Advanced glycation endproducts in ageing and Alzheimer's disease

Brain Research Reviews

Volumn 23, Issue 1-2, 1997, Pages 134-143

  Münch, Gerald ^a   Thome, Johannes ^b   Foley, Paul ^b   Schinzel, Reinhard ^a   Riederer, Peter ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Clinical Neurochemistry   (Germany)

Author keywords

advanced glycation end product; Alzheimer's disease; neurodegeneration; neurotoxicity; oxidative stress; plaque; tangle

Indexed keywords

AGING; ALZHEIMER DISEASE; GLYCATION; HUMAN; HUMAN TISSUE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

AGING; ALZHEIMER DISEASE; ANIMALS; CARDIOVASCULAR DISEASES; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS;

EID: 0343554069     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(96)00016-1     Document Type: Review

References (78)

1. Araki, N., Higashi, T. Mori, T., Shibayama, R., Kawabe, Y., Kodama, T., Takahashi, K., Shichiri, M. and Horiuchi, S., Macrophage scavenge receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction, Eur. J. Biochem., 230 (1995) 408-415.
2. Braak, H. and Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes, Neurobiol. Aging, 16 (1995) 271-278.
3. Braak, E., Braak, H. and Mandelkow, E.M., A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads, Acta Neuropathol., 87 (1994) 554-567.
4. Brownlee, M., Advanced protein glycosylation in diabetes and aging, Annu. Rev. Med., 46 (1995) 223-234.
5. Buccala, R. and Cerami, A., Advanced glycosylation: chemistry, biology, and implications for diabetes and aging, Adv. Pharmacol., 23 (1992) 1-34.
6. Cameron, N.E. and Cotter, M.A., Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: evidence from experimental studies, Diabetes Med., 10 (1993) 593-605.
7. Carnegie, P.R., Ilic, M.Z., Etheridge, M.O. and Collins, M.G., Improved high performance liquid chromatograph method for analysis of histidine dipeptides anserine, carnosine and balenin present in fresh meat, J. Chromatogr., 211 (1983) 153-157.
8. Chun, M. R. and Mayeux, R., Alzheimer's disease, Curr. Opin. Neurol., 1 (1994) 299-304.
9. Connor, J.R., Tucker, P., Johnson, M. and Snyder, B., Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease, Neurosci. Lett., 159 (1994) 88-90.
10. Cras, P., Smith, M.A., Richey, P.L., Siedlak, S.L., Mulvihill, P. and Perry, G., Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease, Acta Neuropathol., 89 (1995) 291-295.
11. Christie, R.H., Freeman, M. and Hyman, B.T., Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease, Am. J. Pathol., 148 (1996) 399-403.
12. Czech, C., Förstl, H., Hentschel, F., Monning, U., Besthorn, C., Geiger-Kabisch, C., Sattel, H., Masters, C. and Beyreuther K, Apolipoprotein ∈-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change, Eur. Arch. Psychiatry Clin. Neurosci., 243 (1995) 291-292.
13. Dierks, T., Maurer, K. and Ihl, R., Influence of tenilsetam on AEP-300 in Alzheimer's disease, J. Neural Transm., [P-D-Sect] 1 (1989) 49.
14. Eckert, A., Förstl, H., Hartmann, H., Czech, C., Monning, U., Beyreuther, K. and Müller, W.E., The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease, NeuroReport, 6 (1995) 1199-1202.
15. Finot, P.A. and Furniss, D.E., Metabolic transit and toxicity of Maillard reaction products, Prog. Clin. Biol. Res., 304 (1989) 343-358.
16. Friedlander, M.A., Wu, Y.C., Schulak, J.A., Monnier, V.M. and Hricik, D.E., Influence of dialysis modality on plasma and tissue concentrations of pentosidine in patients with end-stage renal disease, Am. J. Kidney. Dis., 25 (1995) 445-451.
17. Götz, M.E., Künig, G., Riederer, P. and Youdim, M.B., Oxidative stress: free radical production in neural degeneration, Pharmacol. Ther., 63 (1994) 37-122.
18. Guzdek, A. and Stalinska, K, Glycated proteins as inducers of acute phase cytokines, Fol. Histochem. Cytobiol., 30 (1992) 167-169.
19. Hammes, H.P., Brownlee, M., Edelstein, D., Saleck, M., Martin, S. and Federlin, K, Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat, Diabetologia, 37 (1994) 32-35.
20. Harrington, C.R. and Colaco, C.A., Alzheimer's disease. A glycation connection, Nature, 370 (1994) 247-248.
21. Hipkiss, A.R., Michaelis, J., Syrris, P., Kumar, S. and Lam, Y., Carnosine protects proteins against in vitro glycation and cross-linking, Biochem. Soc. Trans., 2 (1994) 399.
22. Hipkiss, A.R., Michaelis, J. and Syrris, P., Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent, FEBS Lett., 371 (1995) 81-85.
23. Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J.X., Nagashima, M., Lundh, E.R., Vijay S, Nitecki, D. and Stern, D.; The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system, J. Biol. Chem., 270 (1995) 25752-25761.
24. Hoyer, S., Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity, Life Sci., 55 (1994) 1977-1983.
25. Hoyer, S., Age-related changes in cerebral oxidative metabolism. Implications for drug therapy, Drugs Aging, 6 (1995) 210-218
26. Hüll, M., Strauss, S., Volk, B., Berger, M. and Bauer, J., Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients, Acta Neuropathol., 89 (1995) 544-551.
27. Ihl, R., Perisic, I., Maurer, K. and Dierks, T., Effect of 3 months treatment with tenilsetam in patients suffering from dementia of Alzheimer type (DAT), J. Neural Transm., [P-D Sect] 1 (1989) 84-85.
28. Johnson, P. and Hammer, J.L., Histidine dipeptide levels in ageing and hypertensive rat skeletal and cardiac muscles, Comp. Biochem. Physiol., [B] 103 (1992) 981-984.
29. Kimura, T., Takamatsu, J and Araki, K., Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease? NeuroReport, 6 (1995) 866-868.
30. Kimura, T., Takamatzsu, J., Ikeda, K., Kondo, A., Miyakawa, T. and Horiuchi, S., Accumulation of advanced glycation end products of the maillard reaction with age in human hippocampal neurons, Neurosci. Lett., 208 (1996) 53-56.
31. Kurz, A., Lautenschläger, N., Haupt, M., Zimmer, R., von Thulen, B., Altland, K., Lauter, H. and Müller, U., Das Apolipoprotein E-∈4-Allel ist ein Risikofaktor für die Alzheimer-Krankheit mit frühem und spätem Beginn, Nervenarzt, 65 (1994) 774-779
32. Lambert, M.P., Stevens, G., Sabo, S., Barber, K., Wang, G., Wade, W., Krafft, G., Snyder, S., Holzman, T.F. and Klein, W.L., Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells, J. Neurosci. Res., 39 (1994) 377-385.
33. Ledesma, M.D., Bonay, P. and Avila, J., T protein from Alzheimer's disease patients is glycated at its tubulin-binding domain, J. Neurochem., 65 (1995) 1658-1664.
34. Li J.J., Voisin, D., Quiquerez, A.L. and Bouras C., Differential expression of advanced glycation end-products in neurons of different species, Brain Res., 641 (1994) 285-288.
35. Li, J.J., Surini, M., Catsicas, S., Kawashima, E. and Bouras, C., Age-dependent accumulation of advanced glycosylation end products in human neurons, Neurobiol. Aging 16 (1995) 69-76.
36. Mandelkow, E.M., Schweers, O., Drewes, G., Biernat, J., Gustke, N., Trinczek, B. and Mandelkow, E., Structure, microtubule interactions, and phosphorylation of τ protein, Ann. NY Acad. Sci., 777 (1996) 96-106.
37. Mannion, A.F., Jakeman, P.M., Dummett, M., Harris, R.C. and William, P.L. (1992) Carnosine and anserine concentrations in the quadriceps muscle of healthy humans, Eur. J. Appl. Physiol., 64 (1992) 47-50.
38. McFarland, G.M. and Holliday, R., Retardation of the senescence of cultured human diploid fibroblasts by carnosine, Exp. Cell Res., 212 (1994) 167-175.
39. McGeer, P.L., Rogers, J. and McGeer, E.G., Neuroimmune mechanisms in Alzheimer disease pathogenesis, Alzheimer Dis. Assoc. Disord., 8 (1994) 149-158.
40. McGeer, P.L., Walker, D.G., Akiyama, H., Yasuhara, O. and McGeer, E.G., Involvement of microglia in Alzheimer's disease, Neuropathol. Appl. Neurobiol, 20 (1994) 191-192.
41. McMillian, M., Kong, L.Y., Sawin, S.M., Wilson, B., Das, K., Hudson, P., Hong, J.S. and Bing, G., Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures, Biochem. Biophys. Res. Commun., 215 (1995) 572-577.
42. Monnier, V.M., Towards a Maillard reaction theory of aging, Prog. Clin. Biol. Res., 304 (1989) 1-22.
43. Monnier, V.M. and Cerami, A., Nonenzymatic browning in vivo: possible process for aging of long-lived proteins, Science, 211 (1981) 491-493.
44. Munch, G., Taneli, Y., Schraven, E., Schindler, U., Schinzel, R., Palm, D. and Riederer, P., The cognition-enhancing drug Tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation, J. Neural Transm., [P-D-Sect] 8 (1994) 193-208.
45. Münch, G., Mayer, S., Michaelis, J., Hipkiss, A.R., Schinzel, R., Riederer, P. and Cunningham, A.M., Influence of advanced glycosylation endproducts and AGE-inhibit ors on nucleation-dependent polymerization of β-amyloid peptide, Biochem. Biophys. Acta, (1996) in press.
46. Mullarkey, C.J., Edelstein, D. and Brownlee, M., Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes, Biochem. Biophys. Res. Commun., 173 (1990) 932-939.
47. Namiki, M., Chemistry of Maillard reactions: recent studies on the browning reaction mechanism and the development of antioxidants and mutagens, Adv. Food Res., 32 (1988) 115-184.
48. Nagaraj, R.H. and Monnier, V.M., Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose, Biochim. Biophys. Acta, 1116 (1992) 34-42
49. Nagaraj, R.H, Kern, T.S., Sell, D.R., Fogarty, J., Engerman, R.L. and Monnier, V.M., Evidence for a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen, Diabetes, 45 (1996) 587-594.
50. Novak, M., Kabat, J. and Wischik, C. M., Molecular characterization of the minimal protease resistant τ unit of the Alzheimer's disease paired helical filament, EMBO J., 12 (1993) 365-370
51. O'Dowd, J.J., Cairns, M.T., Trainor, M., Robins, D.J. and Miller, D.J., Analysis of carnosine, homocarnosine, and other histidyl derivatives in rat brain, J. Neurochem., 55 (1990) 446-452.
52. Palinski, W., Koschinsky, T., Butler, S.W., Miller, E., Vlassara, H., Cerami, A. and Witztum, J.L., Immunological evidence for the presence of advanced glycosylation end products in atherosclerotic lesions of euglycemic rabbits, Arterioscler. Thromb. Vasc. Biol., 15 (1995) 571-582
53. Papanastasiou, P., Grass, L., Rodela, H., Patrikarea, A., Oreopoulos, D. and Diamandis, E.P., Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD, Kidney Int., 46 (1994) 216-222.
54. Price, D.L. and Sisodia, S.S., Cellular and molecular biology of Alzheimer's disease and animal models, Annu. Rev. Med., 45 (1994) 435-446.
55. Quinn, P.J., Boldyrev, A.A. and Formazuyk, V.E., Carnosine: its properties, function and potential therapeutic applications, Mol. Aspects Med., 13 (1992) 379-444.
56. Shaw, S.M. and Crabbe, M.J., Characterisation of a putative scavenger receptor for advanced glycosylation end-products, Biochem. Soc. Trans., 22 (1994) 82S.
57. Schmidt, A.M., Yan, S.D., Brett, J., Mora, R., Nowygrod, R. and Stern D., Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products, J. Clin. Invest., 91 (1993) 2155-2168.
58. Schmidt, A.M., Hori, O., Brett, J., Yan, S.D., Wautier, J.L. and Stern, D., Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions, Arterioscler. Thromb., 14 (1994) 1521-1528.
59. Schmidt, A.M., Hori, O., Chen, J.X., Li, J.F., Crandall, J., Zhang, J., Cao, R., Yan, S.D., Brett, J and Stern, D., Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes, J. Clin. Invest., 96 (1995) 1395-1403.
60. Schweers, O., Mandelkow, E. M., Biernat, J. and Mandelkow, E., Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein T controls the in vitro assembly of paired helical filaments, Proc. Natl. Acad. Sci. USA, 92 (1995) 8463-8467.
61. Sebetkova, K., Ling, H., Schinzel, R., Simm, A., Vamvakas, S., Schenk, O., Münch, G., and Heidland, A., Advanced glycation endproducts (AGEs) impair protein degradation in LLC-PK1 cells, (1996) (submitted).
62. Smith, M.A. and Perry, G., Alzheimer disease: an imbalance of proteolytic regulation? Med. Hypotheses, 42 (1994) 277-279.
63. Smith, M.A., Taneda, S., Richey, P.L., Miyata, S., Yan, S,D., Stern, D., Sayre, L,M., Monnier, V.M. and Perry G., Advanced Maillard reaction end products are associated with Alzheimer disase pathology, Proc. Natl. Acad. Sci. USA, 91 (1994) 5710-5714.
64. Smith, M.A., Sayre, L.M., Monnier, V.M. and Perry, G., Radical AGEing in Alzheimer's disease, Trends Neurosci., 18 (1995) 172-176.
65. Suarez, G., Etlinger, J.D., Maturana, J. and Weitman, D., Fructated protein is more resistant to ATP-dependent proteolysis than glucated protein possibly as a result of higher content of Maillard fluorophores, Arch. Biochem. Biophys., 321 (1995) 209-213.
66. Thome, J., Kornhuber, J., Munch, G., Schinzel, R., Taneli, Y., Zielke, B., Rösler, M. and Riederer, P., Eine neue Hypothese zur Ätiopathogenese des Alzheimer-Syndroms: advanced glycation end-products (AGEs), Nervenarzt, (1996) (in press).
67. Thome, J., Münch, G., Müller, R., Schinzel, R., Kornhuber, J., Blum-Degen, D., Sitzmann, L., Rösler, M., Heidland, A. and Riederer, P., Advanced glycosylation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's syndrome, Life Sci., (1996) in press.
68. Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K. and Cerami, A., Advanced glycation end products contribute to amyloidosis in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91 (1994) 4766-4770.
69. Vlassara, H., Brownlee, M. and Cerami, A., Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors, J. Exp. Med., 164 (1986) 1301-1309.
70. Vlassara, H., Brownlee, M., Manogue, K., Dinarello, C. and Pasagian, A., Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling, Science, 240 (1988) 1546.
71. Vlassara, H., Serum advanced glycosylation end products: a new class of uremic toxins? Blood Purif., 12 (1994) 54-59.
72. Vlassara, H., Li, Y.M., Imani, F., Wojciechowicz, D., Yang, Z., Liu, F.T. and Cerami, A., Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex, Mol. Med., 1 (1995) 634-646.
73. Walker, D.G. and McGeer, P.L., Complement gene expression in human brain: comparison between normal and Alzheimer's disease cases, Mol. Brain Res., 14 (1992) 109-116.
74. Wautier, J.L., Wautier, M.P., Schmidt, A.M., Anderson, G.M., Hori, O., Zoukourian, C., Capron, L., Chappey, O., Yan, S.D. and Brett, J., Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications, Proc. Natl. Acad. Sci. USA, 91 (1994) 7742-7746.
75. Wells-Knecht, K.J., Zyzak, D.V, Litchfield, J.E., Thorpe, S.R. and Baynes, J.W., Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose, Biochemistry, 34 (1995) 3702-3709.
76. Wells-Knecht, M.C., Thorpe, S.R. and Baynes, J.W., Pathways of formation of glycoxidation products during glycation of collagen, Biochemistry, 34 (1995) 15134-15141.
77. Yan, S.D., Yan, S.F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A., Perry, G., Godman, G.C., Nawroth, P. and Stern, D., Non-enzymatically glycated τ in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide, Nature Med., 1 (1995) 693-699.
78. Yen, S.H., Liu, W.K., Hall, F.L., Yan, S.D., Stern, D. and Dickson, D.W., Alzheimer neurofibrillary lesions: molecular nature and potential roles of different components, Neurobiol. Aging, 16 (1995) 381-387.