Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer℉s disease model

Nature Neuroscience

Volumn 5, Issue 5, 2002, Pages 452-457

  Dodart, Jean Cosme ^a   Bales, Kelly R ^a   Gannon, Kimberley S ^a   Greene, Stephen J ^a   DeMattos, Ronald B ^b   Mathis, Chantal ^c   DeLong, Cynthia A ^a   Wu, Su ^a   Wu, Xin ^a   Holtzman, David M ^b   Paul, Steven M ^a  

^a ELI LILLY AND COMPANY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; M266; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M266; UNCLASSIFIED DRUG;

AGE; ALZHEIMER DISEASE; AMNESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; LEARNING; MALE; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN CONTENT; RECOGNITION; TASK PERFORMANCE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNIZATION, PASSIVE; IMMUNOTHERAPY; LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; RECOGNITION (PSYCHOLOGY);

EID: 0036240395     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn842     Document Type: Article

References (23)

1. Alzheimer's disease: The amyloid cascade hypothesis
2. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease
3. Alzheimer's disease: A re-examination of the amyloid hypothesis
4. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
5. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease
6. Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
7. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
8. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
9. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
10. Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
11. Behavioral disturbances in transgenic mice overexpressing the V717F β-amyloid precursor protein
12. Behavioral deficits in APPV 717F transgenic mice deficient for the apolipoprotein E gene
13. Neuroanatomical abnormalities in behaviorally characterized APPV 717F transgenic mice
14. The β-amyloid precursor protein and its derivatives: From biology to learning and memory processes
15. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease
16. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
17. Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
18. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
19. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
20. A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data
21. Scopolamine-induced deficits in a two-trial object recognition task in mice
22. Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease
23. Amyloid precursor protein processing and Aβ 42 deposition in a transgenic mouse model of Alzheimer disease