Aberrant expression of bcl-2 gene family in Down's syndrome brains

Molecular Brain Research

Volumn 48, Issue 1, 1997, Pages 53-59

  Sawa, Akira ^a   Oyama, Fumitaka ^b   Cairns, Nigel J ^c   Amano, Naoji ^a   Matsushita, Masaaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Apoptosis; Bax; Bcl 2; Bcl x; Down's syndrome

Indexed keywords

PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BRAIN; CELL LOSS; CONTROLLED STUDY; DOWN SYNDROME; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MULTIGENE FAMILY; NERVE DEGENERATION; PRIORITY JOURNAL; TEMPORAL LOBE;

AMYLOID BETA-PROTEIN PRECURSOR; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BRAIN; DNA PRIMERS; DOWN SYNDROME; GENES, BCL-2; HUMANS; MULTIGENE FAMILY; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TEMPORAL LOBE;

EID: 0030811487     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00078-8     Document Type: Article

References (49)

1. Bargou, R.C., Daniel, P.T., Mapara, M.Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H.D. and Dorken, B., Expression of the bcl-2 gene family in normal and malignant breast tissue. Low bax-α expression in tumor cells correlates with resistance towards apoptosis, Int. J. Cancer, 60 (1995) 854-859.
2. Boise, L.H., Ginzakez-Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunez, G. and Thompson, C.B., Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death, Cell, 74 (1993) 597-608.
3. Burger, C.P. and Vogel, F.S., The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome, Am. J. Pathol., 73 (1973) 457-456.
4. Busciglio, J. and Yankner, B.A., Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vivo, Nature, 378 (1995) 776-779.
5. Chartier-Harlin, M.C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J. and Mullan, M., Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene, Nature, 353 (1991) 844-846.
6. Choi, D.W., Koh, J., Wie, M.B., Gwag, B.J., Lobner, D., Canzoniero, L.M.T., Sensi, S.L., Oh, Y.J. and O'Malley, K.L., Bcl-2 transfection protects MN9D cells against β-amyloid toxicity and glucose deprivation, but not several other insults, Soc. Neurosci. Abstr., 604 (1994).
7. Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162 (1987) 156-159.
8. Cribbs, D.H., Martinou, I.C., Knowles, I.K. and Cotman, C.W., β-Amyloid induced neurotoxicity is blocked by overexpression of bcl-2 in transgenic mice, Soc. Neurosci. Abstr., 604 (1994).
9. Dragunow, M., Faull, R.L.M., Lawlor, P., Beiharz, E.J., Singleton, K., Walker, E.B. and Mee, E., In situ evidence for DNA fragmentation in Huntington's dissease striatum and Alzheimer's disease temporal lobes, NeuroReport, 6 (1995) 1053-1057.
10. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B. and Zhao, J., Alzheimer-type neuropathology in trasgenic mice overexpressing V717F β-amyloid precursor protein, Nature, 373 (1995) 523-527.
11. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W. and Schulte-Hermann R., In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note, Hepatology, 21 (1995) 1465-1468.
12. Hockenbery, D.M., Oltvai, Z.M., Yin, X-M., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75 (1993) 241-251.
13. Howland, D.S., Savage, M., Huntress, F.A., Wallace, R.E., Schwartz, D.A., Loh, T., Melloni, R.H., Degennaro, L.J., Greenberg, B.D., Siman, R., Swanson, M.E. and Scott, R.W., Mutant and native human β-amyloid precursor proteins in transgenic mouse brain, Neurobiol. Aging, 16 (1995) 685-699.
14. Hsiao, K.K., Borchelt, D.R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, S., Xu, S., Eckman, C., Younkin, S., Price, D., Ladecola, C., Brent Clark, H. and Carlson, G., Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins, Neuron, 15 (1995) 1203-1218.
15. Kane, D.C., Sarafian, T.A., Anton, R., Hahn, H., Gralla, E.B., Valentine, J.S., Ord, T. and Bredesen, D.E., Bcl-2 inhibition of neural death. Decreased generation of reactive oxygen species, Science, 262 (1993) 1274-1277.
16. Korsmeyer, S.J., Regulators of cell death, Trends Genet., 11 (1995) 101-105.
17. Krajewski, S., Krajewska, M., Shabaik, A., Miyashita, T., Wang, H.G. and Reed, J.C., Immunohistochemical determination of in vivo distribution of bax, a dominant inhibitor of bcl-2, Am. J. Pathol., 145 (1994) 1323-1336.
18. Krajewski, S., Krajewska, M., Shabaik, A., Wang, H-G., Irie, W., Fong, L. and Reed, J.C., Immunohistochemical analysis of in vivo patterns of bcl-x expression, Cancer Res., 54 (1994) 5501-5507.
19. Krajewski, S., Mai, J.K., Krajewska, M., Sikorska, M., Mossakowski, M.J. and Reed, J.C., Upregulation of bax protein levels in neruons following cerebral ischemia, J. Neurosci., 15 (1995) 6364-6376.
20. Laferla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C. and Jay, G., The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice, Nature Genet., 9 (1995) 21-29.
21. Lai, F. and Williams, R.S., A prospective study of Alzheimer disease in Down syndrome, Arch. Neurol., 46 (1989) 849-853.
22. Lassman, H., Bancher, C., Breitschopf, H., Wegiel, J., Bobinski, M., Jellinger, K. and Wisniewski, H.M., Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ, Acta Neuropathol., 89 (1995) 35-41.
23. Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J. and Cotman, C.W., Apoptosis is induced by β-amyloid in cultured central nervous system neurons, Proc. Natl. Acad. Sci. USA, 90 (1993) 7951-7955.
24. Mann, D.M.A., The pathological association between Down syndrome and Alzheimer disease, Mech. Aging Dev., 43 (1988) 99-136.
25. Mann, D.M.A. and Esiri, M.M., The site of the earliest lesions of Alzheimer's disease, N. Engl. J. Med., 318 (1988) 789-790.
26. Mann, D.M.A., Marcyniuk, B., Yates, P.O., Neary, D. and Snowden, J.S., The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy, Neuropathol. Appl. Neurobiol., 14 (1988) 177-196.
27. Martinou, J-C., Dubois-Dauphin, M., Staple, J.K., Rodriguez, I., Frankowski, H., Missotten M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C. and Huarte, J., Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia, Neuron, 13 (1994) 1017-1030.
28. Maruyama, K., Ikeda, S. and Yanagisawa, S., Correlative study of the brain CT and clinical features of patients with Down's syndrome in three clinical stages of Alzheimer type dementia, Clin. Neurol., 35 (1995) 775-780.
29. Miyashita, T., Krajewski, S., Krajewska M., Wang, H.G., Lin, H.K., Liebermann, D.A., Hoffman, B. and Reed, J.C., Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo, Oncogene, 9 (1994) 1799-1805.
30. Miyashita, T. and Reed, J.C., Tumor suppressor p53 is a direct transcriptional activator of the human bax gene, Cell, 80 (1995) 293-299.
31. Motoyama, N., Wang, F., Roth, K.A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S. and Loh D.Y., Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice, Science, 267 (1995) 1506-1510.
32. O'Barr, S., Schultz, J. and Rogers, J., Expressions of the protooncogene bcl-2 in Alzheimer's disease brain, Neurobiol. Aging, 17 (1996) 131-136.
33. Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 Heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death, Cell, 74 (1993) 609-619.
34. Oyama, F., Cairns, N.J., Shimada, H., Oyama, R., Titani, K. and Ihara, Y., Down's syndrome: upregulation of β-amyloid prtein precursor and tau mRNAs and their defective coordination, J. Neurochem., 62 (1994) 1062-1066.
35. Satou, T., Cummings, B.J. and Cotman, C.W., Immunoreactivity for bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity, Brain Res., 697 (1995) 35-43.
36. Sedlak, T.W., Oltvai, Z.N., Yang, E., Wang, K., Boise, L.H., Thompson, C.B. and Korsmeyer, S.J., Multiple bcl-2 family members demonstrate selective dimerizations with bax, Proc. Natl. Acad. Sci. USA, 92 (1995) 7834-7838.
37. Su, J.H., Anderson, A.J., Commings, B.J. and Cotman, C.W., Immunohistochemical evidence for apoptosis in Alzheimer's disease, NeuroReport, 5 (1994) 2529-2533.
38. Su, J.H., Satou, T., Anderson, A.J. and Cotman, C.W., Up-regulation of bcl-2 is associated with neuronal DNA damage in Alzheimer's disease, NeuroReport, 7 (1996) 437-440.
39. Tanzi, R.E., McClatchey, A.I., Lampperti, E.D., Villa-Komaroff, L., Gusella, J.F. and Neve, R.L., Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease, Nature, 331 (1988) 528-530.
40. Tilly, J.L., Tilly, K.I., Kenton, M.L. and Johnson, A.L., Expression of members of the bcl-2 gene family in the immature rat ovary. Equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong Messener ribonucleic acid levels, Endocrinology, 136 (1995) 232-241.
41. Tsujimoto, Y., Cossman, J., Jette, E. and Croce, C.M., Involvement of the bcl-2 gene in human follicular lymphoma, Science, 228 (1985) 1440-1443.
42. Tsujimoto, Y. and Croce, C.M., Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma, Proc. Natl. Acad. Sci. USA, 83 (1986) 5214-5218.
43. Vaux, D.L., Cory, S. and Adams, J.M., Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells, Nature, 335 (1988) 440-442.
44. Vyas, S., Strada, O., Hebner, Y., Agid, Y. and Javoyagid, F., Expression of bcl-2 oncogene in the human brain postmortem, Soc. Neurosci. Abstr., 685 (1995).
45. Yamatsuji, T., Matsui, T., Okamoto, T., Komatsuzaki, K., Takeda, S., Fukumoto, H., Iwatsubo, K., Suzuki, N., Asami-Odaka, A., Ireland, S., Kinane, T.B., Giambarella, U. and Nishimoto I., G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease associated mutants of APP, Science, 272 (1996) 1349-1352.
46. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B. and Korsmeyer, S.J., Bad, a heterodimeric partner for bcl-xL and bcl-2 displaces bax and promotes cell death, Cell, 80 (1995) 285-291.
47. Yankner, B.A., Dawes, L.R., Fisher, S., Villa-Komanof, L., Oster-Granite, M.L. and Neve, R.L., Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease, Science, 245 (1989) 417-420.
48. Yin, X- M., Oltvai, Z.N. and Korsmeyer, S.J., BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax, Nature, 369 (1994) 321-323.
49. Yoshikawa, K., Aizawa, T. and Hayashi, Y., Degeneration in vivo of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor, Nature, 359 (1992) 64-67.