Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function

Pharmacology Biochemistry and Behavior

Volumn 75, Issue 3, 2003, Pages 513-527

  Howes, Melanie Jayne R ^a   Houghton, Peter J ^b  

^a JODRELL LABORATORY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Anti inflammatories; Antioxidants; Dementia; Plants

Indexed keywords

ACORAS CALAMUS EXTRACT; ANGELICA ARCHANGELICA EXTRACT; AYURVEDIC DRUG; BIOTA ORIENTALIS EXTRACT; CELASTRUS PANICULUTAS EXTRACT; CENTELLA ASIATICA EXTRACT; CLITOREA TERNATEA EXTRACT; CODONOPSIS PILOSULA EXTRACT; COPTIS CHINENSIS EXTRACT; CROCUS SATIVUS EXTRACT; CURCUMA LONGA EXTRACT; DALBERGIA ODORIFERA EXTRACT; EVODIA RUTAECARPA EXTRACT; GINKGO BILOBA EXTRACT; HUPERZIA SERRATA EXTRACT; LYCORIS RADIATA EXTRACT; MAGNOLIA OFFICINALIS EXTRACT; PLANT EXTRACT; POLYGALA TENUIFOLIA EXTRACT; POLYGONUM MULTIFLORUM EXTRACT; SALVIA MILTIORRHIZA EXTRACT; TERMINALIA CHEBULA EXTRACT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CHINESE MEDICINE; CLINICAL TRIAL; COGNITION; HUMAN; LYCORIS RADIATA; MEDICINAL PLANT; MEMORY; PRIORITY JOURNAL; REVIEW; UNITED KINGDOM;

LYCORIS; LYCORIS RADIATA;

EID: 0043204252     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(03)00128-X     Document Type: Review

References (221)

1. Abe K., Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res. 14:2000;149-152.
2. Acuna U.M., Atha D.E., Ma J., Nee M.H., Kennely E.J. Antioxidant capacities of ten edible North American plants. Phytother. Res. 16(1):2002;63-65.
3. Advokat C., Pellegrin A.I. Excitatory amino acids and memory: evidence from research on Alzheimer's disease and behavioural pharmacology. Neurosci. Biobehav. Rev. 16:1992;13-24.
4. Ahmad F., Khan R.A., Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J. Ethnopharmacol. 42:1994;193-198.
5. Asakawa Y., Matsuda R., Takemoto T. Monoterpenoids and sesquiterpenoids from Hydrocotyle and Centella species. Phytochemistry. 21(10):1982;2590-2592.
6. Ashani Y., Peggins J.O., Doctor B.P. Mechanism of inhibition of cholinesterases by huperzine A. Biochem. Biophys. Res. Commun. 184(2):1992;719-726.
7. Balfour D.J.K., Fagerström K.O. Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disorders. Pharmacol. Ther. 72(1):1996;51-81.
8. Barth S.A., Inselmann G., Engemann R., Heidemann H.T. Influences of Ginkgo biloba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetylcysteine. Biochem. Pharmacol. 41:1991;1521-1526.
9. Bastianetto S., Ramassamy C., Dore S., Christen Y., Poirier J., Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid. Eur. J. Neurosci. 12(6):2000;1882-1890.
10. Bastianetto S., Zheng W.H., Quiron R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J. Neurochem. 74(6):2000;2268-2277.
11. Bickel U., Thomsen T., Weber W., Fischer J.P., Bachus R., Nitz M.et al. Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition. Clin. Pharmacol. 50:1991;420-428.
12. Bidwai P.P., Wangoo D., Bhullar N.K. Effect of Celastrus paniculatus seed extract on the brain of albino rats. J. Ethnopharmacol. 21:1987;307-314.
13. Bierer L.M., Haroutunian V., Gabriel S., Knott P.J., Carlin L.S., Purohit D.P.et al. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64:1995;749-760.
14. Bores G.M., Huger F.P., Petko W., Mutlib A.E., Camacho F., Rush D.K.et al. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. Am. Soc. Pharmacol. Exp. Ther. 277:1996;728-738.
15. Braquet P.G., Hosford D., Koltai M. Ginkgolide B (BN 52021): a natural PAF receptor antagonist. Neuropsychopharmacology. 10(Suppl. 3):1994;693S.
16. Breitner J.C.S. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu. Rev. Med. 47:1996;401-411.
17. 2 blocking drugs. Neurobiol. Aging. 16(4):1995;523-530.
18. Brinkhaus B., Lindner M., Schuppan D., Hahn E.G. Chemical, pharmacological and clinical profile of the East Asian medicinal plant Centella asiatica. Phytomedicine. 7(5):2000;427-448.
19. Chandrasekaran K., Mehrabian Z., Spinnewyn B., Drieu K., Kiskum G. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res. 922:2001;282-292.
20. Chang H., But P.P. Pharmacology and applications of Chinese materia medica. vol. 1-2:2001;World Scientific, Singapore.
21. Chang H.M., Chui K.Y., Tan F.W.L., Yang Y., Zhong Z.P. Structure-activity relationship of miltirone, an active benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen). J. Med. Chem. 34:1991;1675-1692.
22. Chen Y.L., Lin K.F., Shiao M.S., Chen Y.T., Hong C.Y., Lin S.J. Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res. Cardiol. 96(4):2001;353-363.
23. Chiu J.H., Ho C.T., Wei Y.H., Lui W.Y., Hong C.Y. In vitro and in vivo protective effect of honokiol on rat liver from peroxidative injury. Life Sci. 61(19):1997;1961-1971.
24. Chopin P., Briley M. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology. 106:1992;26-30.
25. Chung I.W., Moore N.A., Oh W.K., O'Neill M.F., Ahn J.S., Park J.B.et al. Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy. Pharmacol. Biochem. Behav. 71(1-2):2002;191-195.
26. Collerton D. Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience. 19:1986;1-28.
27. Cuéllar M.J., Giner R.M., Recio M.C., Máñez S., Ríos J.L. Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 72(3):2001;221-229.
28. Dai Y., Miki K., Fukuoka T., Tokunaga A., Tachibana T., Kondo E.et al. Suppression of neuropeptides' mRNA expression by herbal medicines in a rat model of peripheral inflammation. Life Sci. 66(1):2000;19-29.
29. Das K.C., Das C.K. Curcumin (diferuloylmethane), a singlet oxygen (O-1(2)) quencher. Biochem. Biophys. Res. Commun. 295(1):2002;62-66.
30. Desgranges B., Baron J.-C., de la Sayette V., Petit-Taboué M.-C., Benali K., Landeau B.et al. The neural substrates of memory systems impairment in Alzheimer's disease. Brain. 121:1998;611-631.
31. Dev S. Ethnotherapeutics and modern drug development: the potential of Ayurveda. Curr. Sci. 73(11):1997;909-928.
32. Du G.H., Qiu Y., Zhang J.T. Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice. J. Asian Nat. Prod. Res. 2(2):2000;145-152.
33. Duke J.A., Ayensu E.S. Medicinal plants of China. Vols. 1-2. 2nd ed. 1985;Reference Publications, Algonac (MI).
34. Dutar P., Vaillend C., Viollet C., Billard J.M., Potier B., Carlo A.S.et al. Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice. Neuroscience. 112(2):2002;455-466.
35. Fan S., Sun L., Wang Z., Wang W., Xu S. Experimental analysis of the prompt curative effect of Salvia compositus. Acta Pharmacol. Sin. 14(4):1979;199-207.
36. Flores C.M., Rogers S.W., Pabreza L.A., Wolfe B., Kellar K.J. A subtype of nicotinic cholinergic receptor is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment. Mol. Pharmacol. 41:1992;31-37.
37. Förstl H., Hentschel F., Sattel H., Geiger-Kabisch C., Besthorn C., Czech C.et al. Age-associated memory impairment and early Alzheimer' disease. Drug Res. 45(1):1995;394-397.
38. Foster S. Huperzia: hype or hope? HerbalGram. 18/19:1989;21-23.
39. Fowler C.J., O'Neill C., Winblad B., Cowburn R.T. Neurotransmitter, receptor and signal transduction disturbances in Alzheimer's disease. Acta Neurol. Scand. 85(Suppl. 139):1992;59-62.
40. Francis P.T., Palmer A.M., Snape M., Wilcock G.K. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J. Neurol. Neurosurg. Psychiatry. 66(2):1999;137-147.
41. Fukutake M., Miura N., Yamamoto M., Fukuda K., Iijima O., Ishikawa H.et al. Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. Cancer Lett. 157(1):2000;9-14.
42. Fulton B., Benfield P. Galantamine. Drugs Aging. 1:1996;60-65.
43. Fushitani S., Minakuchi K., Tsuchiya M., Murakami K. Studies on attenuation of postischemic brain injury by kampo medicines - inhibitory effects of free radical production. Yakugaku Zasshi. 115(8):1995;611-617.
44. Gattu M., Boss K.L., Terry A.V., Buccafusco J.J. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol. Biochem. Behav. 57(4):1997;793-799.
45. Giacobini E. The cholinergic system in Alzheimer disease. Prog. Brain Res. 84:1990;321-332.
46. Grafman J., Weingartner H., Lawlor B., Mellow A.M., Thompsen-Putnam K., Sunderland T. Automatic memory processes in patients with dementia - Alzheimer's type (DAT). Cortex. 26:1990;361-371.
47. Grosse D.A., Gilley D.W., Wilson R.S. Episodic and semantic memory in early versus late onset Alzheimer's disease. Brain Lang. 41:1991;531-537.
48. Guanhua D., Juntian Z. Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice. Chin. Med. J. (Engl.). 110(1):1997;65-68.
49. Haji A., Momose Y., Takeda R., Nakanishi S. Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa. J. Nat. Prod. 57(3):1994;387-389.
50. Hammel P., Larrey D., Bernuau J., Kalafat M., Fréneaux E., Babany G.et al. Acute hepatitis after tetrahydroaminoacridine administration for Alzheimer's disease. J. Clin. Gastroenterol. 12(3):1990;329-331.
51. Harvey A.L. The pharmacology of galanthamine and its analogues. Pharmacol. Ther. 68(1):1995;113-128.
52. Hayashi T., Ohta Y., Inagaki S., Harada N. Inhibitory action of Oren-gedoku-to extract on enzymatic lipid peroxidation in rat liver microsomes. Biol. Pharm. Bull. 24(10):2001;1165-1170.
53. Heiss W.D., Zeiler K. Drug influence on cerebral circulation. Pharmakotherapie. 1:1978;137-144.
54. Hofferberth B. The efficacy of EGb 761 in patients with senile dementia of the Alzheimer type: a double-blind, placebo-controlled study on different levels of investigation. Hum. Psychopharmacol. 9:1994;215-222.
55. Hou Y.C., Chao P.D., Chen S.Y. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. Am. J. Chin. Med. 28(3-4):2000;379-384.
56. Hsieh M.T., Peng W.H., Wu C.R., Wang W.H. The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother. Res. 14(5):2000;375-377.
57. Huang K.C. The pharmacology of Chinese herbs. 1993;CRC Press, Boca Raton (FL).
58. Huang Y.S., Zhang J.T. Antioxidative effect of three water-soluble components isolated from Salvia miltiorrhiza in vitro. Acta Pharmacol. Sin. 27(2):1992;96-100.
59. Irwin R.L., Smith H.J. Cholinesterase inhibition by galantamine and lycoramine. Biochem. Pharmacol. 3(2):1960;147-148.
60. Iversen T., Fiirgaard K.M., Schriver P., Rasmussen O., Andreasen F. The effect of NaO Li Su on memory functions and blood chemistry in elderly people. J. Ethnopharmacol. 56:1997;109-116.
61. Jenkinson M.L., Bliss M.R., Brain A.T., Scott D.L. Rheumatoid arthritis and senile dementia of the Alzheimer's type. Br. J. Rheumatol. 28:1989;86-88.
62. Kabuto H., Asanuma M., Nishibayashi S., Iida M., Ogawa N. Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil. Neurochem. Res. 22(1):1997;33-36.
63. Kang H.S., Chung H.Y., Jung J.H., Kang S.S., Choi J.S. Antioxidant effect of Salvia miltiorrhiza. Arch. Pharm. Res. 20(5):1997;496-500.
64. Kanowski S., Herrmann W.M., Stephan K., Wierch W., Hörr R. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Phytomedicine. 4(1):1997;3-13.
65. Kapoor L.D. Handbook of Ayurvedic medicinal plants. 1990;CRC Press, Boca Raton (FL).
66. Kenner D., Requena Y. Botanical medicine: a European professional perspective. 1996;Paradigm Publications, Brookline.
67. Kim D.S.H.L., Kim J.Y. Total synthesis of calebin-A, preparation of its analogues, and their neuronal cell protectivity against β-amyloid insult. Bioorg. Med. Chem. Lett. 11(18):2001;2541-2543.
68. Kim H.M., Lee E.H., Na H.J., Lee S.B., Shin T.Y., Lyu Y.S.et al. Effect of Polygala tenuifolia root extract on the tumour necrosis factor-α secretion from mouse astrocytes. J. Ethnopharmacol. 61(3):1998;201-208.
69. Kim D.S.H.L., Park S.Y., Kim J.Y. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA(1-42) insult. Neurosci. Lett. 303(1):2001;57-61.
70. Kim S.Y., Moon T.C., Chang H.W., Son K.H., Kang S.S., Kim H.P. Effects of tanshinone I isolated from Salvia miltiorrhiza Bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother. Res. 16(7):2002;616-620.
71. Kondo Y., Kondo F., Asanuma M., Tanaka K., Ogawa N. Protective effect of Oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse. Neurochem. Res. 25(2):2000;205-209.
72. Kong C.W., Tsai K., Chin J.H., Chan W.L., Hong C.Y. Magnolol attenuates peroxidative damage and improves survival of rats with sepsis. Shock. 13(1):2000;24-28.
73. Kong L.D., Cheng C.H., Tan R.X. Monoamine oxidase inhibitors from rhizoma of Coptis chinensis. Planta Med. 67(1):2001;74-76.
74. Koo H.N., Jeong H.J., Kim K.R., Kim J.C., Kim K.S., Kang B.K.et al. Inhibitory effect of interleukin-1α-induced apoptosis by Polygala tenuifolia in Hep H2 cells. Immunopharmacol. Immunotoxicol. 22(3):2000;531-544.
75. Kristofiková Z., Benesová O., Tejkalová H. Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (tacrine and Ginkgo biloba extract). Dementia. 3:1992;304-307.
76. Kuang P., Xiang J. Effect of Radix Salviae Miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study. J. Tradit. Chin. Med. 14(1):1994;45-50.
77. Kuang P., Wu W., Zhang F., Liu J., Pu C. The effect of Radix Salviae Miltiorrhizae on vasoactive intestinal peptide in cerebral ischaemia: an animal experiment. J. Tradit. Chin. Med. 9(3):1989;203-206.
78. Kuang P., Wu W., Liu J., Zhang F., Pu C. The effect of Radix Salviae Miltiorrhizae (RSM) on substance P in cerebral ischemia - animal experiment. J. Tradit. Chin. Med. 11(2):1991;123-127.
79. Kuang P., Wu W., Zhu K. Evidence for amelioration of cellular damage in ischemic rat brain by Radix Salviae Miltiorrhizae treatment - immunochemistry and histopathology studies. J. Tradit. Chin. Med. 13(1):1993;38-41.
80. Kuang P., Li Z., Zhang F., Tao Y., Liu J., Wu W. Protective effect of Radix Salviae Miltiorrhizae composita on cerebral ischemia. J. Tradit. Chin. Med. 15(2):1995;135-140.
81. Kuang P., Tao Y., Tian Y. Effect of Radix Salviae Miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury. J. Tradit. Chin. Med. 16(3):1996;224-227.
82. Kuang P., Tao Y., Tian Y. Radix Salviae Miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J. Tradit. Chin. Med. 16(2):1996;138-142.
83. Kuboto Y., Tanaka N., Umegaki K., Takenaka H., Mizuno H., Nakamura K.et al. Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci. 69(20):2001;2327-2336.
84. Kulkarni C., Pattanshetty J.R., Amruthraj G. Effect of alcoholic extract of Clitoria ternatea Linn. on central nervous system in rodents. Indian J. Exp. Biol. 26:1988;957-960.
85. Kumar M.H.V., Gupta Y.K. Antioxidant property of Celastrus paniculatus Willd.: a possible mechanism in enhancing cognition. Phytomedicine. 9(4):2002;302-311.
86. Kumar M.H.V., Gupta Y.K. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J. Ethnopharmacol. 79:2002;253-260.
87. Kumar V., Durai N.B., Jobe T. Pharmacologic management of Alzheimer's disease. Clin. Geriatr. Med. 14(1):1998;129-146.
88. Kuribara H., Kishi E., Hattori N., Yuzurihara M., Maruyama Y. Application of the elevated plus-maze test in mice for evaluation of the content of honokiol in water extracts of Magnolia. Phytother. Res. 13(7):1999;593-596.
89. Kuribara H., Kishi E., Hattori N., Okada M., Maruyama Y. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from Magnolia bark. J. Pharm. Pharmacol. 52(11):2000;1425-1429.
90. Laganière S., Corey J., Tang X.-C., Wülfert E., Hanin I. Acute and chronic studies with the anticholinesterase huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology. 30(7):1991;763-768.
91. Lake J.T., Grossberg G.T. Management of psychosis, agitation, and other behavioural problems in Alzheimer's disease. Psychiatr. Ann. 17:1987;371-374.
92. Lamirault L., Guillou J.L., Micheau J., Jaffard R. Intrahippocampal injections of somatostatin dissociate acquisition from the flexible use of place responses. Eur. J. Neurosci. 14(3):2001;567-570.
93. Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., Schatzberg A.F. A placebo-controlled, double-blind, randomised trial of an extract of Ginkgo biloba for dementia. JAMA. 278(16):1997;1327-1332.
94. Le Bars P.L., Kieser M., Itil K.Z. A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761 in dementia. Dement. Geriatr. Cogn. Disord. 11(4):2000;230-237.
95. Le Bars P.L., Velasco F.M., Ferguson J.M., Dessain E.C., Kieser M., Hoerr R. Influence of the severity of cognitive impairment on the effect of the Ginkgo biloba extract EGb 761((R)) in Alzheimer's disease. Neuropsychobiology. 45(1):2002;19-26.
96. Lebert F., Pasquier F., Petit H. Behavioural effects of trazodone in Alzheimer's disease. J. Clin. Psychiatry. 55(12):1994;536-538.
97. Lee M.M., Hseih M.T., Kuo J.S., Yeh F.T., Huang H.M. Magnolol protects cortical neuronal cells from chemical hypoxia in rats. NeuroReport. 9(15):1998;3451-3456.
98. Lee M.K., Kim S.R., Sung S.H., Lim D.Y., Kim H., Choi H.et al. Asiatic acid derivatives protect cultured neurons from glutamate-induced excitotoxicity. Res. Commun. Mol. Pathol. Pharmacol. 108(1-2):2000;75-86.
99. Liu F., Ng T.B. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci. 66(8):2000;725-735.
100. Liu G., Zhang T., Wang B., Wang Y. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem. Pharmacol. 43(2):1992;147-152.
101. Lo Y.C., Teng C.M., Chen C.F., Chen C.C., Hong C.Y. Magnolol and honokiol from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 47(3):1994;549-553.
102. Loffler T., Lee S.K., Noldner M., Chatterjee S.S., Hoyer S., Schliebs R. Effect of Ginkgo biloba extract (EGb 761) on glucose metabolism-related markers in streptozotocin-damaged rat brain. J. Neural Transm. 108(12):2001;1457-1474.
103. Lu W.-H., Shou J., Tang X.-C. Improving effect of huperzine A in aged rats and adult rats with experimental cognitive impairment. Acta Pharmacol. Sin. 9(1):1988;11-15.
104. Luo L., Nong Wang J., Kong L.D., Jiang Q.G., Tan R.X. Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. J. Ethnopharmacol. 73(1-2):2000;277-281.
105. Manyam B.V. Dementia in Ayurveda. J. Altern. Complement. Med. 5(1):1999;81-88.
106. Marcocci L., Packer L., Droy-Lefaix M.-T., Sekaki A., Gardès-Albert M. Antioxidant action of Ginkgo biloba extract EGb 761. Methods Enzymol. 234:1994;462-475.
107. Matsuda H., Yoshikawa M., Iinuma M., Kubo M. Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri. Planta Med. 64(4):1998;339-342.
108. Maurer K., Ihl R., Dierks T., Frölich L. Clinical efficacy of Ginkgo biloba extract EGb 761 in dementia of the Alzheimer type. J. Psychiatr. Res. 31(6):1997;645-655.
109. Maxwell S.J. Prospects for the use of anti-oxidant therapies. Drugs. 49:1995;345.
110. McGeer P.L., McGeer E., Rogers J., Sibley J. Anti-inflammatory drugs and Alzheimer's disease. Lancet. 335:1990;1037.
111. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. 47:1996;425-432.
112. McGuffey E.C. Alzheimer's disease: an overview for the pharmacist. JAMA. NS37(3):1997;347-352.
113. McKinney M., Miller J.H., Yamada F., Tuckmantel W., Kozikowski A.P. Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase. Eur. J. Pharmacol. 203:1991;303-305.
114. Miquel J., Bernd A., Sempere J.M., Diaz-Alperi J., Ramirez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch. Gerentol. Geriatr. 34(1):2002;37-46.
115. Misra R. Modern drug development from traditional medicinal plants using radioligand receptor-binding assays. Med. Res. Rev. 18:1998;383-402.
116. Miyazawa M., Watanabe H., Kameoka H. Inhibition of acetylcholinesterase activity by monoterpenoids with a p-menthane skeleton. J. Agric. Food Chem. 45:1997;677-679.
117. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43(2):1991;109-142.
118. Moon T.C., Murakami M., Kudo I., Son K.H., Kim H.P., Kang S.S.et al. A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflamm. Res. 48(12):1999;621-625.
119. Nadkarni K.M. Indian materia medica. 3rd ed. 1976;Popular Prakashan, Bombay.
120. Naik G.H., Priyadarsini K.I., Naik D.B., Satav J.G., Mohan H. Antioxidant activity and phytochemical analysis of the aqueous extract of Terminalia chebula. Free Radic. Biol. Med. 33(Suppl. 1):2002;547.
121. Nalini K., Aroor A.R., Karanth K.S., Rao A. Effect of Centella asiatica fresh leaf aqueous extract on learning and memory and biogenic amine turnover in albino rats. Fitoterapia. 63(3):1992;232-237.
122. Nalini K., Karanth K.S., Rao A., Aroot A.R. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J. Ethnopharmacol. 47:1995;101-108.
123. Nishiyama N., Yuan-Liang W., Kaimori J., Ishihara A., Saito H. Biota (Po-Tzu-Jen), a traditional Chinese medicine, ameliorates the memory acquisition disorder induced by amygdala lesion in mice. Phytother. Res. 6:1992;289-293.
124. Nishiyama N., Zhou Y., Saito H. Ameliorative effects of chronic treatment using DX-9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse. Biol. Pharm. Bull. 17(11):1994;1481-1484.
125. Nishiyama N., Zhou Y., Saito H. Beneficial effects of DX-9386, a traditional Chinese prescription, on memory disorder produced by lesioning the amygdala in mice. Biol. Pharm. Bull. 17(12):1994;1679-1681.
126. Nishiyama N., Zhou Y., Takashina K., Saito H. Effects of DX-9386, a traditional Chinese preparation, on passive and active avoidance performances in mice. Biol. Pharm. Bull. 17(11):1994;1472-1476.
127. Nishiyama N., Chu P.J., Saito H. Beneficial effects of Biota, a traditional Chinese herbal medicine on learning impairment induced by basal forebrain-lesion in mice. Biol. Pharm. Bull. 28(11):1995;1513-1517.
128. Nishiyama N., Wang Y.L., Saito H. Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice. Biol. Pharm. Bull. 18(11):1995;1498-1503.
129. Nordberg A. Neuroreceptor changes in Alzheimer disease. Cerebrovasc. Brain Metab. Rev. 4:1992;303-328.
130. Ohta Y., Sasaki E., Nishida K., Hayashi T., Nagata M., Ishiguro I. Preventive effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on progression of carbon tetrachloride-induced acute liver injury in rats. Am. J. Chin. Med. 25(1):1997;57-68.
131. Oken B.S., Storzbach D.M., Kaye J.A. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch. Neurol. 55:1998;1409-1415.
132. Ou L.Y., Tang X.C., Cai J.X. Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys. Eur. J. Pharmacol. 433(2-3):2001;151-156.
133. Palmer A.M., Francis C.T., Benton J.S., Sims J.R., Mann D.M.A., Neary D.et al. Presynaptic serotonergic dysfunction in patients with Alzheimer's disease. J. Neurochem. 48:1987;8-15.
134. Palmer A.M., Francis C.T., Bowen D.M., Benton J.S., Neary D., Mann D.M.A.et al. Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease. Brain Res. 414:1987;365-375.
135. Park S.Y., Kim D.S.H.L. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease. J. Nat. Prod. 65(9):2002;1227-1231.
136. Park C.H., Kim S., Choi W., Lee Y., Kim J., Kang S.S.et al. Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia ruraecarpa. Planta Med. 62:1996;405-409.
137. Park C.H., Choi S.H., Koo J.W., Seo J.H., Kim H.S., Jeong S.J.et al. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J. Neurosci. Res. 70(3):2002;484-492.
138. Paulus K., Bauer R. Inhibitory effects from Salvia miltiorrhiza on leukotriene biosynthesis. Natural products research in the new millenium abstract book. 48th Annual Meeting of the Society for Medicinal Plant Research: Zurich, Switzerland:2000;2A/73 Society of Medicinal Plant Research, Munster, Germany.
139. Pearson V.E. Galantamine: a new Alzheimer drug with a past life. Ann. Pharmacother. 35(11):2001;1406-1413.
140. Peigen K., Yi T., Yaping T. Radix Salviae Miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J. Tradit. Chin. Med. 16(2):1996;138-142.
141. Perry E. The cholinergic hypothesis: 10 years on. Br. Med. Bull. 42:1986;63-69.
142. Perry E., Tomlinson E., Blessed G., Bergmann K., Gibson P., Perry R. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 2:1978;1457-1459.
143. Perry N., Court G., Bidet N., Court J., Perry E. European herbs with cholinergic activities: potential in dementia therapy. Int. J. Geriatr. Psychiatry. 11:1996;1063-1069.
144. Perry N.S.L., Houghton P.J., Theobald A., Jenner P., Perry E.K. In-vitro inhibition of human erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes. J. Pharm. Pharmacol. 52:2000;895-902.
145. Perry N.S.L., Howes M.-J.R., Houghton P.J., Perry E. Why sage may be a wise remedy: effects of Salvia on the nervous system. Kintzios S.E. Sage: the genus Salvia. 2000;207-223 Harwood Academic, Amsterdam.
146. Petkov V.D., Kehayov R., Belcheva S., Konstantinova E., Petkov V.V., Getova D.et al. Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK501) and their combination Ginkosan (PHL-00701). Planta Med. 59:1993;106-114.
147. Plotkin D.A., Jarvik L.F. Cholinergic dysfunction in Alzheimer disease: cause or effect? Prog. Brain Res. 65:1986;91-103.
148. Priyadarsini K.I. Free radical reactions of curcumin in membrane models. Free Radic. Biol. Med. 23(6):1997;838-843.
149. Quigley B.J., Kowall N.W. Substance P-like immunoreactive neurons are depleted in Alzheimer's disease cerebral cortex. Neuroscience. 41:1991;41-60.
150. Rai G.S., Shovlin C., Wesnes K.A. A double-blind, placebo controlled study of Ginkgo biloba extract (Tanakan) in elderly outpatients with mild to moderate memory impairment. Curr. Med. Res. Opin. 12(6):1991;350-355.
151. Rai K.S., Murthy K.D., Karanth K.S., Nalini K., Rao M.S., Srinivasan K.K. Clitoria ternatea root extract enhances acetylcholine content in rat hippocampus. Fitoterapia. 73(7-8):2002;685-689.
152. Rajakrishnan V., Viswanathan P., Rajasekharan K.N., Menon V.P. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother. Res. 13(7):1999;571-574.
153. Ramsewak R.S., DeWitt D.L., Nair M.G. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine. 7(4):2000;303-308.
154. Read S.L. Update on cholinergic enhancement therapy for Alzheimer disease. Bull. Clin. Neurosci. 52:1987;34-37.
155. Reinikainen K.J., Paljarvi L., Halonen T., Malminen O., Kosma V.-M., Laakso M.et al. Dopaminergic system and monoamine oxidase-B activity in Alzheimer's disease. Neurobiol. Aging. 9:1988;245-252.
156. Reisberg B., Ferris S., Mobius H.J., Schmitt F., Doody R. Long-term treatment with the NMDA antagonist memantine: results of a 24-week, open-label extension study in moderately severe-to-severe Alzheimer's disease. Neurobiol. Aging. 23(Suppl. 1):2002;2039.
157. Rigney U., Kimber S., Hindmarch I. The effects of acute doses of standardised Ginkgo biloba extract on memory and psychomotor performance in volunteers. Phytother. Res. 13:1999;408-415.
158. Ross I.A. Medicinal plants of the world. Chemical constituents, traditional and modern medicinal uses. vol. 2:2001;Humana Press, Clifton (NJ).
159. Ryan M.F., Byrne O. Plant-insect coevolution and inhibition of acetylcholinesterase. J. Chem. Ecol. 14(10):1988;1965-1975.
160. Sakina M.R., Dandiya P.C. A psycho-neuropharmacological profile of Centella asiatica extract. Fitoterapia. 61(4):1990;291-296.
161. Scartezzini P., Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 71(1-2):2000;23-43.
162. Schindowski K., Leutner S., Kressmann S., Eckert A., Muller W.E. Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb 761). J. Neural Transm. 108(8-9):2001;969-978.
163. Schinella G.R., Tournier H.A., Prieto J.M., Mordujovich de Buschiazzo P., Ríos J.L. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 70:2002;1023-1033.
164. Seidl R., Cairns N., Singewald N., Kaehler S.T., Lubec G. Differences between GABA levels in Alzheimer's disease and down syndrome with Alzheimer-like neuropathology. Naunyn Schmiedebergs Arch. Pharmacol. 363(2):2001;139-145.
165. Shigeta K., Ootaki K., Tatemoto H., Nakanishi T., Inada A., Muto N. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci. Biotechnol. Biochem. 66(11):2002;2491-2494.
166. Shu Y.-Z. Recent natural products based drug development: a pharmaceutical industry perspective. J. Nat. Prod. 61:1998;1053-1071.
167. Shukla P.K., Khanna V.K., Ali M.M., Maurya R.R., Handa S.S., Srimal R.C. Protective effect of Acorus calamus against acrylamide induced neurotoxicity. Phytother. Res. 16(3):2002;256-260.
168. Simpson P.M., Foster D. Improvement in organically disturbed behaviour with trazodone treatment. J. Clin. Psychiatry. 47:1986;191-193.
169. Skolnick A.A. Old herbal Chinese medicine used for fever yields possible new Alzheimer disease therapy. JAMA. 277(10):1997;776.
170. Skrzypczak-Jankun E., McCabe N.P., Selman S.H., Jankun J. Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int. J. Mol. Med. 6(5):2000;521-526.
171. Slater T.F. Free-radical mechanisms in tissue injury. Biochem. J. 222:1984;1-15.
172. Small G.W., Rabins R.V., Barry P.P., Buckholtz N.S., DeKosky S.T., Ferros S.H.et al. Diagnosis and treatment of Alzheimer's disease and related disorders. JAMA. 278(16):1997;1363-1371.
173. Soeda S., Ochiai T., Paopong L., Tanaka H., Shoyama Y., Shimeno H. Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells. Life Sci. 69:2001;2881-2898.
174. Song LC, Chen KZ, Zhu JY. The effect of Coptis chinensis on lipid peroxidation and antioxidases activity in rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 1992;12(7):421-3, 390.
175. Spiteller G. Review: on the chemistry of oxidative stress. J. Lipid Mediat. 7:1993;199-221.
176. 3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites. Neurochem. Res. 24(12):1999;1593-1602.
177. Srivastava K.C., Bordia A., Verma S.K. Curcumin, a major component of food spice tumeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot. Essent. Fatty Acids. 52(4):1995;223-227.
178. Stoll S., Scheuer K., Pohl O., Müller W.E. Ginkgo biloba extract
179. Storga D., Vrecko K., Birkmayer J.G., Reibnegger G. Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients. Neurosci. Lett. 203(1):1996;29-32.
180. Sugiura M., Shoyama Y., Saito H., Nishiyama N. Crocin improves the ethanol-induced impairment of learning behaviours of mice in passive avoidance tasks. Proc. Jpn. Acad. 71:1995;319-324.
181. Sugiura M., Saito H., Abe K., Shoyama Y. Ethanol extract of Crocus sativus L. antagonises the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. Phytother. Res. 9(2):1995;100-104.
182. Tang W., Eisenbrand G. Chinese drugs of plant origin. 1992;Springer-Verlag, Berlin, Germany.
183. Taranalli A.D., Cheeramkuzhy T.C. Influence of Clitoria ternatea extracts on memory and central cholinergic activity in rats. Pharm. Biol. 38(1):2000;51-56.
184. Tea S., Celsis P., Clanet M., Marc-Vergnes J.-P., Boeters U. Quantified parameters for the proof of the enhancement of cerebral circulation and metabolism. Therapiewoche. 37:1987;2655-2657.
185. Topic B., Tani E., Tsiakitzis K., Kourounakis P.N., Dere E., Hasenöhrl R.U.et al. Enhanced maze performance and reduced oxidative stress by combined extracts of Zinziber officinale and Ginkgo biloba in the aged rat. Neurobiol. Aging. 23(1):2002;135-143.
186. Traystman R.J., Kirsch J.R., Koehler R.C. Oxygen radical mechanisms of brain injury following ischaemia and reperfusion. J. Appl. Physiol. 71(4):1991;1185-1195.
187. Uchihara T., Kondo H., Kosaka K., Tsukagoshi H. Selective loss of nigral neurons in Alzheimer's disease: a morphometric study. Acta Neuropathol. 83:1992;271-276.
188. Ved H.S., Koenig M.L., Dave J.R., Doctor B.P. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. NeuroReport. 8(4):1997;963-968.
189. Vohora S.B., Shah S.A., Dandiya P.C. Central nervous system studies on an ethanol extract of Acorus calamus rhizomes. J. Ethnopharmacol. 28:1990;53-62.
190. Wang L.M., Mineshita S. Preventive effects of Unsei-in and Oren-gedoku-to, Chinese traditional medicines, against rat paw oedema and abdominal constriction in mice. J. Pharm. Pharmacol. 48(3):1996;327-331.
191. Wang Y.-E., Yue D.-X., Tang X.-C. Anti-cholinesterase activity of huperzine A. Acta Pharmacol. Sin. 7(2):1986;110-113.
192. Wang J.P., Hsu M.F., Raung S.L., Chen C.C., Kuo J.S., Teng C.M. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch. Pharmacol. 346(6):1992;707-712.
193. Wang J.P., Ho T.F., Chang L.C., Chen C.C. Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J. Pharm. Pharmacol. 47(10):1995;857-860.
194. Wang L.J., Zou J.X., Liu G.Z. Extract of dangshen (Codonopsis pilosula) can reduce the impairment of memory acquisition in mice. Naunyn Schmiedebergs Arch. Pharmacol. 358(Suppl. 2):1998;5174.
195. Wang X.D., Zhang J.M., Yang H.H., Hu G.Y. Modulation of NMDA receptor by huperzine A in rat cerebral cortex. Acta Pharmacol. Sin. 20(1):1999;31-35.
196. Wang L.M., Han Y.F., Tang X.C. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur. J. Pharmacol. 398(1):2000;65-72.
197. Warrier P.K., Nambiar V.P.K., Ramankutty C. Indian medicinal plants. vol. 2:1995;Orient Longman, India.
198. Watkins P.B., Zimmerman H.J., Knapp M.J., Gracon S.I., Lewis K.W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA. 271:1994;992-998.
199. Weng X.C., Gordon M.H. Antioxidant activity of quinones extracted from tanshen (Salvia miltiorrhiza Bunge). J. Agric. Food Chem. 40:1992;1331-1336.
200. Whitehouse P.J., Kalaria R.N. Nicotinic receptors and neurodegenerative dementing diseases: basic research and clinical implications. Alzheimer Dis. Assoc. Disord. 9(Suppl. 2):1995;3-5.
201. Wilcock G.K., Lilienfeld S., Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. BMJ. 321:2000;1445-1449.
202. Wilkinson D., Murray J. Galantamine: a randomised, double-blind, dose comparison in patients with Alzheimer's disease. Int. J. Geriatr. Psychiatry. 16(9):2001;852-857.
203. 9M-BEST study (benefit and efficacy in severely demented patients during treatment with mementine). Int. J. Geriatr. Psychiatry. 14:1999;135-146.
204. Woodruff-Pak D.S., Vogel R.W., Wenk G.L. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc. Natl. Acad. Sci. U. S. A. 98(4):2001;2089-2094.
205. Wragg R.E., Jeste D.V. Overview of depression and psychosis in Alzheimer's disease. Am. J. Psychiatry. 146:1989;577-587.
206. Xiao X.Q., Yang J.W., Tang X.C. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci. Lett. 275:1999;73-76.
207. Xiao X.Q., Zhang H.Y., Tang X.C. Huperzine A attenuates amyloid β-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and capase-3 activation. J. Neurosci. Res. 67(1):2002;30-36.
208. Yabe T., Iizuka S., Komatsu Y., Yamada H. Enhancements of choline acetyltransferase activity and nerve growth factor secretion by Polygalae Radix-extract containing active ingredients in Kami-utan-to. Phytomedicine. 4(3):1997;199-205.
209. Yamada H., Yabe T. Anti-dementia actions of Kampo (Japanese-herbal) medicines effects of Kampo medicines on central nervous system. Curr. Top. Phytochem. 1:1997;157-168.
210. Yao Z., Drieu K., Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands. Brain Res. 889(1-2):2001;181-190.
211. Yu Z.F., Kong L.D., Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J. Ethnopharmacol. 83(1-2):2002;161-165.
212. Zanoli P., Avallone R., Baraldi M. Sedative and hypothermic effects induced by β-asarone, a main component of Acorus calamus. Phytother. Res. 12(Suppl. 1):1998;S114-S116.
213. Zhang L., Liu G.Z. Nootropic effect of dangshen, Radix-Codonopsis-Pilosulae. Eur. J. Pharmacol. 183(4):1990;1461.
214. Zhang K., Bao Y., Wu P., Rosen R.T., Ho C. Anti-oxidative components of tanshen (Salvia miltiorrhiza Bung). J. Agric. Food Chem. 38:1990;1194-1197.
215. Zhang X., Kuang P., Wu W., Yin X., Kanazawa T., Onodera K.et al. The effect of Radix Salviae Miltiorrhizae composita on peroxidation of low density lipoprotein due to copper dichloride. J. Tradit. Chin. Med. 14(3):1994;195-201.
216. Zhang Y., Takashina K., Saito H., Nishiyama N. Anti-aging effect of DX-9368 in senescence accelerated mouse. Biol. Pharm. Bull. 17(6):1994;866-868.
217. Zhao B., Jiang W., Zhao Y., Hou J., Xin W. Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Biochem. Mol. Biol. Int. 38(6):1996;1171-1182.
218. Zhou J., Tang X.C. Huperzine A attenuates apoptosis and mitochondria-dependent capase-3 in rat cortical neurons. FEBS Lett. 526:2002;21-25.
219. Zhou Y., Xu R. Antioxidative effect of Chinese drugs. Zhongguo Zhong Yao Za Zhi. 17(6):1992;368-369.
220. Zhou J., Fu Y., Tang X.C. Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation. Neurosci. Lett. 306:2001;53-56.
221. Zhou J., Zhang H.Y., Tang X.C. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci. Lett. 313(3):2001;137-140.