Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis

Cancer Genetics and Cytogenetics

Volumn 124, Issue 1, 2001, Pages 71-75

  Maluf, Sharbel Weidner ^a   Erdtmann, Bernardo ^b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; DOWN SYNDROME; FANCONI ANEMIA; FEMALE; GENOME; HUMAN; HUMAN CELL; INFANT; LEUKOCYTE; MALE; MICRONUCLEUS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COMET ASSAY; DOWN SYNDROME; FANCONI ANEMIA; FEMALE; HUMANS; INFANT; MALE; MICRONUCLEUS TESTS; SENSITIVITY AND SPECIFICITY;

EID: 0035140477     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(00)00322-8     Document Type: Article

References (35)

1. Down syndrome and acute leukemia in children; a 10-year retrospective survey from Children's Cancer Study Group
2. Sister chromatid exchange frequency and lymphocyte proliferation in a Down's syndrome mosaic developing an acute lymphoblastic leukemia
3. In vivo chromosomal radiosensitivity in 'chromosomal breakage syndromes.'
4. Alzheimer's disease in Down's syndrome; a review
5. Down's syndrome and Alzheimer's disease; a review
6. Radiation sensitivity of Down's syndrome fibroblasts might be due to overexpressed Cu/Zn-superoxide dismutase (EC 1.15.11.1)
7. Bleomycin-induced chromosomal aberrations and sister chromatid exchanges in Down lymphocyte cultures
8. Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome
9. Chromosome damage in Down syndrome induced by chicken pox infection
10. Chromosome breakage syndromes
11. Molecular and cellular biology of Fanconi anemia
12. Genetically determined chromosome instability syndromes
13. International Fanconi anemia registry; relation of clinical symptoms to diepoxybutane sensitivity
14. Spontaneous chromosomal aberrations in Fanconi anaemia, ataxia telandiectasia fibroblasts and Bloom's syndrome lymphoblastoid cell lines as detected by conventional cytogenetic analysis and fluorescence in situ hybridisation (FISH) technique
15. Cytogenetische und cytologische befunde bei enzymopenichen panmyelophatien und pancytopenien
16. Susceptibility of Fanconi's anemia fibroblasts to chromosome damage by carcinogens
17. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment
18. The induction of micronuclei as a measure of genotoxicity; a report of U.S. Environmental Protection Agency Gen- Tox Program
19. Mutation cytogenetics; past, present and future
20. Microelectrophoretic study of radiation-induced DNA damages in individual cells
21. The single cell microgel electrophoresis assay (comet assay); Technical aspects and applications. Report on the 5th LH Gray Trust Workshop, Institute of Cancer Research 1994
22. Measurement of micronuclei in lymphocytes
23. The cytokinesis-block micronucleus technique; A detailed description of the method and its application to genotoxicity studies in human populations
24. The advantages and disadvantages of the cytokinesis-block micronucleus method
25. Expression of human CuZn superoxide dismutase gene in transgenic mice; model for gene dosage effect in Down's syndrome
26. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes
27. The effect of aging on cell-cyle kinetics and X-ray-induced chromosome aberrations in cultured lymphocytes from patients with Down syndrome
28. Fragile sites and chromosome instability; in the distribution of breaks induced by cis-diamine-dichloro-platinum (II) in Fanconi anemia lymphocytes cultures
29. Spontaneous chromosome aberrations in Fanconi's anemia patients are located at fragile sites and acute myeloid leukemia breakpoints
30. Micronuclei in cytokinesis blocked lymphocytes of cancer patients following fractionated partial-body radiotherapy
31. Cytogenetic studies of PCB77 on brown trout (Salmo trutta fario) using the micronucleus test and the alkaline comet assay
32. In vivo genotoxicity of dichloroacetic acid; evaluation with the mouse peripheral blood micronucleus assay and the single cell gel assay
33. Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents; genotoxic effects of cobalt powder, tungsten carbide and cobalt-tungsten carbide
34. Genotoxic activity of potassum permanganate in acidic solutions
35. The single cell gel/comet assay; A microgel electrophoretic technique for the detection of DNA damage and repair in individual cells