The Alzheimer's disease-associated Presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

Molecular Medicine

Volumn 2, Issue 6, 1996, Pages 673-691

  Walter, Jochen ^a   Capell, Anja ^a   Grünberg, Jürgen ^a   Pesold, Brigitte ^a   Schindzielorz, Alice ^a   Prior, Reinhard ^b   Podlisny, Marcia B ^c   Fraser, Paul ^d,e   Hyslop, Peter St George ^d,e   Selkoe, Dennis J ^c   Haass, Christian ^a,f  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f Ctrl Institute of Mental Health J5   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; PRESENILIN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; GENE MUTATION; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENILE PLAQUE;

EID: 8044231311     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401652     Document Type: Article

References (50)

1. Selkoe DJ. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17: 489-517.
2. Cummings BJ, Cotman CW. (1995) Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet 346: 1524-1528.
3. Kang J, Lemaire H-G, Unterbeck A, et al. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736.
4. Price DL, Sisodia SS, Gandy SE. ( 1995) Amyloid β amyloidosis in Alzheimer's disease. Curr. Opin. Neurol. 8: 268-274.
5. Goate A, Chartier-Harlin MC, Mullan M, et al. (1991) Segregation of a missense mutation in the amyloid precursor gene with familial Alzheimer's disease. Nature 349: 704-706.
6. Schellenberg GD, Bird TD, Wijsman E, et al. (1992) Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science 3: 1-4.
7. St. George-Hyslop P, Haines J, Rogaev E, et al. (1992) Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat. Genet. 2: 330-334.
8. van Broeckhoven C, Backhovens H, Cruts M, et al. (1992) Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat. Genet. 2: 335-339.
9. Levy-Lahad E, Wijsman EM, Nemens E, et al. (1995) A familial Alzheimer's disease locus on chromosome I. Science 269: 970-973.
10. Strittmatter WJ, Roses AD. (1995) Apolipoprotein E and Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 92: 4725-4727.
11. Mullan M, Crawford F. (1993) Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16: 398-414.
12. Haass C, Selkoe DJ. (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75: 1039-1042.
13. Citron M, Oltersdorf T, Haass C, et al. (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360: 672-674.
14. Cai XD, Golde TE, Younkin SG. (1993) Release of excess amyloid βprotein from a mutant amyloid βprotein precursor. Science 259: 514-516.
15. Haass C, Hung AY, Selkoe DJ, Teplow DB. (1994) Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J. Biol. Chem. 269: 17741-17748.
16. 717) mutants. Science 264: 1336-1340.
17. Sherrington R, Rogaev EI, Liang Y, et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375: 754-760.
18. Levy-Lahad E, Wasco W, Poorkaj P, et al. (1995) Candidate gene tor the chromosome I familial Alzheimer's disease locus. Science 269: 973-977.
19. Rogaev EI, Sherrington R, Rogaeva EA, et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775-778.
20. Haass C (1996) Presenile because of presenilin: The presenilin genes and early dementia. Curr. Opin. Neurol. 9: 254-259.
21. Alzheimer's Disease Collaborative Group. (1995) The structure of the presenilin 1 (S 182) gene and identification of six novel mutations in early onset AD families. Nat. Genet. 11: 219-222.
22. Cruts M, Hendriks L, van Broeckhoven C. (1996) The presenilin genes: A new family involved in Alzheimer's disease pathology. Hum. Mol. Genet. 5: 1449-1455.
23. Cruts M, Backhovens H, Wang SY, et al. (1995) Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3. Hum. Mol. Genet. 4: 2363-2371.
24. Campion D, Flaman JM, Brice A, et al. (1995) Mutations of the presenilin 1 gene in families with early-onset Alzheimer's disease. Hum. Mol. Genet. 4: 2373-2377.
25. Wasco W, Pettingell WP, Jondro PD, et al. (1995) Familial Alzheimer's chromosome 14 mutations. Nat. Med. 1: 848.
26. Boteva K, Vitek M, Mitsuda H, et al. (1996) Mutation analysis of the presenilin 1 gene in Alzheimer's disease. Lancet 347: 130-131.
27. Perez-Tur J, Froelich S, Prihar G, et al. (1995) A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport 7: 297-301.
28. Hutton M, Busfield F, Clark R, et al. (1996) Complete analysis of the presenilin-1 gene in families with early-onset Alzheimer's disease. NeuroReport 7: 130-131.
29. Kovacs DM, Fausett HJ, Page KJ, et al. (1996) Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2: 224-229.
30. Suzuki T, Nishiyama K, Murayama S, et al. (1996) Regional and cellular presenilin 1 gene expression in human and rat tissues. Biochem. Biophys. Res. Commun. 219: 708-713.
31. L'Hernault SW, Arduengo PM. (1992) Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J. Cell Biol. 119: 55-68.
32. Levitan D, Greenwald I. (1995) Facilitation of lin-12-mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351-354.
33. Podlisny MB, Tolan DR, Selkoe DJ. (1991) Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am. J. Pathol. 138: 1423-1435.
34. Haass C, Hung AY, Selkoe DJ. (1991) Processing of β-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J. Neurosci. 11: 3783-3793.
35. Hung AY, Haass C, Nitsch RM, et al. (1993) Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J. Biol. Chem. 268: 22959-22962.
36. Boyle WJ, van der Geer P, Hunter T. (1991) Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201: 110-149.
37. Haass C, Lemere C, Capell A, et al. (1995) The Swedish mutation causes early onset Alzheimer's disease by β-secretase cleavage within the secretory pathway. Nat. Med. 1: 1291-1296.
38. Koo EH, Squazzo S. (1994) Evidence that production and release of amyloid β-protein involves the endocytic pathway. J. Biol. Chem. 269: 17386-17389.
39. Huttner WB. (1987) Proteine tyrosine sulfation. TIBS 12: 361-363.
40. Weidemann A, König G, Bunke D, et al. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57: 115-126.
41. Roche KW, Tingley WG, Huganir RL. (1994) Glutamate receptor phosphorylation and synaptic plasticity. Curr. Opin. Neurobiol. 4: 383-388.
42. Buxbaum JD, Gandy SE, Cicchetti P, et al. (1990) Processing of Alzheimer β/A4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 87: 6003-6006.
43. Bodenbach L, Fauss J, Robitzki A, et al. (1994) Recombinant human Casein Kinase II: A study with a complete set of subunits (α, α′, and β) site directed autophosphorylation mutants and a bicistronically expressed holoenzyme. Eur. J. Biochem. 220: 262-273.
44. Bonifacino JS, Cosson P, Sha N, Klausner RD. (1994) Calnexin: a membrane bound chaperone of the endoplasmic reticulum. TIBS 19: 1124-1128.
45. Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. (1992) Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258: 304-307.
46. Buxbaum JD, Koo EH, Greengard P. (1993) Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc. Natl. Acad. Sci. U.S.A. 90: 9195-9198.
47. Lorenz P, Pepperkok R, Ansorge W, Pyerin W. (1993) Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit β demonstrate participation of the kinase in mitogenic signaling. J. Biol. Chem. 268: 90-97.
48. Issinger OG. (1993) Casein kinases: Pleiotropic mediators of cellular regulation. Pharmacol. Ther. 59: 1-30.
49. Jones BG, Thomas L, Molloy SS, et al. (1995) Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. EMBO J. 14: 5869-5883.
50. Tartakoff AM, Vassali P. (1983) Lectin-binding sites as markers of Golgi subcompartments: Proximal-to-distal maturation of oligisaccharides. J. Cell Biol. 97: 1243-1248.