Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

Biochemistry

Volumn 37, Issue 8, 1998, Pages 2263-2270

  Grünberg, Jürgen ^a   Walter, Jochen ^a   Loetscher, Hansruedi ^b   Deuschle, Ulrich ^b   Jacobsen, Helmut ^b   Haass, Christian ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; PRESENILIN 1; PROTEINASE; SERINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME SUBSTRATE; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN STABILITY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL DEATH; CELL LINE; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; HUMANS; MEMBRANE PROTEINS; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0038785079     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972106l     Document Type: Article

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