Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 11539-11544

  Schneider, Ilka ^a   Reversé, Delphine ^b   Dewachter, Ilse ^c   Ris, Laurence ^b   Caluwaerts, Nathalie ^c   Kuipér, Cuno ^c   Gilis, Martine ^c   Geerts, Hugo ^d   Kretzschmar, Hans ^a   Godaux, Emile ^b   Moechars, Dieder ^d   Van Leuven, Fred ^c,e   Herms, Jochen ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MONS   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d JANSSEN RESEARCH FOUNDATION   (Belgium)

^e CENTER FOR HUMAN GENETICS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CALCIUM; CARDIOVASCULAR SYSTEM; HEAVY IONS; PROTEINS; TOXICITY;

ENDOPLASMIC RETICULUM; TRANSGENIC MICE;

BIOCHEMISTRY;

BRADYKININ; CALCIUM; DANTROLENE; MUTANT PROTEIN; PRESENILIN 1; THAPSIGARGIN; KAINIC ACID; MEMBRANE PROTEIN; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; IN VIVO STUDY; LONG TERM POTENTIATION; MOUSE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSGENIC MOUSE; ANIMAL; DRUG EFFECT; GENETICS; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY;

ANIMALIA; MUS MUSCULUS;

ANIMALS; BRADYKININ; CALCIUM; HIPPOCAMPUS; HOMEOSTASIS; HUMANS; KAINIC ACID; LONG-TERM POTENTIATION; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PRESENILIN-1;

EID: 0035853828     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010977200     Document Type: Article

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