597 scopus 로고    scopus 로고
    • Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation
    • Govoni S., Bergamaschi S., Gasparini L., Quaglia C., Racchi M., Cattaneo E., et al. Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. Neurology 47 4 (1996) 1069-1075
    • (1996) Neurology , vol.47 , Issue.4 , pp. 1069-1075
    • Govoni, S.1    Bergamaschi, S.2    Gasparini, L.3    Quaglia, C.4    Racchi, M.5    Cattaneo, E.6
  • 134
    • 84942069413 scopus 로고
    • Glutathione peroxidase activity, lipid peroxides and selenium status in blood in patients with Down's syndrome
    • Gromadzinska J., Wasowicz W., Sklodowska M., and Strozynski H. Glutathione peroxidase activity, lipid peroxides and selenium status in blood in patients with Down's syndrome. J Clin Chem Clin Biochem 26 5 (1988) 255-258
    • (1988) J Clin Chem Clin Biochem , vol.26 , Issue.5 , pp. 255-258
    • Gromadzinska, J.1    Wasowicz, W.2    Sklodowska, M.3    Strozynski, H.4
  • 135
    • 0022994947 scopus 로고
    • Piracetam combined with lecithin in the treatment of Alzheimer's disease
    • Growdon J.H., Corkin S., Huff F.J., and Rosen T.J. Piracetam combined with lecithin in the treatment of Alzheimer's disease. Neurobiol Aging 7 4 (1986) 269-276
    • (1986) Neurobiol Aging , vol.7 , Issue.4 , pp. 269-276
    • Growdon, J.H.1    Corkin, S.2    Huff, F.J.3    Rosen, T.J.4
  • 136
    • 0028842244 scopus 로고
    • Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type
    • Gsell W., Conrad R., Hickethier M., Sofic E., Frolich L., Wichart I., et al. Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J Neurochem 64 3 (1995) 1216-1223
    • (1995) J Neurochem , vol.64 , Issue.3 , pp. 1216-1223
    • Gsell, W.1    Conrad, R.2    Hickethier, M.3    Sofic, E.4    Frolich, L.5    Wichart, I.6
  • 137
    • 0242332645 scopus 로고    scopus 로고
    • Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and l-cysteine
    • Gualandri W., Gualandri L., Demartini G., Esposti R., Marthyn P., Volonte S., et al. Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and l-cysteine. Int J Clin Pharmacol Res 23 1 (2003) 23-30
    • (2003) Int J Clin Pharmacol Res , vol.23 , Issue.1 , pp. 23-30
    • Gualandri, W.1    Gualandri, L.2    Demartini, G.3    Esposti, R.4    Marthyn, P.5    Volonte, S.6
  • 138
    • 29844435497 scopus 로고    scopus 로고
    • Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease
    • Guidi I., Galimberti D., Lonati S., Novembrino C., Bamonti F., Tiriticco M., et al. Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 27 2 (2006) 262-269
    • (2006) Neurobiol Aging , vol.27 , Issue.2 , pp. 262-269
    • Guidi, I.1    Galimberti, D.2    Lonati, S.3    Novembrino, C.4    Bamonti, F.5    Tiriticco, M.6
  • 139
    • 0035233607 scopus 로고    scopus 로고
    • Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome
    • Gulesserian T., Engidawork E., Fountoulakis M., and Lubec G. Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome. J Neural Transm 61 Suppl (2001) 71-84
    • (2001) J Neural Transm , vol.61 , Issue.SUPPL , pp. 71-84
    • Gulesserian, T.1    Engidawork, E.2    Fountoulakis, M.3    Lubec, G.4
  • 140
    • 0035144524 scopus 로고    scopus 로고
    • Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome
    • Gulesserian T., Seidl R., Hardmeier R., Cairns N., and Lubec G. Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J Investig Med 49 1 (2001) 41-46
    • (2001) J Investig Med , vol.49 , Issue.1 , pp. 41-46
    • Gulesserian, T.1    Seidl, R.2    Hardmeier, R.3    Cairns, N.4    Lubec, G.5
  • 141
    • 0028792111 scopus 로고
    • Lipid peroxidation and antioxidants as biomarkers of tissue damage
    • Gutteridge J.M. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 41 12 Pt 2 (1995) 1819-1828
    • (1995) Clin Chem , vol.41 , Issue.12 PART 2 , pp. 1819-1828
    • Gutteridge, J.M.1
  • 142
    • 0345104375 scopus 로고    scopus 로고
    • Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down's syndrome and Alzheimer's disease
    • Hayn M., Kremser K., Singewald N., Cairns N., Nemethova M., Lubec B., et al. Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down's syndrome and Alzheimer's disease. Life Sci 59 7 (1996) 537-544
    • (1996) Life Sci , vol.59 , Issue.7 , pp. 537-544
    • Hayn, M.1    Kremser, K.2    Singewald, N.3    Cairns, N.4    Nemethova, M.5    Lubec, B.6
  • 144
    • 1842610580 scopus 로고    scopus 로고
    • Down syndrome and beta-amyloid deposition
    • Head E., and Lott I.T. Down syndrome and beta-amyloid deposition. Curr Opin Neurol 17 2 (2004) 95-100
    • (2004) Curr Opin Neurol , vol.17 , Issue.2 , pp. 95-100
    • Head, E.1    Lott, I.T.2
  • 145
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 9326 (2002) 23-33
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 23-33
  • 146
    • 0028807137 scopus 로고
    • Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation
    • Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., et al. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem 65 5 (1995) 2146-2156
    • (1995) J Neurochem , vol.65 , Issue.5 , pp. 2146-2156
    • Hensley, K.1    Hall, N.2    Subramaniam, R.3    Cole, P.4    Harris, M.5    Aksenov, M.6
  • 147
    • 0032531735 scopus 로고    scopus 로고
    • Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
    • Hensley K., Maidt M.L., Yu Z., Sang H., Markesbery W.R., and Floyd R.A. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 18 20 (1998) 8126-8132
    • (1998) J Neurosci , vol.18 , Issue.20 , pp. 8126-8132
    • Hensley, K.1    Maidt, M.L.2    Yu, Z.3    Sang, H.4    Markesbery, W.R.5    Floyd, R.A.6
  • 148
    • 0032541109 scopus 로고    scopus 로고
    • Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down syndrome and Alzheimer's disease
    • Hermon M., Cairns N., Egly J.M., Fery A., Labudova O., and Lubec G. Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down syndrome and Alzheimer's disease. Neurosci Lett 251 1 (1998) 45-48
    • (1998) Neurosci Lett , vol.251 , Issue.1 , pp. 45-48
    • Hermon, M.1    Cairns, N.2    Egly, J.M.3    Fery, A.4    Labudova, O.5    Lubec, G.6
  • 150
    • 0041833480 scopus 로고    scopus 로고
    • Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine
    • Ho P.I., Ashline D., Dhitavat S., Ortiz D., Collins S.C., Shea T.B., et al. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 14 1 (2003) 32-42
    • (2003) Neurobiol Dis , vol.14 , Issue.1 , pp. 32-42
    • Ho, P.I.1    Ashline, D.2    Dhitavat, S.3    Ortiz, D.4    Collins, S.C.5    Shea, T.B.6
  • 151
    • 0034669062 scopus 로고    scopus 로고
    • The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis
    • Hogervorst E., Williams J., Budge M., Riedel W., and Jolles J. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience 101 3 (2000) 485-512
    • (2000) Neuroscience , vol.101 , Issue.3 , pp. 485-512
    • Hogervorst, E.1    Williams, J.2    Budge, M.3    Riedel, W.4    Jolles, J.5
  • 152
    • 0037269433 scopus 로고    scopus 로고
    • Measuring serum oestradiol in women with Alzheimer's disease: the importance of the sensitivity of the assay method
    • Hogervorst E., Williams J., Combrinck M., and David S.A. Measuring serum oestradiol in women with Alzheimer's disease: the importance of the sensitivity of the assay method. Eur J Endocrinol 148 1 (2003) 67-72
    • (2003) Eur J Endocrinol , vol.148 , Issue.1 , pp. 67-72
    • Hogervorst, E.1    Williams, J.2    Combrinck, M.3    David, S.A.4
  • 153
    • 0034653321 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 in adults with Down syndrome and protection against macrovascular disease
    • Hopkins W.E., Fukagawa N.K., Sobel B.E., and Schneider D.J. Plasminogen activator inhibitor type 1 in adults with Down syndrome and protection against macrovascular disease. Am J Cardiol 85 6 (2000) 784-786
    • (2000) Am J Cardiol , vol.85 , Issue.6 , pp. 784-786
    • Hopkins, W.E.1    Fukagawa, N.K.2    Sobel, B.E.3    Schneider, D.J.4
  • 154
    • 0043204252 scopus 로고    scopus 로고
    • Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
    • Howes M.J., and Houghton P.J. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav 75 3 (2003) 513-527
    • (2003) Pharmacol Biochem Behav , vol.75 , Issue.3 , pp. 513-527
    • Howes, M.J.1    Houghton, P.J.2
  • 157
    • 0036468772 scopus 로고    scopus 로고
    • Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
    • Isacson O., Seo H., Lin L., Albeck D., and Granholm A.C. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25 2 (2002) 79-84
    • (2002) Trends Neurosci , vol.25 , Issue.2 , pp. 79-84
    • Isacson, O.1    Seo, H.2    Lin, L.3    Albeck, D.4    Granholm, A.C.5
  • 158
    • 0028919919 scopus 로고
    • Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome
    • Iwatsubo T., Mann D.M., Odaka A., Suzuki N., and Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Ann Neurol 37 3 (1995) 294-299
    • (1995) Ann Neurol , vol.37 , Issue.3 , pp. 294-299
    • Iwatsubo, T.1    Mann, D.M.2    Odaka, A.3    Suzuki, N.4    Ihara, Y.5
  • 159
    • 0028342424 scopus 로고
    • Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein
    • Jaffe A.B., Toran-Allerand C.D., Greengard P., and Gandy S.E. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J Biol Chem 269 18 (1994) 13065-13068
    • (1994) J Biol Chem , vol.269 , Issue.18 , pp. 13065-13068
    • Jaffe, A.B.1    Toran-Allerand, C.D.2    Greengard, P.3    Gandy, S.E.4
  • 161
    • 13844272542 scopus 로고    scopus 로고
    • Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds
    • Joseph J.A., Shukitt-Hale B., and Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 81 1 Suppl (2005) 313S-316S
    • (2005) Am J Clin Nutr , vol.81 , Issue.1 SUPPL
    • Joseph, J.A.1    Shukitt-Hale, B.2    Casadesus, G.3
  • 162
    • 31744434516 scopus 로고    scopus 로고
    • In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): Insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders
    • Joshi G., Perluigi M., Sultana R., Agrippino R., Calabrese V., and Butterfield D.A. In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): Insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochem Int 48 4 (2006) 318-327
    • (2006) Neurochem Int , vol.48 , Issue.4 , pp. 318-327
    • Joshi, G.1    Perluigi, M.2    Sultana, R.3    Agrippino, R.4    Calabrese, V.5    Butterfield, D.A.6
  • 163
    • 0032401643 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress are significantly elevated in Down syndrome
    • Jovanovic S.V., Clements D., and MacLeod K. Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic Biol Med 25 9 (1998) 1044-1048
    • (1998) Free Radic Biol Med , vol.25 , Issue.9 , pp. 1044-1048
    • Jovanovic, S.V.1    Clements, D.2    MacLeod, K.3
  • 164
    • 4544225426 scopus 로고    scopus 로고
    • Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease
    • Kadioglu E., Sardas S., Aslan S., Isik E., and Esat K.A. Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease. Biomarkers 9 2 (2004) 203-209
    • (2004) Biomarkers , vol.9 , Issue.2 , pp. 203-209
    • Kadioglu, E.1    Sardas, S.2    Aslan, S.3    Isik, E.4    Esat, K.A.5
  • 165
    • 0028271474 scopus 로고
    • Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia
    • Kalman J., Dey I., Ilona S.V., Matkovics B., Brown D., Janka Z., et al. Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia. Biol Psychiatry 35 3 (1994) 190-194
    • (1994) Biol Psychiatry , vol.35 , Issue.3 , pp. 190-194
    • Kalman, J.1    Dey, I.2    Ilona, S.V.3    Matkovics, B.4    Brown, D.5    Janka, Z.6
  • 166
    • 0029871249 scopus 로고    scopus 로고
    • Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
    • Kanowski S., Herrmann W.M., Stephan K., Wierich W., and Horr R. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29 2 (1996) 47-56
    • (1996) Pharmacopsychiatry , vol.29 , Issue.2 , pp. 47-56
    • Kanowski, S.1    Herrmann, W.M.2    Stephan, K.3    Wierich, W.4    Horr, R.5
  • 167
    • 0346373723 scopus 로고    scopus 로고
    • Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial
    • Kanowski S., and Hoerr R. Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial. Pharmacopsychiatry 36 6 (2003) 297-303
    • (2003) Pharmacopsychiatry , vol.36 , Issue.6 , pp. 297-303
    • Kanowski, S.1    Hoerr, R.2
  • 168
    • 0034928785 scopus 로고    scopus 로고
    • The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense
    • Karelson E., Bogdanovic N., Garlind A., Winblad B., Zilmer K., Kullisaar T., et al. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochem Res 26 4 (2001) 353-361
    • (2001) Neurochem Res , vol.26 , Issue.4 , pp. 353-361
    • Karelson, E.1    Bogdanovic, N.2    Garlind, A.3    Winblad, B.4    Zilmer, K.5    Kullisaar, T.6
  • 170
    • 0033980370 scopus 로고    scopus 로고
    • Progress in cancer chemoprevention: development of diet-derived chemopreventive agents
    • Kelloff G.J., Crowell J.A., Steele V.E., Lubet R.A., Malone W.A., Boone C.W., et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 130 2S Suppl (2000) 467S-471S
    • (2000) J Nutr , vol.130 , Issue.2 S SUPPL
    • Kelloff, G.J.1    Crowell, J.A.2    Steele, V.E.3    Lubet, R.A.4    Malone, W.A.5    Boone, C.W.6
  • 171
    • 0033679409 scopus 로고    scopus 로고
    • Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome
    • Kim S.H., Vlkolinsky R., Cairns N., and Lubec G. Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome. Cell Mol Life Sci 57 12 (2000) 1810-1816
    • (2000) Cell Mol Life Sci , vol.57 , Issue.12 , pp. 1810-1816
    • Kim, S.H.1    Vlkolinsky, R.2    Cairns, N.3    Lubec, G.4
  • 172
    • 0034912851 scopus 로고    scopus 로고
    • NAD(P)H, a directly operating antioxidant?
    • Kirsch M., and De Groot H. NAD(P)H, a directly operating antioxidant?. FASEB J 15 9 (2001) 1569-1574
    • (2001) FASEB J , vol.15 , Issue.9 , pp. 1569-1574
    • Kirsch, M.1    De Groot, H.2
  • 173
    • 0025170497 scopus 로고
    • Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype
    • Korenberg J.R., Kawashima H., Pulst S.M., Ikeuchi T., Ogasawara N., Yamamoto K., et al. Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. Am J Hum Genet 47 2 (1990) 236-246
    • (1990) Am J Hum Genet , vol.47 , Issue.2 , pp. 236-246
    • Korenberg, J.R.1    Kawashima, H.2    Pulst, S.M.3    Ikeuchi, T.4    Ogasawara, N.5    Yamamoto, K.6
  • 174
    • 0036368653 scopus 로고    scopus 로고
    • Relation of medial temporal lobe volumes to age and memory function in non-demented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease
    • Krasuski J.S., Alexander G.E., Horwitz B., Rapoport S.I., and Schapiro M.B. Relation of medial temporal lobe volumes to age and memory function in non-demented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease. Am J Psychiatry 159 1 (2002) 74-81
    • (2002) Am J Psychiatry , vol.159 , Issue.1 , pp. 74-81
    • Krasuski, J.S.1    Alexander, G.E.2    Horwitz, B.3    Rapoport, S.I.4    Schapiro, M.B.5
  • 176
    • 0025095410 scopus 로고
    • Sensitive enzyme immunoassay for human Cu/Zn superoxide dismutase
    • Kurobe N., Suzuki F., Okajima K., and Kato K. Sensitive enzyme immunoassay for human Cu/Zn superoxide dismutase. Clin Chim Acta 187 1 (1990) 11-20
    • (1990) Clin Chim Acta , vol.187 , Issue.1 , pp. 11-20
    • Kurobe, N.1    Suzuki, F.2    Okajima, K.3    Kato, K.4
  • 177
    • 0017226223 scopus 로고
    • DNA repair and frequency of X-ray and UV-light induced chromosome aberrations in leukocytes from patients with Down's syndrome
    • Lambert B., Hansson K., Bui T.H., Funes-Cravioto F., and Lindsten J. DNA repair and frequency of X-ray and UV-light induced chromosome aberrations in leukocytes from patients with Down's syndrome. Ann Hum Genet 39 3 (1976) 293-303
    • (1976) Ann Hum Genet , vol.39 , Issue.3 , pp. 293-303
    • Lambert, B.1    Hansson, K.2    Bui, T.H.3    Funes-Cravioto, F.4    Lindsten, J.5
  • 178
    • 2342608923 scopus 로고    scopus 로고
    • Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study
    • Laurin D., Masaki K.H., Foley D.J., White L.R., and Launer L.J. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol 159 10 (2004) 959-967
    • (2004) Am J Epidemiol , vol.159 , Issue.10 , pp. 959-967
    • Laurin, D.1    Masaki, K.H.2    Foley, D.J.3    White, L.R.4    Launer, L.J.5
  • 179
    • 0041825230 scopus 로고    scopus 로고
    • Response patterns of EGb 761 in Alzheimer's disease: influence of neuropsychological profiles
    • Le Bars P.L. Response patterns of EGb 761 in Alzheimer's disease: influence of neuropsychological profiles. Pharmacopsychiatry 36 Suppl 1 (2003) S50-S55
    • (2003) Pharmacopsychiatry , vol.36 , Issue.SUPPL. 1
    • Le Bars, P.L.1
  • 180
    • 0030759072 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group
    • Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., and Schatzberg A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 278 16 (1997) 1327-1332
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1327-1332
    • Le Bars, P.L.1    Katz, M.M.2    Berman, N.3    Itil, T.M.4    Freedman, A.M.5    Schatzberg, A.F.6
  • 181
    • 0036164525 scopus 로고    scopus 로고
    • Influence of the severity of cognitive impairment on the effect of the Ginkgo biloba extract EGb 761 in Alzheimer's disease
    • Le Bars P.L., Velasco F.M., Ferguson J.M., Dessain E.C., Kieser M., and Hoerr R. Influence of the severity of cognitive impairment on the effect of the Ginkgo biloba extract EGb 761 in Alzheimer's disease. Neuropsychobiology 45 1 (2002) 19-26
    • (2002) Neuropsychobiology , vol.45 , Issue.1 , pp. 19-26
    • Le Bars, P.L.1    Velasco, F.M.2    Ferguson, J.M.3    Dessain, E.C.4    Kieser, M.5    Hoerr, R.6
  • 182
    • 0037362586 scopus 로고    scopus 로고
    • Homocysteine and Alzheimer's disease
    • Leboeuf R. Homocysteine and Alzheimer's disease. J Am Diet Assoc 103 3 (2003) 304-307
    • (2003) J Am Diet Assoc , vol.103 , Issue.3 , pp. 304-307
    • Leboeuf, R.1
  • 183
    • 0028065142 scopus 로고
    • Analysis of microtubule-associated protein tau glycation in paired helical filaments
    • Ledesma M.D., Bonay P., Colaco C., and Avila J. Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem 269 34 (1994) 21614-21619
    • (1994) J Biol Chem , vol.269 , Issue.34 , pp. 21614-21619
    • Ledesma, M.D.1    Bonay, P.2    Colaco, C.3    Avila, J.4
  • 184
    • 0020369780 scopus 로고
    • Repair of single-strand breaks in normal and trisomic lymphocytes
    • Leonard J.C., and Merz T. Repair of single-strand breaks in normal and trisomic lymphocytes. Mutat Res 105 6 (1982) 417-422
    • (1982) Mutat Res , vol.105 , Issue.6 , pp. 417-422
    • Leonard, J.C.1    Merz, T.2
  • 185
    • 17544399111 scopus 로고    scopus 로고
    • Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis
    • Leverenz J.B., and Raskind M.A. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis. Exp Neurol 150 2 (1998) 296-304
    • (1998) Exp Neurol , vol.150 , Issue.2 , pp. 296-304
    • Leverenz, J.B.1    Raskind, M.A.2
  • 186
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., and Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21 21 (2001) 8370-8377
    • (2001) J Neurosci , vol.21 , Issue.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 187
    • 16444382590 scopus 로고    scopus 로고
    • Gender differences in glutathione metabolism in Alzheimer's disease
    • Liu H., Harrell L.E., Shenvi S., Hagen T., and Liu R.M. Gender differences in glutathione metabolism in Alzheimer's disease. J Neurosci Res 79 6 (2005) 861-867
    • (2005) J Neurosci Res , vol.79 , Issue.6 , pp. 861-867
    • Liu, H.1    Harrell, L.E.2    Shenvi, S.3    Hagen, T.4    Liu, R.M.5
  • 188
    • 21844441151 scopus 로고    scopus 로고
    • Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
    • Liu J., and Ames B.N. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci 8 2 (2005) 67-89
    • (2005) Nutr Neurosci , vol.8 , Issue.2 , pp. 67-89
    • Liu, J.1    Ames, B.N.2
  • 189
    • 0043286304 scopus 로고    scopus 로고
    • Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals
    • Liu R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78 3 Suppl (2003) 517S-520S
    • (2003) Am J Clin Nutr , vol.78 , Issue.3 SUPPL
    • Liu, R.H.1
  • 191
    • 11444269588 scopus 로고    scopus 로고
    • Alzheimer disease and Down syndrome: factors in pathogenesis
    • Lott I.T., and Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging 26 3 (2005) 383-389
    • (2005) Neurobiol Aging , vol.26 , Issue.3 , pp. 383-389
    • Lott, I.T.1    Head, E.2
  • 192
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • Lovell M.A., Ehmann W.D., Butler S.M., and Markesbery W.R. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45 8 (1995) 1594-1601
    • (1995) Neurology , vol.45 , Issue.8 , pp. 1594-1601
    • Lovell, M.A.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 193
    • 0032933750 scopus 로고    scopus 로고
    • Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF
    • Lovell M.A., Gabbita S.P., and Markesbery W.R. Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF. J Neurochem 72 2 (1999) 771-776
    • (1999) J Neurochem , vol.72 , Issue.2 , pp. 771-776
    • Lovell, M.A.1    Gabbita, S.P.2    Markesbery, W.R.3
  • 194
    • 0033984570 scopus 로고    scopus 로고
    • Decreased base excision repair and increased helicase activity in Alzheimer's disease brain
    • Lovell M.A., Xie C., and Markesbery W.R. Decreased base excision repair and increased helicase activity in Alzheimer's disease brain. Brain Res 855 1 (2000) 116-123
    • (2000) Brain Res , vol.855 , Issue.1 , pp. 116-123
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 195
    • 0142010609 scopus 로고    scopus 로고
    • Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid
    • Lovell M.A., Xie C., Xiong S., and Markesbery W.R. Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid. J Alzheimers Dis 5 3 (2003) 229-239
    • (2003) J Alzheimers Dis , vol.5 , Issue.3 , pp. 229-239
    • Lovell, M.A.1    Xie, C.2    Xiong, S.3    Markesbery, W.R.4
  • 196
    • 4544306972 scopus 로고    scopus 로고
    • Dietary factors and Alzheimer's disease
    • Luchsinger J.A., and Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol 3 10 (2004) 579-587
    • (2004) Lancet Neurol , vol.3 , Issue.10 , pp. 579-587
    • Luchsinger, J.A.1    Mayeux, R.2
  • 197
    • 0037320324 scopus 로고    scopus 로고
    • Antioxidant vitamin intake and risk of Alzheimer disease
    • Luchsinger J.A., Tang M.X., Shea S., and Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 60 2 (2003) 203-208
    • (2003) Arch Neurol , vol.60 , Issue.2 , pp. 203-208
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 199
    • 0030898724 scopus 로고    scopus 로고
    • An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease
    • Lyras L., Cairns N.J., Jenner A., Jenner P., and Halliwell B. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem 68 5 (1997) 2061-2069
    • (1997) J Neurochem , vol.68 , Issue.5 , pp. 2061-2069
    • Lyras, L.1    Cairns, N.J.2    Jenner, A.3    Jenner, P.4    Halliwell, B.5
  • 200
    • 0034805892 scopus 로고    scopus 로고
    • Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studies
    • Maki P.M., and Resnick S.M. Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studies. Neuroimage 14 4 (2001) 789-801
    • (2001) Neuroimage , vol.14 , Issue.4 , pp. 789-801
    • Maki, P.M.1    Resnick, S.M.2
  • 205
    • 0035140477 scopus 로고    scopus 로고
    • Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis
    • Maluf S.W., and Erdtmann B. Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer Genet Cytogenet 124 1 (2001) 71-75
    • (2001) Cancer Genet Cytogenet , vol.124 , Issue.1 , pp. 71-75
    • Maluf, S.W.1    Erdtmann, B.2
  • 206
    • 0032031780 scopus 로고    scopus 로고
    • Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
    • Marcus D.L., Thomas C., Rodriguez C., Simberkoff K., Tsai J.S., Strafaci J.A., et al. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Exp Neurol 150 1 (1998) 40-44
    • (1998) Exp Neurol , vol.150 , Issue.1 , pp. 40-44
    • Marcus, D.L.1    Thomas, C.2    Rodriguez, C.3    Simberkoff, K.4    Tsai, J.S.5    Strafaci, J.A.6
  • 207
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23 1 (1997) 134-147
    • (1997) Free Radic Biol Med , vol.23 , Issue.1 , pp. 134-147
    • Markesbery, W.R.1
  • 208
    • 0031980065 scopus 로고    scopus 로고
    • Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
    • Markesbery W.R., and Lovell M.A. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol Aging 19 1 (1998) 33-36
    • (1998) Neurobiol Aging , vol.19 , Issue.1 , pp. 33-36
    • Markesbery, W.R.1    Lovell, M.A.2
  • 209
    • 0031028078 scopus 로고    scopus 로고
    • Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment
    • Martin-Aragon S., Benedi J.M., and Villar A.M. Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment. J Pharm Pharmacol 49 1 (1997) 49-52
    • (1997) J Pharm Pharmacol , vol.49 , Issue.1 , pp. 49-52
    • Martin-Aragon, S.1    Benedi, J.M.2    Villar, A.M.3
  • 211
    • 0037983267 scopus 로고    scopus 로고
    • Antioxidant enzymes and human diseases
    • Mates J.M., Perez-Gomez C., and Nunez dC I. Antioxidant enzymes and human diseases. Clin Biochem 32 8 (1999) 595-603
    • (1999) Clin Biochem , vol.32 , Issue.8 , pp. 595-603
    • Mates, J.M.1    Perez-Gomez, C.2    Nunez dC, I.3
  • 212
    • 22144483112 scopus 로고    scopus 로고
    • Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia
    • Maxwell C.J., Hicks M.S., Hogan D.B., Basran J., and Ebly E.M. Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement Geriatr Cogn Disord 20 1 (2005) 45-51
    • (2005) Dement Geriatr Cogn Disord , vol.20 , Issue.1 , pp. 45-51
    • Maxwell, C.J.1    Hicks, M.S.2    Hogan, D.B.3    Basran, J.4    Ebly, E.M.5
  • 213
    • 26444571697 scopus 로고    scopus 로고
    • Elderly psychiatric patients at risk of folic acid deficiency: a case controlled study
    • Mazeh D., Cholostoy A., Zemishlani C., and Barak Y. Elderly psychiatric patients at risk of folic acid deficiency: a case controlled study. Arch Gerontol Geriatr 41 3 (2005) 297-302
    • (2005) Arch Gerontol Geriatr , vol.41 , Issue.3 , pp. 297-302
    • Mazeh, D.1    Cholostoy, A.2    Zemishlani, C.3    Barak, Y.4
  • 214
    • 0242580631 scopus 로고    scopus 로고
    • "Brain-specific" nutrients: a memory cure?
    • McDaniel M.A., Maier S.F., and Einstein G.O. "Brain-specific" nutrients: a memory cure?. Nutrition 19 11-12 (2003) 957-975
    • (2003) Nutrition , vol.19 , Issue.11-12 , pp. 957-975
    • McDaniel, M.A.1    Maier, S.F.2    Einstein, G.O.3
  • 215
  • 217
    • 0038369866 scopus 로고    scopus 로고
    • Plasma amyloid beta protein 1-42 levels are increased in old Down syndrome but not in young Down syndrome
    • Mehta P.D., Mehta S.P., Fedor B., Patrick B.A., Emmerling M., and Dalton A.J. Plasma amyloid beta protein 1-42 levels are increased in old Down syndrome but not in young Down syndrome. Neurosci Lett 342 3 (2003) 155-158
    • (2003) Neurosci Lett , vol.342 , Issue.3 , pp. 155-158
    • Mehta, P.D.1    Mehta, S.P.2    Fedor, B.3    Patrick, B.A.4    Emmerling, M.5    Dalton, A.J.6
  • 218
  • 219
    • 18044364799 scopus 로고    scopus 로고
    • Down syndrome, Alzheimer's disease and seizures
    • Menendez M. Down syndrome, Alzheimer's disease and seizures. Brain Dev 27 4 (2005) 246-252
    • (2005) Brain Dev , vol.27 , Issue.4 , pp. 246-252
    • Menendez, M.1
  • 220
    • 0035957712 scopus 로고    scopus 로고
    • Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity
    • Midorikawa K., and Kawanishi S. Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity. FEBS Lett 495 3 (2001) 187-190
    • (2001) FEBS Lett , vol.495 , Issue.3 , pp. 187-190
    • Midorikawa, K.1    Kawanishi, S.2
  • 221
    • 13644253800 scopus 로고    scopus 로고
    • Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
    • Migliore L., Fontana I., Colognato R., Coppede F., Siciliano G., and Murri L. Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases. Neurobiol Aging 26 5 (2005) 587-595
    • (2005) Neurobiol Aging , vol.26 , Issue.5 , pp. 587-595
    • Migliore, L.1    Fontana, I.2    Colognato, R.3    Coppede, F.4    Siciliano, G.5    Murri, L.6
  • 222
    • 13644270565 scopus 로고    scopus 로고
    • Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients
    • Migliore L., Fontana I., Trippi F., Colognato R., Coppede F., Tognoni G., et al. Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging 26 5 (2005) 567-573
    • (2005) Neurobiol Aging , vol.26 , Issue.5 , pp. 567-573
    • Migliore, L.1    Fontana, I.2    Trippi, F.3    Colognato, R.4    Coppede, F.5    Tognoni, G.6
  • 224
    • 0034643895 scopus 로고    scopus 로고
    • Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
    • Misonou H., Morishima-Kawashima M., and Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 39 23 (2000) 6951-6959
    • (2000) Biochemistry , vol.39 , Issue.23 , pp. 6951-6959
    • Misonou, H.1    Morishima-Kawashima, M.2    Ihara, Y.3
  • 225
    • 0032538529 scopus 로고    scopus 로고
    • Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids
    • Miyata T., Inagi R., Asahi K., Yamada Y., Horie K., Sakai H., et al. Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids. FEBS Lett 437 1-2 (1998) 24-28
    • (1998) FEBS Lett , vol.437 , Issue.1-2 , pp. 24-28
    • Miyata, T.1    Inagi, R.2    Asahi, K.3    Yamada, Y.4    Horie, K.5    Sakai, H.6
  • 227
    • 0037347231 scopus 로고    scopus 로고
    • Meta-analysis of double blind randomized controlled clinical trials of acetyl-l-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
    • Montgomery S.A., Thal L.J., and Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-l-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 18 2 (2003) 61-71
    • (2003) Int Clin Psychopharmacol , vol.18 , Issue.2 , pp. 61-71
    • Montgomery, S.A.1    Thal, L.J.2    Amrein, R.3
  • 228
    • 0842346368 scopus 로고    scopus 로고
    • Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
    • Montine K.S., Quinn J.F., Zhang J., Fessel J.P., Roberts L.J., Morrow J.D., et al. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids 128 1-2 (2004) 117-124
    • (2004) Chem Phys Lipids , vol.128 , Issue.1-2 , pp. 117-124
    • Montine, K.S.1    Quinn, J.F.2    Zhang, J.3    Fessel, J.P.4    Roberts, L.J.5    Morrow, J.D.6
  • 229
    • 0035984342 scopus 로고    scopus 로고
    • Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease
    • Montine T.J., Quinn J.F., Milatovic D., Silbert L.C., Dang T., Sanchez S., et al. Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann Neurol 52 2 (2002) 175-179
    • (2002) Ann Neurol , vol.52 , Issue.2 , pp. 175-179
    • Montine, T.J.1    Quinn, J.F.2    Milatovic, D.3    Silbert, L.C.4    Dang, T.5    Sanchez, S.6
  • 231
    • 0036141861 scopus 로고    scopus 로고
    • Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease
    • Morocz M., Kalman J., Juhasz A., Sinko I., McGlynn A.P., Downes C.S., et al. Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. Neurobiol Aging 23 1 (2002) 47-53
    • (2002) Neurobiol Aging , vol.23 , Issue.1 , pp. 47-53
    • Morocz, M.1    Kalman, J.2    Juhasz, A.3    Sinko, I.4    McGlynn, A.P.5    Downes, C.S.6
  • 233
    • 0037178579 scopus 로고    scopus 로고
    • Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    • Morris M.C., Evans D.A., Bienias J.L., Tangney C.C., Bennett D.A., Aggarwal N., et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287 24 (2002) 3230-3237
    • (2002) JAMA , vol.287 , Issue.24 , pp. 3230-3237
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5    Aggarwal, N.6
  • 234
  • 235
    • 2942739009 scopus 로고    scopus 로고
    • Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides
    • Mruthinti S., Buccafusco J.J., Hill W.D., Waller J.L., Jackson T.W., Zamrini E.Y., et al. Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides. Neurobiol Aging 25 8 (2004) 1023-1032
    • (2004) Neurobiol Aging , vol.25 , Issue.8 , pp. 1023-1032
    • Mruthinti, S.1    Buccafusco, J.J.2    Hill, W.D.3    Waller, J.L.4    Jackson, T.W.5    Zamrini, E.Y.6
  • 236
    • 0035882353 scopus 로고    scopus 로고
    • Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients
    • Muchova J., Sustrova M., Garaiova I., Liptakova A., Blazicek P., Kvasnicka P., et al. Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients. Free Radic Biol Med 31 4 (2001) 499-508
    • (2001) Free Radic Biol Med , vol.31 , Issue.4 , pp. 499-508
    • Muchova, J.1    Sustrova, M.2    Garaiova, I.3    Liptakova, A.4    Blazicek, P.5    Kvasnicka, P.6
  • 238
    • 0025297786 scopus 로고
    • Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
    • Mullaart E., Boerrigter M.E., Ravid R., Swaab D.F., and Vijg J. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiol Aging 11 3 (1990) 169-173
    • (1990) Neurobiol Aging , vol.11 , Issue.3 , pp. 169-173
    • Mullaart, E.1    Boerrigter, M.E.2    Ravid, R.3    Swaab, D.F.4    Vijg, J.5
  • 239
    • 5444221945 scopus 로고    scopus 로고
    • Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment
    • Mulnard R.A., Corrada M.M., and Kawas C.H. Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment. Curr Neurol Neurosci Rep 4 5 (2004) 368-373
    • (2004) Curr Neurol Neurosci Rep , vol.4 , Issue.5 , pp. 368-373
    • Mulnard, R.A.1    Corrada, M.M.2    Kawas, C.H.3
  • 240
    • 0034704547 scopus 로고    scopus 로고
    • Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study
    • Mulnard R.A., Cotman C.W., Kawas C., van Dyck C.H., Sano M., Doody R., et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA 283 8 (2000) 1007-1015
    • (2000) JAMA , vol.283 , Issue.8 , pp. 1007-1015
    • Mulnard, R.A.1    Cotman, C.W.2    Kawas, C.3    van Dyck, C.H.4    Sano, M.5    Doody, R.6
  • 242
  • 246
    • 0033559462 scopus 로고    scopus 로고
    • RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
    • Nunomura A., Perry G., Pappolla M.A., Wade R., Hirai K., Chiba S., et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 19 6 (1999) 1959-1964
    • (1999) J Neurosci , vol.19 , Issue.6 , pp. 1959-1964
    • Nunomura, A.1    Perry, G.2    Pappolla, M.A.3    Wade, R.4    Hirai, K.5    Chiba, S.6
  • 248
    • 0028969073 scopus 로고
    • Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: seven case reports
    • Ohkura T., Isse K., Akazawa K., Hamamoto M., Yaoi Y., and Hagino N. Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: seven case reports. Dementia 6 2 (1995) 99-107
    • (1995) Dementia , vol.6 , Issue.2 , pp. 99-107
    • Ohkura, T.1    Isse, K.2    Akazawa, K.3    Hamamoto, M.4    Yaoi, Y.5    Hagino, N.6
  • 249
    • 0030587582 scopus 로고    scopus 로고
    • Aging and superoxide dismutase activity in cerebrospinal fluid
    • Okabe T., Hamaguchi K., Inafuku T., and Hara M. Aging and superoxide dismutase activity in cerebrospinal fluid. J Neurol Sci 141 1-2 (1996) 100-104
    • (1996) J Neurol Sci , vol.141 , Issue.1-2 , pp. 100-104
    • Okabe, T.1    Hamaguchi, K.2    Inafuku, T.3    Hara, M.4
  • 250
    • 0031788259 scopus 로고    scopus 로고
    • The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease
    • Oken B.S., Storzbach D.M., and Kaye J.A. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 55 11 (1998) 1409-1415
    • (1998) Arch Neurol , vol.55 , Issue.11 , pp. 1409-1415
    • Oken, B.S.1    Storzbach, D.M.2    Kaye, J.A.3
  • 251
    • 1542364225 scopus 로고    scopus 로고
    • Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
    • Ono K., Hasegawa K., Naiki H., and Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J Neurosci Res 75 6 (2004) 742-750
    • (2004) J Neurosci Res , vol.75 , Issue.6 , pp. 742-750
    • Ono, K.1    Hasegawa, K.2    Naiki, H.3    Yamada, M.4
  • 252
    • 4544227975 scopus 로고    scopus 로고
    • Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro
    • Ono K., Yoshiike Y., Takashima A., Hasegawa K., Naiki H., and Yamada M. Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro. Exp Neurol 189 2 (2004) 380-392
    • (2004) Exp Neurol , vol.189 , Issue.2 , pp. 380-392
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasegawa, K.4    Naiki, H.5    Yamada, M.6
  • 253
    • 0036144386 scopus 로고    scopus 로고
    • Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease
    • Padovani A., Borroni B., Colciaghi F., Pettenati C., Cottini E., Agosti C., et al. Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease. Arch Neurol 59 1 (2002) 71-75
    • (2002) Arch Neurol , vol.59 , Issue.1 , pp. 71-75
    • Padovani, A.1    Borroni, B.2    Colciaghi, F.3    Pettenati, C.4    Cottini, E.5    Agosti, C.6
  • 254
    • 0029844969 scopus 로고    scopus 로고
    • Estrogen replacement therapy and risk of Alzheimer disease
    • Paganini-Hill A., and Henderson V.W. Estrogen replacement therapy and risk of Alzheimer disease. Arch Intern Med 156 19 (1996) 2213-2217
    • (1996) Arch Intern Med , vol.156 , Issue.19 , pp. 2213-2217
    • Paganini-Hill, A.1    Henderson, V.W.2
  • 255
    • 0031039538 scopus 로고    scopus 로고
    • Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging
    • Pallister C., Jung S.S., Shaw I., Nalbantoglu J., Gauthier S., and Cashman N.R. Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging. Neurobiol Aging 18 1 (1997) 97-103
    • (1997) Neurobiol Aging , vol.18 , Issue.1 , pp. 97-103
    • Pallister, C.1    Jung, S.S.2    Shaw, I.3    Nalbantoglu, J.4    Gauthier, S.5    Cashman, N.R.6
  • 256
    • 0031896581 scopus 로고    scopus 로고
    • Antioxidant enzymes and fatty acid status in erythrocytes of Down's syndrome patients
    • Pastor M.C., Sierra C., Dolade M., Navarro E., Brandi N., Cabre E., et al. Antioxidant enzymes and fatty acid status in erythrocytes of Down's syndrome patients. Clin Chem 44 5 (1998) 924-929
    • (1998) Clin Chem , vol.44 , Issue.5 , pp. 924-929
    • Pastor, M.C.1    Sierra, C.2    Dolade, M.3    Navarro, E.4    Brandi, N.5    Cabre, E.6
  • 257
    • 0038020053 scopus 로고    scopus 로고
    • Glutathione metabolism and antioxidant enzymes in children with Down syndrome
    • Pastore A., Tozzi G., Gaeta L.M., Giannotti A., Bertini E., Federici G., et al. Glutathione metabolism and antioxidant enzymes in children with Down syndrome. J Pediatr 142 5 (2003) 583-585
    • (2003) J Pediatr , vol.142 , Issue.5 , pp. 583-585
    • Pastore, A.1    Tozzi, G.2    Gaeta, L.M.3    Giannotti, A.4    Bertini, E.5    Federici, G.6
  • 259
    • 0025319496 scopus 로고
    • Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease
    • Percy M.E., Dalton A.J., Markovic V.D., McLachlan D.R., Hummel J.T., Rusk A.C., et al. Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease. Am J Med Genet 35 4 (1990) 459-467
    • (1990) Am J Med Genet , vol.35 , Issue.4 , pp. 459-467
    • Percy, M.E.1    Dalton, A.J.2    Markovic, V.D.3    McLachlan, D.R.4    Hummel, J.T.5    Rusk, A.C.6
  • 260
    • 0025670273 scopus 로고
    • Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study
    • Perrin R., Briancon S., Jeandel C., Artur Y., Minn A., Penin F., et al. Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study. Gerontology 36 5-6 (1990) 306-313
    • (1990) Gerontology , vol.36 , Issue.5-6 , pp. 306-313
    • Perrin, R.1    Briancon, S.2    Jeandel, C.3    Artur, Y.4    Minn, A.5    Penin, F.6
  • 261
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin E and donepezil for the treatment of mild cognitive impairment
    • Petersen R.C., Thomas R.G., Grundman M., Bennett D., Doody R., Ferris S., et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352 23 (2005) 2379-2388
    • (2005) N Engl J Med , vol.352 , Issue.23 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3    Bennett, D.4    Doody, R.5    Ferris, S.6
  • 262
    • 0032816455 scopus 로고    scopus 로고
    • Alzheimer's disease and down syndrome: from meiosis to dementia
    • Petronis A. Alzheimer's disease and down syndrome: from meiosis to dementia. Exp Neurol 158 2 (1999) 403-413
    • (1999) Exp Neurol , vol.158 , Issue.2 , pp. 403-413
    • Petronis, A.1
  • 263
    • 0032945331 scopus 로고    scopus 로고
    • Effect of Vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome
    • Pincheira J., Navarrete M.H., de la T.C., Tapia G., and Santos M.J. Effect of Vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome. Clin Genet 55 3 (1999) 192-197
    • (1999) Clin Genet , vol.55 , Issue.3 , pp. 192-197
    • Pincheira, J.1    Navarrete, M.H.2    de la, T.C.3    Tapia, G.4    Santos, M.J.5
  • 265
    • 1342306400 scopus 로고    scopus 로고
    • Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease
    • Pocernich C.B., and Butterfield D.A. Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotox Res 5 7 (2003) 515-520
    • (2003) Neurotox Res , vol.5 , Issue.7 , pp. 515-520
    • Pocernich, C.B.1    Butterfield, D.A.2
  • 266
    • 0034969415 scopus 로고    scopus 로고
    • Homocysteine metabolism in children with Down syndrome: in vitro modulation
    • Pogribna M., Melnyk S., Pogribny I., Chango A., Yi P., and James S.J. Homocysteine metabolism in children with Down syndrome: in vitro modulation. Am J Hum Genet 69 1 (2001) 88-95
    • (2001) Am J Hum Genet , vol.69 , Issue.1 , pp. 88-95
    • Pogribna, M.1    Melnyk, S.2    Pogribny, I.3    Chango, A.4    Yi, P.5    James, S.J.6
  • 267
    • 14544284095 scopus 로고    scopus 로고
    • Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders
    • Poon H.F., Farr S.A., Thongboonkerd V., Lynn B.C., Banks W.A., Morley J.E., et al. Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders. Neurochem Int 46 2 (2005) 159-168
    • (2005) Neurochem Int , vol.46 , Issue.2 , pp. 159-168
    • Poon, H.F.1    Farr, S.A.2    Thongboonkerd, V.3    Lynn, B.C.4    Banks, W.A.5    Morley, J.E.6
  • 268
    • 0023866528 scopus 로고
    • A rapid and sensitive enzyme immunoassay for Cu/Zn superoxide dismutase with polyclonal and monoclonal antibodies
    • Porstmann T., Wietschke R., Schmechta H., Grunow R., Porstmann B., Bleiber R., et al. A rapid and sensitive enzyme immunoassay for Cu/Zn superoxide dismutase with polyclonal and monoclonal antibodies. Clin Chim Acta 171 1 (1988) 1-10
    • (1988) Clin Chim Acta , vol.171 , Issue.1 , pp. 1-10
    • Porstmann, T.1    Wietschke, R.2    Schmechta, H.3    Grunow, R.4    Porstmann, B.5    Bleiber, R.6
  • 270
    • 0033762711 scopus 로고    scopus 로고
    • Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a non-invasive index of lipid peroxidation with disease severity
    • Pratico D., Clark C.M., Lee V.M., Trojanowski J.Q., Rokach J., and FitzGerald G.A. Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a non-invasive index of lipid peroxidation with disease severity. Ann Neurol 48 5 (2000) 809-812
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 809-812
    • Pratico, D.1    Clark, C.M.2    Lee, V.M.3    Trojanowski, J.Q.4    Rokach, J.5    FitzGerald, G.A.6
  • 271
    • 0033765735 scopus 로고    scopus 로고
    • Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease
    • Pratico D., and Delanty N. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med 109 7 (2000) 577-585
    • (2000) Am J Med , vol.109 , Issue.7 , pp. 577-585
    • Pratico, D.1    Delanty, N.2
  • 272
    • 0033761958 scopus 로고    scopus 로고
    • Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo
    • Pratico D., Iuliano L., Amerio G., Tang L.X., Rokach J., Sabatino G., et al. Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo. Ann Neurol 48 5 (2000) 795-798
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 795-798
    • Pratico, D.1    Iuliano, L.2    Amerio, G.3    Tang, L.X.4    Rokach, J.5    Sabatino, G.6
  • 273
    • 0032238783 scopus 로고    scopus 로고
    • Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo
    • Pratico D., Lee V.M., Trojanowski J.Q., Rokach J., and FitzGerald G.A. Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. FASEB J 12 15 (1998) 1777-1783
    • (1998) FASEB J , vol.12 , Issue.15 , pp. 1777-1783
    • Pratico, D.1    Lee, V.M.2    Trojanowski, J.Q.3    Rokach, J.4    FitzGerald, G.A.5
  • 274
    • 0026806423 scopus 로고
    • Lipids and lipoproteins in persons with Down's syndrome
    • Pueschel S.M., Craig W.Y., and Haddow J.E. Lipids and lipoproteins in persons with Down's syndrome. J Intellect Disabil Res 36 4 (1992) 365-369
    • (1992) J Intellect Disabil Res , vol.36 , Issue.4 , pp. 365-369
    • Pueschel, S.M.1    Craig, W.Y.2    Haddow, J.E.3
  • 277
    • 0032509749 scopus 로고    scopus 로고
    • Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients
    • Raji N.S., and Rao K.S. Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients. Mech Ageing Dev 100 1 (1998) 85-101
    • (1998) Mech Ageing Dev , vol.100 , Issue.1 , pp. 85-101
    • Raji, N.S.1    Rao, K.S.2
  • 278
    • 0019976635 scopus 로고
    • In vitro life span and "unscheduled DNA synthesis" in subconfluent cultures and clones of trisomic and normal diploid fibroblasts
    • Rebhorn H., and Pfeiffenberger H. In vitro life span and "unscheduled DNA synthesis" in subconfluent cultures and clones of trisomic and normal diploid fibroblasts. Mech Ageing Dev 18 3 (1982) 201-208
    • (1982) Mech Ageing Dev , vol.18 , Issue.3 , pp. 201-208
    • Rebhorn, H.1    Pfeiffenberger, H.2
  • 280
    • 0035252562 scopus 로고    scopus 로고
    • Too much of a good thing: mechanisms of gene action in Down syndrome
    • Reeves R.H., Baxter L.L., and Richtsmeier J.T. Too much of a good thing: mechanisms of gene action in Down syndrome. Trends Genet 17 2 (2001) 83-88
    • (2001) Trends Genet , vol.17 , Issue.2 , pp. 83-88
    • Reeves, R.H.1    Baxter, L.L.2    Richtsmeier, J.T.3
  • 281
    • 0028239163 scopus 로고
    • Oxidative damage to proteins: spectrophotometric method for carbonyl assay
    • Reznick A.Z., and Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Meth Enzymol 233 (1994) 357-363
    • (1994) Meth Enzymol , vol.233 , pp. 357-363
    • Reznick, A.Z.1    Packer, L.2
  • 282
    • 11844250512 scopus 로고    scopus 로고
    • Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts"
    • Richter T., Munch G., Luth H.J., Arendt T., Kientsch-Engel R., Stahl P., et al. Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts". Neurobiol Aging 26 4 (2005) 465-474
    • (2005) Neurobiol Aging , vol.26 , Issue.4 , pp. 465-474
    • Richter, T.1    Munch, G.2    Luth, H.J.3    Arendt, T.4    Kientsch-Engel, R.5    Stahl, P.6
  • 283
    • 0042591280 scopus 로고    scopus 로고
    • Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease
    • Rinaldi P., Polidori M.C., Metastasio A., Mariani E., Mattioli P., Cherubini A., et al. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging 24 7 (2003) 915-919
    • (2003) Neurobiol Aging , vol.24 , Issue.7 , pp. 915-919
    • Rinaldi, P.1    Polidori, M.C.2    Metastasio, A.3    Mariani, E.4    Mattioli, P.5    Cherubini, A.6
  • 285
    • 0032453635 scopus 로고    scopus 로고
    • Plasma protein glycation in Alzheimer's disease
    • Riviere S., Birlouez-Aragon I., and Vellas B. Plasma protein glycation in Alzheimer's disease. Glycoconj J 15 10 (1998) 1039-1042
    • (1998) Glycoconj J , vol.15 , Issue.10 , pp. 1039-1042
    • Riviere, S.1    Birlouez-Aragon, I.2    Vellas, B.3
  • 286
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • Roizen N.J., and Patterson D. Down's syndrome. Lancet 361 9365 (2003) 1281-1289
    • (2003) Lancet , vol.361 , Issue.9365 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 287
    • 0031047350 scopus 로고    scopus 로고
    • Altered amyloid protein processing in platelets of patients with Alzheimer disease
    • Rosenberg R.N., Baskin F., Fosmire J.A., Risser R., Adams P., Svetlik D., et al. Altered amyloid protein processing in platelets of patients with Alzheimer disease. Arch Neurol 54 2 (1997) 139-144
    • (1997) Arch Neurol , vol.54 , Issue.2 , pp. 139-144
    • Rosenberg, R.N.1    Baskin, F.2    Fosmire, J.A.3    Risser, R.4    Adams, P.5    Svetlik, D.6
  • 288
    • 0032853101 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
    • Rosenblatt D.S. Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome. Am J Clin Nutr 70 4 (1999) 429-430
    • (1999) Am J Clin Nutr , vol.70 , Issue.4 , pp. 429-430
    • Rosenblatt, D.S.1
  • 290
    • 18344363918 scopus 로고    scopus 로고
    • Relationship between dementia and nutrition-related factors and disorders: an overview
    • Salerno-Kennedy R., and Cashman K.D. Relationship between dementia and nutrition-related factors and disorders: an overview. Int J Vitam Nutr Res 75 2 (2005) 83-95
    • (2005) Int J Vitam Nutr Res , vol.75 , Issue.2 , pp. 83-95
    • Salerno-Kennedy, R.1    Cashman, K.D.2
  • 291
    • 0036378556 scopus 로고    scopus 로고
    • Systematic review of the effect of therapeutic dietary supplements and drugs on cognitive function in subjects with Down syndrome
    • Salman M. Systematic review of the effect of therapeutic dietary supplements and drugs on cognitive function in subjects with Down syndrome. Eur J Paediatr Neurol 6 4 (2002) 213-219
    • (2002) Eur J Paediatr Neurol , vol.6 , Issue.4 , pp. 213-219
    • Salman, M.1
  • 292
    • 0035812834 scopus 로고    scopus 로고
    • Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome
    • Sanij E., Hatzistavrou T., Hertzog P., Kola I., and Wolvetang E.J. Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome. Biochem Biophys Res Commun 287 4 (2001) 1003-1008
    • (2001) Biochem Biophys Res Commun , vol.287 , Issue.4 , pp. 1003-1008
    • Sanij, E.1    Hatzistavrou, T.2    Hertzog, P.3    Kola, I.4    Wolvetang, E.J.5
  • 293
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
    • Sano M., Ernesto C., Thomas R.G., Klauber M.R., Schafer K., Grundman M., et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 336 17 (1997) 1216-1222
    • (1997) N Engl J Med , vol.336 , Issue.17 , pp. 1216-1222
    • Sano, M.1    Ernesto, C.2    Thomas, R.G.3    Klauber, M.R.4    Schafer, K.5    Grundman, M.6
  • 298
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • Scharf S., Mander A., Ugoni A., Vajda F., and Christophidis N. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 53 1 (1999) 197-201
    • (1999) Neurology , vol.53 , Issue.1 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 299
    • 28244446721 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type
    • Schneider L.S., DeKosky S.T., Farlow M.R., Tariot P.N., Hoerr R., and Kieser M. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr Alzheimer Res 2 5 (2005) 541-551
    • (2005) Curr Alzheimer Res , vol.2 , Issue.5 , pp. 541-551
    • Schneider, L.S.1    DeKosky, S.T.2    Farlow, M.R.3    Tariot, P.N.4    Hoerr, R.5    Kieser, M.6
  • 301
    • 0033967558 scopus 로고    scopus 로고
    • Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome
    • Schuchmann S., and Heinemann U. Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome. Free Radic Biol Med 28 2 (2000) 235-250
    • (2000) Free Radic Biol Med , vol.28 , Issue.2 , pp. 235-250
    • Schuchmann, S.1    Heinemann, U.2
  • 302
    • 4544354817 scopus 로고    scopus 로고
    • Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain
    • Schuessel K., Leutner S., Cairns N.J., Muller W.E., and Eckert A. Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain. J Neural Transmemb 111 9 (2004) 1167-1182
    • (2004) J Neural Transmemb , vol.111 , Issue.9 , pp. 1167-1182
    • Schuessel, K.1    Leutner, S.2    Cairns, N.J.3    Muller, W.E.4    Eckert, A.5
  • 303
    • 0037911529 scopus 로고    scopus 로고
    • Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider
    • Schulz V. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider. Phytomedicine 10 Suppl 4 (2003) 74-79
    • (2003) Phytomedicine , vol.10 , Issue.SUPPL. 4 , pp. 74-79
    • Schulz, V.1
  • 305
    • 0036261357 scopus 로고    scopus 로고
    • Genetic and host factors for dementia in Down's syndrome
    • Schupf N., and Sergievsky G.H. Genetic and host factors for dementia in Down's syndrome. Br J Psychiatry 180 (2002) 405-410
    • (2002) Br J Psychiatry , vol.180 , pp. 405-410
    • Schupf, N.1    Sergievsky, G.H.2
  • 306
  • 307
    • 0030763372 scopus 로고    scopus 로고
    • Evidence against increased glycoxidation in patients with Alzheimer's disease
    • Seidl R., Schuller E., Cairns N., and Lubec G. Evidence against increased glycoxidation in patients with Alzheimer's disease. Neurosci Lett 232 1 (1997) 49-52
    • (1997) Neurosci Lett , vol.232 , Issue.1 , pp. 49-52
    • Seidl, R.1    Schuller, E.2    Cairns, N.3    Lubec, G.4
  • 308
    • 0036224435 scopus 로고    scopus 로고
    • The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease
    • Selley M.L., Close D.R., and Stern S.E. The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging 23 3 (2002) 383-388
    • (2002) Neurobiol Aging , vol.23 , Issue.3 , pp. 383-388
    • Selley, M.L.1    Close, D.R.2    Stern, S.E.3
  • 309
    • 0029984062 scopus 로고    scopus 로고
    • Antioxidant and redox regulation of gene transcription
    • Sen C.K., and Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 10 7 (1996) 709-720
    • (1996) FASEB J , vol.10 , Issue.7 , pp. 709-720
    • Sen, C.K.1    Packer, L.2
  • 310
    • 0035107245 scopus 로고    scopus 로고
    • Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease
    • Seshadri S., Zornberg G.L., Derby L.E., Myers M.W., Jick H., and Drachman D.A. Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease. Arch Neurol 58 3 (2001) 435-440
    • (2001) Arch Neurol , vol.58 , Issue.3 , pp. 435-440
    • Seshadri, S.1    Zornberg, G.L.2    Derby, L.E.3    Myers, M.W.4    Jick, H.5    Drachman, D.A.6
  • 311
    • 0031045614 scopus 로고    scopus 로고
    • Whither Down syndrome critical regions?
    • Shapiro B.L. Whither Down syndrome critical regions?. Hum Genet 99 3 (1997) 421-423
    • (1997) Hum Genet , vol.99 , Issue.3 , pp. 421-423
    • Shapiro, B.L.1
  • 312
    • 0027974132 scopus 로고
    • Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection
    • Shigenaga M.K., Aboujaoude E.N., Chen Q., and Ames B.N. Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Meth Enzymol 234 (1994) 16-33
    • (1994) Meth Enzymol , vol.234 , pp. 16-33
    • Shigenaga, M.K.1    Aboujaoude, E.N.2    Chen, Q.3    Ames, B.N.4
  • 314
    • 0027345921 scopus 로고
    • The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging
    • Sikora E., Radziszewska E., Kmiec T., and Maslinska D. The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging. Acta Biochim Pol 40 2 (1993) 269-272
    • (1993) Acta Biochim Pol , vol.40 , Issue.2 , pp. 269-272
    • Sikora, E.1    Radziszewska, E.2    Kmiec, T.3    Maslinska, D.4
  • 315
    • 12744250280 scopus 로고    scopus 로고
    • Antioxidant gene expression imbalance, aging and Down syndrome
    • Sinha S. Antioxidant gene expression imbalance, aging and Down syndrome. Life Sci 76 12 (2005) 1407-1426
    • (2005) Life Sci , vol.76 , Issue.12 , pp. 1407-1426
    • Sinha, S.1
  • 316
    • 27444433997 scopus 로고    scopus 로고
    • Increase in plasma homocysteine levels induced by drug treatments in neurologic patients
    • Siniscalchi A., Mancuso F., Gallelli L., Ferreri I.G., Biagio M.N., and De Sarro G. Increase in plasma homocysteine levels induced by drug treatments in neurologic patients. Pharmacol Res 52 5 (2005) 367-375
    • (2005) Pharmacol Res , vol.52 , Issue.5 , pp. 367-375
    • Siniscalchi, A.1    Mancuso, F.2    Gallelli, L.3    Ferreri, I.G.4    Biagio, M.N.5    De Sarro, G.6
  • 320
  • 321
    • 0031776586 scopus 로고    scopus 로고
    • Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine
    • Smith M.A., Sayre L.M., Anderson V.E., Harris P.L., Beal M.F., Kowall N., et al. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J Histochem Cytochem 46 6 (1998) 731-735
    • (1998) J Histochem Cytochem , vol.46 , Issue.6 , pp. 731-735
    • Smith, M.A.1    Sayre, L.M.2    Anderson, V.E.3    Harris, P.L.4    Beal, M.F.5    Kowall, N.6
  • 323
    • 0028233977 scopus 로고
    • Advanced Maillard reaction end-products are associated with Alzheimer disease pathology
    • Smith M.A., Taneda S., Richey P.L., Miyata S., Yan S.D., Stern D., et al. Advanced Maillard reaction end-products are associated with Alzheimer disease pathology. Proc Natl Acad Sci USA 91 12 (1994) 5710-5714
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.12 , pp. 5710-5714
    • Smith, M.A.1    Taneda, S.2    Richey, P.L.3    Miyata, S.4    Yan, S.D.5    Stern, D.6
  • 324
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R.S., and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273 5271 (1996) 59-63
    • (1996) Science , vol.273 , Issue.5271 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 326
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    • Stadelmann C., Bruck W., Bancher C., Jellinger K., and Lassmann H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol 57 5 (1998) 56-464
    • (1998) J Neuropathol Exp Neurol , vol.57 , Issue.5 , pp. 56-464
    • Stadelmann, C.1    Bruck, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 327
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadtman E.R. Protein oxidation and aging. Science 257 5074 (1992) 1220-1224
    • (1992) Science , vol.257 , Issue.5074 , pp. 1220-1224
    • Stadtman, E.R.1
  • 328
    • 0019974086 scopus 로고
    • Normal formation and repair of gamma-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts
    • Steiner M.E., and Woods W.G. Normal formation and repair of gamma-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts. Mutat Res 95 2-3 (1982) 515-523
    • (1982) Mutat Res , vol.95 , Issue.2-3 , pp. 515-523
    • Steiner, M.E.1    Woods, W.G.2
  • 329
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., and Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48 3 (1997) 626-632
    • (1997) Neurology , vol.48 , Issue.3 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 330
    • 33644693101 scopus 로고    scopus 로고
    • Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    • Stott D.J., MacIntosh G., Lowe G.D., Rumley A., McMahon A.D., Langhorne P., et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr 82 6 (2005) 1320-1326
    • (2005) Am J Clin Nutr , vol.82 , Issue.6 , pp. 1320-1326
    • Stott, D.J.1    MacIntosh, G.2    Lowe, G.D.3    Rumley, A.4    McMahon, A.D.5    Langhorne, P.6
  • 331
    • 0031558654 scopus 로고    scopus 로고
    • Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
    • Su J.H., Deng G., and Cotman C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res 774 1-2 (1997) 193-199
    • (1997) Brain Res , vol.774 , Issue.1-2 , pp. 193-199
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 332
    • 13644265462 scopus 로고    scopus 로고
    • Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity
    • Sultana R., Ravagna A., Mohmmad-Abdul H., Calabrese V., and Butterfield D.A. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem 92 4 (2005) 749-758
    • (2005) J Neurochem , vol.92 , Issue.4 , pp. 749-758
    • Sultana, R.1    Ravagna, A.2    Mohmmad-Abdul, H.3    Calabrese, V.4    Butterfield, D.A.5
  • 333
    • 3242803587 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
    • Szekely C.A., Thorne J.E., Zandi P.P., Ek M., Messias E., Breitner J.C., et al. Non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 23 4 (2004) 159-169
    • (2004) Neuroepidemiology , vol.23 , Issue.4 , pp. 159-169
    • Szekely, C.A.1    Thorne, J.E.2    Zandi, P.P.3    Ek, M.4    Messias, E.5    Breitner, J.C.6
  • 335
    • 0035985937 scopus 로고    scopus 로고
    • Endogenous antioxidant activities in relation to concurrent Vitamins A, C, and E intake in dementia
    • Tabet N., Mantle D., Walker Z., and Orrell M. Endogenous antioxidant activities in relation to concurrent Vitamins A, C, and E intake in dementia. Int Psychogeriatr 14 1 (2002) 7-15
    • (2002) Int Psychogeriatr , vol.14 , Issue.1 , pp. 7-15
    • Tabet, N.1    Mantle, D.2    Walker, Z.3    Orrell, M.4
  • 336
    • 0030591669 scopus 로고    scopus 로고
    • Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    • Tang M.X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348 9025 (1996) 429-432
    • (1996) Lancet , vol.348 , Issue.9025 , pp. 429-432
    • Tang, M.X.1    Jacobs, D.2    Stern, Y.3    Marder, K.4    Schofield, P.5    Gurland, B.6
  • 338
    • 0037076783 scopus 로고    scopus 로고
    • Platelets in atherosclerosis: a new role for beta-amyloid peptide beyond Alzheimer's disease
    • Tedgui A., and Mallat Z. Platelets in atherosclerosis: a new role for beta-amyloid peptide beyond Alzheimer's disease. Circ Res 90 11 (2002) 1145-1146
    • (2002) Circ Res , vol.90 , Issue.11 , pp. 1145-1146
    • Tedgui, A.1    Mallat, Z.2
  • 340
    • 0036250622 scopus 로고    scopus 로고
    • Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid
    • Teunissen C.E., de Vente J., Steinbusch H.W., and De Bruijn C. Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid. Neurobiol Aging 23 4 (2002) 485-508
    • (2002) Neurobiol Aging , vol.23 , Issue.4 , pp. 485-508
    • Teunissen, C.E.1    de Vente, J.2    Steinbusch, H.W.3    De Bruijn, C.4
  • 341
    • 11144249334 scopus 로고    scopus 로고
    • Can cognitive deterioration associated with Down syndrome be reduced?
    • Thiel R., and Fowkes S.W. Can cognitive deterioration associated with Down syndrome be reduced?. Med Hypotheses 64 3 (2005) 524-532
    • (2005) Med Hypotheses , vol.64 , Issue.3 , pp. 524-532
    • Thiel, R.1    Fowkes, S.W.2
  • 342
    • 0034603412 scopus 로고    scopus 로고
    • Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease
    • Thomas T. Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease. Neurobiol Aging 21 2 (2000) 343-348
    • (2000) Neurobiol Aging , vol.21 , Issue.2 , pp. 343-348
    • Thomas, T.1
  • 343
    • 0029670094 scopus 로고    scopus 로고
    • beta-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T., Thomas G., McLendon C., Sutton T., and Mullan M. beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380 6570 (1996) 168-171
    • (1996) Nature , vol.380 , Issue.6570 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 344
    • 0030598233 scopus 로고    scopus 로고
    • Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease
    • Thome J., Gsell W., Rosler M., Kornhuber J., Frolich L., Hashimoto E., et al. Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease. Life Sci 60 1 (1997) 13-19
    • (1997) Life Sci , vol.60 , Issue.1 , pp. 13-19
    • Thome, J.1    Gsell, W.2    Rosler, M.3    Kornhuber, J.4    Frolich, L.5    Hashimoto, E.6
  • 345
    • 0030593444 scopus 로고    scopus 로고
    • Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease
    • Thome J., Munch G., Muller R., Schinzel R., Kornhuber J., Blum-Degen D., et al. Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease. Life Sci 59 8 (1996) 679-685
    • (1996) Life Sci , vol.59 , Issue.8 , pp. 679-685
    • Thome, J.1    Munch, G.2    Muller, R.3    Schinzel, R.4    Kornhuber, J.5    Blum-Degen, D.6
  • 346
    • 0027489203 scopus 로고
    • Alkylation damage and repair in Alzheimer's disease lymphocytes
    • Tobi S.E., Neary D., and Itzhaki R.F. Alkylation damage and repair in Alzheimer's disease lymphocytes. Gerontology 39 5 (1993) 241-251
    • (1993) Gerontology , vol.39 , Issue.5 , pp. 241-251
    • Tobi, S.E.1    Neary, D.2    Itzhaki, R.F.3
  • 347
    • 0031056184 scopus 로고    scopus 로고
    • Plasma levels of amyloid beta proteins Aβ1-40 and Aβ1-42(43) are elevated in Down's syndrome
    • Tokuda T., Fukushima T., Ikeda S., Sekijima Y., Shoji S., Yanagisawa N., et al. Plasma levels of amyloid beta proteins Aβ1-40 and Aβ1-42(43) are elevated in Down's syndrome. Ann Neurol 41 2 (1997) 271-273
    • (1997) Ann Neurol , vol.41 , Issue.2 , pp. 271-273
    • Tokuda, T.1    Fukushima, T.2    Ikeda, S.3    Sekijima, Y.4    Shoji, S.5    Yanagisawa, N.6
  • 348
    • 0037069290 scopus 로고    scopus 로고
    • Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study
    • Truelsen T., Thudium D., and Gronbaek M. Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology 59 9 (2002) 1313-1319
    • (2002) Neurology , vol.59 , Issue.9 , pp. 1313-1319
    • Truelsen, T.1    Thudium, D.2    Gronbaek, M.3
  • 349
    • 0035570942 scopus 로고    scopus 로고
    • Free radical oxidative damage and Alzheimer's disease
    • Tuppo E.E., and Forman L.J. Free radical oxidative damage and Alzheimer's disease. J Am Osteopath Assoc 101 12 Suppl Pt 1 (2001) S11-S15
    • (2001) J Am Osteopath Assoc , vol.101 , Issue.12 SUPPL. PART 1
    • Tuppo, E.E.1    Forman, L.J.2
  • 350
    • 0035867047 scopus 로고    scopus 로고
    • Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease
    • Tuppo E.E., Forman L.J., Spur B.W., Chan-Ting R.E., Chopra A., and Cavalieri T.A. Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. Brain Res Bull 54 5 (2001) 565-568
    • (2001) Brain Res Bull , vol.54 , Issue.5 , pp. 565-568
    • Tuppo, E.E.1    Forman, L.J.2    Spur, B.W.3    Chan-Ting, R.E.4    Chopra, A.5    Cavalieri, T.A.6
  • 351
    • 0030026736 scopus 로고    scopus 로고
    • Analysis of amyloid precursor protein mRNAs in skin fibroblasts in Down's syndrome
    • Urakami K., Kataoka J., Okada A., Isoe K., Wakutani Y., Ji Y., et al. Analysis of amyloid precursor protein mRNAs in skin fibroblasts in Down's syndrome. Dementia 7 2 (1996) 82-85
    • (1996) Dementia , vol.7 , Issue.2 , pp. 82-85
    • Urakami, K.1    Kataoka, J.2    Okada, A.3    Isoe, K.4    Wakutani, Y.5    Ji, Y.6
  • 352
    • 0037951799 scopus 로고    scopus 로고
    • Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial
    • Van Dongen M., van Rossum E., Kessels A., Sielhorst H., and Knipschild P. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J Clin Epidemiol 56 4 (2003) 367-376
    • (2003) J Clin Epidemiol , vol.56 , Issue.4 , pp. 367-376
    • Van Dongen, M.1    van Rossum, E.2    Kessels, A.3    Sielhorst, H.4    Knipschild, P.5
  • 353
    • 0033785945 scopus 로고    scopus 로고
    • The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial
    • van Dongen M.C., van Rossum E., Kessels A.G., Sielhorst H.J., and Knipschild P.G. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial. J Am Geriatr Soc 48 10 (2000) 1183-1194
    • (2000) J Am Geriatr Soc , vol.48 , Issue.10 , pp. 1183-1194
    • van Dongen, M.C.1    van Rossum, E.2    Kessels, A.G.3    Sielhorst, H.J.4    Knipschild, P.G.5
  • 354
    • 0033860372 scopus 로고    scopus 로고
    • Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity
    • Varadarajan S., Yatin S., Aksenova M., and Butterfield D.A. Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130 2-3 (2000) 184-208
    • (2000) J Struct Biol , vol.130 , Issue.2-3 , pp. 184-208
    • Varadarajan, S.1    Yatin, S.2    Aksenova, M.3    Butterfield, D.A.4
  • 355
    • 0033016186 scopus 로고    scopus 로고
    • Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system
    • Vedder H., Anthes N., Stumm G., Wurz C., Behl C., and Krieg J.C. Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system. J Neurochem 72 6 (1999) 2531-2538
    • (1999) J Neurochem , vol.72 , Issue.6 , pp. 2531-2538
    • Vedder, H.1    Anthes, N.2    Stumm, G.3    Wurz, C.4    Behl, C.5    Krieg, J.C.6
  • 356
    • 1642463824 scopus 로고    scopus 로고
    • Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress
    • Vina J., Lloret A., Orti R., and Alonso D. Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress. Mol Aspects Med 25 1-2 (2004) 117-123
    • (2004) Mol Aspects Med , vol.25 , Issue.1-2 , pp. 117-123
    • Vina, J.1    Lloret, A.2    Orti, R.3    Alonso, D.4
  • 358
    • 18844462415 scopus 로고    scopus 로고
    • Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
    • Wang J., Xiong S., Xie C., Markesbery W.R., and Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem 93 4 (2005) 953-962
    • (2005) J Neurochem , vol.93 , Issue.4 , pp. 953-962
    • Wang, J.1    Xiong, S.2    Xie, C.3    Markesbery, W.R.4    Lovell, M.A.5
  • 359
    • 30144433689 scopus 로고    scopus 로고
    • Role of melatonin in Alzheimer-like neurodegeneration
    • Wang J.Z., and Wang Z.F. Role of melatonin in Alzheimer-like neurodegeneration. Acta Pharmacol Sin 27 1 (2006) 41-49
    • (2006) Acta Pharmacol Sin , vol.27 , Issue.1 , pp. 41-49
    • Wang, J.Z.1    Wang, Z.F.2
  • 360
    • 0034643897 scopus 로고    scopus 로고
    • Effects of estrogen on cognition, mood, and cerebral blood flow in AD: a controlled study
    • Wang P.N., Liao S.Q., Liu R.S., Liu C.Y., Chao H.T., Lu S.R., et al. Effects of estrogen on cognition, mood, and cerebral blood flow in AD: a controlled study. Neurology 54 11 (2000) 2061-2066
    • (2000) Neurology , vol.54 , Issue.11 , pp. 2061-2066
    • Wang, P.N.1    Liao, S.Q.2    Liu, R.S.3    Liu, C.Y.4    Chao, H.T.5    Lu, S.R.6
  • 361
    • 2142695733 scopus 로고    scopus 로고
    • Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
    • Warner T.D., and Mitchell J.A. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18 7 (2004) 790-804
    • (2004) FASEB J , vol.18 , Issue.7 , pp. 790-804
    • Warner, T.D.1    Mitchell, J.A.2
  • 363
    • 4444226105 scopus 로고    scopus 로고
    • Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
    • Weinreb O., Mandel S., Amit T., and Youdim M.B. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem 15 9 (2004) 506-516
    • (2004) J Nutr Biochem , vol.15 , Issue.9 , pp. 506-516
    • Weinreb, O.1    Mandel, S.2    Amit, T.3    Youdim, M.B.4
  • 364
    • 0033656278 scopus 로고    scopus 로고
    • Cholinesterase inhibitors and Gingko extracts-are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least 6 months' duration
    • Wettstein A. Cholinesterase inhibitors and Gingko extracts-are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least 6 months' duration. Phytomedicine 6 6 (2000) 393-401
    • (2000) Phytomedicine , vol.6 , Issue.6 , pp. 393-401
    • Wettstein, A.1
  • 365
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • Wisniewski K.E., Wisniewski H.M., and Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 17 3 (1985) 278-282
    • (1985) Ann Neurol , vol.17 , Issue.3 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 366
    • 0037426387 scopus 로고    scopus 로고
    • DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study
    • Wolkowitz O.M., Kramer J.H., Reus V.I., Costa M.M., Yaffe K., Walton P., et al. DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Neurology 60 7 (2003) 1071-1076
    • (2003) Neurology , vol.60 , Issue.7 , pp. 1071-1076
    • Wolkowitz, O.M.1    Kramer, J.H.2    Reus, V.I.3    Costa, M.M.4    Yaffe, K.5    Walton, P.6
  • 367
    • 0029926224 scopus 로고    scopus 로고
    • Sister chromatid exchanges in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light
    • Wu F.Y., Iijima K., Nishida A., and Higurashi M. Sister chromatid exchanges in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light. Mutat Res 367 4 (1996) 261-264
    • (1996) Mutat Res , vol.367 , Issue.4 , pp. 261-264
    • Wu, F.Y.1    Iijima, K.2    Nishida, A.3    Higurashi, M.4
  • 368
    • 0036227488 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
    • Xiang Z., Ho L., Valdellon J., Borchelt D., Kelley K., Spielman L., et al. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol Aging 23 3 (2002) 327-334
    • (2002) Neurobiol Aging , vol.23 , Issue.3 , pp. 327-334
    • Xiang, Z.1    Ho, L.2    Valdellon, J.3    Borchelt, D.4    Kelley, K.5    Spielman, L.6
  • 369
    • 0032481568 scopus 로고    scopus 로고
    • Estrogen therapy in postmenopausal women: effects on cognitive function and dementia
    • Yaffe K., Sawaya G., Lieberburg I., and Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA 279 9 (1998) 688-695
    • (1998) JAMA , vol.279 , Issue.9 , pp. 688-695
    • Yaffe, K.1    Sawaya, G.2    Lieberburg, I.3    Grady, D.4
  • 370
    • 0028023944 scopus 로고
    • Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress
    • Yan S.D., Chen X., Schmidt A.M., Brett J., Godman G., Zou Y.S., et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci USA 91 16 (1994) 7787-7791
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.16 , pp. 7787-7791
    • Yan, S.D.1    Chen, X.2    Schmidt, A.M.3    Brett, J.4    Godman, G.5    Zou, Y.S.6
  • 371
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    • Yang F., Lim G.P., Begum A.N., Ubeda O.J., Simmons M.R., Ambegaokar S.S., et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280 7 (2005) 5892-5901
    • (2005) J Biol Chem , vol.280 , Issue.7 , pp. 5892-5901
    • Yang, F.1    Lim, G.P.2    Begum, A.N.3    Ubeda, O.J.4    Simmons, M.R.5    Ambegaokar, S.S.6
  • 372
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides
    • Yankner B.A., Duffy L.K., and Kirschner D.A. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250 4978 (1990) 279-282
    • (1990) Science , vol.250 , Issue.4978 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 373
    • 0033133579 scopus 로고    scopus 로고
    • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42)
    • Yatin S.M., Varadarajan S., Link C.D., and Butterfield D.A. In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42). Neurobiol Aging 20 3 (1999) 325-330
    • (1999) Neurobiol Aging , vol.20 , Issue.3 , pp. 325-330
    • Yatin, S.M.1    Varadarajan, S.2    Link, C.D.3    Butterfield, D.A.4
  • 374
    • 0032585829 scopus 로고    scopus 로고
    • Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease
    • Yoo B.C., Seidl R., Cairns N., and Lubec G. Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease. J Neural Transmemb 57 Suppl (1999) 315-322
    • (1999) J Neural Transmemb , vol.57 , Issue.SUPPL , pp. 315-322
    • Yoo, B.C.1    Seidl, R.2    Cairns, N.3    Lubec, G.4
  • 375
    • 0018861501 scopus 로고
    • Comparative study of X-ray and UV induced cytotoxicity, DNA repair, and mutagenesis in Down's syndrome and normal fibroblasts
    • Yotti L.P., Glover T.W., Trosko J.E., and Segal D.J. Comparative study of X-ray and UV induced cytotoxicity, DNA repair, and mutagenesis in Down's syndrome and normal fibroblasts. Pediatr Res 14 2 (1980) 88-92
    • (1980) Pediatr Res , vol.14 , Issue.2 , pp. 88-92
    • Yotti, L.P.1    Glover, T.W.2    Trosko, J.E.3    Segal, D.J.4
  • 376
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J., and Yankner B.A. Apoptosis in the nervous system. Nature 407 6805 (2000) 802-809
    • (2000) Nature , vol.407 , Issue.6805 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 377
    • 0037167542 scopus 로고    scopus 로고
    • Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
    • Zandi P.P., Anthony J.C., Hayden K.M., Mehta K., Mayer L., and Breitner J.C. Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 59 6 (2002) 880-886
    • (2002) Neurology , vol.59 , Issue.6 , pp. 880-886
    • Zandi, P.P.1    Anthony, J.C.2    Hayden, K.M.3    Mehta, K.4    Mayer, L.5    Breitner, J.C.6
  • 378
    • 0346688728 scopus 로고    scopus 로고
    • Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study
    • Zandi P.P., Anthony J.C., Khachaturian A.S., Stone S.V., Gustafson D., Tschanz J.T., et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61 1 (2004) 82-88
    • (2004) Arch Neurol , vol.61 , Issue.1 , pp. 82-88
    • Zandi, P.P.1    Anthony, J.C.2    Khachaturian, A.S.3    Stone, S.V.4    Gustafson, D.5    Tschanz, J.T.6
  • 379
    • 0035991633 scopus 로고    scopus 로고
    • Involvement of glutathione and glutathione-related enzymes in the protection of normal and trisomic human fibroblasts against daunorubicin
    • Zatorska A., and Jozwiak Z. Involvement of glutathione and glutathione-related enzymes in the protection of normal and trisomic human fibroblasts against daunorubicin. Cell Biol Int 26 5 (2002) 383-391
    • (2002) Cell Biol Int , vol.26 , Issue.5 , pp. 383-391
    • Zatorska, A.1    Jozwiak, Z.2
  • 380
    • 0024490143 scopus 로고
    • Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation
    • Zemlan F.P., Thienhaus O.J., and Bosmann H.B. Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation. Brain Res 476 1 (1989) 160-162
    • (1989) Brain Res , vol.476 , Issue.1 , pp. 160-162
    • Zemlan, F.P.1    Thienhaus, O.J.2    Bosmann, H.B.3
  • 381
    • 0024652076 scopus 로고
    • Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals
    • Zhao B.L., Li X.J., He R.G., Cheng S.J., and Xin W.J. Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals. Cell Biophys 14 2 (1989) 175-185
    • (1989) Cell Biophys , vol.14 , Issue.2 , pp. 175-185
    • Zhao, B.L.1    Li, X.J.2    He, R.G.3    Cheng, S.J.4    Xin, W.J.5
  • 383
    • 1642358352 scopus 로고    scopus 로고
    • Alzheimer's disease: the two-hit hypothesis
    • Zhu X., Raina A.K., Perry G., and Smith M.A. Alzheimer's disease: the two-hit hypothesis. Lancet Neurol 3 4 (2004) 219-226
    • (2004) Lancet Neurol , vol.3 , Issue.4 , pp. 219-226
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 384
    • 1142273252 scopus 로고    scopus 로고
    • Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
    • Zitnanova I., Korytar P., Aruoma O.I., Sustrova M., Garaiova I., Muchova J., et al. Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?. Clin Chim Acta 341 1-2 (2004) 139-146
    • (2004) Clin Chim Acta , vol.341 , Issue.1-2 , pp. 139-146
    • Zitnanova, I.1    Korytar, P.2    Aruoma, O.I.3    Sustrova, M.4    Garaiova, I.5    Muchova, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.