Involvement of Maillard reactions in Alzheimer disease

Neurotoxicity Research

Volumn 4, Issue 3, 2002, Pages 191-209

  Prakash Reddy, V ^a   Obrenovich, M E ^b   Atwood, C S ^b   Perry, G ^b   Smith, M A ^c  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c NONE

Author keywords

Advanced glycation end products; Alzheimer disease; Amyloid ; Glycation; Maillard reaction; Neurodegeneration

Indexed keywords

2 IMIDAZOLIDINONE DERIVATIVE; 3 DEOXYGLUCOSONE; 4 HYDROXYNONENAL; 6 N CARBOXYMETHYLLYSINE; ACETYLSALICYLIC ACID; ADVANCED GLYCATION END PRODUCT; ALPHA TOCOPHEROL; AMINOGUANIDINE; AMYLOID BETA PROTEIN; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARGININE DERIVATIVE; ASCORBIC ACID; CARNOSINE; CHOLINESTERASE INHIBITOR; COCARBOXYLASE; DONEPEZIL; GINKGO BILOBA EXTRACT; GLYOXAL DERIVATIVE; INDOMETACIN; LYSINE DERIVATIVE; METHYLGLYOXAL; PENICILLAMINE; PENTOSIDINE; PYRIDOXAMINE; PYRIMIDINE DERIVATIVE; SELEGILINE; TENILSETAM; THIAZOLE DERIVATIVE; UNINDEXED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; GLYCATION; HUMAN; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PAIRED HELICAL FILAMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN CROSS LINKING; RAT; REGULATORY MECHANISM;

ANIMALIA; GINKGO BILOBA;

EID: 0036080646     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1080/1029840290007321     Document Type: Article

References (149)

1. "Role of oxidative stress in diabetic complications-a new perspective on an old paradigm"
2. "Impairment of the ubiquitin-proteasome system by protein aggregation"
3. 15N isotope studies and analysis by electrospray ionization-mass spectrometry"
4. "In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways"
5. "Advanced protein glycosylation in diabetes and aging"
6. "Identification and quantitation of N-(carboxymethyl)valine adduct in hemoglobin by gas chromatography mass spectrometry"
7. "Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease"
8. "Advanced glycation modification of Rosenthal fibers in patients with Alexander disease"
9. "Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(Carboxymethyl) lysine and hexitol-lysine"
10. "Protein crosslinking by the Maillard reaction: Dicarbonyl-derived imidazolium crosslinks in aging and diabetes"
11. "Inhibitors of the Maillard reaction-potential in the treatment of Alzheimer's disease"
12. "The role of the Maillard reaction in other pathologies: Alzheimer's disease"
13. "SPME-GC-MS detection analysis of Maillard reaction products"
14. "The use of capillary electrophoresis to monitor Maillard reaction products (MRP) by glyceraldehyde and the epsilon amino group of lysine"
15. "Antioxidant activity of Maillard reaction products formed during extrusion"
16. "Glycoxidation in Alzheimer's disease: A specific mechanism of early lesion pathogenesis?"
17. "AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?"
18. "Investigations on oxidative stress and therapeutical implications in dementia"
19. "Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo"
20. "Detection of Maillard reaction intermediates by high-pressure liquid chromatography (HPLC) and gas chromatography"
21. "Novel approaches to the analysis of the Maillard reaction of proteins"
22. "Renoprotective effects of a novel inhibitor of advanced glycation"
23. "New aspects in antidemential drug therapy of Alzheimer's disease"
24. "beta-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1"
25. "N-delta-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-L-ornithine, a novel methylglyoxal-arginine modification in beer"
26. "Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors"
27. "Aging of proteins: Immunological detection of a glucose-derived pyrrole formed during the Maillard reaction in vivo"
28. "Identification of the Modified structure of Arginine residues in proteins with 3-Deoxyglucosone, a Maillard reaction intermediate"
29. "Pharmacotherapy in Alzheimer's dementia: Treatment of cognitive symptoms-results of new studies"
30. "Methylglyoxal determination from different carbohydrates during heat processing"
31. "Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons"
32. "Synthesis of novel imidazolidinones from hexose-peptide adducts: Model studies of the Maillard reaction with possible significance in protein glycation"
33. "Synthesis of hexose-related imidazolidinones: Novel glycation products in the Maillard reaction"
34. "Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease?"
35. "Identification of advanced glycation end products of the Maillard reaction in Pick's disease"
36. "An immunochemical study on tau glycation in paired helical filaments"
37. "Advanced glycation end products: A highly complex set of biologically relevant compounds detected by mass spectrometry"
38. "On the reaction of L-ascorbic acid with propylamine under various conditions. Quantification of the main products by HPLC/DAD"
39. "Cross-linking of proteins by Maillard processes-characterization and detection of a lysine-arginine cross-link derived from D-glucose"
40. "Cross-linking of proteins by Maillard processes-model reactions of D-glucose or methylglyoxal with butylamine and guanidine derivatives"
41. "Cross-linking of proteins by Maillard processes: Characterization and detection of lysine-arginine cross-links derived from glyoxal and methylglyoxal"
42. "Analysis of microtubule-associated protein tau glycation in paired helical filaments"
43. "New aspects of the Maillard reaction in foods and in the human body"
44. "Age-Dependent accumulation of advanced glycosylation end-products in human neurons"
45. "Receptors for advanced glycosylation endproducts in human brain: Role in brain homeostasis"
46. Sugar-mediated crosslinking of alpha-biotinylated-Lys to cysteamine-agarose support: A method to isolate Maillard Lys-Lys-like crosslinks
47. "Oxygen is not required for the browning and crosslinking of protein by pentoses: Relevance to Maillard reactions in vivo"
48. "Transition metal-mediated glycoxidation accelerates cross-linking of beta-amyloid peptide"
49. "6-Deoxy-6-fluoro-L-ascorbic acid: Crystal structure and oxidative degradation"
50. "A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide"
51. "Progress of the Maillard reaction and antioxidant action of Maillard reaction products in preheated model systems during storage"
52. "A tombstone in Alzheimer's?"
53. "Role of fructose in glycation and cross-linking of proteins"
54. "Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline"
55. "Photo-enhanced modification of human skin elastin in actinic elastosis by N-epsilon-(carboxymethyl)lysine, one of the glycoxidation products of the Maillard reaction"
56. "Glycation, glycoxidation, and other Maillard reaction products"
57. "Structure of advanced Maillard reaction products and their pathological role"
58. "LC/MS analysis and antioxidative efficiency of Maillard reaction products from a lactose-lysine model system"
59. "Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments"
60. "The Cognition-enhancing drug tenilsetam is an inhibitor of protein cross-linking by advanced glycosylation"
61. "Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide"
62. "Advanced glycation endproducts in ageing and Alzheimer's disease"
63. "Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease"
64. "Alzheimer's disease-synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts"
65. "Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library"
66. "Crosslinking of alpha-synuclein by advanced glycation endproducts-an early pathophysiological step in Lewy body formation?"
67. "The presence of a glucose-derived Maillard reaction product in the human lens"
68. "Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes"
69. "Protein cross-linking by the Maillard reaction-isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal"
70. "Crosslines A and B as candidates for the fluorophores in age-and diabetes-related cross-linked proteins, and their diacetates produced by Maillard reaction of a-N-acetyl-L-lysine with D-glucose"
71. "High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kappa B activation and cytokine expression"
72. "3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone"
73. "Amyloid beta(2)-microglobulin is modified with N-epsilon-(carboxymethyl)lysine in dialysis-related amyloidosis"
74. "Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients"
75. "Amyloid beta 2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis"
76. "Amyloid beta(2)-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis"
77. "Accelerated formation of N epsilon-(carboxymethyl) lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons"
78. "Formation of crossline as a fluorescent advanced glycation end product in vitro and in vivo"
79. "First evidence for accumulation of protein-bound and protein-free pyrraline in human uremic plasma by mass spectrometry"
80. "Early glycoxidation damage in brains from Down's syndrome"
81. "Early glycoxidation damage in brains from Down's syndrome"
82. "Lipoperoxidation is selectively involved in progressive supranuclear palsy"
83. "CD36, a member of class B scavenger receptor family, as a receptor for advanced glycation end products"
84. "CD36, a member of the class B scavenger receptor family, as a receptor for advanced glycation end products"
85. "Scavenging of active oxygen species by glycated proteins"
86. "Beta-Carbolines that accumulate in human tissues may serve a protective role against oxidative stress"
87. "The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells"
88. "Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal"
89. "Antioxidant reversal of oxidative stress-induced memory deficits"
90. "Chromatographic analysis of Maillard reaction products"
91. "Chromatographic evidence for Pyrraline formation during protein glycation in-vitro and in-vivo"
92. "Novel inhibitors of advanced glycation end-products"
93. "Free radical formation from secondary amines in the Maillard reaction"
94. "The early glycation products of the Maillard reaction: Mass spectrometric characterization of novel imidazolidinones derived from an opioid pentapeptide and glucose"
95. "Free radicals in Alzheimer's dementia: Currently available therapeutic strategies"
96. "Separation of Maillard reaction products from xylose-glycine and glucoseglycine model systems by capillary electrophoresis and comparison to reverse phase HPLC"
97. "Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease"
98. "Increasing neurite outgrowth capacity of β-amyloid precursor protein proteoglycan in Alzheimer's disease"
99. "Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease"
100. "Analysis of N-glycans of pathological tau: Possible occurrence of aberrant processing of tau in Alzheimer's disease"
101. "Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: Relevance to diseases of glycoxidative stress"
102. "4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease"
103. "Chemistry and biochemistry of oxidative stress in neurodegenerative disease"
104. "Increased lipoprotein oxidation in Alzheimer's disease"
105. "Activation of receptor for advanced glycation end products-a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis"
106. "The biology of the receptor for advanced glycation end products and its ligands"
107. "Evidence against increased glycoxidation in patients with Alzheimer's disease"
108. "Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process"
109. "Pentosidine: A molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia"
110. "Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo"
111. "Protein modification by methylglyoxal: Chemical nature and synthetic mechanism of a major fluorescent adduct"
112. "Inhibitory effects of tenilsetam on the maillard reaction"
113. "Increased protein glycation in cerebrospinal fluid of Alzheimer's disease"
114. "Advanced glycation end-products: A review"
115. "Advanced Maillard reaction end-products. Free-radicals, and protein oxidation in Alzheimer's-disease"
116. "Advanced Maillard reaction end products are associated with Alzheimer disease pathology"
117. "Early aging and Alzheimers"
118. "Advanced Maillard reaction end-products are associated with Alzheimer-disease pathology"
119. "Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine"
120. "Structure-activity relationships of acetylcholinesterase inhibitors: Donepezil hydrochloride for the treatment of Alzheimer's disease"
121. "Is amyloid beta-protein glycated in Alzheimer's disease?"
122. "Glycosylation of microtubule-associated protein tau in Alzheimer's disease brain"
123. "Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain"
124. "In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification"
125. "Neuronal and glial advanced glycation end product [N-epsilon-(carboxymethyl)lysine] in Alzheimer's disease brains"
126. "Neurotoxicity of advanced glycation end-products for cultured cortical neurons"
127. "Structure and mechanism of formation of human lens fluorophore LM-1-relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis"
128. "Role of the maillard reaction in diabetes mellitus and diseases of aging"
129. "Buffer conditions affecting the separation of Maillard reaction products by capillary electrophoresis"
130. "Glycoxidative modification of AA amyloid deposits in renal tissue"
131. "Protein glycation, diabetes, and aging"
132. "Advanced glycation end products contribute to amyloidosis in Alzheimer disease"
133. "Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging"
134. "Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B"
135. "Glycosylation of microtubule-associated protein tau: An abnormal post-translational modification in Alzheimer's disease"
136. "Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1"
137. "Two novel β-Carboline compounds from the Maillard reaction between Xylose and Tryptophan"
138. "Distribution of advanced glycation end products in the cerebellar neurons of dogs"
139. "Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: Comparison with pentosidine"
140. "Breakers of advanced glycation end products restore large artery properties in experimental diabetes"
141. "ALT-711, a breaker of advanced glycation endproducts (AGEs), restores large artery elasticity in experimental diabetes"
142. "Immunochemical quantification of crossline as a fluorescent advanced glycation endproduct in erythrocyte membrane proteins from diabetic patients with or without retinopathy"
143. "Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress"
144. "RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease"
145. "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease"
146. "RAGE-a beta interactions in the pathophysiology of Alzheimer's disease"
147. "Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide"
148. "Antioxidative effect of Maillard reaction products using glucose-glycine model system"
149. "Formation of reactive intermediates from Amadori compounds under physiological Conditions"