Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E

Annals of Pharmacotherapy

Volumn 39, Issue 12, 2005, Pages 2009-2014

  Fillenbaum, Gerda G ^a,b   Kuchibhatla, Maragatha N ^a,b   Hanlon, Joseph T ^c   Artz, Margaret B ^d   Pieper, Carl F ^a,b   Schmader, Kenneth E ^a   Dysken, Maurice W ^e   Gray, Shelly L ^f  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alzheimer's disease; Antioxidant; Dementia; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID;

AFRICAN AMERICAN; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEMENTIA; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FOLLOW UP; HEALTH CARE UTILIZATION; HEALTH STATUS; HUMAN; INTERVIEW; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; OXIDATIVE STRESS; PATIENT MOBILITY; PRIORITY JOURNAL; RISK FACTOR; UNITED STATES; VITAMIN SUPPLEMENTATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIOXIDANTS; ASCORBIC ACID; COHORT STUDIES; DATA INTERPRETATION, STATISTICAL; DEMENTIA; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; NEUROPSYCHOLOGICAL TESTS; NORTH CAROLINA; OXIDATIVE STRESS; PROSPECTIVE STUDIES; VITAMIN E;

EID: 28544453282     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1G280     Document Type: Article

References (30)

1. Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, et al. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News Perspect 2005;18(1):13-9.
2. Grundman M. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr 2000;71(suppl):630S-6S.
3. Helmer C, Peuchant E, Letenneur L, Bourdel-Marchasson I, Larrieu S, Dartigues JF, et al. Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUDD prospective cohort study. Eur J Clin Nutr 2003;57:1555-61.
4. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Vitamin E and cognitive decline in older persons. Arch Neurol 2002;59:1125-32.
5. Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovich H, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54:1265-72.
6. Englehart MJ, Geerlings MI, Ruitenberg A, van Swieten CJ, Hofman A, Witteman JCM, et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002;287:3223-9.
7. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alphatocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22.
8. Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community dwelling elderly women. Am J Clin Nutr 2003;77:975-84.
9. Launer LJ, Kalmijn S. Anti-oxidants and cognitive function: a review of clinical and epidemiologic studies. J Neural Transmission Supplement 1998;53:1-8.
10. Mendelsohn AB, Belle SH, Stoehr GP, Ganguli M. Use of antioxidant Supplements and its association with cognitive function in a rural elderly cohort. Am J Epidemiol 1998;148:38-44.
11. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 2002;287:3230-7.
12. Martin A, Youdim K, Szprengiel A, Shukitt-Hale B, Joseph J. Roles of vitamins E and C on neurodegenerative diseases and cognitive performance. Nutr Rev 2002;60:308-34.
13. Prasad KN, Cole WC, Prasad KC. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr 2002;21:506-22.
14. Blazer D, Burchett B, Service C, George LK. The association of age and depression among the elderly: an epidemiologic exploration. J Gerontol 1991;46:M210-5.
15. Pfeiffer EA. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 1975;23:433-41.
16. Fillenbaum GG, Heyman A, Huber MS, Woodbury MA, Leiss J, Schmader KE, et al. The prevalence and 3-year incidence of dementia in older Black and White community residents. J Clin Epidemiol 1998;51:587-95.
17. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39:1159-65.
18. Diagnostic and statistical manual of mental disorders. 3rd ed., revised. Washington, DC: American Psychiatric Association, 1987.
19. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA workgroup under the auspices of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44.
20. Hanlon JT, Fillenbaum GG, Burchett B, Wall WE Jr, Service C, Blazer DG, et al. Drug use patterns in black and nonblack community-dwelling elderly. Ann Pharmacother 1992;26:679-85.
21. DeVito CA, Aldridge GW, Wilson A, Vidis JS, Goldberg T, Dickson WM, et al. Framework and development of a comprehensive drug product coding system. Contemp Pharm Pract 1979;2:62-5.
22. Helling DK, Lemke JH, Semla TP, Wallace RB, Lipson DF, Cornoni-Huntley J. Medication use characteristics in the elderly: the Iowa 65+ Rural Health Study. J Am Geriatr Soc 1987;35:4-12.
23. Katz S, Akpom CA. A measure of primary sociobiological functions. Int J Health Serv 1976;6:493-508.
24. Fillenbaum GG. Screening the elderly: a brief instrumental ADL measure. J Am Geriatr Soc 1985;33:698-706.
25. Rosow I, Breslau K. A Guttman Health Scale for the aged. J Gerontol 1966;21:556-9.
26. Allison PD. Survival analysis using the SAS system: a practical guide. Cary, NC: SAS Institute, 1995.
27. Luchsinger JA, Tang M-X, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer's disease. Arch Neurol 2003;60:203-8.
28. Morris MC, Beckett LA, Scherr PA, Hebert LE, Bennett DA, Field TS, et al. Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alz Dis Assoc Disord 1998;12:121-6.
29. Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements. Arch Neurol 2004;61:82-8.
30. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment N Engl J Med 2005;352:2379-88.