Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity

Journal of Structural Biology

Volumn 130, Issue 2-3, 2000, Pages 184-208

  Varadarajan, Sridhar ^a   Yatin, Servet ^a   Aksenova, Marina ^b   Butterfield, D Allan ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Electron paramagnetic resonance (EPR); Fibrils; Free radicals; Lipid peroxidation; Neurotoxicity; Protein oxidation; Reactive oxygen species (ROS); Spin trapping

Indexed keywords

AMYLOID BETA PROTEIN; FREE RADICAL;

ALZHEIMER DISEASE; CALCIUM MOBILIZATION; CONFORMATIONAL TRANSITION; ELECTRON SPIN RESONANCE; HUMAN; LIPID PEROXIDATION; MOLECULAR DYNAMICS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVIEW;

EID: 0033860372     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2000.4274     Document Type: Review

References (251)

1. Lipid peroxide overcomes the inability of platelet secretory phospholipase A2 to hydrolyze membrane phospholipids in rabbit platelets
2. Enhancement of Aβ(1-40) neurotoxicity by glutamine synthetase
3. Glutamine synthetase-induced enhancement of β-amyloid peptide Aβ(1-40) neurotoxicity accompanied by abrogation of fibril formation and Aβ fragmentation
4. Oxidative modification of glutamine synthetase by amyloid beta peptide
5. Amyloid β-peptide(1-40)-mediated oxidative stress in cultured hippocampal neurons: Protein carbonyl formation, CK BB expression and the level of Cu, Zn and Mn SOD mRNA
6. The expression of key oxidative stress handling genes in different brain regions in Alzheimer's disease
7. The expression of several mitochondrial and nuclear genes encoding the subunits of the electron transport chain enzyme complexes, cytochrome C oxidase in NADH dehydrogenases, in different brain regions in Alzheimer's disease
8. Alpha 1-antichymotrysin interaction with Aβ(1-40) inhibits fibril formation but does not affect the peptide toxicity
9. Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal cortex in different neurodegenerative disorders
10. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
11. Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis
12. Amyloid β-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes
13. Mitochondrial dysfunction in neurodegenerative diseases
14. Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches
15. Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection
16. Hydrogen peroxide mediates amyloid β-protein toxicity
17. Vitamin E protects nerve cells from amyloid beta protein toxicity
18. Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins
19. Increased immunostaining for L-ornithine decarbolylase occurs in neocortical neurons of Alzheimer's disease patients
20. Spin trapping: ESR parameters of spin adducts
21. Age and regional structural characterization of lipid hydrocarbon chains from human lenses by infrared and near-infrared Raman, spectroscopies
22. Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesi
23. β-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
24. Bc1-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid β-peptide
25. 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats
26. Decreased level of creatine kinases BB in the frontal cortex of Alzheimer patients
27. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells
28. Spin labeling in disease
29. Alzheimer's disease: A disorder of oxidative stress
30. β-Amyloid-associated free radical oxidative stress and neurotoxicity: Implications for Alzheimer's disease
31. Alzheimer's amyloid β-peptide and free radical oxidative stress
32. Alzheimer's amyloid β-peptide associated oxidative stress: Brain membrane lipid peroxidation and protein oxidation
33. Amyloid β-peptide-associated free radical oxidative stress and Alzheimer's disease
34. Protein oxidation processes in aging brain
35. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
36. β-Amyloid-derived free radical oxidation: A fundamental process in Alzheimer's disease
37. 2+, nitroxide spin probes, and synaptosomal membrane proteins
38. Oxidatively-induced structural alteration of glutamine synthetase assessed by analysis of spin labeled incorporation kinetics: Relevance to Alzheimer's disease
39. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-β-phenylnitrone
40. Amyloid β-peptide-associated free radical oxidative stress, neurotoxicity and Alzheimer's disease
41. On methionine and Alzheimer's amyloid β-peptide(1-42) induced oxidative stress
42. Vitamin E as an antioxidant/free radical scavenger against amyloid β-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: Insights into Alzheimer's disease
43. Neuron loss in APP transgenic mice
44. Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
45. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone
46. Glutathione level is altered in lymphoblasts from patients with familial Alzheimer's disease
47. Phenyl N-tert-butyl nitrone forms nitric oxide as a result of its Fe(III)-catalyzed hydrolysis or hydroxyl radical adduct formation
48. EPR spin trapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides
49. Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease
50. Potent neuroprotective properties against the Alzheimer β-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid
51. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
52. Redox control of secondary structure in a designed peptide
53. Melatonin prevents β-amyloid-induced lipid peroxidation
54. Oxidative stress: The paradox of aerobic life
55. Alzheimer neuropathologic alterations in aged cognitively normal subjects
56. The 'amyloid cascade hypothesis' in AD: Decoy or real McCoy?
57. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
58. Amyloid β peptides do not form radical adducts spontaneously, but can enhance metal catalyzed oxidation of hydroxylamines to nitroxides
59. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes
60. Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by neurotrophic factors
61. Potentially amyloidogenic, carboxy-terminal derivatives of the amyloid protein precursor
62. Modified-peptide inhibitors of amyloid β-peptide polymerization
63. Effects of injected Alzheimer β-amyloid cores in rat brain
64. Microglial response to amyloid plaques in APPSW transgenic mice
65. Protease inhibitor coinfusion with amyloid β-protein results in enhanced deposition and toxicity in rat brain
66. Quantitation of amyloid β-protein (A β) in the cortex during aging and in Alzheimer's disease
67. Increased nuclear DNA oxidation in the brain in Alzheimer's disease
68. Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain
69. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
70. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
71. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
72. Evidence of neuronal oxidative damage in Alzheimer's disease
73. Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attentuates free radical and calcium accumulation
74. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid-β toxicity in hippocampal neurons
75. Low concentrations of estradiol reduce β-amyloid (25-35)-induced toxicity, lipid peroxidation, and glucose utilization in human SK-N-SH neuroblastoma cells
76. Vitamin E and Alzheimer's disease: The basis for additional clinical trials
77. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
78. Amyloid β-peptide is produced by cultured cells during normal metabolism
79. Brain membrane fluidity and lipid peroxidation in Alzheimer's disease
80. Ischemica/reperfusion induced changes in membrane proteins and lipids of gerbil cortical synaptosomes
81. Prevention of Ischemica/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-α-phenylnitrone and diflurormethylornithine
82. Structural alterations in synaptosomal membrane-associated proteins and lipids by transient middle cerebral artery occulusion in the cat
83. Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids
84. Comment
85. Alzheimer's disease: The amyloid cascade hypothesis
86. Direct evidence of oxidative injury by the Alzheimer's amyloid β peptide in cultured hippocampal neurons
87. β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: Implications to Alzheimer's disease
88. +-dependent glutamate uptake in rat hippocampal astrocyte cultures
89. Modifications of neurofilament proteins by possible metabolites of allyl chloride in vitro
90. Electron paramagnetic resonance investigation of free radical induced alterations in neocortical synaptosomal membrane protein infrastructure
91. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
92. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation
93. Amyloid β-peptide spin trapping I: Enzyme toxicity is related to free radical spin trap reactivity
94. Amyloid β-peptide spin trapping II: Evidence for decomposition of the PBN spin adduct
95. A model for β-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: Implications of peptide-derived free radicals to Alzheimer's disease
96. Vulnerable neurons in Alzheimer disease accumulate mitochondrial DNA with the common 5KB deletion
97. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
98. Relationships between cell density, glutathione and proliferation of A549 human lung adenocarcinoma cells treated with acrolein
99. Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-α-phenylnitrone (PBN) and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol)
100. Aggregation state and neurotoxic properties of Alzheimer β-amyloid peptide
101. Transgenic mice expressing Alzheimer amyloid precursor proteins
102. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
103. Zinc-induced Alzheimer's Aβ aggregation is mediated by conformational factors
104. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
105. Cu(II) potentiation of Alzheimer Aβ neurotoxicity: Correlation with cell-free hydrogen peroxide production and metal reduction
106. α2-Macroglobulin associates with β-amyloid peptide and prevents fibril formation
107. APP(SW) transgenic mice devlop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
108. A critical review of spin trapping in biological systems
109. The carboxy terminus of the β-amyloid protein is critical in the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
110. One-dimensional crystallization of amyloid: A pathogenic mechanism in Alzheimer's disease?
111. The precursor of Alzheimer's disease A4 protein resembles a cell-surface receptor
112. Advances in Alzheimer's disease
113. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid β-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
114. Amyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons: Involvement of free radicals
115. Vitamin E protects against amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition
116. Peroxynitrite-induced alterations in synaptosomal membrane proteins: Insight into oxidative stress in Alzheimer's disease
117. In-vivo modulation of rodent glutothione and its role in peroxynitrite-induced neocortical synaptosomal membrane damage
118. An in vivo model for the neurodegenerative effects of β amyloid and protection by substance P
119. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
120. The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the antioxidant U-78517F
121. Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains
122. NMDA-dependent superoxide production and neurotoxicity
123. 3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: Insights into Huntington's disease
124. Diffusible, nonfibrillar ligands derived from Aβ 1-42 are potent central nervous system neurotoxins
125. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
126. Methionine residues may protect proteins from critical oxidative damage
127. Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages
128. Inhibitors of free radical formation fail to attenuate direct β-amyloid 25-35 peptide mediated neurotoxicity in rat hippocampal cultures
129. β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
130. Decreased glutathione transferase in brain and ventricular fluid in Alzheimer's disease
131. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
132. Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease
133. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
134. Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF
135. An assessment of oxidative damage to proteins, lipids and DNA in brains from patients with Alzheimer's disease
136. β-Amylold-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals
137. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
138. Metallothionein/disulfide interactions, oxidative stress and mobilization of cellular zinc
139. Inhibitory sites in enzymes: Zinc removal and reactivation by thionein
140. 2+ homeostasis and cell death
141. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide
142. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation
143. Characterization of 8-epiprostaglandin F2α as a marker of amyloid β-peptide-induced oxidative damage
144. Oxidative stress hypothesis in Alzheimer disease
145. 4-Hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
146. Oxidative alterations in Alzheimer's disease
147. Brain trace metals in Alzheimer disease
148. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein
149. Alzheimer's disease amyloid β peptide 25-35 is localized in the membrane hydrocarbon core: X-ray diffraction analysis
150. Strategic thoughts on the Alzheimer's disease amyloid protein precursor: The way forward
151. Amyloid plaque core protein in Alzheimer disease and Down syndrome
152. 2+ homeostasis Alzheimer's disease
153. Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom
154. β-Amyloid peptide in vitro toxicity: Lot-to-lot variability
155. Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes
156. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
157. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
158. Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and trauma-induced dementia of the Alzheimer type
159. E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures
160. Cerebrospinal fluid F2 isoprostane levels are increased in Alzheimer's disease
161. Protective effects of asiaticoside derivatives against β-amyloid neurotoxicity
162. The isoprostanes: Unique bioactive products of lipid peroxidation
163. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
164. Advanced glycation endproducts in aging and Alzheimer's disease
165. Alzheimer's disease - Synergistic effects of glucose deficit oxidative stress and advanced glycation endproducts
166. Relative abundance of Alzheimer Aβ amyloid peptide variants in Alzheimer disease and normal aging
167. Evidence for a membrane defect in Alzheimer disease brain
168. Clusterin (apo J) alters the aggregation of amyloid β peptide (Aβ) and forms slowly sedimenting Aβ complexes that cause oxidative stress
169. Altered energy metabolism in Alzheimer's disease
170. Age-related changes in oxidized proteins
171. Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
172. Coupling of m1 muscarinic receptors to G protein in Alzheimer's disease
173. 31P nuclear magnetic resonance study of the brain in Alzheimer's disease
174. In vitro aging of β-amyloid protein causes peptide aggregation and neruotoxicity
175. Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity
176. β-Amyloid neurotoxicity in vitro: Evidence of oxidative stress but not protection by antioxidants
177. In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain
178. Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red
179. Enhanced phosphodiestric breakdown of phosphatidylinositiol bisphosphate after experimental brain injury
180. Regional membrane phospholipid alterations in Alzheimer's disease
181. Inhibition of age-induced β-amyloid neurotoxicity in rat hippocampal cells
182. Binding of amyloid β-protein to intracellular brain proteins in rat and human
183. Eicosanoids and isoeicosanoids: Indices of cellular function and oxidant stress
184. Free radicals in Alzheimer's disease
185. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid
186. Morphology and toxicity of Aβ-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
187. Apolipoprotein E affects the rate of Alzheimer's disease expression: β-Amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease
188. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia
189. A controlled trail of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study
190. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
191. Side chain fragmentation of N-terminal threonine or serine residue induced through intramolecular protien transfer to hydroxyl sulfuranyl radical formed at neighboring methionine in dipeptides
192. Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy16 mice: A model of Down's syndrome
193. Aging, amyloid, and Alzheimer's disease
194. The molecular pathology of Alzheimer's disease
195. Alzheimer's disease: A central role of amyloid
196. Amyloid β-protein and the genetics of Alzheimer's disease
197. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
198. Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro
199. The role of amyloid precursor (APP) in Alzheimer's disease: Does the normal function of APP explain the topography of degeneration?
200. Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer disease
201. Protein oxidation in aging brain
202. Advanced maillard reaction end products are associated with Alzheimer disease pathology
203. Radical aging in Alzheimer's disease
204. Oxidative damage in Alzheimer's
205. Widespread peroxynitrite-mediated damage in Alzheimer's disease
206. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
207. Opposing actions of thrombin and protease nexin-1 on amyloid β-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons
208. Amyloid-beta aggregation: Selective inhibition of aggregation in mixtures of amyloid with different chain lengths
209. Alzheimer's β-amyloid peptide is conformationally modified by apolipoprotein E in vitro
210. Protein oxidation and aging
211. Protein oxidation and proteolysis during aging and oxidative stress
212. Cytosolic phospholipase A(2) is induced in reactive glia following different forms of neurodegeneration
213. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
214. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro
215. The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins
216. The free radical antioxidant vitamin E protects cortical synaptosomal membrane proteins from amyloid β-peptide (25-35) toxicity but not from hydroxynonenal toxicity: Relevance to the free radical hypothesis of Alzheimer's disease
217. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset (type I) and demyelination in late-onset form (type II)
218. Reduced neuronal activity and reactivation in Alzheimer's disease
219. Amyloid-β aggregation: Selective inhibition of aggregation in mixtures of amyloid with different chain lengths
220. Presence of soluble amyloid β-peptide precedes amyloid plaque formation in Down's syndrome
221. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
222. Alzheimer β-amyloid peptide 25-35: Electrostatic interactions with phospholipid membranes
223. Amyloid β-peptide polymerization studied using fluorescence correlation spectroscopy
224. Inhibition of amyloid β protein aggregation and neurotoxicity by rifampicin
225. Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX
226. Modification of histidine residues in proteins by reaction with 4-hydroxynonenal
227. Acrolein is a product of lipid peroxidation: Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
228. Protein-bound acrolein: Potential markers for oxidative stress
229. Methionine residue 35 is important in amyloid β-peptide-associated free radical oxidative stress
230. Alzheimer's amyloid β-peptide (1-42) fibrils are not always neurotoxic
231. Alzheimer's amyloid β-peptide(1-42) induced oxidative stress and neurotoxicity: Role of methionine residue 35 and Cu(II)
232. Advanced glycation end products contribute to amyloidosis in Alzheimer disease
233. Oxidation of methionyl residues in proteins: Tools, targets, and reversal
234. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
235. Amyloid β-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
236. Glutathione transferase protects neuronal cultures against 4-hydroxynonenal toxicity
237. Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease
238. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
239. Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death
240. The antioxidant vitamin E modulates amyloid β-peptide-induced creatine kinase inhibition and increased protein oxidation: Implications for the free radical hypothesis of Alzheimer's disease
241. In Vitro and In vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42)
242. Effect of transglutaminase on Aβ(1-40) fibril formation and neurotoxicity
243. Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: Protective effect of vitamin E
244. Temporal relations between amyloid β-peptide-induced free radical oxidative stress and neuronal toxicity and neuronal defensive responses
245. Vitamin E prevents Alzheimer's amyloid β-peptide (1-42)-induced protein oxidation and reactive oxygen species formation
246. Spermine and amyloid β-peptide (1-42) associated free radical induced neurotoxicity
247. Actions of neurotoxic β-amyloid on calcium homeostasis and viability of PC12 cells are blocked by antioxidants but not by calcium channel antagonists