메뉴 건너뛰기




Volumn 5, Issue 3, 2003, Pages 229-239

Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid

Author keywords

Alzheimer's disease; Antioxidants; Free radicals; Lipid peroxidation; Neuron cultures

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; DIHYDROLIPOATE; FREE RADICAL; HYDROGEN PEROXIDE; IRON; THIOCTIC ACID;

EID: 0142010609     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2003-5306     Document Type: Article
Times cited : (88)

References (81)
  • 1
    • 0021849883 scopus 로고
    • Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione
    • M.E. Anderson, F. Powrie, R.N. Puri and A. Meister, Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione, Arch Biochem Biophys 239 (1985), 538-548.
    • (1985) Arch Biochem Biophys , vol.239 , pp. 538-548
    • Anderson, M.E.1    Powrie, F.2    Puri, R.N.3    Meister, A.4
  • 2
    • 0034067261 scopus 로고    scopus 로고
    • In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy
    • L. Androne, N.A. Gavan, I.A. Veresiu and R. Orasan, In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy, In Vivo 14 (2000), 327-330.
    • (2000) In Vivo , vol.14 , pp. 327-330
    • Androne, L.1    Gavan, N.A.2    Veresiu, I.A.3    Orasan, R.4
  • 3
    • 0024208540 scopus 로고
    • Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation
    • A. Bast and G.R. Haenen, Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation, Biochim Biophys Acta 963 (1988), 558-561.
    • (1988) Biochim Biophys Acta , vol.963 , pp. 558-561
    • Bast, A.1    Haenen, G.R.2
  • 4
    • 0025031958 scopus 로고
    • Regulation of lipid peroxidation by glutathione and lipoic acid: Involvement of liver microsomal vitamin E free radical reductase
    • A. Bast and G.R. Haenen, Regulation of lipid peroxidation by glutathione and lipoic acid: involvement of liver microsomal vitamin E free radical reductase, Adv Exp Med Biol 264 (1990), 111-116.
    • (1990) Adv Exp Med Biol , vol.264 , pp. 111-116
    • Bast, A.1    Haenen, G.R.2
  • 5
    • 0023040732 scopus 로고
    • Removal of ferritin-bound iron by DL-dihydrolipoate and DL-dihydrolipoamide
    • F. Bonomi and S. Pagani, Removal of ferritin-bound iron by DL-dihydrolipoate and DL-dihydrolipoamide, Eur J Biochem 155 (1986), 295-300.
    • (1986) Eur J Biochem , vol.155 , pp. 295-300
    • Bonomi, F.1    Pagani, S.2
  • 7
    • 0142034674 scopus 로고
    • Effect of lipoic acid on short-term ischemia-reperfusion in rat intestine
    • L. Packer and E. Cadenas, eds, Verlag, Stuttgart
    • A. Boveris, E.J.A. Roldan and S. Alvarez, Effect of lipoic acid on short-term ischemia-reperfusion in rat intestine, in: Biological oxidants and antioxidants, L. Packer and E. Cadenas, eds, Verlag, Stuttgart, 1994.
    • (1994) Biological Oxidants and Antioxidants
    • Boveris, A.1    Roldan, E.J.A.2    Alvarez, S.3
  • 8
    • 0032905632 scopus 로고    scopus 로고
    • Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
    • N.Y. Calingasan, K. Uchida and G.E. Gibson, Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease, J Neurochem 72 (1999), 751-756.
    • (1999) J Neurochem , vol.72 , pp. 751-756
    • Calingasan, N.Y.1    Uchida, K.2    Gibson, G.E.3
  • 9
    • 0018338513 scopus 로고
    • Biosynthesis of lipoic acid via unsaturated fatty acids
    • J.P. Carreau, Biosynthesis of lipoic acid via unsaturated fatty acids, Methods Enzymol 62 (1979), 152-158.
    • (1979) Methods Enzymol , vol.62 , pp. 152-158
    • Carreau, J.P.1
  • 10
    • 0031800225 scopus 로고    scopus 로고
    • Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain
    • C.R. Cornett, W.R. Markesbery and W.D. Ehmann, Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain, Neurotoxicology 19 (1998), 339-345.
    • (1998) Neurotoxicology , vol.19 , pp. 339-345
    • Cornett, C.R.1    Markesbery, W.R.2    Ehmann, W.D.3
  • 11
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • J.T. Coyle and P. Puttfarcken, Oxidative stress, glutamate, and neurodegenerative disorders, Science 262 (1993), 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 12
    • 0025975753 scopus 로고
    • Singlet oxygen induced single-strand breaks in plasmid pBR322 DNA: The enhancing effect of thiols
    • T.P. Devasagayam, P. Di Mascio, S. Kaiser and H. Sies, Singlet oxygen induced single-strand breaks in plasmid pBR322 DNA: the enhancing effect of thiols, Biochim Biophys Acta 1088 (1991), 409-412.
    • (1991) Biochim Biophys Acta , vol.1088 , pp. 409-412
    • Devasagayam, T.P.1    Di Mascio, P.2    Kaiser, S.3    Sies, H.4
  • 15
    • 0032823578 scopus 로고    scopus 로고
    • Decrease in peptide methionine sulfoxide redactase in Alzheimer's disease brain
    • S.P. Gabbita, M.Y. Aksenov, M.A. Lovell and W.R. Markesbery, Decrease in peptide methionine sulfoxide redactase in Alzheimer's disease brain, J Neurochem 73 (1999), 1660-1666.
    • (1999) J Neurochem , vol.73 , pp. 1660-1666
    • Gabbita, S.P.1    Aksenov, M.Y.2    Lovell, M.A.3    Markesbery, W.R.4
  • 16
    • 0031754202 scopus 로고    scopus 로고
    • Increased nuclear DNA oxidation in the brain in Alzheimer's disease
    • S.P. Gabbita, M.A. Lovell and W.R. Markesbery, Increased nuclear DNA oxidation in the brain in Alzheimer's disease, J Neurochem 71 (1998), 2034-2040.
    • (1998) J Neurochem , vol.71 , pp. 2034-2040
    • Gabbita, S.P.1    Lovell, M.A.2    Markesbery, W.R.3
  • 17
    • 0022339431 scopus 로고
    • Lipoic acid and diabetes II: Mode of action of lipoic acid
    • V.M. Gandhi, S.S. Wagh, C.V. Natraj and K.K.G. Menon, Lipoic acid and diabetes II: Mode of action of lipoic acid, J. Biosci. (1985), 117-127.
    • (1985) J Biosci , pp. 117-127
    • Gandhi, V.M.1    Wagh, S.S.2    Natraj, C.V.3    Menon, K.K.G.4
  • 18
    • 0024147201 scopus 로고
    • Thioredoxin and related proteins in procaryotes
    • F.K. Gleason and A. Holmgren, Thioredoxin and related proteins in procaryotes, FEMS Microbiol Rev 4 (1988), 271-297.
    • (1988) FEMS Microbiol Rev , vol.4 , pp. 271-297
    • Gleason, F.K.1    Holmgren, A.2
  • 19
    • 0029902166 scopus 로고    scopus 로고
    • Evidence of neuronal oxidative damage in Alzheimer's disease
    • P.F. Good, P. Werner, A. Hsu, C.W. Olanow and D.P. Perl, Evidence of neuronal oxidative damage in Alzheimer's disease, Am J Pathol 149 (1996), 21-28.
    • (1996) Am J Pathol , vol.149 , pp. 21-28
    • Good, P.F.1    Werner, P.2    Hsu, A.3    Olanow, C.W.4    Perl, D.P.5
  • 21
    • 0025949295 scopus 로고
    • Scavenging of hypochlorous acid by lipoic acid
    • G.R. Haenen and A. Bast, Scavenging of hypochlorous acid by lipoic acid, Biochem Pharmacol 42 (1991), 2244-2246.
    • (1991) Biochem Pharmacol , vol.42 , pp. 2244-2246
    • Haenen, G.R.1    Bast, A.2
  • 22
    • 0028358550 scopus 로고
    • Alphalipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium
    • G.J. Handelman, D. Han, H. Tritschler and L. Packer, Alphalipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium, Biochem Pharmacol 47 (1994), 1725-1730.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1725-1730
    • Handelman, G.J.1    Han, D.2    Tritschler, H.3    Packer, L.4
  • 23
    • 0015986669 scopus 로고
    • The metabolism of dl-(1,6-14C)lipoic acid in the rat
    • E.H. Harrison and D.B. McCormick, The metabolism of dl-(1,6-14C)lipoic acid in the rat, Arch Biochem Biophys 160 (1974), 514-522.
    • (1974) Arch Biochem Biophys , vol.160 , pp. 514-522
    • Harrison, E.H.1    McCormick, D.B.2
  • 24
    • 0014967406 scopus 로고
    • Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro
    • N. Haugaard and E.S. Haugaard, Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro, Biochim Biophys Acta 222 (1970), 583-586.
    • (1970) Biochim Biophys Acta , vol.222 , pp. 583-586
    • Haugaard, N.1    Haugaard, E.S.2
  • 26
    • 0018723651 scopus 로고
    • Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide
    • A. Holmgren, Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide, J Biol Chem 254 (1979), 9627-9632.
    • (1979) J Biol Chem , vol.254 , pp. 9627-9632
    • Holmgren, A.1
  • 27
    • 0032840875 scopus 로고    scopus 로고
    • Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: A placebo-controlled pilot trial
    • S. Jacob, P. Ruus, R. Hermann, H.J. Tritschler, E. Maerker, W. Renn, H.J. Augustin, G.J. Dietze and K. Rett, Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial, Free Radic Biol Med 27 (1999), 309-314.
    • (1999) Free Radic Biol Med , vol.27 , pp. 309-314
    • Jacob, S.1    Ruus, P.2    Hermann, R.3    Tritschler, H.J.4    Maerker, E.5    Renn, W.6    Augustin, H.J.7    Dietze, G.J.8    Rett, K.9
  • 28
    • 0026778866 scopus 로고
    • Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals
    • V.E. Kagan, A. Shvedova, E. Serbinova, S. Khan, C. Swanson, R. Powell and L. Packer, Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals, Biochem Pharmacol 44 (1992), 1637-1649.
    • (1992) Biochem Pharmacol , vol.44 , pp. 1637-1649
    • Kagan, V.E.1    Shvedova, A.2    Serbinova, E.3    Khan, S.4    Swanson, C.5    Powell, R.6    Packer, L.7
  • 29
    • 0023221068 scopus 로고
    • Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
    • J.Y. Koh and D.W. Choi, Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay, J Neurosci Methods 20 (1987), 83-90.
    • (1987) J Neurosci Methods , vol.20 , pp. 83-90
    • Koh, J.Y.1    Choi, D.W.2
  • 30
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • M.A. Lovell, W.D. Ehmann, S.M. Butler and W.R. Markesbery, Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease, Neurology 45 (1995), 1594-1601.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Lovell, M.A.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 31
    • 0030714092 scopus 로고    scopus 로고
    • Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease
    • M.A. Lovell, W.D. Ehmann, M.P. Mattson and W.R. Markesbery, Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease, Neurobiol Aging 18 (1997), 457-461.
    • (1997) Neurobiol Aging , vol.18 , pp. 457-461
    • Lovell, M.A.1    Ehmann, W.D.2    Mattson, M.P.3    Markesbery, W.R.4
  • 32
    • 0033969616 scopus 로고    scopus 로고
    • Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain
    • M.A. Lovell, C. Xie, S.P. Gabbita and W.R. Markesbery, Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain, Free Radic Biol Med 28 (2000), 418-427.
    • (2000) Free Radic Biol Med , vol.28 , pp. 418-427
    • Lovell, M.A.1    Xie, C.2    Gabbita, S.P.3    Markesbery, W.R.4
  • 33
    • 0035112495 scopus 로고    scopus 로고
    • Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    • M.A. Lovell, C. Xie and W.R. Markesbery, Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures, Neurobiol Aging 22 (2001), 187-194.
    • (2001) Neurobiol Aging , vol.22 , pp. 187-194
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 34
    • 0033984570 scopus 로고    scopus 로고
    • Decreased base excision repair and increased helicase activity in Alzheimer's disease brain
    • M.A. Lovell, C. Xie and W.R. Markesbery, Decreased base excision repair and increased helicase activity in Alzheimer's disease brain, Brain Res 855 (2000), 116-123.
    • (2000) Brain Res , vol.855 , pp. 116-123
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 35
    • 0031678044 scopus 로고    scopus 로고
    • Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
    • M.A. Lovell, C. Xie and W.R. Markesbery, Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease, Neurology 51 (1998), 1562-1566.
    • (1998) Neurology , vol.51 , pp. 1562-1566
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 36
    • 0025863547 scopus 로고
    • Oxygen free radical effects in sciatic nerve in experimental diabetes
    • P.A. Low and K.K. Nickander, Oxygen free radical effects in sciatic nerve in experimental diabetes, Diabetes 40 (1991), 873-877.
    • (1991) Diabetes , vol.40 , pp. 873-877
    • Low, P.A.1    Nickander, K.K.2
  • 37
    • 0031020993 scopus 로고    scopus 로고
    • Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation
    • R.J. Mark, Z. Pang, J.W. Geddes, K. Uchida and M.P. Mattson, Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation, J Neurosci 17 (1997), 1046-1054.
    • (1997) J Neurosci , vol.17 , pp. 1046-1054
    • Mark, R.J.1    Pang, Z.2    Geddes, J.W.3    Uchida, K.4    Mattson, M.P.5
  • 38
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • W.R. Markesbery, Oxidative stress hypothesis in Alzheimer's disease, Free Radic Biol Med 23 (1997), 134-147.
    • (1997) Free Radic Biol Med , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 39
    • 0032733691 scopus 로고    scopus 로고
    • The role of oxidative stress in Alzheimer disease
    • W.R. Markesbery, The role of oxidative stress in Alzheimer disease, Arch Neurol 56 (1999), 1449-1452.
    • (1999) Arch Neurol , vol.56 , pp. 1449-1452
    • Markesbery, W.R.1
  • 40
    • 0032902974 scopus 로고    scopus 로고
    • Oxidative alterations in Alzheimer's disease
    • W.R. Markesbery and J.M. Carney, Oxidative alterations in Alzheimer's disease, Brain Pathol 9 (1999), 133-146.
    • (1999) Brain Pathol , vol.9 , pp. 133-146
    • Markesbery, W.R.1    Carney, J.M.2
  • 41
    • 0031980065 scopus 로고    scopus 로고
    • Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
    • W.R. Markesbery and M.A. Lovell, Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease, Neurobiol Aging 19 (1998), 33-36.
    • (1998) Neurobiol Aging , vol.19 , pp. 33-36
    • Markesbery, W.R.1    Lovell, M.A.2
  • 42
    • 0032872050 scopus 로고    scopus 로고
    • Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: Implications for health recommendations
    • A. Martin, D. Janigian, B. Shukitt-Hale, R.L. Prior and J.A. Joseph, Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations, Brain Res 845 (1999), 50-59.
    • (1999) Brain Res , vol.845 , pp. 50-59
    • Martin, A.1    Janigian, D.2    Shukitt-Hale, B.3    Prior, R.L.4    Joseph, J.A.5
  • 43
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • P. Mecocci, U. MacGarvey and M.F. Beal, Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease, Ann Neurol 36 (1994), 747-751.
    • (1994) Ann Neurol , vol.36 , pp. 747-751
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3
  • 45
    • 0031594916 scopus 로고    scopus 로고
    • Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease
    • T.J. Montine, W.R. Markesbery, J.D. Morrow and L.J. Roberts, 2nd, Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease, Ann Neurol 44 (1998), 410-413.
    • (1998) Ann Neurol , vol.44 , pp. 410-413
    • Montine, T.J.1    Markesbery, W.R.2    Morrow, J.D.3    Roberts L.J. II4
  • 46
    • 0037178579 scopus 로고    scopus 로고
    • Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    • M.C. Morris, D.A. Evans, J.L. Bienias, C.C. Tangney, D.A. Bennett, N. Aggarwal, R.S. Wilson and P.A. Scherr, Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study, Jama 287 (2002), 3230-3237.
    • (2002) Jama , vol.287 , pp. 3230-3237
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5    Aggarwal, N.6    Wilson, R.S.7    Scherr, P.A.8
  • 47
    • 0021751342 scopus 로고
    • Lipoic acid and diabetes: Effect of dihydrolipoic acid administration diabetic rats and rabbits
    • C.B. Natraj, V.M. Gandhi and K.K.G. Menon, Lipoic acid and diabetes: Effect of dihydrolipoic acid administration diabetic rats and rabbits, J. Biosci. 6 (1984), 37-46.
    • (1984) J Biosci , vol.6 , pp. 37-46
    • Natraj, C.B.1    Gandhi, V.M.2    Menon, K.K.G.3
  • 48
    • 0029031443 scopus 로고
    • Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
    • P. Ou, H.J. Tritschler and S.P. Wolff, Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem Pharmacol 50 (1995), 123-126.
    • (1995) Biochem Pharmacol , vol.50 , pp. 123-126
    • Ou, P.1    Tritschler, H.J.2    Wolff, S.P.3
  • 49
    • 0029909010 scopus 로고    scopus 로고
    • Neuroprotection by the metabolic antioxidant alpha-lipoic acid
    • L. Packer, H.J. Tritschler and K. Wessel, Neuroprotection by the metabolic antioxidant alpha-lipoic acid, Free Radic Biol Med 22 (1997), 359-378.
    • (1997) Free Radic Biol Med , vol.22 , pp. 359-378
    • Packer, L.1    Tritschler, H.J.2    Wessel, K.3
  • 51
    • 0028171830 scopus 로고
    • Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency
    • M. Podda, H.J. Tritschler, H. Ulrich and L. Packer, Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency, Biochem Biophys Res Commun 204 (1994), 98-104.
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 98-104
    • Podda, M.1    Tritschler, H.J.2    Ulrich, H.3    Packer, L.4
  • 54
    • 0002908647 scopus 로고
    • Crystalline alpha-lipoic acid: A catalytic agent associated with pryvate dehydrogenase
    • D.B.G. Reed, I.C. Gunsalus and C.S. Hornberger, Jr., Crystalline alpha-lipoic acid: a catalytic agent associated with pryvate dehydrogenase, Science 114 (1951), 93-94.
    • (1951) Science , vol.114 , pp. 93-94
    • Reed, D.B.G.1    Gunsalus, I.C.2    Hornberger C.S., Jr.3
  • 55
    • 0032881613 scopus 로고    scopus 로고
    • Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alphalipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy
    • M. Reljanovic, G. Reichel, K. Rett, M. Lobisch, K. Schuette, W. Moller, H.J. Tritschler and H. Mehnert, Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alphalipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy, Free Radic Res 31 (1999), 171-179.
    • (1999) Free Radic Res , vol.31 , pp. 171-179
    • Reljanovic, M.1    Reichel, G.2    Rett, K.3    Lobisch, M.4    Schuette, K.5    Moller, W.6    Tritschler, H.J.7    Mehnert, H.8
  • 58
    • 0002741844 scopus 로고
    • Effect of alpha-lipoic acid on vitamin C and vitamin E deficiencies
    • H.R. Rosenberg and R. Culik, Effect of alpha-lipoic acid on vitamin C and vitamin E deficiencies, Arch Biochem Biophys 202 (1959), 86-93.
    • (1959) Arch Biochem Biophys , vol.202 , pp. 86-93
    • Rosenberg, H.R.1    Culik, R.2
  • 62
    • 0026660407 scopus 로고
    • Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart
    • E. Serbinova, S. Khwaja, A.Z. Reznick and L. Packer, Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart, Free Radic Res Commun 17 (1992), 49-58.
    • (1992) Free Radic Res Commun , vol.17 , pp. 49-58
    • Serbinova, E.1    Khwaja, S.2    Reznick, A.Z.3    Packer, L.4
  • 63
    • 0017877241 scopus 로고
    • Stability and structure of binary and ternary complexes of alpha-lipoate and lipoate derivatives with Mn2+, Cu2+, and Zn2+ in solution
    • H. Sigel, B. Prijs, D.B. McCormick and J.C. Shih, Stability and structure of binary and ternary complexes of alpha-lipoate and lipoate derivatives with Mn2+, Cu2+, and Zn2+ in solution, Arch Biochem Biophys 187 (1978), 208-214.
    • (1978) Arch Biochem Biophys , vol.187 , pp. 208-214
    • Sigel, H.1    Prijs, B.2    McCormick, D.B.3    Shih, J.C.4
  • 64
    • 0014938472 scopus 로고
    • Effect of DL-alpha-lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats
    • H.P. Singh and R.H. Bowman, Effect of DL-alpha-lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats, Biochem Biophys Res Commun 41 (1970), 555-561.
    • (1970) Biochem Biophys Res Commun , vol.41 , pp. 555-561
    • Singh, H.P.1    Bowman, R.H.2
  • 68
    • 0016354217 scopus 로고
    • The photoperoxidation of unsaturated organic molecules. XIII. O2AG quenching by alpha-tocopherol
    • B. Stevens, R.D. Small, Jr. and S.R. Perez, The photoperoxidation of unsaturated organic molecules. XIII. O2AG quenching by alpha-tocopherol, Photochem Photobiol 20 (1974), 515-517.
    • (1974) Photochem Photobiol , vol.20 , pp. 515-517
    • Stevens, B.1    Small R.D., Jr.2    Perez, S.R.3
  • 69
    • 0027519721 scopus 로고
    • The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: Putative relationship to NMDA receptor deficits
    • S. Stoll, H. Hartmann, S.A. Cohen and W.E. Muller, The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits, Pharmacol Biochem Behav 46 (1993), 799-805.
    • (1993) Pharmacol Biochem Behav , vol.46 , pp. 799-805
    • Stoll, S.1    Hartmann, H.2    Cohen, S.A.3    Muller, W.E.4
  • 71
    • 0035059891 scopus 로고    scopus 로고
    • The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: Effect of antioxidant therapy
    • I.A. Strokov, E.B. Manukhina, L.Y. Bakhtina, I.Y. Malyshev, G.K. Zoloev, S.I. Kazikhanova and A.S. Ametov, The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy, Bull Exp Biol Med 130 (2000), 986-990.
    • (2000) Bull Exp Biol Med , vol.130 , pp. 986-990
    • Strokov, I.A.1    Manukhina, E.B.2    Bakhtina, L.Y.3    Malyshev, I.Y.4    Zoloev, G.K.5    Kazikhanova, S.I.6    Ametov, A.S.7
  • 72
    • 0026356525 scopus 로고
    • Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
    • Y.J. Suzuki, M. Tsuchiya and L. Packer, Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species, Free Radic Res Commun 15 (1991), 255-263.
    • (1991) Free Radic Res Commun , vol.15 , pp. 255-263
    • Suzuki, Y.J.1    Tsuchiya, M.2    Packer, L.3
  • 73
    • 0028157335 scopus 로고
    • Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)
    • L. Svennerholm and C.G. Gottfries, Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II), J Neurochem 62 (1994), 1039-1047.
    • (1994) J Neurochem , vol.62 , pp. 1039-1047
    • Svennerholm, L.1    Gottfries, C.G.2
  • 75
    • 51249175293 scopus 로고
    • Lipoic acid and diabetes: Part III. Metabolic role of acetyl dihydrolipoic acid
    • S.S. Wagh, V.M. Gandhi, C.V. Natraj and K.K.G. Menon, Lipoic acid and diabetes: Part III. Metabolic role of acetyl dihydrolipoic acid, J. Biosci. 10 (1986), 171-179.
    • (1986) J Biosci , vol.10 , pp. 171-179
    • Wagh, S.S.1    Gandhi, V.M.2    Natraj, C.V.3    Menon, K.K.G.4
  • 76
    • 51249176054 scopus 로고
    • Mode of action of lipoic acid in diabetes
    • S.S. Wagh, C.V. Natraj and K.K.G. Menon, Mode of action of lipoic acid in diabetes, J. Biosci. 11 (1987), 59-74.
    • (1987) J Biosci , vol.11 , pp. 59-74
    • Wagh, S.S.1    Natraj, C.V.2    Menon, K.K.G.3
  • 77
    • 0034103644 scopus 로고    scopus 로고
    • Survival of hippocampal and cortical neurons in a mixture of MEM+ and B27-supplemented neurobasal medium
    • C. Xie, W.R. Markesbery and M.A. Lovell, Survival of hippocampal and cortical neurons in a mixture of MEM+ and B27-supplemented neurobasal medium, Free Radic Biol Med 28 (2000), 665-672.
    • (2000) Free Radic Biol Med , vol.28 , pp. 665-672
    • Xie, C.1    Markesbery, W.R.2    Lovell, M.A.3
  • 79
    • 0035955513 scopus 로고    scopus 로고
    • Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway
    • L. Zhang, G.Q. Xing, J.L. Barker, Y. Chang, D. Maric, W. Ma, B.S. Li and D.R. Rubinow, Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway, Neurosci Lett 312 (2001), 125-128.
    • (2001) Neurosci Lett , vol.312 , pp. 125-128
    • Zhang, L.1    Xing, G.Q.2    Barker, J.L.3    Chang, Y.4    Maric, D.5    Ma, W.6    Li, B.S.7    Rubinow, D.R.8
  • 80
    • 0032788081 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant alphalipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy
    • D. Ziegler, M. Hanefeld, K.J. Ruhnau, H. Hasche, M. Lobisch, K. Schutte, G. Kerum and R. Malessa, Treatment of symptomatic diabetic polyneuropathy with the antioxidant alphalipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy, Diabetes Care 22 (1999), 1296-1301.
    • (1999) Diabetes Care , vol.22 , pp. 1296-1301
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3    Hasche, H.4    Lobisch, M.5    Schutte, K.6    Kerum, G.7    Malessa, R.8
  • 81
    • 0032702870 scopus 로고    scopus 로고
    • Alphalipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials
    • D. Ziegler, M. Reljanovic, H. Mehnert and F.A. Gries, Alphalipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials, Exp Clin Endocrinol Diabetes 107 (1999), 421-430.
    • (1999) Exp Clin Endocrinol Diabetes , vol.107 , pp. 421-430
    • Ziegler, D.1    Reljanovic, M.2    Mehnert, H.3    Gries, F.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.