Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease

Neuroscience Letters

Volumn 251, Issue 1, 1998, Pages 45-48

  Hermon, Michael ^a   Cairns, Nigel ^b   Egly, Jean Marc ^c   Fery, Anabel ^c   Olga Labudova, ^a   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Alzheimer's disease; Brain; DNA repair; Down Syndrome; ERCC2; ERCC3; Excision repair; Nucleotide excision repair; P80; P89; Western blot

Indexed keywords

DNA; GENE PRODUCT;

ADULT; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOWN SYNDROME; EXCISION REPAIR; FRONTAL LOBE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEMPORAL LOBE;

ALZHEIMER DISEASE; BRAIN; BRAIN CHEMISTRY; CEREBELLUM; CHOLINE O-ACETYLTRANSFERASE; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; DOWN SYNDROME; DROSOPHILA PROTEINS; FRONTAL LOBE; HUMANS; MIDDLE AGED; OCCIPITAL LOBE; ORGAN SPECIFICITY; PARIETAL LOBE; PROTEINS; REFERENCE VALUES; TEMPORAL LOBE; TRANSCRIPTION FACTORS; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0032541109     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00488-1     Document Type: Article

References (27)

1. Au W.W., Wilkinson G.S., Tyring S.K., Legator M.S., El-Zein R., Hallberg L., Heo M.Y. Monitoring populations for DNA repair deficiency and for cancer susceptibility. Environ. Health Perspect. 104:1996;579-584.
2. Baran H., Cairns N., Lubec B., Lubec G. Increased Kynurenic acid levels and decreased brain kynurenine aminotransferases in patients with Down Syndrome. Life Sci. 58:1996;1891-1899.
3. Bootsma D., Weeda G., Vermeulen W., van Vuuren H., Troelstra C., van der Spek P., Hoeijmakers J. Nucleotide excision repair syndromes: molecular basis and clinical symptoms, Philos. Trans. R. Soc. Lond. B. Biol. Sci. 347:1995;75-81.
4. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann. Biochem. 72:1976;248-254.
5. Busciglio J., Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down syndrome neurons in vitro. Nature. 378:1995;776-779.
6. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
7. Link C.J. Jr., Robbins J.H., Bohr V.A. Gene specific DNA repair of damage induced in familial Alzheimer disease cells by UV irradiation or by nitrogen mustard. Mutat. Res. 336:1995;115-121.
8. Ma L., Westbroek A., Jochemsen A.G., Weeda G., Bosch A., Bootsma D., Hoeijmakers J.H., van der Erb A.J. Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function. Mol. Cell. Biol. 14:1994;4126-4134.
9. Marionnet C., Quilliet X., Benoit A., Armier J., Sarasin A., Stary A. Recovery of normal DNA repair and mutagenesis in trichothiodystrophy cells after transduction of the XPD human gene. Cancer Res. 56:1996;5450-5456.
10. Otsuka F., Tarone R.E., Sequin L.R., Robbins J.H. Hypersensitivity to ionizing radiation in cultured cells from Down syndrome patients. J. Neurol. Sci. 69:1985;103-112.
11. Parshad R.P., Sanford K.K., Price F.M., Melnick L. K, Nee, L.E., Schapiro, M.B., Tarone, R.E. and Robbins, J.H., Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc. Natl. Acad. Sci. USA. 93:1996;5146-5150.
12. Robbins J.H., Otsuka F., Tarone R.E., Polinsky R.J., Brumback R.A., Nee I.E. Parkinson disease and Alzheimer disease: hypersensitivity to X-rays in cultured cell lines. J. Neurol. Neurosurg. Psychiatry. 48:1985;916-923.
13. Robison S.H., Munzer J.S., Tandan R., Bradley W.G. Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage. Ann. Neurol. 21:1987;250-258.
14. Sanford K.K., Parshad R., Price F.M., Tarone R.E., Lehmann A.R. G2 phase repair of X-ray induced chromosomal DNA damage in trichothiodystrophy cells. Mutat. Res. 346:1995;107-114.
15. Sanford K.K., Parshad R., Price F.M., Tarone R.E., Schapiro M.B. X-ray induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness. Cancer Genet. Cytogenet. 70:1993;25-30.
16. Schaeffer L., Moncollin V., Roy R., Staub A., Mezzina M., Sarasin A., Weeda G., Hoeijmakers J.H.J., Egly J.M. The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. EMBO. J. 13:1994;2388-2392.
17. Schwaiger H., Weirich H.G., Brunner P., Rass C., Hirsch-Kauffmann M., Groner Y., Schweiger M. Radiation sensitivity of Down syndrome fibroblasts might be due to overexpressed Cu/Zn superoxide dismutase. Eur. J. Cell Biol. 48:1989;79-87.
18. Seidl R., Greber S., Schuller E., Bernert G., Cairns N., Lubec G. Evidence against increased oxidative DNA-damage in Down Syndrome. Neurosci. Lett. 235:1997;137-140.
19. Shubber E.K., Hamami H.A., Allak B.M., Khaleel A.H. Sister-chromatid exchange in lymphocytes from infants with Down syndrome. Mutat. Res. 248:1991;61-72.
20. Sung P., Batty V., Weber C., Thompson L.H., Prakash L., Prakash S. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature. 365:1993;852-855.
21. Tarone R.E., Liao K.H., Robbins J.H. Effects of DNA-damaging agents on Down syndrome cells: implications for defective DNA repair mechanisms. Prog. Clin. Biol. Res. 246:1987;93-113.
22. Wang X.W., Vermeulen W., Coursen J.D., Gibson M., Lupold S.E., Forrester K., Xu G., Elmore L., Yeh H., Hoeijmakers J.H.J., Harris C.C. The XPB and XPD DNA helicases are components of the p53 mediated apoptosis pathway. Genes. Dev. 10:1996;1219-1232.
23. Warbrick E. Apoptosis: a new twist to the tale? Curr. Biol. 6:1996;1057-1059.
24. Weeda G., Eveno E., Donker I., Vermeulen W., Chevallier-Lagente O., Taieb A., Stary A., Hoeijmakers J.H., Mezzina M., Sarasin A. A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. Am. J. Human. Genet. 60:1997;320-329.
25. Weirich-Schwaiger H., Weirich H.G., Gruber B., Schweiger M., Hirsch-Kauffmann M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316:1994;37-48.
26. Wu F.Y., Iijima K., Nishida A., Higurashi M. Sister chromatid exchanges in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light. Mutat. Res. 367:1996;261-264.
27. Yoo H., Li L., Sacks P.G., Thompson L.H., Becker F.F., Chan J.Y. Alterations in expression and structure of the DNA repair gene XRCC1. Biochem. Biophys. Res. Commun. 186:1992;900-910.