Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2008, Pages

  Malouf, Reem ^a,c   Evans, John Grimley ^b  

^a OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

*Dietary Supplements; Cognition Disorders drug therapy; etiology ; Cognition drug effects ; Dementia *drug therapy; etiology ; Drug Therapy, Combination; Folic Acid Deficiency complications ; Folic Acid *therapeutic use

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ASCORBIC ACID; CHOLINESTERASE INHIBITOR; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO;

ALLERGY; ALZHEIMER DISEASE; ATTENTION DEFICIT DISORDER; CINAHL; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DAILY LIFE ACTIVITY; DARK URINE; DEMENTIA; DRUG WITHDRAWAL; EMBASE; FORGETFULNESS; HUMAN; INFORMATION PROCESSING; LEARNING; MEMORY; MEMORY CONSOLIDATION; MOOD; MULTIINFARCT DEMENTIA; REVIEW; SAMPLING; SENSORIMOTOR FUNCTION; SIDE EFFECT; SYSTEMATIC REVIEW; TINNITUS; TREATMENT DURATION; VERBAL BEHAVIOR; VITAMIN SUPPLEMENTATION; WEIGHT GAIN; WORKING MEMORY;

EID: 55049095215     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD004514.pub2     Document Type: Review

References (123)

1. Bryan 2002 {publisheddata only} Bryan J, Calvaresi E, Hughes D. Short term folate vitamin B12 or vitamin B6 supplementation slightly affects memory performance but not mood in women of various ages. Journal of Nutrition 2002;132(6):1345-56.
2. Clarke 2003 {publisheddata only} Clarke R, Harrison G, Richards S, VITAL Trial Collaborative Group. Effect of vitamins and aspirin on markers of platelet activations oxidative stress and homocysteine in people at high risk of dementia. Journal of Internal Medicine 2003;254(1): 67-75.
3. Connelly 2008 {publisheddata only} Connelly PJ, Prentice NP, Cousland G, Bonham J. A randomised double-blind placeblo controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. International Journal of Geriatric Psychiatry 2008;23(2):155-60.
4. Durga 2007 {publisheddata only} * Durga J, Van Boxtel MPV, Schouten EG, Kok FJ, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognition function in older adults in the FACIT trial a randomized double blind controlled trial. The Lancet 2007;369:208- 16.
5. Eussen 2006 {publisheddata only} Eussen SJ, Groot LC, Joosten LW, Bloo RJ, Clarke R, et al.Effect of oral vitamin B12 with or without folic acid on cognitive function in older people with mild vitamin deficiency a randomized placebo controlled trial. American Journal of Clinical Nutrition 2006;84:361-70.
6. Fioravanti 1997 {publisheddata only} Fioravanti M, Ferrario E, Massaia M, Cappa G, Rivolta G, Grossi E, Buckley AE. Low folate levels in the cognitive decline of elderly patients and efficacy of folate as a treatment for improving memory deficits. Archives of Gerontology and Geriatrics 1997;26(1):1-13.
7. Pathansali 2006 {publisheddata only} Pathansali R, Mangoni A, Creagh-Brown B, Lan Z, Ngow G, et al.Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Archives of Gerontology and Geriatrics 2006;43:127-37.
8. Sommer 2003 {publisheddata only} * Sommer BR, Hoff AL, Costa M. Folic acid supplementation in dementia: a preliminary report. Journal of Geriatric Psychiatry and Neurology 2003;16:156-9.
9. Sommer BR, Hoff AL, Costa M. Folic acid supplementation in dementia a preliminary report. Proceedings of the 11th Annual Meeting of the American Association for Geriatric Psychiatry, 1998 8-11 March, San Diego. 1998.
10. Brouwer 2000 {publisheddata only} * Brouwer IA, Van Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TK, et al.Low dose folic acid supplementation decreases plasma homocysteine concentrations a randomised trial. Indian Heart Journal 2000;7(S52):S53-8.
11. Cockle 2000 {publisheddata only} Cockle SM, Haller J, Kimber S, Dawe RA, Hindmarch I. The influence ofmultivitamins on cognitive function andmood in the elderly. Aging and Mental Health 2000;4(4):339-53.
12. Jong 2001 {publisheddata only} Jong ND, Paw MC, Groot L, Rutten R, Swinkels DW, Kok FJ, Staveren WAV. Nutrient dense foods and exercise in frail elderly effects on B vitamins homocysteine methylmalonic acid and neuropsychological functioning. American Journal of Clinical Nutrition 2001;73:338-46.
13. Lewerin 2005 {publisheddata only} Lewerin C, Matousek M, Steen G, Johansson B, Steen B, Nilson-Ehle H. Significant correlations of plasma homocysteine and serum methylmalonic acid withmovement and cognitive performance in elderly subjects but no improvement fromshort-term vitamin therapy: a placebo-controlled randomized study. American Journal of Clinical Nutrition 2005;81:1155-62.
14. McMahon 2006 {publisheddata only} McMahon JA, Green TJ, Skeaff M, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. New England Journal of Medicine 2006;354:2764-72.
15. Passeri 1993 {publisheddata only} Passeri M, Cucinotta D, Abate G, Senin U, Ventura A, Badiale MS, Diana R, Greca PL, Grazie L. Oral 5 methyltetrahydrofolic acid in senile organic mental disorders with depression results of a double blind multicenter study. Aging Clinical and Experimental Research 1993;5(1):63-71.
16. Ralph 1974 {publisheddata only} Magnus RV, Cooper AJ. A controlled study of reactivan in geriatrics. Modern Geriatrics 1974;June:270-76.
17. Stott 2005 {publisheddata only} Stott DJ, MacIntosh G, DO Lowe J, Rumley A, MacMahon AD, Langhorne P, et al.Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. The American Journal of Clinical Nutrition 2005;82:1320- 6.
18. Tucker 2004 {publisheddata only} * Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH. Breakfast cereal fortified with folic acid, vitamin B6, and vitamin B12 increases vitamin concentrations and reduces homocysteine concentrations a randomized trial. American Journal of Clinical Nutrition 2004;79:805-11.
19. Walker J, Christensen H. Beyond ageing: A study for the prevention of depression cognitive impairment and the improvement of knowledge about mental health. www.clinicaltrials.gov 2007.
20. Abalan 1996 Abalan F, Zittoun J, Boutami C. Plasma red cell and cerebrospinal fluid folate in Alzheimer's disease. Encephale 1996;6:430-4.
21. Antony 1995 Antony AC. Heamatology basic principles and practice. 2nd Edition. New York: Chirchill Livingstone, 1995:552-86.
22. APA 1987 Americam Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd Edition. Washington: APA, 1987.
23. APA 1994 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington DC: APA, 1994.
24. Aronow 1997 Aronow WS, Ahn C, Schoenfed MR. Association between plasma homocysteine and extracranial carotid disease in older persons. American Journal of Cardiology 1997;79:1432.
25. Baddeley 1988 Baddeley A, Emslie H, Nimmo-Smith I. Estimating premorbid intelligence. Journal of Clinical Neuropsychology 1988;10:326.
26. Benton 1955 Benton AL. Revised Visual Retention Test. 5th Edition. New York: The Psychological Corporation, Harcourt, Brace and Jovanovich, 1955.
27. Benton 1989 Benton AL, Hamsher D. Multilingual Aphasia Examination. Iowa City, IA: Universty of Iowa, 1989.
28. Benton 1994 Benton AL, Hamsher K, Sivan AB. Multilingual aphasia examination. 3rd Edition. Iowa: AJA Associated, 1994.
29. Botez 1979 Botez MT, Reynolds EH. Folic acid in neurology psychiatry and internal medicine. Botez MT, Reynolds EH. New York: Raven press, 1979.
30. Bottiglieri 1994 Bottiglieri T, Crellin R, Reynolds EH. Folate and Neuropsychiatry. In Bailey. New York: Marcel Dekker, 1994:435-63.
31. Bottiglieri 2000 Bottiglieri T, Reynolds EH. Folate in CSF and age. Journal of Neurology, Neurosurgry and Psychiatry 2000;69:562.
32. Breteler 1994 Breteler MMB, Claus JJ, Grobbee DE. Cardiovascular disease and distribution of cognitive function in elderly people the Rotterdam study. British Medical Journal 1994;308:1604-8.
33. Brocker 1986 Brocker P, Lebel C, Maurine H, Lods JC. Carences en folates chez les sujets ages interet de leir correction dans le traitment des troubles du comportement [Carences en folates chez les sujets ages interet de leir correction dans le traitment des troubles du comportement]. Semaine Hopital. Paris 1986;27:2135-39.
34. Bryant 1998 Bryant CA, Farmer A, Tiplady J, Sherwood R, Swift CG, Jackson SH. Psychomotor performance: investigating the dose-response relationship for caffeine and theophylline in elderly volunteers. European Journal of Clinical Pharmacology 1998;54:309-13.
35. Bucks 1996 Bucks RS, Ashworth D, Wilcock GK, Siegfried K. Assessment of activities of daily living in dementia development of the Bristol activities of daily living scale. Age and Ageing 1996;25:113-20.
36. Chalmers 1983 Chalmers TC, Celano P, Sacks HS, Smith H. Bais in treatment assignment in controlled clinical trials. New England Journal of Medicine 1983;309:1358-61.
37. Chanarin 1979 Chanarin I. The Megaloblastic Anemias. Oxford: Blackwell Scientific Publications, 1979.
38. Chanarin 1989 Chanarin I, Deacon R, Lumb M, Perry J. Cobalamin folate interrelations. Blood Review 1989;3:211-15.
39. Clarke 1998 Clarke R, Smith AD, Jobst KA. Folate vitamin B12 and serum total homocysteine levels in confirmed Alzehimer's disease. Archives of Neurology 1998;55:1449-55.
40. Clarke 2007 Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede J. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clinical Chemistry 2007;53:963-70.
41. Cole 2007 Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, et al.Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. Journal of the American Medical Association 2007;297:2351-9.
42. Cooper 1986 Cooper BA. Nutritional Pharmacological and Physiological Aspects /Folate nutrition in man and animals. Blakley R. New York: Blakley RL, Whitehead VM, 1986.
43. Corrada 2005 Corrada M, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer's disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimer Disease and Associated Disorders 2005;1:11-18.
44. Dodrill 1978 Dodrill CB. A neuropsychological battery for epilepsy. Epilepsia 1978;19:611-23.
45. Earles 1995 Earles JL, Salthouse TA. Interrelations of age health and speed. Journals of Gerontology B. Psychology and Social Sciences 1995;50B:33-41.
46. Ebly 1998 Ebly EM, Schaefer JP, Campbell NRC. Folate status vascular disease and cognition in elderly Canadians. Age and Ageing 1998;27:485-91.
47. Feher 1992 Feher EP, Mahurin RK, Doody RS, Cooke N, Sims J, Prizzolo FJ. Establishing the limits of the mini mental state examination of subtests. Archives of Neurology 1992;49(1):87-92.
48. Ferri 2005 Ferri PC, Prince M, Brayne C, Brodaty H, Fratiglioni H, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, et al.Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-7.
49. Folstein 1975 Folstein MF, Folstein SE, McHugh PR. Minimental state, a practical method for grading cognitive state of patients for the clinician. Journal of Psychiatric Research 1975;313:1419-20.
50. Galasko 1990 Galasko D, Klauber MR, Hofstetter CR. The Mini Mental State examination in the early diagnosis of Alzheimer's disease. Archives of Neurology 1990;47:49-52.
51. Getzels 1962 Getzels JW, Jackson PW. Creativity and Intelligence. New York: Wiley, 1962.
52. Gospe 1995 Gospe SM, Gietzen DW, Summers PJ, Lunetta JM, Miller JW, Selhub J. Behavioral and neurochemical changes in folate deficient mice. Journal of Physiology and Behavior 1995;58:935-41.
53. Gottfries 1998 Gottfries CG, Lehman W, Regland B. Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease. Journal of Neural Transmission 1998;105:773-86.
54. Hassing 1999 Hassing L, Wahlin A, Winblad B. Further evidence for the effects of vitamin B12 and folate status on episodic memory functioning a population based study of very old adults. Biological Psychiatry 1999;45(11):1472-80.
55. Herbert 1985 Herbert V. Megaloblastic anemias. Laboratory Investigation 1985;52:3.
56. Herbet 1961 Herbet V. Experimental nutritional folate deficiency in men. Transactions of the Association of American Physicians 1961;75:307-20.
57. Higgins 2008 Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochranehandbook.org.
58. Hirsch 2002 Hirsch S, Maza P, Barrera G, Gattas V, Petermann M, Bunout D. The Chilean folic acid fortification program reduces serum homocysteine levels and masks vitamin B12 deficiency in elderly people. Journal of Nutrition 2002;132:289-91.
59. Hofman 1997 Hofman A, Ott A, Breteler MMB. Atherosclerosis apolipoprotein E and the prevalence of dementia and Alzheimer's disease in the Rotterdam Study. The Lancet 1997;349:151-4.
60. ICD-10 1992 World Health Organizition. The ICD-10 classification of mental and behavioural disorders clinical description and diagnostic guidelines. Geneva: World Health Organisation, Division of Mental Health, 1992.
61. Jacques 1999 Jacques PF, Selhub J, Bostom A, Peter WF, Wilson P, et al.The effect of folic acid fortification on plasma and total homocysteine concentrations. The New England Journal of Medicine 1999;340:1449- 54.
62. Jorm 1987 Jorm AF, Korten AE, Henderson AS. The prevalence of dementia a quantitative integration of the literature. Acta Psychiatrica Scandanavica 1987;76:465-79.
63. Kalra 1993 Kalra L, Jakson SH, Swift CG. Assessment of changes in psychomotor performance in elderly subjects. British Journal of Pharmacology 1993;36:383-89.
64. Kaplan 1983 Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Philadelphia: Lea and Febiger, 1983.
65. Keane 1998 Keane EM, O'Broin S, Kelleher B, Coakley D, Walsh JB. Use of folic acid fortified milk in the elderly population. Gerontology 1998;44:336-9.
66. Kruman 2002 Kruman Inna I, Kumaravel TS, Lohani A. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of alzheimer's disease. Journal of Neuroscience 2002;22:1752-62.
67. La Rue 1997 La Rue A, Koehler Km, Wayne SJ, Chiulli SJ, Haaland KY, Garry PJ. Nutritional status and cognitive functioning in a normally aging sample a 6 year reassessment. American Journal of Clinical Nutrition 1997;65:20-9.
68. Levitt 1989 Levitt AJ, Joffe RT. Folate vitamin B12 and life course of depressive illness. Biological Psychiatry 1989;25:867- 72.
69. Lezak 1995 Lezak MD. Neuropsychological Assessment. Third Edition. Oxford University Press, 1995.
70. Malouf 2003 a Malouf R, Areosa Sastre A. Vitamin B12 for cognition. Cochrane Database of Systematic Reviews 2003, Issue 4.[Art. No.: CD004394. DOI: 10.1002/14651858.CD004394]
71. Marcus 1998 Marcus EL, Berry EM. Refused to eat in the elderly. Nutrition Reviews 1998;56:163-171.
72. Mason 2007 Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, et al.A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiology Biomarkers and Prevention 2007;16:1325-9.
73. Mayer 1996 Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. Journal of the American College of Cardiology 1996;27:517.
74. McCaddon 1998 McCaddon A, Davis G, Hudson P, Tandy S, Cattell H. Total serum homocysteine in senile dementia of Alzheimer type. International Journal of Geriatric Psychiatry 1998;13:235-9.
75. McKhann 1984 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimers disease report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimers disease. Neurology 1984;4:939- 44.
76. McNair 1971 McNair PM. Profile of mood states manual. San Diego, CA: Education and Industrial Testing Service, 1971.
77. Meindok 1970 Meindok H, Dvorsky R. Serum folate and vitamin B12 levels in the elderly. Journal of the American Geriatrics Society 1970;18:317-26.
78. Morris 2005 Morris MC, Evans DA, Bienias JL, et al.Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Archives of Neurology 2005;62:641-5.
79. Morris 2007 Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. American Journal of Clinical Nutrition 2007;85:193-200.
80. NICE 2006a NICE. Donepezil, galantamine, revastigmine andmemantine for the treatment of Alzheimer's disease. www.nice.org/uk 2006.
81. Nygard 1997 Nygard O, Nordrehauge JE, Refsum H. Plasma homocysteine levels and mortality in patients with coronary artery disease. New England Journal of Medicine 1997;337:230.
82. Ortega 1996 Ortega RM, Manas LR, Andres P, Gaspar MJ, Agudo FR, et al.Functional and psychic deterioration in elderly people may be aggravated by folate deficiency. Journal of Nutrition 1996;126:1992-9.
83. Perry 1995 Perrt IJ, Refsum H, Morris RW. Protictive study of serum total homocysteine concentaration and risk of stroke in middle aged British men. The Lancet 1995;346:1395.
84. Petrides 1982 Petrides M, Milner B. Deficts on subject ordered tasks after frontal and temporal lobe lesions in man. Neuropsychologia 1982;20:249-62.
85. Prince 1999 Prince M, MacDonald AM, Sham PC, Richards M, Quraishi S, Horn I. The development and validation of a telephone administered cognitive test battery (TACT). The International Journal of Methods in Psychiatric Research 1999;8:49-57.
86. Radloff 1977 Radloff LS. The CES-D scale a self report depression scale for research in the general population. Applied Psychological Measurement 1977;1(3):385-401.
87. Randt 1983 Randt CT, Brown ER. Randt memory test administration manual. Bayport, NY: Life Science Associates, 1983.
88. Ravaglia 2005 Ravaglia G, Forti P, Maioli F, et al.Homocysteine and folate as risk factors for dementia and Alzheimer disease. American Journal of Clinical Nutrition 2005;82:636-43.
89. Reisberg 1982 Reisberg B, Ferris SH, de Leon MJ, Crook T. The global deterioration scale for the assessment of primary degenerative dementia. American Journal of Psychiatry 1982;139:1136-39.
90. Reitan 1974 Reitan RM, Davidson LA. Clinical neuropsychology: Current status and applications. New York: Hemisphere, 1974.
91. Reitan 1985 Reitan RM, Wolfson D. The Halstead Reitan Neuropsychological Test Battery. Tucson, AZ: Neuropsychology Press, 1985.
92. Reitan 1992 Reitan RM. Trial making test : Manual for administration and scoring. Tucson: Reitan Neuropsychological Laboratory, 1992.
93. Renvall 1989 Renvall MJ, Spindler AA, Ramsdell JW. Nutritional status of free living Alzheimer's patients. American Journal of Medical Science 1989;298:20-7.
94. Rey 1964 Rey A. Psychological clinical examination. L'examen clinique en psychologie. Paris, France: Presses Universitaires de France, 1964.
95. Reynolds 1976 Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clinics in Haematology 1976;5:661-96.
96. Rosen 1984 Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. American Journal of Psychiatry 1984;141:1356- 64.
97. Rosenberg 1985 Rosenberg IH, Zimmerman J, Selhub J. Folate transport. Chemioterapia 1985;4:354.
98. Schulz 1995 Schulz KF, Chalmers I, Hayes RJ, Altman D. Empirical evidence of bias. Journal of the American Medical Association 1995;273:408-12.
99. Selhub 1993 Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Journal of the American Medical Association 1993;270(22):2693-8.
100. Senti 1985 Snti. Analysis of folate data from the second national health examination study (NHANESII). Journal of Niutrition 1985;115(11):1398-402.
101. Seshadri 2002 Seshadri S, Beiser A, Selhub J, Jacques P, Jacques PF, Rosenberg IH. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. The New Engalnd Journal of Medicine 2002;346:476-83.
102. Shane 1985 Shane B, Stokstad ELB. Vitamin B12 folate interrelationships. Annual Review of Nutrition 1985;5:115-41.
103. Small 1997 Small GW, Rabins PV, Barry PP. Diagnosis and treatment of Alzheimer disease and related disorders. Journal of the American Medical Association 1997;278:1363-71.
104. Smith 2002 Smith PG. Clinical Pharmacology and Drug Therapy. 3rd Edition. Oxford Textbook, 2002.
105. Smith 2008 Smith DA. The worldwide challenge of the dementias: a role for B vitamins and homocysteine?. Food and Nutrition Bulletin 2008;29(2):S143-72.
106. Sneath 1973 Sneath P, Chanarin I, Hodkinson HM, McPherson CK, Reynolds EH. Folate status in a geriatric population and its relation to dementia. Age and Ageing 1973;2:177-82.
107. Snowdon 2000 Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR. Serumfolate and the severity of atrophy of the neocortex in Alzheimer disease finding from the nun study. American Journal of Clinical Nutrition 2000;71(4):993-8.
108. Spiegel 1991 Spiegel R, Brunner C, Ermini-Funfschilling D, et al.A new behavioural assessment scale for geriatric out and in patients the NOSGER (Nurses' Observation scale for geriatric patients). Journal of The American Geriatrics Society 1991;39(4):339-47.
109. Spreen 1998 Spreen O, Strauss E. A compendium of neuropsychological test administration. 2nd Edition. New York: Oxford University Press, 1998.
110. Stabler 1986 Stabler SP, Marcell PD, Podell ER. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography mass spectrometry. Journal of Clinical Investigation 1986;77(5):1606-12.
111. Stabler 1988 Stabler SP, Marcell PD, Podell ER. Elevation of total homocysteine in the serumof patients with cobalamin or folate deficiency detected by capillary gas chromatography mass spectrometry. Journal of Clinical Investigation 1988;81:466.
112. Stehouwer 1998 Stehouwer CDA, Weijenberg MP, Van den Berg M. Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men a ten year follow up. Arteriosclerosis Thrombosis and Vascular Biology 1998;18:1895-901.
113. Ueland 1993 Ueland PM, Refsum H, Stabler SP, Malinow MR, Anderson A, Allen RH. Total homocysteine in plasma or serum methods and clinical applications. Clinical Chemistry 1993;39:1764-79.
114. Van der Elst 2006 a Van der Elst W, van Boxtel Mp, Van Breukelen GJ, Jolles J. Rey's verbal learning test: normative data for 1855 healthy participants ages 24-81 years and the influence of age, sex, education and mood of presentation. Journal of the International Neuropsychological Society 2005;11:290-301.
115. Van der Elst 2006 b Van der Elst W, Boxtel MP, Breukelen GJ, Jolles J. The concept shifting test: adult normative data. Psychological Assessment 2006;18:424-32.
116. Wahlin 1996 Wahlin A, Hill RD, Winblad B. Effects of serum vitamin B12 and folate status on episodic memeory performance in very old age a population based study. Psychology and Aging 1996;11:487-96.
117. Wang 2001 Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology 2001;56(9):1188-94.
118. Wechsler 1955 Wechsler D, Stone CP. Wechsler Memory Scale manual. New York: The Psychological Corporation, Harcourt, Brace and Jovanovich, 1955.
119. Wechsler 1997 Wechsler D. Wechsler adult intelligence scale. 3rd Edition. San Antonio, TX: The Psychological Corporation/Harcourt Brace, 1997.
120. Wecshler 1981 Wecshler D. Wecshler Adult Intelligence Scale Revised. New York: The psychological Corporation, 1981.
121. Welchsler 1982 Wechsler D. Wechsler Adult Intelligence Scale-Revised manual. New-York: The Psychological Corporation, Harcourt, Brace and Jovanovich, 1982.
122. Whitehead 1995 Whitehead AS, Gallagher PM, Mills JM, Kirke P, Burke H, Molloy AM, Weir DG, Shields DC, Scott JM. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. Quarterly Journal of Medicine 1995;88:763-5.
123. Malouf 2003 b Malouf R, Grimley Evans J, Areosa Sastre A. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database of Systematic Reviews 2003, Issue 4.