The multiple paradoxes of presenilins

Journal of Neurochemistry

Volumn 76, Issue 6, 2001, Pages 1621-1627

  Checler, F ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; PRESENILIN 1;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ENZYME ACTIVITY; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; SENILE PLAQUE; SEQUENCE HOMOLOGY; SHORT SURVEY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MUTATION; PRESENILIN-1; PRESENILIN-2;

EID: 0035103358     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00244.x     Document Type: Short Survey

References (47)

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2. Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val->Met βAPP-770 mutation responsible for probable early-onset Alzheimer's disease
3. Human presenilin-1 but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
4. Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling
5. Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
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10. The structure and function of the aspartyl proteinases
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12. Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein
13. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
14. Mice lacking both presenilin genes exhibit early embryonic patterning defects
15. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
16. Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells
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21. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
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27. Effects of PS1 deficiency on membrane protein trafficking in neurons
28. The catalytic mechanism of aspartic proteinases
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41. A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity
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44. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
45. Nicastrin modulates presenilin-mediated notch/glp1 signal transduction and βAPP processing
46. Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin1 causes increased A beta secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans
47. Presenilins are required for γ-secretase cleavage of βAPP and transmembrane cleavage of Notch