Biomarkers of oxidative stress are significantly elevated in Down syndrome

Free Radical Biology and Medicine

Volumn 25, Issue 9, 1998, Pages 1044-1048

  Jovanovic, Slobodan V ^a   Clements, Debbie ^a   MacLeod, Kent ^a  

^a Intl Center for Metabolic Testing   (Canada)

Author keywords

8 Hydroxy 2' deoxyguanosine; Down syndrome; Oxidative stress; TBARS

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; BIOLOGICAL MARKER; DNA; LIPID; MALONALDEHYDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ARTICLE; CHILD; CONTROLLED STUDY; DNA DAMAGE; DOWN SYNDROME; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL;

BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DEOXYGUANOSINE; DIET; DOWN SYNDROME; HUMANS; MALONDIALDEHYDE; OXIDATIVE STRESS; STATISTICS, NONPARAMETRIC; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0032401643     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00137-3     Document Type: Article

References (29)

1. Sinet P.M. Metabolism of oxygen derivatives in Down's syndrome. Ann. NY Acad. Sci. 83:1982.
2. Jenner P. Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Path. Biol. 15:1996;57.
3. de Haan J.B., Wolvetang E.J., Cristiano F., Iannello R., Bladier C., Kelner M., Kola M. Reactive oxygen species and their contribution to pathology in Down syndrome. Adv. Pharmacol. 38:1997;379.
4. de Haan J.B., Cristiano F., Iannello R.C., Kola I. Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem. Mol. Biol. Int. 35:1995;1281.
5. de Haan J.B., Newman J.D., Kola I. Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains. Brain Res. Mol. Brain Res. 13:1992;179.
6. Ceballos-Picot I. Transgenic mice overexpressing copper-zinc superoxide dismutase A model for the study of radical mechanisms and aging . Compt. Rend. Sean. Soc. Biol. Ses Fil. 187:1993;308.
7. Kolata G. Down syndrome-Alzheimer's linked. Science. 230:1985;1152.
8. Simonian N.A., Coyle J.T. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36:1996;83.
9. Busciglio J., Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 378:1995;776.
10. Odetti P., Angelini G., Dapino D., Zaccheo D., Garibaldi S., Dagna-Bricarelli F., Piombo G., Perry G., Smith M., Traverso N., Tabaton M. Early glycoxidation damage in brains from Down's syndrome. Biochem. Biophys. Res. Comm. 243:1998;849.
11. Seidl R., Greber S., Schuller E., Bernert G., Cairns N., Lubec G. Evidence against increased oxidative damage in Down syndrome. Neurosci. Lett. 235:1997;137.
12. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.B., Woodall A.A., Yeo H.C., Ames B.N. DNA oxidation matters The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine . Proc. Natl. Acad. Sci. USA. 95:1998;288.
13. Halliwell B., Chirico S. Lipid peroxidation Its mechanism, measurement, and significance . Am. J. Clin. Nutr. 57:(suppl):1993;715S.
14. Kaplan, L. A.; Pesce, A. J. Clinical chemistry. St. Louis: Mosby; 1989:1015.
15. Peled-Kamar M., Lotem J., Wirguin I., Weiner L., Hermalin A., Groner Y. Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase. Proc. Natl. Acad. Sci. USA. 94:1997;3883.
16. Yim M.B., Chock P.B., Stadtman E.R. Enzyme function of copper, zinc superoxide dismutase as a free radical generator. J. Biol. Chem. 268:1993;4099.
17. Yim M.B., Chock P.B., Stadtman E.R. Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc. Natl. Acad. Sci. USA. 87:1990;5006.
18. Smith M.A., Sayre L., Perry G. Is Alzhemier's a disease of oxidative stress? Alzhemier's Dis. Rev. 1:1996;63.
19. von Sonntag C. The chemical basis of radiation biology. 1987;Taylor and Francis, London.
20. Shigenaga M.K., Gimeno C.J., Ames B.N. Urinary 8-hydroxy-2′-deoxyguanosine as a marker of in-vivo oxidative DNA damage. Proc. Natl. Acad. Sci. USA. 1989:1989;9697.
21. Shigenaga, M.; Park, J.-W.; Cundy, K. C.; Gimeno, C. J.; Ames, B. N. In Vivo Oxidative DNA Damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection. In: Packer, L.; Glazer, A. N. eds. Oxygen radicals in biological systems. Part B. Oxygen radicals and antioxidants, Vol. 186, San Diego: Academic Press; 1990:521.
22. Smith M.A., Harris P.L.R., Sayre L.M., Beckan J.S., Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17:1997;2653.
23. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., Kowall N. Oxidative damage in Alzheimer's. Nature. 382:1996;120.
24. Smith M.A., Perry G. Oxidative stress and protein modification in neurodegenerative diseases. Packer L., Hiramatsu M., Yoshikawa T. Free radicals in brain physiology and disorders. 1996;287-292 Academic Press, New York.
25. Sayre L.M., Zelasko D.A., Harris P.L.R., Perry G., Salomon R.G., Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68:1997;2092.
26. Loft S., Vistisen K., Ewertz M., Tjønneland A., Overvad K., Poulsen H.E. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans Influence of smoking, gender and body mass index . Carcinogenesis. 13:1992;2241.
27. Simic M.G., Bergtold D.S. Dietary modulation of DNA damage in human. Mutat. Res. 250:1991;17.
28. Grant W.B. Dietary links to Alzheimer's disease. Alz. Dis. Rev. 2:1997;42.
29. Smith M.A., Petot G.J., Perry G. Commentary Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease . Alz. Dis. Rev. 2:1997;58.