An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease

Journal of Neurochemistry

Volumn 68, Issue 5, 1997, Pages 2061-2069

  Lyras, Leonidas ^a   Cairns, Nigel J ^a   Jenner, Andrew ^a   Jenner, Peter ^a   Halliwell, Barry ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; DNA oxidized bases; Lipid peroxidation; Oxidative stress; Protein carbonyls

Indexed keywords

CARBONYL DERIVATIVE; DNA BASE; LIPID; PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MALE; MASS SPECTROMETRY; NERVE CELL DEGENERATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TEMPORAL LOBE;

EID: 0030898724     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68052061.x     Document Type: Article

References (43)

1. Balázs L. and Leon M. (1994) Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem. Res. 19, 1131-1137.
2. Behl C., Davis J., Cole G. M., and Schubert D. (1992) Vitamin E protects nerve cells from β-amyloid protein toxicity. Biochem. Biophys. Res. Commun. 186, 944-950.
3. Braak H. and Braak E. (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82, 239-259.
4. Chirico S., Smith C., Marchant C., Mitchinson M. J., and Halliwell B. (1993) Lipid peroxidation in hyperlipidemic patients. A study of plasma using an HPLC-based thiobarbituric acid test. Free Radic. Res. Commun. 19, 51-57.
5. Connor J. R., Menzies S. L., St-Martin S. M., and Mufson E. J. (1992) A histochemical study of iron, transferrin and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31, 75-83.
6. Cruz-Sanchez F. F., Ravid R., and Cuzner M. L., eds (1995) Biomedical and Health Research, Vol. 10: Neuropathological Diagnostic Criteria for Brain Banking. IOS Press, Oxford.
7. Davies C. A., Mann D. M. A., Sumpter P. Q., and Yates P. O. (1987) A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with AD. J. Neurol. Sci. 78, 151-164.
8. DeKosky S. T. and Scheff S. W. (1990) Synapse loss in frontal cortex biopsies in AD: correlation with cognitive severity. Ann. Neurol. 27, 457-464.
9. Dizdaroglu M. (1994) Chemical determination of oxidative DNA damage by GC-MS. Methods Enzymol. 234, 3-16.
10. Friedlich A. L. and Butcher L. L. (1993) Involvement of free oxygen radicals in β-amyloidosis: an hypothesis. Neurobiol. Aging 15, 443-455.
11. Frolich L. and Riederer P. (1995) Free radical mechanisms in dementia of Alzheimer type and the potential for anti-oxidative treatment. Arzneimittelforschung Drug Res. 45, 443-446.
12. Good P. F., Perl D. P., Bierer L. M., and Schmeidler J. (1992) Selective accumulation of aluminium and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Ann. Neurol. 31, 286-292.
13. Gotz M. E., Kunig G., Riederer P., and Youdim M. B. H. (1994) Oxidative stress: free radical production in neuronal degeneration. Pharmacol. Ther. 63, 37-122.
14. Gsell W., Conrad R., Hickethier M., Sofic E., Frölich L., Wichart I., Jellinger K., Moll G., Ransmayr G., Beckmann H., and Riederer P. (1995) Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J. Neurochem. 64, 1216-1223.
15. Halliwell B. (1992a) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
16. Halliwell B. (1992b) Oxygen radicals as key mediators in neurological disease: fact or fiction? Ann Neurol. 32 (Suppl.), S10-S15.
17. Halliwell B. (1996) Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic. Res. 25, 57-74.
18. Halliwell B. and Dizdaroglu M. (1992) The measurement of oxidative damage to DNA by HPLC and GC/MS techniques. Free Radic. Res. Commun. 16, 75-87.
19. Hardy J. and Allsop D. (1991) Amyloid deposition as the central event in the aetiology of AD. Trends Neurosci. 12, 383-385.
20. Harman D. (1993) Free radical theory of aging: a hypothesis on pathogenesis of senile dementia of the Alzheimer's type. Age 16, 23-30.
21. Hayn M., Kremser K., Singewald N., Cairns N., Nemethova M., Lubec B., and Lubec G. (1996) Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down's syndrome and Alzheimer's disease. Life Sci. 59, 537-544.
22. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S. P., Wu J. F., Carney J. M., Lovell M., Markesbury W. R., and Butterfield D. A. (1995) Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65, 2146-2156.
23. Hermes-Lima M., Willmore W. G., and Storey K. B. (1995) Quantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation. Free Radic. Biol. Med. 19, 271-280.
24. Jenner P. (1994) Oxidative damage in neurodegenerative disease. Lancet 344, 796-798.
25. Lovell M. A., Ehmann W. D., Butler S. M., and Markesbury W. R. (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45, 1594-1601.
26. Lyras L., Evans P. J., Shaw P. J., Ince P. G., and Halliwell B. (1996) Oxidative damage and motor neurone disease. Difficulties in the measurement of protein carbonyls in human brain tissue. Free Radic. Res. 24, 397-406.
27. Martins R. N., Harper C. G., Stokes G. B., and Masters C. L. (1986) Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress. J. Neurochem. 46, 1042-1045.
28. Mecocci P., MacGarvey U., and Beal M. F. (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747-751.
29. Mirra S.S., Heyman A., McKeel D., Sumi S. M., Crain B. J., Brownlee L. M., Vogel F. S., Hughes J. P., vanBelle G., and Berg L. (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 41, 479-486.
30. Nixon R. A. and Cataldo A. M. (1994) Free radicals, proteolysis and the degeneration of neurons in Alzheimer disease: how essential is the β-amyloid link? Neurobiol. Aging 15, 463-469.
31. Olanow C. W. (1993) A radical hypothesis for neurodegeneration. Trends Neurosci. 16, 439-444.
32. Palmer A. M. and Burns M. A. (1994) Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease. Brain Res. 645, 338-342.
33. Pearson R. C. A., Esiri M. M., Hiorns R. W., Wilcock G. K., and Powell T. P. S. (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in AD. Proc. Natl. Acad. Sci. USA 82, 1-4.
34. Ravanat J. L., Turesky R. J., Gremaud E., Trudel L. J., and Stadler R. H. (1995) Determination of 8-oxyguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: overestimation of the background level of the oxidised base by the gas chromatography-mass spectrometry assay. Chem. Res. Toxicol. 8, 1039-1045.
35. Reznick A. Z. and Packer L. (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 223, 357-363.
36. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A., and Markesbury W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Sci. USA 88, 10540-10543.
37. Smith M. A., Sayre L. M., Anderson V. E., Beal M. F., Kowall N., Richey P. L., and Perry G. (1996) Oxidative damage in Alzheimer's. Nature 382, 120-121.
38. Spencer J. P. E., Jenner A., Aruoma O. I., Evans P. J., Kaur H., Dexter D. T., Jenner J., Lees A. J., Marsden D. C., and Halliwell B. (1994) Intense oxidative damage promoted by L-DOPA and its metabolites. Implications for neurodegenerative disease. FEBS Lett. 353, 246-250.
39. Spencer J. P. E., Wong J., Jenner A., Aruoma O. I., Cross C. E., and Halliwell B. (1996) Base modification and strand breakage in isolated calf thymus DNA and in DNA from human epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine. Chem. Res. Toxicol. 19, 1152-1158.
40. Subbarao K. V., Richardson J. S., and Ang L. C. (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J. Neurochem. 55, 342-345.
41. Thierry D., Thierry D., Bianchinni F., and Cadet J. (1996) Observation and prevention of an artefactual formation of oxidized DNA bases and nucleosides in the GC-EIMS method. Carcinogenesis 17, 347-353.
42. Tierney M. C., Fisher R. H., Lewis A. J., Zorgitto M. L., Snow W. G., Reid D. W., and Nieuwstraten P. (1988) The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease. Neurology 38, 359-364.
43. Volicer L. and Crino P. B. (1990) Involvement of free radicals in dementia of the Alzheimer type: a hypothesis. Neurobiol. Aging 11, 567-571.