Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome

Neuron

Volumn 33, Issue 5, 2002, Pages 677-688

  Busciglio, Jorge ^a   Pelsman, Alejandra ^a   Wong, Caine ^b   Pigino, Gustavo ^a   Yuan, Menglan ^b   Mori, Hiroshi ^c   Yankner, Bruce A ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYLTHIAZOL 2 YL) 5 (3 CARBOXYMETHOXYPHENYL) 2 (4 SULPHOPHENYL) 2H TETRAZOLIUM; ALPHA 1 ANTICHYMOTRYPSIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; COPPER ZINC SUPEROXIDE DISMUTASE; FORMAZAN; NERVE GROWTH FACTOR; PROTEIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); SYNDECAN; SYNTAXIN; TETRAZOLIUM; TRICARBOXYLIC ACID; TRITON X 100; TUBULIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; ASTROCYTE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN SYNDROME; ENERGY; FETUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MITOCHONDRIAL RESPIRATION; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEUROPROTECTION; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SECRETION;

EID: 0037186074     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(02)00604-9     Document Type: Article

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