Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: Relevance to Alzheimer's disease

Journal of Neurochemistry

Volumn 68, Issue 6, 1997, Pages 2451-2457

  Butterfield, D Allan ^a,c   Hensley, Kenneth ^a,d   Cole, Pamela ^a   Subramaniam, Ramachandran ^a   Aksenov, Michael ^a   Aksenova, Marina ^a   Bummer, Paul M ^b   Haley, Boyd E ^b   Carney, John M ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Kentucky   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Alzheimer's disease; Glutamine synthetase; Protein oxidation; Spin labeling

Indexed keywords

GLUTAMATE AMMONIA LIGASE;

ALZHEIMER DISEASE; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ELECTRON SPIN RESONANCE; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME METABOLISM; HUMAN; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0030921729     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68062451.x     Document Type: Article

References (55)

1. Aksenov M. Y., Aksenova M. V., Harris M. E., Hensley K., VigoPelfrey C., Butterfield D. A., and Carney J. M. (1995) Enhancement of β-amyloid peptide Aβ(1-40) neurotoxicity by glutamine synthetase. J. Neurochem. 65, 1899-1902.
2. Aksenov M. Y., Aksenova M. V., Butterfield D. A., Hensley K., Vigo-Pelfrey K., and Carney J. M. (1996) Glutamine synthetase-induced neurotoxicity accompanied by abrogation of fibril formation and amyloid β-peptide fragmentation. J. Neurochem. 66, 2050-2056.
3. Aksenova M. V., Aksenov M. Y., Butterfield D. A., and Carney J. M. (1996) Alpha l-antichymotrypsin interaction with Aβ(1-40) inhibits fibril formation but does not affect the peptide toxicity. Neurosci. Lett. 211, 45-48.
4. Appel P. and Brown W. D. (1971) Stability characteristics of denatured myoglobin. Biopolymers 10, 2309-2322.
5. Bairoch A. and Boeckmann B. (1992) The SWISS-PROT protein sequence data bank. Nucleic Acids Res. 20, 2019-2022.
6. Bellary S. S., Anderson K. A., Arden W. A., and Butterfield D. A. (1995) Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins. Life Sci. 56, 91-98.
7. Berliner L. J., Greenwald J., Hankovsky H. O., and Hideg K. (1982) A novel thio-specific spin label: papain active site labeling and inhibition. Anal. Biochem. 119, 450-455.
8. Bhardwaj A., Lee J., Glauner K., Ganapathi S., Bhattacharyya D., and Butterfield D. A. (1996) Biofunctional membranes: an EPR study of active site structure and stability of papain noncovalently immobilized on the surface of modified poly (ether) sulfone membranes through the avidin-biotin linkage. J. Membr. Sci. 119, 241-252.
9. Burbaeva G. S., Aksenova M. V., and Makarenko I. G. (1992) Decreased level of creatine kinase BB in the frontal cortex of Alzheimer patients. Dementia 3, 91-94.
10. Butterfield D. A. (1982) Spin labeling in disease. Biol. Magn. Reson. 4, 1-78.
11. Butterfield D. A. (1989) Biological and Synthetic Membranes. Wiley-Liss, New York.
12. Butterfield D. A. (1990) Principles of biological membrane structure: alteration in the physical state of one side of the membrane by modulation of the physical state of the opposite side. J. Membr. Sci. 53, 3-17.
13. Butterfield D. A. (1996a) Biofunctional Membranes. Plenum Press, New York.
14. Butterfield D. A. (1996b) Alzheimer's disease: a disorder of oxidative stress. Alzheimer's Dis. Rev. 1, 68-70.
15. Butterfield D. A. (1997) β-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chem. Res. Toxicol. (in press).
16. Butterfield D. A. and Lee J. (1994) Active site structure and stability of a thiol protease, papain, studied by electron paramagnetic resonance employing a methanethiosulfonate spin label. Arch. Biochem. Biophys. 310, 167-171.
17. Butterfield D. A., Lee J., Ganapathi S., and Bhattacharyya D. (1994a) Biofunctional membranes IV: active site structure and stability of an immobilized enzyme, papain, on modified polysulfone membranes studied by electron paramagnetic resonance and kinetics. J. Membr. Sci. 91, 47-64.
18. Butterfield D. A., Hensley K., Harris M., Mattson M., and Carney J. (1994b) β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications for Alzheimer's disease. Biochem. Biophys. Res. Commun. 200, 710-715.
19. Butterfield D. A., Hensley K., Hall N., Subramaniam R., Howard B. J., Cole P., Yatin S., LaFontaine M., Harris M. E., Aksenova M., Aksenov M., and Carney J. M. (1996a) β-Amyloid-derived free radical oxidation: a fundamental process in Alzheimer's disease, in Molecular Models of Dementia (Wasco W. and Tanzi R. E., eds), pp. 145-167. Humana Press, Totowa, New Jersey.
20. 2+, nitroxide spin probes, and synaptosomal membrane proteins. Life Sci. 58, 217-228.
21. Butterfield D. A., Howard B. J., Yatin S., Allen K. L., and Carney J. M. (1997) Free radical oxidation on brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone. Proc. Natl. Acad. Sci. USA 94, 674-678.
22. Chan K. M., Decker E. A., Lee J. B., and Butterfield D. A. (1994) ESR spin-trapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides. J. Agric. Food Chem. 42, 1407-1410.
23. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-700.
24. Gunnersen D. and Haley B. (1992) Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA 89, 11949-11953.
25. Hall N. C., Carney J. M., Cheng M. S., and Butterfield D. A. (1995a) Ischemia/reperfusion-induced changes in membrane proteins . and lipids of gerbil cortical synaptosomes. Neuroscience 64, 81-89.
26. Hall N. C., Carney J. M., Cheng M. S., and Butterfield D. A. (1995b) Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-α-phenylnitrone and difluoromethylornithine. Neuroscience 69, 591-600.
27. Hall N. C., Dempsey R. J., Carney J. M., Donaldson D. L., and Butterfield D. A. (1995c) Structural alterations in synaptosomal membrane-associated proteins and lipids by transient middle cerebral artery occlusion in the cat. Neurochem. Res. 20, 1161-1169.
28. Hall N. C., Carney J. M., Plante O. J., Cheng M., and Butterfield D. A. (1997) Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids. Neuroscience (in press).
29. Harris M. E., Carney J. M., Cole P., Hensley K., Howard B. J., Martin L., Bummer P., Wang Y., Pedigo N., and Butterfield D. A. (1995a) β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamine uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport 6, 1875-1879.
30. Harris M. E., Hensley K., Butterfield D. A., Leedle R. A., and Carney J. M. (1995b) Direct evidence of oxidative injury produced by the Alzheimer's amyloid beta peptide (1-40) in cultured hippocampal neurons. Exp. Neurol. 131, 193-202.
31. +-dependent glutamate uptake in rat hippocampal astrocyte cultures. J. Neurochem. 67, 277-286.
32. Hensley K., Carney J. M., Hall N., Shaw W., and Butterfield D. A. (1994a) Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure. Free Radic. Biol. Med. 17, 321-331.
33. Hensley K., Carney J., Mattson M., Aksenova M., Harris M., Wu J. F., Floyd R., and Butterfield D. A. (1994b) A new model for α-amyloid aggregation and neurotoxicity based on free radical generating capacity of the peptide. Proc. Natl. Acad. Sci. USA 91, 3270-3274.
34. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S. P., Wu J. F., Carney J. M., Lovell M., Markesbery W. R., and Butterfield D. A. (1995a) Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65, 2146-2156.
35. Hensley K., Howard B., Carney J. M., and Butterfield D. A. (1995b) Membrane protein alterations in rodent erythrocytes and synaptosomes due to aging and hyperoxia. Biochim. Biophys. Acta 1270, 203-206.
36. Hensley K., Butterfield D. A., Hall N., Cole P., Subramaniam R., Mark R., Mattson M. P., Markesbery W. R., Harris M. E., Aksenov M., Aksenova M., Wu J. F., and Carney J. M. (1996) Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide. Ann. NY Acad. Sci. 786, 120-134.
37. Howard B. J., Yatin S., Hensley K., Allen K. L., Kelly J. P., Carney J., and Butterfield D. A. (1996) Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-α-phenylnitrone and 4-hydroxy-2,2, 6,6-tetramethylpiperidin-l-oxyl (Tempol). J. Neurochem. 67, 2045-2050.
38. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
39. 2+ homeostasis and cell death. J. Neurosci. 15, 6239-6249.
40. Meister A. (1985) Glutamine synthetase from mammalian tissues. Methods Enzymol. 113, 185-199.
41. Miller R. E., Hadenberg R., and Gersham H. (1978) Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP. Proc. Natl. Acad. Sci. USA 57, 1418-1422.
42. Nutisya E. M., Bowling A. C., and Beal M. F. (1994) Cortical cytochrome oxidase activity is reduced in Alzheimer's disease brain. Neurology 44, 1090-1096.
43. Oda T., Wals P., Osterburg H., Johnson S., Pasinetti G., Morgan T., Rozovski I., Stein W. B., Snyder S., Holzman T., Krafft G., and Finch C. (1995) Clusterin (Apo J) alters the aggregation of amyloid β-peptide (Aβ 1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress. Exp. Neurol. 136, 22-31.
44. Oliver C. N., Starke-Reed P. E., Stadtman E. R., Liu G. J., Carney J. M., and Floyd R. A. (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion injury to gerbil brain. Proc. Natl. Acad. Sci. USA 87, 5144-5147.
45. Rowe W. B., Remzio R. A., Wellner V. P., and Meister A. (1970) Glutamine synthetase. Methods Enzymol. 17, 900-910.
46. Selkoe D. J. (1996) Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271, 18295-18298.
47. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., and Floyd R. A. (1991) Excess brain protein oxidation and enzyme dysfunction in normal and Alzheimer disease. Proc. Natl. Acad. Sci. USA 88, 10540-10543.
48. Subramaniam R., Cole P., Hensley K., Azhar S., Bummer P., Carney J. M., and Butterfield D. A. (1996) Effect of oxidative stress on the model thiol protease papain: an investigation of changes in activity and structure. Biochem. Arch. 12, 105-116.
49. Tomiyama T., Shoji A., Kataoka K., Suwa Y., Asano S., Kaneko H., and Endo N. (1996) Inhibition of amyloid β protein aggregation and neurotoxicity by rifampicin. J. Biol. Chem. 271, 6839-6844.
50. Trad C. H. and Butterfield D. A. (1994) Menadione induced cytotoxicity effects on human erythrocyte membranes studied by electron paramagnetic resonance. Toxicol. Lett. 73, 145-155.
51. Trad C. H., James W., and Butterfield D. A. (1995) Selective labeling of membrane protein sulfhydryl groups with methanethiosulfonate spin label. J. Biochem. Biophys. Methods 30, 287-299.
52. Van den Hoff M. J. B., Geerts W. J. C., Das A. T., Moorman A. F. M., and Lamers W. H. (1991) cDNA sequence of the long mRNA for human glutamine synthetase. Biochim. Biophys. Acta 1090, 249-251.
53. Volterra A., Trotti D., Trombs C., Floridi S., and Racagni G. (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14, 2924-2932.
54. Yamamoto H., Konno H., Yamamoto T., Ito K., Mizugaki M., and Iwasaki Y. (1987) Glutamine synthetase of the human brain: purification and characterization. J. Neurochem. 49, 603-609.
55. Yamaoka K., Edamatsu R., Itoh T., and Mori A. (1994) Effects of low-dose x-irradiation on biomembrane in brain cortex of aged rats. Free Radic. Biol. Med. 16, 529-534.