8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease

Neurobiology of Aging

Volumn 17, Issue 6, 1996, Pages 819-826

  Te Koppele, J M ^a   Lucassen, P J ^b   Sakkee, A N ^a   Van Asten, J G ^a   Ravid, R ^b   Swaab, D F ^b   Van Bezooijen, C F A ^a,c  

^a TNO   (Netherlands)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

8 hydroxy 2' deoxyguanosine; aging; Alzheimer's disease; cortex; DNA damage; hippocampus; HPLC ECD; human brain; oxygen radicals

Indexed keywords

OXYGEN RADICAL;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

ADULT; AGED; ALZHEIMER DISEASE; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DNA; DNA DAMAGE; ELECTROCHEMISTRY; FEMALE; HIPPOCAMPUS; HUMANS; HYDROLYSIS; MALE; MIDDLE AGED; OXIDATIVE STRESS; POSTMORTEM CHANGES; SPECIMEN HANDLING;

EID: 0030293076     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(96)00165-0     Document Type: Article

References (55)

1. 1. Ames, B. N.; Shigenaga, M. K. Oxidants are a major contributor to aging. Ann. NY Acad. Sci. 663:85-96; 1992.
2. 2. Aruoma, O. I.; Halliwell, B.; Gajewski, E.; Dizdaroglu, M. Copperion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem. J. 273:601-604; 1991.
3. 3. Beal, M. F.; Hyman, B. T.; Koroshetz, W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci. 16:125-131; 1993.
4. 4. Boerrigter, M. E.; Wei, J. Y.; Vijg, J. DNA repair and Alzheimer's disease. J. Gerontol. 47:B177-B184; 1992.
5. 5. Bradley, W. G.; Robison, S. H.; Tandan, R. Deficient repair of alkylation damage of DNA in Alzheimer's disease and amyotrophic lateral sclerosis cells. Adv. Exp. Med. Biol. 209:3-6; 1987.
6. 6. Cheng, K. C.; Cahil, D. S.; Kasai, H.; Nishimura, S.; Loeb, L. A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage causes G → T and A → C substitutions. J. Biol. Chem. 267:166-172; 1992.
7. 7. Connor, J. R.; Snyder, B. S.; Beard, J. L.; Fine, R. E.; Mufson, E. J. Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease. J. Neurosci. Res. 31:327-335; 1992.
8. 8. Corral-Debrinski, M.; Horton, T.; Lott, M. T.; Shoffner, J. M.; McKee, A. C.; Beal, M. F.; Graham, B. H.; Wallace, D. C. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics 23:471-476; 1994.
9. 9. Davies, K. J. Protein damage and degradation by oxygen radicals. I. General aspects. J. Biol. Chem. 262:9895-9901; 1987.
10. 10. Dedman, D. J.; Treffy, A.; Candy, J. M., Taylor, G. A. A.; Morris, C. M.; Bloxham, C. A.; Perry, R. H.; Edwardson, J. A.; Harrison, P. M. Iron and aluminium in relation to brain ferritin in normal individuals and Alzheimer's disease and chronic renal dialysis patients. Biochem. J. 287:509-514; 1992.
11. 11. Dizdaroglu, M.; Rao, G.; Halliwell, B.; Gajewski, E. Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch. Biochem. Biophys. 285:317-324; 1991.
12. 12. Edwards, A. A. L. Multiple regression and the analysis of variance and covariance. New York: Freeman; 1985.
13. 13. Fernandes, M. A. S.; Santana, I.; Januario, C.; Cunha, L.; Oliveira, C. R. Decreased superoxide dismutase activity in erythrocytes from patients with Alzheimer's disease. Med. Sci. Res. 21:679-682; 1993.
14. 14. Floyd, R. A. Oxygen radical-mediated damage to brain tissue. Basic Life Sci. 49:1015-1023; 1988.
15. 15. Floyd, R. A.; Carney, J. M. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. Suppl. 32:S22-S27; 1992.
16. 16. Fraga, C. G.; Shigenaga, M. K.; Park, J. W.; Degan, P.; Ames, B. N. Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA 87:4533-4537; 1990.
17. 17. Friedlich, A. L.; Butcher, L. L. Involvement of free oxygen radicals in beta-amyloidosis: An hypothesis. Neurobiol. Aging 15:443-455; 1994.
18. 18. Gaubatz, J. W.; Tan, B. H. Aging affects the levels of DNA damage in postmitotic cells. Ann. NY Acad. Sci. 719:97-107; 1994.
19. 19. Gerlach, M.; Ben-Shachar, D.; Riederer, P.; Youdim, M. B. H. Altered brain metabolism of iron as a cause of neurodegenerative disease? J. Neurochem. 63:793-807; 1994.
20. 20. Halliwell, B. Oxygen radicals as key mediators in neurological disease: Fact or fiction? Ann. Neurol. Suppl. 32:S10-S15; 1992.
21. 21. Halliwell, B. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence? Lancet 344:721-724; 1994.
22. 22. Halliwell, B.; Dizdaroglu, M. The measurement of oxidative damage to DNA by HPLC and GC/MS techniques. Free Radic. Res. Commun. 16:75-87; 1992.
23. 23. Halliwell, B.; Gutteridge, J. M. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch. Biochem. Biophys. 246:501-514; 1986.
24. 24. Hayakawa, M.; Torii, K.; Sugiyama, S.; Tanaka, M.; Ozawa, T. Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem. Biophys. Res. Commun. 179:1023-1029; 1991.
25. 25. Holmes, G. E.; Bernstein, C.; Bernstein, H. Oxidative and other DNA damages as the basis of aging: A review. Mutat. Res. 275:305-315; 1992.
26. 26. Kasai, H.; Crain, P. F.; Kuchino, Y.; Nishimura, S.; Ootsuyama, A.; Tanooka, H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7:1849-1851; 1986.
27. 27. Kasai, H.; Nishimura, S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12:2137-2145; 1984.
28. 28. Leadon, S. A; Cooper, P. K. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl. Acad. Sci. USA 90: 10499-10503; 1993.
29. 29. Lewis, P. N.; Lukiw, W. J.; De Boni, U.; Crapper McLachlan, D. R. Changes in chromatin structure associated with Alzheimer's disease. J. Neurochem. 37:1193-1202; 1981.
30. 30. Linnane, A. W.; Marzuki, S.; Ozawa, T.; Tanaka, M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1(8639):642-645; 1989.
31. 31. Loft, S.; Vistisen, K.; Ewertz, M.; Tjonneland, A.; Overvad, K.; Poulsen, H. E. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: Influence of smoking, gender and body mass index. Carcinogenesis 13:2241-2247; 1992.
32. 32. McKhann, G.; Drachman, D.; Folstein, M.; Katzman, R.; Price, D.; Stadlan, E. M. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944; 1984.
33. 33. Mecocci, P.; MacGarvey, U.; Beal, M. F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36: 747-751; 1994.
34. 34. Mecocci, P.; MacGarvey, U.; Kaufman, A. E.; Koontz, D.; Shoffner, J. M.; Wallace, D. C.; Beal, M. F. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34:609-616; 1993.
35. 35. Mello-Filho, A. C.; Meneghini, R. Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals. Mutat. Res. 251:109-113; 1991.
36. 36. Mullaart, E.; Boerrigter, M. E.; Ravid, R.; Swaab, D. F.; Vijg, J. Increased levels of DNA breaks in cerebral cortex of Alzheimer's dis-ease patients. Neurobiol. Aging 11:169-173; 1990.
37. 37. Nagley, P.; MacKay, I. R.; Baumer, A.; Maxwell, R. J.; Vaillant, F.; Wang, Z.-X.; Linnane, A. W. Mitochondrial DNA mutation associated with aging and degenerative disease. Ann. NY Acad. Sci. 673:92-102; 1992.
38. 38. Ravid, R.; Van Zwieten, E. J.; Swaab, D. F. Brain banking and the human hypothalamus - Factors to match for, pitfalls and potentials. In: Swaab, D. F.; Hofman, M. A.; Mirmiran, M.; Ravid, R.; van Leeuwen, F. W., eds. Progress in brain research, vol. 93, Amsterdam: Elsevier; 1992:83-95.
39. 39. Richter, C.; Park, J. W.; Ames, B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85:6465-6467; 1988.
40. 40. Robbins, J. H; Otsuka, F.; Tarone, R. E.; Polinsky, R. J.; Brumbach, R. A.; Moshell, A. N.; Nee, L.; Ganges, M. B.; Cayeux, S. J. Radiosensitivity in Alzheimer's disease and Parkinson's disease. Lancet 1(8322):468-469; 1983.
41. 41. Robison, S. H.; Bradley, W. G. DNA damage and chronic neuronal degenerations. J. Neurol. Sci. 64:11-20; 1984.
42. 42. Robison, S. H.; Bradley, W. G. Impaired DNA repair replication in Alzheimer's disease cells. In: Hutton, J. T.; Kenney, A. D., eds. Neurology and neurobiology, vol. 18, Senile dementia of the Alzheimer type. New York: Alan R. Liss; 1985:205-218.
43. 43. Robison, S. H.; Munzer, J. S.; Tandan, R.; Bradley, W. G. Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage. Ann. Neurol. 21:250-258; 1987.
44. 44. Sambrook, J.; Fritsch, E. F.; Maniatis, T. Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989
45. 45. Satoh, M. S.; Lindahl, T. Enzymatic repair of oxidative DNA damage. Cancer Res. 54:1899s-1901s; 1994.
46. 46. Shigenaga, M. K.; Ames, B. N. Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage. Free Radic. Biol. Med. 10:211-216; 1991.
47. 47. Shigenaga, M. K.; Park, J. W.; Cundy, K. C.; Gimeno, C. J.; Ames, B. N. In vivo oxidative DNA damage: Measurement of 8-hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection. Methods Enzymol. 186: 521-530; 1990.
48. 48. Sims, N. R.; Finegan, J. M.; Blass, J. P.; Bowen, D. M.; Neary, D. Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res. 436:30-38; 1987.
49. 49. Sinet, P. M.; Ceballos-Picot, I. Role of free radicals in Alzheimer's disease and Down's syndrome. In: Packer, L.; Prilipko, L.; Christen, Y., eds. Free radicals in the brain; Aging, neurological and mental disorders. Berlin: Springer Verlag; 1992:91-98.
50. 50. Subbarao, K. V.; Richardson, J. S.; Ang, L. C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J. Neurochem. 55:342-345; 1990.
51. 51. Takeuchi, T.; Nakajima, M.; Ohta, Y.; Mure, K.; Takeshita, T.; Morimoto, K. Evaluation of 8-hydroxydeoxyguanosine, a typical DNA damage, in human leukocytes. Carcinogenesis 15:1519-1523; 1994.
52. 52. Venema, J.; Mullenders, L. H.; Natarajan, A. T.; van Zeeland, A. A.; Mayne, L. V. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl. Acad. Sci. USA 87:4707-4711; 1990.
53. 53. Wallace, D. C. Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science 256:628-632; 1992.
54. 54. Weirich-Schwaiger, H.; Weirich, H. G.; Gruber, B.; Schweiger, M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316:37-48; 1994.
55. 55. Zubenko, G. S. Hippocampal membrane alteration in Alzheimer's disease. Brain Res. 385:115-121; 1986.