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Volumn 336, Issue 17, 1997, Pages 1216-1222

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CATECHOLAMINE; SELEGILINE;

EID: 0030967165     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199704243361704     Document Type: Article
Times cited : (2371)

References (34)
  • 1
    • 0001815909 scopus 로고
    • Pathology of Alzheimer's disease
    • Calne DB, ed. Philadelphia: W.B. Saunders
    • Braak H, Braak E. Pathology of Alzheimer's disease. In: Calne DB, ed. Neurodegenerative diseases. Philadelphia: W.B. Saunders, 1994:585-613.
    • (1994) Neurodegenerative Diseases , pp. 585-613
    • Braak, H.1    Braak, E.2
  • 2
    • 0020675317 scopus 로고
    • An update on the neurochemistry of Alzheimer disease
    • Mayeux R, Rosen WG, eds. The dementias. New York: Raven Press
    • Davies P. An update on the neurochemistry of Alzheimer disease. In: Mayeux R, Rosen WG, eds. The dementias. Vol. 38 of Advances in neurology. New York: Raven Press, 1983:75-86.
    • (1983) Advances in Neurology , vol.38 , pp. 75-86
    • Davies, P.1
  • 3
    • 0000622878 scopus 로고
    • The free radical theory of aging
    • Pryor WA, ed. New York: Academic Press
    • Harman D. The free radical theory of aging. In: Pryor WA, ed. Free radicals in biology. Vol. 5. New York: Academic Press, 1982:255-75.
    • (1982) Free Radicals in Biology , vol.5 , pp. 255-275
    • Harman, D.1
  • 4
    • 0002566762 scopus 로고
    • Role of oxidative damage in the aging process
    • Chow CK, ed. Boca Raton, Fla.: CRC Press
    • Porta EA. Role of oxidative damage in the aging process. In: Chow CK, ed. Cellular antioxidant defense mechanisms. Vol. 3. Boca Raton, Fla.: CRC Press, 1988:1-52.
    • (1988) Cellular Antioxidant Defense Mechanisms , vol.3 , pp. 1-52
    • Porta, E.A.1
  • 5
    • 0025790342 scopus 로고
    • Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
    • Smith CD, Carney JM, Starke-Reed PE, et al. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A 1991;88:10540-3.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10540-10543
    • Smith, C.D.1    Carney, J.M.2    Starke-Reed, P.E.3
  • 6
    • 0029982815 scopus 로고    scopus 로고
    • Oxidative damage in Alzheimer's
    • Smith MA, Perry G, Richey PL, et al. Oxidative damage in Alzheimer's. Nature 1996;382:120-1.
    • (1996) Nature , vol.382 , pp. 120-121
    • Smith, M.A.1    Perry, G.2    Richey, P.L.3
  • 7
    • 0020997395 scopus 로고
    • Deprenyl (selegiline): The history of its development and pharmacological action
    • Knoll J. Deprenyl (selegiline): the history of its development and pharmacological action. Acta Neurol Scand Suppl 1983;95:57-80.
    • (1983) Acta Neurol Scand , vol.95 , Issue.SUPPL. , pp. 57-80
    • Knoll, J.1
  • 8
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328:176-83.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 9
    • 0025304847 scopus 로고
    • Neuropsychological effects of L-deprenyl in Alzheimer's type dementia
    • Piccinin GL, Finali G, Piccirilli M. Neuropsychological effects of L-deprenyl in Alzheimer's type dementia. Clin Neuropharmacol 1990;13:147-63.
    • (1990) Clin Neuropharmacol , vol.13 , pp. 147-163
    • Piccinin, G.L.1    Finali, G.2    Piccirilli, M.3
  • 10
    • 0025972929 scopus 로고
    • Effects of a MAO-B inhibitor in the treatment of Alzheimer disease
    • Erratum, Eur Neurol 1991;31:433a
    • Mangoni A, Grassi MP, Frattola L, et al. Effects of a MAO-B inhibitor in the treatment of Alzheimer disease. Eur Neurol 1991;31:100-7. [Erratum, Eur Neurol 1991;31:433a.]
    • (1991) Eur Neurol , vol.31 , pp. 100-107
    • Mangoni, A.1    Grassi, M.P.2    Frattola, L.3
  • 13
    • 0025237287 scopus 로고
    • Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus
    • Hara H, Kato H, Kogure K. Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res 1990;510:335-8.
    • (1990) Brain Res , vol.510 , pp. 335-338
    • Hara, H.1    Kato, H.2    Kogure, K.3
  • 14
    • 0023697931 scopus 로고
    • Pretreatment with alpha tocopherol enhances neurologic recovery after experimental spinal cord compression injury
    • Anderson DK, Waters TR, Means ED. Pretreatment with alpha tocopherol enhances neurologic recovery after experimental spinal cord compression injury. J Neurotrauma 1988;5:61-7.
    • (1988) J Neurotrauma , vol.5 , pp. 61-67
    • Anderson, D.K.1    Waters, T.R.2    Means, E.D.3
  • 15
    • 0021859649 scopus 로고
    • Postischemic cerebral lipid peroxidation in vitro: Modification by dietary vitamin E
    • Yoshida S, Busto R, Watson BD, Santiso M, Ginsberg MD. Postischemic cerebral lipid peroxidation in vitro: modification by dietary vitamin E. J Neurochem 1985;44:1593-601.
    • (1985) J Neurochem , vol.44 , pp. 1593-1601
    • Yoshida, S.1    Busto, R.2    Watson, B.D.3    Santiso, M.4    Ginsberg, M.D.5
  • 16
  • 17
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): Current version and scoring rules
    • Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412-4.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 18
    • 9544258368 scopus 로고    scopus 로고
    • Rationale and design of a multicenter study of selegiline and α-tocopherol in the treatment of Alzheimer's disease using novel clinical outcomes
    • Sano M, Ernesto C, Klauber MR, et al. Rationale and design of a multicenter study of selegiline and α-tocopherol in the treatment of Alzheimer's disease using novel clinical outcomes. Alzheimer Dis Assoc Disord 1996;10:132-40.
    • (1996) Alzheimer Dis Assoc Disord , vol.10 , pp. 132-140
    • Sano, M.1    Ernesto, C.2    Klauber, M.R.3
  • 19
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
    • (1968) Br J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 20
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984;141:1356-64.
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 21
    • 0016823810 scopus 로고
    • "Mini-Mental State": A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 23
    • 0029165333 scopus 로고
    • The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease: The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
    • Tariot PN, Mack JL, Patterson MB, et al. The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease: the Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. Am J Psychiatry 1995;152:1349-57.
    • (1995) Am J Psychiatry , vol.152 , pp. 1349-1357
    • Tariot, P.N.1    Mack, J.L.2    Patterson, M.B.3
  • 24
    • 0025831118 scopus 로고
    • Interrater reliability of extrapyramidal signs in a group assessed for dementia
    • Richards M, Marder K, Bell K, Dooneief G, Mayeux R, Stern Y. Interrater reliability of extrapyramidal signs in a group assessed for dementia. Arch Neurol 1991;48:1147-9.
    • (1991) Arch Neurol , vol.48 , pp. 1147-1149
    • Richards, M.1    Marder, K.2    Bell, K.3    Dooneief, G.4    Mayeux, R.5    Stern, Y.6
  • 25
    • 0020993106 scopus 로고
    • What price Kaplan-Meier?
    • Miller RG Jr. What price Kaplan-Meier? Biometrics 1983;39:1077-81.
    • (1983) Biometrics , vol.39 , pp. 1077-1081
    • Miller Jr., R.G.1
  • 26
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure
    • Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979;6:65-70.
    • (1979) Scand J Stat , vol.6 , pp. 65-70
    • Holm, S.1
  • 29
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
    • Knapp MJ, Knopman DS, Solomon PR, Pendlebury WW, Davis CS, Gracon SI. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA 1994;271:985-91.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.I.6
  • 30
    • 9544240348 scopus 로고    scopus 로고
    • A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease
    • Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-11.
    • (1996) Neurology , vol.47 , pp. 705-711
    • Thai, L.J.1    Carta, A.2    Clarke, W.R.3
  • 31
    • 0028856571 scopus 로고
    • Trial of d-a-tocopherol in Huntington's disease
    • Peyser CE, Folstein M, Chase GA, et al. Trial of d-a-tocopherol in Huntington's disease. Am J Psychiatry 1995;152:1771-5.
    • (1995) Am J Psychiatry , vol.152 , pp. 1771-1775
    • Peyser, C.E.1    Folstein, M.2    Chase, G.A.3
  • 32
    • 0029183077 scopus 로고
    • Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease
    • Machlin LJ. Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease. Crit Rev Food Sci Nutr 1995;35:41-50.
    • (1995) Crit Rev Food Sci Nutr , vol.35 , pp. 41-50
    • Machlin, L.J.1
  • 33
    • 0028789676 scopus 로고
    • Antioxidants and immune response in aged persons: Overview of present evidence
    • Meydani SN, Wu D, Santos MS, Hayek MG. Antioxidants and immune response in aged persons: overview of present evidence. Am J Clin Nutr 1995;62:Suppl:1462s-1476s.
    • (1995) Am J Clin Nutr , vol.62 , Issue.SUPPL.
    • Meydani, S.N.1    Wu, D.2    Santos, M.S.3    Hayek, M.G.4
  • 34
    • 0029165426 scopus 로고
    • Epidemiologic studies of antioxidants and cancer in humans
    • Flagg EW, Coates RJ, Greenberg RS. Epidemiologic studies of antioxidants and cancer in humans. J Am Coll Nutr 1995;14:419-27.
    • (1995) J Am Coll Nutr , vol.14 , pp. 419-427
    • Flagg, E.W.1    Coates, R.J.2    Greenberg, R.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.