메뉴 건너뛰기




Volumn 6, Issue 4, 2004, Pages 367-377

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

Author keywords

AD; Alzheimer's disease; Chelation; Chelator; Copper; Curcumin; Desferrioxamine; Iron; Metal; Zinc

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PROTEIN; CHELATING AGENT; CLIOQUINOL; COPPER; CURCUMIN; DEFEROXAMINE; DIKETONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; METAL CHELATE; POLYPHENOL DERIVATIVE; ZINC;

EID: 4644275696     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2004-6403     Document Type: Article
Times cited : (439)

References (64)
  • 1
    • 0032998449 scopus 로고    scopus 로고
    • Pro-oxidant, antioxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin
    • H. Ahsan, N. Parveen and N. Khan et al., Pro-oxidant, antioxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin, Chemico-Biol Interact 121 (1999), 161-175.
    • (1999) Chemico-Biol Interact , vol.121 , pp. 161-175
    • Ahsan, H.1    Parveen, N.2    Khan, N.3
  • 2
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • W.K. Alderton, C.E. Cooper and R.G. Knowles, Nitric oxide synthases: structure, function and inhibition, Biochem J 357 (2001), 593-615.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 3
    • 0035404019 scopus 로고    scopus 로고
    • Biological Activities of Curcuma longa L., Mem Inst Oswaldo Cruz
    • C.A.C. Araújo and L.L. Leon, Biological Activities of Curcuma longa L., Mem Inst Oswaldo Cruz, Rio de Janeiro 96 (2001), 723-728.
    • (2001) Rio de Janeiro , vol.96 , pp. 723-728
    • Araújo, C.A.C.1    Leon, L.L.2
  • 4
    • 0034721809 scopus 로고    scopus 로고
    • Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma
    • A. Asai and T. Miyazawa, Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma, Life Sci 67 (2000), 2785-2793.
    • (2000) Life Sci , vol.67 , pp. 2785-2793
    • Asai, A.1    Miyazawa, T.2
  • 5
    • 0032557425 scopus 로고    scopus 로고
    • Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis
    • C.S. Atwood, R.D. Moir and X. Huang et al., Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis, J Biol Chem 273 (1998), 12817-12826.
    • (1998) J Biol Chem , vol.273 , pp. 12817-12826
    • Atwood, C.S.1    Moir, R.D.2    Huang, X.3
  • 6
    • 0033844944 scopus 로고    scopus 로고
    • Characterization of copper interactions with Alzheimer amyloid β peptides: Identification of an attomolar-affinity copper binding site on amyloid β1-42
    • C.S. Atwood, R.C. Scarpa and X. Huang et al., Characterization of Copper Interactions with Alzheimer Amyloid β Peptides: Identification of an Attomolar-Affinity Copper Binding Site on Amyloid β1-42, J Neurochem 75 (2000), 1219-1233.
    • (2000) J Neurochem , vol.75 , pp. 1219-1233
    • Atwood, C.S.1    Scarpa, R.C.2    Huang, X.3
  • 7
    • 0026041595 scopus 로고
    • Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease
    • H. Basun, L.G. Forssell and L. Wetterberg et al., Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease, J Neural Transm Park Dis Dement Sect 3 (1991), 231-258.
    • (1991) J Neural Transm Park Dis Dement Sect , vol.3 , pp. 231-258
    • Basun, H.1    Forssell, L.G.2    Wetterberg, L.3
  • 8
    • 0037305525 scopus 로고    scopus 로고
    • Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease
    • A. Becaria, S.C. Bondy and A. Campbell, Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease, J Alz Dis 5 (2003), 31-38.
    • (2003) J Alz Dis , vol.5 , pp. 31-38
    • Becaria, A.1    Bondy, S.C.2    Campbell, A.3
  • 9
    • 0032405732 scopus 로고    scopus 로고
    • Inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin
    • G. Began, E. Sudharshan and A.G. Appu Rao, Inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin, Lipids 33 (1998), 1223-1228.
    • (1998) Lipids , vol.33 , pp. 1223-1228
    • Began, G.1    Sudharshan, E.2    Appu Rao, A.G.3
  • 10
    • 0033371673 scopus 로고    scopus 로고
    • Interaction of curcumin with phosphatidylcholine: A spectrofluorometric study
    • G. Began, E. Sudharshan and K.U. Sankar et al., Interaction of Curcumin with Phosphatidylcholine: A Spectrofluorometric Study, J Agric Food Chem 47 (1999), 4992-4997.
    • (1999) J Agric Food Chem , vol.47 , pp. 4992-4997
    • Began, G.1    Sudharshan, E.2    Sankar, K.U.3
  • 11
    • 0037032285 scopus 로고    scopus 로고
    • Red grape juice inhibits iron availability: Application of an in vitro digestion/caco-2 cell model
    • F. Boato, G.M. Wortley, R.H. Liu and R.P. Glahn, Red grape juice inhibits iron availability: application of an in vitro digestion/caco-2 cell model, J Agric Food Chem 50 (2002), 6935-6938.
    • (2002) J Agric Food Chem , vol.50 , pp. 6935-6938
    • Boato, F.1    Wortley, G.M.2    Liu, R.H.3    Glahn, R.P.4
  • 12
    • 0032055394 scopus 로고    scopus 로고
    • Inhibition of nuclear factor κB by direct modification in whole cells - Mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers
    • P. Brennan and L.A.J. O'Neill, Inhibition of Nuclear Factor κB by Direct Modification in Whole Cells - Mechanism of Action of Nordihydroguaiaritic Acid, Curcumin and Thiol Modifiers, Biochemical Pharmacology 55 (1998), 965-973.
    • (1998) Biochemical Pharmacology , vol.55 , pp. 965-973
    • Brennan, P.1    O'Neill, L.A.J.2
  • 13
    • 0031665061 scopus 로고    scopus 로고
    • Prevalence of Alzheimer's disease and other dementias in rural India: The Indo-US Study
    • V. Chandra, M. Ganguli and R. Pandav et al., Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US Study, Neurology 51 (1998), 1000-1008.
    • (1998) Neurology , vol.51 , pp. 1000-1008
    • Chandra, V.1    Ganguli, M.2    Pandav, R.3
  • 14
    • 0030809345 scopus 로고    scopus 로고
    • Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin
    • X. Chen, T. Hasuma and Y. Yano et al., Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin, Anticancer Res 17 (1997), 2555-2564.
    • (1997) Anticancer Res , vol.17 , pp. 2555-2564
    • Chen, X.1    Hasuma, T.2    Yano, Y.3
  • 15
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
    • R.A. Cherny, C.S. Atwood and M.E. Xilinas et al., Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice, Neuron 30 (2001), 665-676.
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1    Atwood, C.S.2    Xilinas, M.E.3
  • 16
    • 0033551782 scopus 로고    scopus 로고
    • Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
    • R.A. Cherny, J.T. Legg and C.A. McLean et al., Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion, J Biol Chem 274 (1999), 23223-23228.
    • (1999) J Biol Chem , vol.274 , pp. 23223-23228
    • Cherny, R.A.1    Legg, J.T.2    McLean, C.A.3
  • 17
    • 0025726462 scopus 로고
    • Intramuscular desferrioxamine in patients with Alzheimer's disease
    • D.R. Crapper McLachlan, A.J. Dalton and T.P. Kruck et al., Intramuscular desferrioxamine in patients with Alzheimer's disease, Lancet 337 (1991), 1304-1308.
    • (1991) Lancet , vol.337 , pp. 1304-1308
    • Crapper McLachlan, D.R.1    Dalton, A.J.2    Kruck, T.P.3
  • 18
    • 0034733705 scopus 로고    scopus 로고
    • Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc
    • M.P. Cuajungco, L.E. Goldstein and A. Nunomura et al., Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc, J Biol Chem 275 (2000), 19439-19442.
    • (2000) J Biol Chem , vol.275 , pp. 19439-19442
    • Cuajungco, M.P.1    Goldstein, L.E.2    Nunomura, A.3
  • 19
    • 0037042299 scopus 로고    scopus 로고
    • Alzheimer disease
    • J.L. Cummings and G. Cole, Alzheimer disease, JAMA 287 (2002), 2335-2338.
    • (2002) JAMA , vol.287 , pp. 2335-2338
    • Cummings, J.L.1    Cole, G.2
  • 20
    • 0037195546 scopus 로고    scopus 로고
    • Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex
    • M.R. D'Andrea, R.G. Nagele and H.Y. Wang et al., Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex, Neurosci Lett 333 (2002), 163-166.
    • (2002) Neurosci Lett , vol.333 , pp. 163-166
    • D'Andrea, M.R.1    Nagele, R.G.2    Wang, H.Y.3
  • 21
    • 0036187751 scopus 로고    scopus 로고
    • Curcumin: A new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor
    • J.L. Dyer, S.Z. Khan and J.G. Bilmen et al., Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor, Cell Calcium 31 (2002), 45-52.
    • (2002) Cell Calcium , vol.31 , pp. 45-52
    • Dyer, J.L.1    Khan, S.Z.2    Bilmen, J.G.3
  • 22
    • 0026730350 scopus 로고
    • Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation
    • T. Dyrks, E. Dyrks and T. Hartmann et al., Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation, J Biol Chem 267 (1992), 18210-18217.
    • (1992) J Biol Chem , vol.267 , pp. 18210-18217
    • Dyrks, T.1    Dyrks, E.2    Hartmann, T.3
  • 23
    • 0030022005 scopus 로고    scopus 로고
    • Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention
    • E.A. Eaton, U.K. Walle and A.J. Lewis et al., Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention, Drug Metab Dispos 24 (1996), 232-237.
    • (1996) Drug Metab Dispos , vol.24 , pp. 232-237
    • Eaton, E.A.1    Walle, U.K.2    Lewis, A.J.3
  • 24
    • 0036772311 scopus 로고    scopus 로고
    • Intracellular A-beta amyloid, a sign for worse things to come?
    • V. Echeverria and A.C. Cuello, Intracellular A-beta amyloid, a sign for worse things to come? Mol Neurobiol 26 (2002), 299-316.
    • (2002) Mol Neurobiol , vol.26 , pp. 299-316
    • Echeverria, V.1    Cuello, A.C.2
  • 26
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic antiinflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
    • S.A. Frautschy, W. Hu and P. Kim et al., Phenolic antiinflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology, Neurobiol Aging 22 (2001), 993-1005.
    • (2001) Neurobiol Aging , vol.22 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3
  • 27
    • 0033062186 scopus 로고    scopus 로고
    • Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers
    • C. Gonzáles, T. Martin and J.B. Cacho et al., Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers, Eur J Clin Invest 29 (1999), 637-642.
    • (1999) Eur J Clin Invest , vol.29 , pp. 637-642
    • Gonzáles, C.1    Martin, T.2    Cacho, J.B.3
  • 28
    • 0035756816 scopus 로고    scopus 로고
    • The chemistry of transition metals in relation to their potential role in neurodegenerative processes
    • D. Hamai, S.C. Bondy and A. Becaria et al., The chemistry of transition metals in relation to their potential role in neurodegenerative processes, Curr Top Med Chem 1 (2001), 541-551.
    • (2001) Curr Top Med Chem , vol.1 , pp. 541-551
    • Hamai, D.1    Bondy, S.C.2    Becaria, A.3
  • 29
    • 0023748491 scopus 로고
    • Evidence for release of copper in the brain: Depolarization-induced release of newly taken-up 67copper
    • D.E. Hartter and A. Barnea, Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper, Synapse 2 (1988), 412-415.
    • (1988) Synapse , vol.2 , pp. 412-415
    • Hartter, D.E.1    Barnea, A.2
  • 30
    • 0030704680 scopus 로고    scopus 로고
    • Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors
    • X. Huang, C.S. Atwood and R.D. Moir et al., Zinc-induced Alzheimer's Aβ1-40 Aggregation Is Mediated by Conformational Factors, J Biol Chem 272 (1997), 26464-26470.
    • (1997) J Biol Chem , vol.272 , pp. 26464-26470
    • Huang, X.1    Atwood, C.S.2    Moir, R.D.3
  • 31
    • 0034054929 scopus 로고    scopus 로고
    • Alzheimer's disease, beta-amyloid protein and zinc
    • X. Huang, M.P. Cuajungco and C.S. Atwood et al., Alzheimer's disease, beta-amyloid protein and zinc, J Nutr 130 (2000), 1488S-1492S.
    • (2000) J Nutr , vol.130
    • Huang, X.1    Cuajungco, M.P.2    Atwood, C.S.3
  • 32
    • 0035114277 scopus 로고    scopus 로고
    • Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production
    • C. Ireson, S. Orr and D.J.L. Jones et al., Characterization of Metabolites of the Chemopreventive Agent Curcumin in Human and Rat Hepatocytes and in the Rat in Vivo, and Evaluation of Their Ability to Inhibit Phorbol Ester-induced Prostaglandin E2 Production, Cancer Res 61 (2001), 1058-1064.
    • (2001) Cancer Res , vol.61 , pp. 1058-1064
    • Ireson, C.1    Orr, S.2    Jones, D.J.L.3
  • 33
    • 0033568674 scopus 로고    scopus 로고
    • Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity
    • C. Jobin, C.A. Bradham and M.P. Russo et al., Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity, The Journal of Immunology 163 (1999), 3474-3483.
    • (1999) The Journal of Immunology , vol.163 , pp. 3474-3483
    • Jobin, C.1    Bradham, C.A.2    Russo, M.P.3
  • 34
    • 0033775590 scopus 로고    scopus 로고
    • Transferrin polymorphism influences iron status in blacks
    • I. Kasvosve, J.R. Delanghe and Z.A.R. Gomo et al., Transferrin Polymorphism Influences Iron Status in Blacks, Clin Chem 46 (2000), 1535-1539.
    • (2000) Clin Chem , vol.46 , pp. 1535-1539
    • Kasvosve, I.1    Delanghe, J.R.2    Gomo, Z.A.R.3
  • 35
    • 0028010030 scopus 로고
    • Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein
    • D.J. Lamb and D.S. Leake, Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein, FEBS Lett 338 (1994), 122-126.
    • (1994) FEBS Lett , vol.338 , pp. 122-126
    • Lamb, D.J.1    Leake, D.S.2
  • 36
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • G.P. Lim, T. Chu and F. Yang et al., The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse, J Neurosci 21 (2001), 8370-8377.
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3
  • 37
    • 0035320968 scopus 로고    scopus 로고
    • Mechanisms of cancer chemoprevention by curcumin
    • J.K. Lin and S.Y. Lin-Shiau, Mechanisms of Cancer Chemoprevention by Curcumin, Proc Natl Sci Counc ROC(B) 25 (2001), 59-66.
    • (2001) Proc Natl Sci Counc ROC(B) , vol.25 , pp. 59-66
    • Lin, J.K.1    Lin-Shiau, S.Y.2
  • 38
    • 0034492793 scopus 로고    scopus 로고
    • Recent studies on the biofunctions and biotransformations of curcumin
    • J.K. Lin, M.H. Pan and S.Y. Lin-Shiau, Recent studies on the biofunctions and biotransformations of curcumin, Biofactors 13 (2000), 153-158.
    • (2000) Biofactors , vol.13 , pp. 153-158
    • Lin, J.K.1    Pan, M.H.2    Lin-Shiau, S.Y.3
  • 39
    • 0028132940 scopus 로고
    • Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease
    • D.A. Loeffler, A.J. DeMaggio and P.L. Juneau et al., Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease, Alzheimer Dis Assoc Disord 8 (1994), 190-197.
    • (1994) Alzheimer Dis Assoc Disord , vol.8 , pp. 190-197
    • Loeffler, D.A.1    DeMaggio, A.J.2    Juneau, P.L.3
  • 40
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • M.A. Lovell, J.D. Robertson and W.J. Teesdale et al., Copper, iron and zinc in Alzheimer's disease senile plaques, J Neurol Sci 158 (1998), 47-52.
    • (1998) J Neurol Sci , vol.158 , pp. 47-52
    • Lovell, M.A.1    Robertson, J.D.2    Teesdale, W.J.3
  • 41
    • 0033608740 scopus 로고    scopus 로고
    • Protection against amyloid beta peptide toxicity by zinc
    • M.A. Lovell, C. Xie and W.R. Markesbery, Protection against amyloid beta peptide toxicity by zinc, Brain Res 823 (1999), 88-95.
    • (1999) Brain Res , vol.823 , pp. 88-95
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 42
    • 0034601251 scopus 로고    scopus 로고
    • Are Hereditary Hemochromatosis Mutations Involved in Alzheimer Disease?
    • S. Moalem, M.E. Percy and D.F. Andrews et al., Are Hereditary Hemochromatosis Mutations Involved in Alzheimer Disease? Amer J Med Genet 93 (2000), 58-66.
    • (2000) Amer J Med Genet , vol.93 , pp. 58-66
    • Moalem, S.1    Percy, M.E.2    Andrews, D.F.3
  • 43
    • 0033528666 scopus 로고    scopus 로고
    • Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Aβ using physiological concentrations
    • R.D. Moir, C.S. Atwood and D.M. Romano et al., Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations, Biochemistry 38 (1999), 4595-4603.
    • (1999) Biochemistry , vol.38 , pp. 4595-4603
    • Moir, R.D.1    Atwood, C.S.2    Romano, D.M.3
  • 44
    • 0030032384 scopus 로고    scopus 로고
    • Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver
    • S. Oetari, M. Sudibyo and J.N.M. Commandeur et al., Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver, Biochem Pharmacol 51 (1996), 39-45.
    • (1996) Biochem Pharmacol , vol.51 , pp. 39-45
    • Oetari, S.1    Sudibyo, M.2    Commandeur, J.N.M.3
  • 45
    • 0034905272 scopus 로고    scopus 로고
    • Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice
    • K. Okada, C. Wangpoengtrakul and T. Tanaka et al., Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice, J Nutr 131 (2001), 2090-2095.
    • (2001) J Nutr , vol.131 , pp. 2090-2095
    • Okada, K.1    Wangpoengtrakul, C.2    Tanaka, T.3
  • 46
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • M.H. Pan, T.M. Huang and J.K. Lin, Biotransformation of curcumin through reduction and glucuronidation in mice, Drug Metab and Disposition 27 (1999), 486-494.
    • (1999) Drug Metab and Disposition , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 47
    • 0037007177 scopus 로고    scopus 로고
    • Protective activities of some phenolic 1,3-diketones against lipid peroxidation: Possible involvement of the 1,3-diketone moiety
    • B.S. Patro, S. Rele and G.J. Chintalwar et al., Protective Activities of Some Phenolic 1,3-Diketones against Lipid Peroxidation: Possible Involvement of the 1,3-Diketone Moiety, ChemBioChem 3 (2002), 364-370.
    • (2002) ChemBioChem , vol.3 , pp. 364-370
    • Patro, B.S.1    Rele, S.2    Chintalwar, G.J.3
  • 48
    • 0036067123 scopus 로고    scopus 로고
    • Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
    • J.L. Quiles, M.D. Mesa and C.L. Ramírez-Tortosa et al., Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits, Arterioscler Thromb Vasc Biol 22 (2002), 1225-1231.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1225-1231
    • Quiles, J.L.1    Mesa, M.D.2    Ramírez-Tortosa, C.L.3
  • 49
    • 0035865905 scopus 로고    scopus 로고
    • Redox-active iron mediates amyloid-beta toxicity
    • C.A. Rottkamp, A.K. Raina and X. Zhu et al., Redox-active iron mediates amyloid-beta toxicity, Free Radic Biol Med 30 (2001), 447-450.
    • (2001) Free Radic Biol Med , vol.30 , pp. 447-450
    • Rottkamp, C.A.1    Raina, A.K.2    Zhu, X.3
  • 50
    • 0034964682 scopus 로고    scopus 로고
    • The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease
    • M. Sampietro, L. Caputo and A. Casatta et al., The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease, Neurobiol Aging 22 (2001), 563-568.
    • (2001) Neurobiol Aging , vol.22 , pp. 563-568
    • Sampietro, M.1    Caputo, L.2    Casatta, A.3
  • 51
    • 0029063462 scopus 로고
    • Elemental imbalances in the olfactory pathway in Alzheimer's disease
    • D.L. Samudralwar, C.C. Diprete and B.F. Ni et al., Elemental imbalances in the olfactory pathway in Alzheimer's disease, J Neurol Sci 130 (1995), 139-145.
    • (1995) J Neurol Sci , vol.130 , pp. 139-145
    • Samudralwar, D.L.1    Diprete, C.C.2    Ni, B.F.3
  • 52
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study
    • M. Sano, C. Ernesto and R.G. Thomas et al., A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study, N Engl J Med 336 (1997), 1216-1222.
    • (1997) N Engl J Med , vol.336 , pp. 1216-1222
    • Sano, M.1    Ernesto, C.2    Thomas, R.G.3
  • 53
    • 0017165123 scopus 로고
    • Ascorbic acid and hepatic drug metabolism
    • P.H. Sato and V.G. Zannoni, Ascorbic acid and hepatic drug metabolism, J Pharmacol Exp Ther 198 (1976), 295-307.
    • (1976) J Pharmacol Exp Ther , vol.198 , pp. 295-307
    • Sato, P.H.1    Zannoni, V.G.2
  • 55
    • 0034321972 scopus 로고    scopus 로고
    • Curcumin inhibits lipoxygenase by binding to its central cavity: Theoretical and X-ray evidence
    • E. Skrzypczak-Jankun, N.P. McCabe, S.H. Selman and J. Jankun, Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence, Int J Mol Med 6 (2000), 521-526.
    • (2000) Int J Mol Med , vol.6 , pp. 521-526
    • Skrzypczak-Jankun, E.1    McCabe, N.P.2    Selman, S.H.3    Jankun, J.4
  • 56
    • 0029888944 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid immunoreactivity in the CNS
    • D.L. Sparks, Intraneuronal beta-amyloid immunoreactivity in the CNS, Neurobiol Aging 17 (1996), 291-299.
    • (1996) Neurobiol Aging , vol.17 , pp. 291-299
    • Sparks, D.L.1
  • 57
    • 0028587702 scopus 로고
    • Curcuminoids as potent inhibitors of lipid peroxidation
    • Sreejayan and M.N.A. Rao, Curcuminoids as Potent Inhibitors of Lipid Peroxidation, J Pharm Pharmacol 46 (1994), 1013-1016.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 1013-1016
    • Sreejayan1    Rao, M.N.A.2
  • 58
    • 0030839940 scopus 로고    scopus 로고
    • Stability of curcumin in buffer solutions and characterization of its degradation products
    • Y.J. Wang, M.H. Pan and A.L. Cheng et al., Stability of curcumin in buffer solutions and characterization of its degradation products, J Pharm Biomed Anal 15 (1997), 1867-1876.
    • (1997) J Pharm Biomed Anal , vol.15 , pp. 1867-1876
    • Wang, Y.J.1    Pan, M.H.2    Cheng, A.L.3
  • 59
    • 0038381436 scopus 로고    scopus 로고
    • Signaling Role of Intracellular Iron in NF-κB Activation
    • S. Xiong, H. She and H. Takeuchi et al., Signaling Role of Intracellular Iron in NF-κB Activation, J Biol Chem 278 (2003), 17646-17654.
    • (2003) J Biol Chem , vol.278 , pp. 17646-17654
    • Xiong, S.1    She, H.2    Takeuchi, H.3
  • 60
    • 0030856114 scopus 로고    scopus 로고
    • Inhibitory effect of curcumin on mammalian phospholipase D activity
    • H. Yamamoto, K. Hanada and K. Kawasaki et al., Inhibitory effect of curcumin on mammalian phospholipase D activity, FEBS Lett 417 (1997), 196-198.
    • (1997) FEBS Lett , vol.417 , pp. 196-198
    • Yamamoto, H.1    Hanada, K.2    Kawasaki, K.3
  • 61
    • 0034986151 scopus 로고    scopus 로고
    • Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid
    • J.J. Yan, J.Y. Cho and H.S. Kim et al., Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid, British J Pharmacol 133 (2001), 89-96.
    • (2001) British J Pharmacol , vol.133 , pp. 89-96
    • Yan, J.J.1    Cho, J.Y.2    Kim, H.S.3
  • 62
    • 85039505570 scopus 로고    scopus 로고
    • Curcumin stimulates microglia phagocytosis of amyloid in vivo and in vitro
    • Abstract Viewer/Itinerary Planner CD-ROM, Washington, DC, Program No. 192.3
    • F. Yang, T. Morihara and W. Beech et al., Curcumin stimulates microglia phagocytosis of amyloid in vivo and in vitro, Abstract Viewer/Itinerary Planner CD-ROM, Washington, DC: Society for Neuroscience (2002), Program No. 192.3.
    • (2002) Society for Neuroscience
    • Yang, F.1    Morihara, T.2    Beech, W.3
  • 63
    • 0035943640 scopus 로고    scopus 로고
    • New insights on how metals disrupt amyloid β-aggregation and their effects on amyloid-β cytotoxicity
    • Y. Yoshiike, K. Tanemura and O. Murayama et al., New Insights on How Metals Disrupt Amyloid β-Aggregation and Their Effects on Amyloid-β Cytotoxicity, J Biol Chem 276 (2001), 32293-32299.
    • (2001) J Biol Chem , vol.276 , pp. 32293-32299
    • Yoshiike, Y.1    Tanemura, K.2    Murayama, O.3
  • 64
    • 0037096251 scopus 로고    scopus 로고
    • A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage
    • K. Zou, J.S. Gong and K. Yanagisawa et al., A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage, J Neurosci 22 (2002), 4833-4841.
    • (2002) J Neurosci , vol.22 , pp. 4833-4841
    • Zou, K.1    Gong, J.S.2    Yanagisawa, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.