메뉴 건너뛰기




Volumn 407, Issue 6805, 2000, Pages 802-809

Apoptosis in the nervous system

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AMYLOID; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; NEUROTROPHIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYGLUTAMINE; PROTEIN BCL 2; PROTEIN KINASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 0034641936     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35037739     Document Type: Review
Times cited : (1652)

References (101)
  • 3
    • 0023851503 scopus 로고
    • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    • (1988) J. Cell Biol. , vol.106 , pp. 829-844
    • Martin, D.P.1
  • 5
    • 23444435250 scopus 로고
    • Prevention of vertebrate neuronal death by the crmA gene
    • (1994) Science , vol.263 , pp. 826-828
    • Gagliardini, V.1
  • 8
    • 0027944004 scopus 로고
    • Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
    • (1994) Neuron , vol.13 , pp. 1017-1030
    • Martinou, J.C.1
  • 10
    • 0028865136 scopus 로고
    • Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease
    • (1995) J. Neurosci. , vol.15 , pp. 7727-7733
    • Sagot, Y.1
  • 12
    • 1842456916 scopus 로고    scopus 로고
    • Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development
    • (1996) Neuron , vol.17 , pp. 75-89
    • Michaelidis, T.M.1
  • 14
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cell and neurons in Bcl-x-deficient mice
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1
  • 15
    • 0030245811 scopus 로고    scopus 로고
    • BAX is required for neuronal death after trophic facto deprivation and during development
    • (1996) Neuron , vol.17 , pp. 401-411
    • Deckwerth, T.L.1
  • 19
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATp-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1
  • 20
    • 0034192466 scopus 로고    scopus 로고
    • Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions
    • (2000) J. Cell Biol. , vol.149 , pp. 613-622
    • Kang, S.J.1
  • 21
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1
  • 22
    • 0029956641 scopus 로고    scopus 로고
    • Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    • (1996) Nature , vol.384 , pp. 368-372
    • Kuida, K.1
  • 23
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspasce 9
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1
  • 24
  • 26
    • 0028820456 scopus 로고
    • Regulation of the Ras signaling pathway by GTPase-activating protein in Pc12 cells
    • (1995) Oncogene , vol.11 , pp. 1607-1614
    • Yao, R.1    Cooper, G.M.2
  • 29
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1
  • 30
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 31
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1
  • 35
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and-independent mechanisms
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1
  • 38
    • 0032864021 scopus 로고    scopus 로고
    • Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
    • (1999) J. Cell Biol. , vol.146 , pp. 955-966
    • Vaillant, A.R.1
  • 40
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • (1994) J. Cell Biol. , vol.127 , pp. 1717-1727
    • Estus, S.1
  • 41
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1
  • 42
    • 0033583218 scopus 로고    scopus 로고
    • The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein
    • (1999) J. Biol. Chem. , vol.274 , pp. 7975-7981
    • Imaizumi, K.1
  • 44
    • 0032192529 scopus 로고    scopus 로고
    • Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c
    • (1998) Neuron , vol.21 , pp. 695-705
    • Deshmukh, M.1    Johnson E.M., Jr.2
  • 48
    • 0032559622 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    • (1998) J. Cell Biol. , vol.140 , pp. 911-923
    • Bamji, S.X.1
  • 49
    • 13144259635 scopus 로고    scopus 로고
    • TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
    • (1998) Curr. Biol. , vol.8 , pp. 915-918
    • Davey, F.1    Davies, A.M.2
  • 52
    • 0032525260 scopus 로고    scopus 로고
    • Activation and cleavage of caspase- 3 in apoptosis induced by experimental cerebral ischemia
    • (1998) J. Neurosci. , vol.18 , pp. 3659-3668
    • Namura, S.1
  • 53
    • 0032125488 scopus 로고    scopus 로고
    • Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
    • (1998) Brain Res. Bull. , vol.46 , pp. 281-309
    • Martin, L.J.1
  • 56
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotypes and treatments
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 57
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 58
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxcity
    • (1998) Nature Med. , vol.4 , pp. 827-831
    • Geula, G.1
  • 62
    • 0013615899 scopus 로고    scopus 로고
    • RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
    • (1996) Nature , vol.382 , pp. 685-691
    • Yan, S.D.1
  • 63
    • 0030723983 scopus 로고    scopus 로고
    • Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease
    • (1997) J. Clin. Invest. , vol.100 , pp. 2333-2340
    • Yaar, M.1
  • 64
    • 0033944538 scopus 로고    scopus 로고
    • Amyloid-β interacts with the amyloid precursor protein: A potential toxic mechansim in Alzheimer's disease
    • (2000) Nature Neurosci. , vol.3 , pp. 460-464
    • Lorenzo, A.1
  • 65
    • 0030808462 scopus 로고    scopus 로고
    • Aggegated amyloid-beta protein induces cortical neuronal apoptosis and concomitant 'apoptotic' pattern of gene induction
    • (1997) J. Neurosci. , vol.17 , pp. 7736-7745
    • Estus, S.1
  • 66
    • 0034652232 scopus 로고    scopus 로고
    • Caspase-2 mediates neuronal cell death induced by beta-amyloid
    • (2000) J. Neurosci. , vol.20 , pp. 1386-1392
    • Troy, C.M.1
  • 67
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1
  • 68
    • 0029087026 scopus 로고
    • Candidate gene for chromosome 1 familial Alzheimer's disease locus
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1
  • 70
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1
  • 71
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1
  • 72
    • 0034621824 scopus 로고    scopus 로고
    • Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
    • (2000) Nature , vol.405 , pp. 689-694
    • Li, Y.M.1
  • 74
    • 0029811105 scopus 로고    scopus 로고
    • Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
    • (1996) J. Neurosci. , vol.16 , pp. 6021-6037
    • Giulian, D.1
  • 75
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1
  • 78
    • 0032933836 scopus 로고    scopus 로고
    • Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type I isolates: Evidence for a role of the envelope
    • (1999) J. Virol. , vol.75 , pp. 897-906
    • Ohagen, A.1
  • 79
    • 18544400323 scopus 로고    scopus 로고
    • Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
    • (1997) Cell , vol.90 , pp. 549-558
    • Scherzinger, E.1
  • 80
    • 0030669689 scopus 로고    scopus 로고
    • Polyglutamines, nuclear inclusions and neurodegeneration
    • (1997) Nature Med. , vol.3 , pp. 1201-1202
    • Lunkes, A.M.1
  • 81
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntington in neuronal intranuclear inclusions and dystrophic neurites in brain
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1
  • 83
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1
  • 85
    • 0032475941 scopus 로고    scopus 로고
    • Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
    • (1998) Cell , vol.95 , pp. 41-53
    • Klement, I.A.1
  • 86
    • 0033103523 scopus 로고    scopus 로고
    • Caspase-8 is required for cell death induced by expanded polyglutamine repeats
    • (1999) Neuron , vol.22 , pp. 623-633
    • Sanchez, L.1
  • 87
    • 0033587128 scopus 로고    scopus 로고
    • Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
    • (1999) Nature , vol.399 , pp. 204-205
    • Ona, V.O.1
  • 89
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1
  • 90
  • 91
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1
  • 92
    • 0033231494 scopus 로고    scopus 로고
    • From Charcot to SOD 1: Mechanisms of selective motor neuron death in ALS
    • (1999) Neuron , vol.24 , pp. 515-520
    • Cleveland, D.W.1
  • 93
    • 0028915976 scopus 로고
    • Mutations associated with amyotrophic lateral sclerosis covert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3024-3028
    • Rabizadeh, S.1
  • 94
    • 0032430185 scopus 로고    scopus 로고
    • Caspase-1 is activated in neuron1 cells and tissue with amytrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15763-15768
    • Pasinelli, P.1
  • 98
    • 0033510160 scopus 로고    scopus 로고
    • Mice deficient in interleukin- 1 converting enzyme are resistant to neonatal hypoxic-isehemic brain damage
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 1099-1108
    • Liu, X.H.1
  • 99
    • 0032493870 scopus 로고    scopus 로고
    • Differential requirement for caspase 9 in apoptotic pathways in vivo
    • (1998) Cell , vol.94 , pp. 339-352
    • Hakem, R.1
  • 101
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.