Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration

Progress in Retinal and Eye Research

Volumn 24, Issue 2, 2005, Pages 275-306

  Wenzel, Andreas ^a   Grimm, Christian ^a   Samardzija, Marijana ^a   Remé, Charlotte E ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE; CILIARY NEUROTROPHIC FACTOR; DNA FRAGMENT; ENDONUCLEASE; ERYTHROPOIETIN; LENS EPITHELIUM DERIVED GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEASOME; REACTIVE OXYGEN METABOLITE; RETINOID; RHODOPSIN; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; CHROMATOPHORE; HUMAN; LIGHT EXPOSURE; LYSOSOME; MITOCHONDRION; MOLECULAR MECHANICS; NEUROPROTECTION; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; RETINA DEGENERATION; RETINA DYSTROPHY; REVIEW;

ANIMALS; APOPTOSIS; HUMANS; LIGHT; PHOTORECEPTORS, VERTEBRATE; RADIATION INJURIES, EXPERIMENTAL; RADIATION PROTECTION; RETINAL DEGENERATION;

EID: 11144273817     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2004.08.002     Document Type: Review

References (255)

1. H. Abeliovich, and D.J. Klionsky Autophagy in yeast mechanistic insights and physiological function Microbiol. Mol. Biol. Rev. 65 2001 463 479 table of contents
2. C. Adrain, and S.J. Martin The mitochondrial apoptosome a killer unleashed by the cytochrome seas Trends Biochem. Sci. 26 2001 390 397
3. P. Ahuja, A.R. Caffe, I. Holmqvist, A.K. Soderpalm, D.P. Singh, T. Shinohara, and T. van Veen Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina Neuroreport 12 2001 2951 2955
4. M. Akimoto, S. Miyatake, J. Kogishi, M. Hangai, K. Okazaki, J.C. Takahashi, M. Saiki, M. Iwaki, and Y. Honda Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats Invest. Ophthalmol. Vis. Sci. 40 1999 273 279
5. S. Altairac, S.C. Wright, Y. Courtois, and A. Torriglia L-DNase II activation by the 24 kDa apoptotic protease (AP24) in TNFalpha-induced apoptosis Cell Death Differ. 10 2003 1109 1111
6. N. Alteheld, G. Roessler, M. Vobig, P. Walter, P. Troyk, M. Bak, J. Berg, D. Bradley, S. Cogan, R. Erickson, C. Kufta, D. McCreery, E. Schmidt, and V. Towle The retina implant - new approach to a visual prosthesis. A model for intracortical visual prosthesis research Biomed. Tech. (Berl) 49 2004 99 103
7. J. Ambati, A. Anand, S. Fernandez, E. Sakurai, B.C. Lynn, W.A. Kuziel, B.J. Rollins, and B.K. Ambati An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice Nat. Med. 2003 Epub 2003 Oct 1319
8. D.H. Anderson, R.F. Mullins, G.S. Hageman, and L.V. Johnson A role for local inflammation in the formation of drusen in the aging eye Am. J. Ophthalmol. 134 2002 411 431
9. M.G. Annis, J.A. Yethon, B. Leber, and D.W. Andrews There is more to life and death than mitochondria Bcl-2 proteins at the endoplasmic reticulum Biochim. Biophys. Acta 1644 2004 115 123
10. M. Barry, J.A. Heibein, M.J. Pinkoski, S.F. Lee, R.W. Moyer, D.R. Green, and R.C. Bleackley Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid Mol. Cell. Biol. 20 2000 3781 3794
11. J. Beatrice, A. Wenzel, C.E. Reme, and C. Grimm Increased light damage susceptibility at night does not correlate with RPE65 levels and rhodopsin regeneration in rats Exp. Eye Res. 76 2003 695 700
12. J. Bennett, Y. Zeng, R. Bajwa, L. Klatt, Y. Li, and A.M. Maguire Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouse Gene Ther. 5 1998 1156 1164
13. A. Bergmann, A.Y. Yang, and M. Srivastava Regulators of IAP function coming to grips with the grim reaper Curr. Opin. Cell Biol. 15 2003 717 724
14. A.C. Bird Retinal photoreceptor dystrophies LI. Edward Jackson Memorial Lecture Am. J. Ophthalmol. 119 1995 543 562
15. A.C. Bird What should a clinician know to be prepared for the advent of treatment of retinal dystrophies? Novartis Found Symp. 255 2004 85 90 discussion 90-84, 177-178
16. C. Bode, and U. Wolfrum Caspase-3 inhibitor reduces apototic photoreceptor cell death during inherited retinal degeneration in tubby mice Mol. Vis. 9 2003 144 150
17. D. Bok New insights and new approaches toward the study of age-related macular degeneration Proc. Natl. Acad. Sci. USA 99 2002 14619 14621 Epub 12002 Nov 14615
18. D. Bok, D. Yasumura, M.T. Matthes, A. Ruiz, J.L. Duncan, A.V. Chappelow, S. Zolutukhin, W. Hauswirth, and M.M. LaVail Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation Exp. Eye Res. 74 2002 719 735
19. Brouckaert, G., Kalai, M., Krysko, D.V., Saelens, X., Vercammen, D., Ndlovu, M., Haegeman, G., D'Herde, K., Vandenabeele, P., 2004. Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol. Biol. Cell 15, 1089-1100.
20. I. Budihardjo, H. Oliver, M. Lutter, X. Luo, and X. Wang Biochemical pathways of caspase activation during apoptosis Annu. Rev. Cell Dev. Biol. 15 1999 269 290
21. W. Bursch The autophagosomal-lysosomal compartment in programmed cell death Cell Death Differ. 8 2001 569 581
22. R.A. Bush, C.E. Reme, and A. Malnoe Light damage in the rat retina the effect of dietary deprivation of N-3 fatty acids on acute structural alterations Exp. Eye Res. 53 1991 741 752
23. R.A. Bush, L. Kononen, S. Machida, and P.A. Sieving The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro213His rat Invest. Ophthalmol. Vis. Sci. 41 2000 2697 2701
24. A.R. Caffe, A.K. Soderpalm, I. Holmqvist, and T. van Veen A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants Invest. Ophthalmol. Vis. Sci. 42 2001 275 282
25. P.D. Calvert, N.V. Krasnoperova, A.L. Lyubarsky, T. Isayama, M. Nicolo, B. Kosaras, G. Wong, K.S. Gannon, R.F. Margolskee, R.L. Sidman, E.N. Pugh Jr., C.L. Makino, and J. Lem Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha-subunit Proc. Natl. Acad. Sci. USA 97 2000 13913 13918
26. W. Cao, J. Tombran-Tink, R. Elias, S. Sezate, D. Mrazek, and J.F. McGinnis In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor Invest. Ophthalmol. Vis. Sci. 42 2001 1646 1652
27. R.J. Casson, J.P. Wood, J. Melena, G. Chidlow, and N.N. Osborne The effect of ischemic preconditioning on light-induced photoreceptor injury Invest. Ophthalmol. Vis. Sci. 44 2003 1348 1354
28. R.J. Casson, G. Chidlow, J.P. Wood, M. Vidal-Sanz, and N.N. Osborne The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration Invest. Ophthalmol. Vis. Sci. 45 2004 685 693
29. M. Cayouette, D. Behn, M. Sendtner, P. Lachapelle, and C. Gravel Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse J. Neurosci. 18 1998 9282 9293
30. M. Cayouette, S.B. Smith, S.P. Becerra, and C. Gravel Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations Neurobiol. Dis. 6 1999 523 532
31. G.J. Chader Animal models in research on retinal degenerations past progress and future hope Vis. Res. 42 2002 393 399
32. G.Q. Chang, Y. Hao, and F. Wong Apoptosis final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice Neuron 11 1993 595 605
33. S. Chatterjee, S.J. Berger, and N.A. Berger Poly(ADP-ribose) polymerase a guardian of the genome that facilitates DNA repair by protecting against DNA recombination Mol. Cell Biochem. 193 1999 23 30
34. E. Chaum Retinal neuroprotection by growth factors a mechanistic perspective J. Cell Biochem. 88 2003 57 75
35. J. Chen, J.G. Flannery, M.M. LaVail, R.H. Steinberg, J. Xu, and M.I. Simon bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations Proc. Natl. Acad. Sci. USA 93 1996 7042 7047
36. C.K. Chen, M.E. Burns, M. Spencer, G.A. Niemi, J. Chen, J.B. Hurley, D.A. Baylor, and M.I. Simon Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase Proc. Natl. Acad. Sci. USA 96 1999 3718 3722
37. J. Chen, M.I. Simon, M.T. Matthes, D. Yasumura, and M.M. LaVail Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness) Invest. Ophthalmol. Vis. Sci. 40 1999 2978 2982
38. A. Chiarugi Poly(ADP-ribose) polymerase killer or conspirator? The 'suicide hypothesis' revisited Trends Pharmacol. Sci. 23 2002 122 129
39. N.H. Chong, R.A. Alexander, L. Waters, K.C. Barnett, A.C. Bird, and P.J. Luthert Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration Invest. Ophthalmol. Vis. Sci. 40 1999 1298 1305
40. M.S. Cortina, W.C. Gordon, W.J. Lukiw, and N.G. Bazan Light-induced photoreceptor damage triggers DNA repair differential fate of rods and cones Adv. Exp. Med. Biol. 533 2003 229 240
41. M.S. Cortina, W.C. Gordon, W.J. Lukiw, and N.G. Bazan DNA repair in photoreceptor survival Mol. Neurobiol. 28 2003 111 122
42. J.W. Crabb, M. Miyagi, X. Gu, K. Shadrach, K.A. West, H. Sakaguchi, M. Kamei, A. Hasan, L. Yan, M.E. Rayborn, R.G. Salomon, and J.G. Hollyfield Drusen proteome analysis an approach to the etiology of age-related macular degeneration Proc. Natl. Acad. Sci. USA 2002 Epub 12002 Oct 14621
43. S.P. Cregan, V.L. Dawson, and R.S. Slack Role of AIF in caspase-dependent and caspase-independent cell death Oncogene 23 2004 2785 2796
44. M. Danciger, M.T. Matthes, D. Yasamura, N.B. Akhmedov, T. Rickabaugh, S. Gentleman, T.M. Redmond, M.M. La Vail, and D.B. Farber A QTL on distal chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors Mamm. Genome 11 2000 422 427
45. N.S. Dejneka, T.S. Rex, and J. Bennett Gene therapy and animal models for retinal disease Dev. Ophthalmol. 37 2003 188 198
46. T. Dentchev, A.H. Milam, V.M. Lee, J.Q. Trojanowski, and J.L. Dunaief Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas Mol. Vis. 9 2003 184 190
47. C.W. Distelhorst, and G.C. Shore Bcl-2 and calcium controversy beneath the surface Oncogene 23 2004 2875 2880
48. M. Donovan, and T.G. Cotter Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development Cell Death Differ. 9 2002 1220 1231
49. M. Donovan, and T.G. Cotter Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death Biochim. Biophys. Acta 1644 2004 133 147
50. M. Donovan, R.J. Carmody, and T.G. Cotter Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent J. Biol. Chem. 276 2001 23000 23008
51. F. Doonan, M. Donovan, and T.G. Cotter Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration J. Neurosci. 23 2003 5723 5731
52. H.C. Drexler, and S. Pebler Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors Cell Death Differ. 10 2003 290 301
53. C. Du, M. Fang, Y. Li, L. Li, and X. Wang Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Cell 102 2000 33 42
54. J.L. Dunaief, T. Dentchev, G.S. Ying, and A.H. Milam The role of apoptosis in age-related macular degeneration Arch. Ophthalmol. 120 2002 1435 1442
55. W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases structure, activation, substrates, and functions during apoptosis Annu. Rev. Biochem. 68 1999 383 424
56. R. Eckmiller Learning retina implants with epiretinal contacts Ophthalmic Res. 29 1997 281 289
57. A.L. Edinger, and C.B. Thompson Defective autophagy leads to cancer Cancer Cell 4 2003 422 424
58. R. Eferl, and E.F. Wagner AP-1 a double-edged sword in tumorigenesis Nat. Rev. Cancer 3 2003 859 868
59. I.B. Fedorovich, E.M. Semenova, K. Grant, C.A. Converse, and M.A. Ostrovsky Photosensitized light-induced damage of IRBP (interphotoreceptor retinoid-binding protein) effects on binding properties Curr. Eye Res. 21 2000 975 980
60. S.C. Finnemann, and E. Rodriguez-Boulan Macrophage and retinal pigment epithelium phagocytosis apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkage J. Exp. Med. 190 1999 861 874
61. A. Fleischmann, F. Hafezi, C. Elliott, C.E. Reme, U. Ruther, and E.F. Wagner Fra-1 replaces c-Fos-dependent functions in mice Genes Dev. 14 2000 2695 2700
62. D.A. Fox, A.T. Poblenz, and L. He Calcium overload triggers rod photoreceptor apoptotic cell death in chemical-induced and inherited retinal degenerations Ann. NY Acad. Sci. 893 1999 282 285
63. M. Frasson, S. Picaud, T. Leveillard, M. Simonutti, S. Mohand-Said, H. Dreyfus, D. Hicks, and J. Sabel Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse Invest. Ophthalmol. Vis. Sci. 40 1999 2724 2734
64. M. Frasson, J.A. Sahel, M. Fabre, M. Simonutti, H. Dreyfus, and S. Picaud Retinitis pigmentosa rod photoreceptor rescue by a calcium-channel blocker in the rd mouse Nat. Med. 5 1999 1183 1187
65. J. Friedman, and D. Xue To live or die by the sword the regulation of apoptosis by the proteasome Dev. Cell 6 2004 460 461
66. D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, J. Kempen, R. Klein, T. Peto, A. Bird, and M.R. Vannewkirk Prevalence of age-related macular degeneration in the United States; The epidemiology of age-related macular degeneration Arch. Ophthalmol. 122 2004 564 572
67. M. Gassmann, K. Heinicke, J. Soliz, O.O. Ogunshola, H.H. Marti, T. Hofer, C. Grimm, I. Heinicke, and B. Egli Non-erythroid functions of erythropoietin Adv. Exp. Med. Biol. 543 2003 323 330
68. Gollapalli, D.R., Rando, R.R., 2004. The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Proc. Natl. Acad. Sci. USA.
69. W.C. Gordon, D.M. Casey, W.J. Lukiw, and N.G. Bazan DNA damage and repair in light-induced photoreceptor degeneration Invest. Ophthalmol. Vis. Sci. 43 2002 3511 3521
70. O. Goureau, J.C. Jeanny, F. Becquet, M.P. Hartmann, and Y. Courtois Protection against light-induced retinal degeneration by an inhibitor of NO synthase Neuroreport 5 1993 233 236
71. D. Gozuacik, and A. Kimchi Autophagy as a cell death and tumor suppressor mechanism Oncogene 23 2004 2891 2906
72. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312
73. E.S. Green, K.G. Rendahl, S. Zhou, M. Ladner, M. Coyne, R. Srivastava, W.C. Manning, and J.G. Flannery Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18 Mol. Ther. 3 2001 507 515
74. C. Grimm, C.E. Reme, P.O. Rol, and T.P. Williams Blue light's effects on rhodopsin photoreversal of bleaching in living rat eyes Invest. Ophthalmol. Vis. Sci. 41 2000 3984 3990
75. C. Grimm, A. Wenzel, F. Hafezi, and C.E. Reme Gene expression in the mouse retina the effect of damaging light Mol. Vis. 6 2000 252 260
76. C. Grimm, A. Wenzel, F. Hafezi, S. Yu, T.M. Redmond, and C.E. Reme Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration Nat. Genet. 25 2000 63 66
77. C. Grimm, A. Wenzel, A. Behrens, F. Hafezi, E.F. Wagner, and C.E. Reme AP-1 mediated retinal photoreceptor apoptosis is independent of N-terminal phosphorylation of c-Jun Cell Death Differ. 8 2001 859 867
78. C. Grimm, A. Wenzel, T. Williams, P. Rol, F. Hafezi, and C. Reme Rhodopsin-mediated blue-light damage to the rat retina effect of photoreversal of bleaching Invest. Ophthalmol. Vis. Sci. 42 2001 497 505
79. C. Grimm, A. Wenzel, M. Groszer, H. Mayser, M. Seeliger, M. Samardzija, C. Bauer, M. Gassmann, and C.E. Reme HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration Nat. Med. 8 2002 718 724
80. C. Grimm, A. Wenzel, D. Stanescu, M. Samardzija, S. Hotop, M. Groszer, M. Naash, M. Gassmann, and C. Reme Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration J. Neurosci. 24 2004 5651 5658
81. M.E. Guicciardi, M. Leist, and G.J. Gores Lysosomes in cell death Oncogene 23 2004 2881 2890
82. F. Hafezi, J.P. Steinbach, A. Marti, K. Munz, Z.Q. Wang, E.F. Wagner, A. Aguzzi, and C.E. Reme The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo Nat. Med. 3 1997 346 349
83. F. Hafezi, M. Abegg, C. Grimm, A. Wenzel, K. Munz, J. Sturmer, D.B. Farber, and C.E. Reme Retinal degeneration in the rd mouse in the absence of c-fos Invest. Ophthalmol. Vis. Sci. 39 1998 2239 2244
84. F. Hafezi, C. Grimm, A. Wenzel, M. Abegg, M. Yaniv, and C.E. Reme Retinal photoreceptors are apoptosis-competent in the absence of JunD/AP-1 Cell Death Differ. 6 1999 934 936
85. F. Hafezi, A. Marti, C. Grimm, A. Wenzel, and C.E. Reme Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors Vis. Res. 39 1999 2511 2518
86. G.S. Hageman, P.J. Luthert, N.H. Victor Chong, L.V. Johnson, D.H. Anderson, and R.F. Mullins An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration Prog. Retin. Eye Res. 20 2001 705 732
87. Hahn, P., Lindsten, T., Lyubarsky, A.L., Ying, G.S., Pugh, E.N., Thompson, C.B., Dunaief, J.L., 2004. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ. 10.1038/sj.cdd.4401486 [doi].
88. R. Hanayama, M. Tanaka, K. Miyasaka, K. Aozasa, M. Koike, Y. Uchiyama, and S. Nagata Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice Science 304 2004 1147 1150
89. W. Hao, A. Wenzel, M.S. Obin, C.K. Chen, E. Brill, N.V. Krasnoperova, P. Eversole-Cire, Y. Kleyner, A. Taylor, M.I. Simon, C. Grimm, C.E. Reme, and J. Lem Evidence for two apoptotic pathways in light-induced retinal degeneration Nat. Genet. 32 2002 254 260
90. T. Harada, C. Harada, N. Nakayama, S. Okuyama, K. Yoshida, S. Kohsaka, H. Matsuda, and K. Wada Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration Neuron 26 2000 533 541
91. C. Hayward, X. Shu, A.V. Cideciyan, A. Lennon, P. Barran, S. Zareparsi, L. Sawyer, G. Hendry, B. Dhillon, A.H. Milam, P.J. Luthert, A. Swaroop, N.D. Hastie, S.G. Jacobson, and A.F. Wright Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration a genetic model for age-related macular degeneration Hum. Mol. Genet. 12 2003 2657 2667 Epub 2003 Aug 2627
92. J.A. Heibein, I.S. Goping, M. Barry, M.J. Pinkoski, G.C. Shore, D.R. Green, and R.C. Bleackley Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax J. Exp. Med. 192 2000 1391 1402
93. T. Hisatomi, T. Sakamoto, K.H. Sonoda, C. Tsutsumi, H. Qiao, H. Enaida, I. Yamanaka, T. Kubota, T. Ishibashi, S. Kura, S.A. Susin, and G. Kroemer Clearance of apoptotic photoreceptors elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin alphavbeta3 Am. J. Pathol. 162 2003 1869 1879
94. A.H. Hobson, M. Donovan, M.M. Humphries, G. Tuohy, N. McNally, R. Carmody, T. Cotter, G.J. Farrar, P.F. Kenna, and P. Humphries Apoptotic photoreceptor death in the rhodopsin knockout mouse in the presence and absence of c-fos Exp. Eye Res. 71 2000 247 254
95. T. Hoppeler, P. Hendrickson, C. Dietrich, and C. Reme Morphology and time-course of defined photochemical lesions in the rabbit retina Curr. Eye Res. 7 1988 849 860
96. S.P. Huang, P.K. Lin, J.H. Liu, C.N. Khor, and Y.J. Lee Intraocular gene transfer of ciliary neurotrophic factor rescues photoreceptor degeneration in RCS rats J. Biomed. Sci. 11 2004 37 48
97. H.P. Iseli, A. Wenzel, F. Hafezi, C.E. Reme, and C. Grimm Light damage susceptibility and RPE65 in rats Exp. Eye Res. 75 2002 407 413
98. Y. Ishizawa, R. Sharp, P.A. Liebman, and R.G. Eckenhoff Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling Biochemistry 39 2000 8497 8502
99. J.H. Jang, and Y.J. Surh Potentiation of cellular antioxidant capacity by Bcl-2 implications for its antiapoptotic function Biochem. Pharmacol. 66 2003 1371 1379
100. P.A. Jeggo DNA repair PARP - another guardian angel? Curr. Biol. 8 1998 R49 51
101. V. Jesenberger, and S. Jentsch Deadly encounter ubiquitin meets apoptosis Nat. Rev. Mol. Cell Biol. 3 2002 112 121
102. D.E. Johnson Noncaspase proteases in apoptosis Leukemia 14 2000 1695 1703
103. C. Jomary, M.J. Neal, and S.E. Jones Characterization of cell death pathways in murine retinal neurodegeneration implicates cytochrome c release, caspase activation, and bid cleavage Mol. Cell Neurosci. 18 2001 335 346
104. R.M. Joseph, and T. Li Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration Invest. Ophthalmol. Vis. Sci. 37 1996 2434 2446
105. H. Jung, and C. Reme Light-evoked arachidonic acid release in the retina illuminance/duration dependence and the effects of quinacrine, mellitin and lithium. Light-evoked arachidonic acid release Graefes Arch. Clin. Exp. Ophthalmol. 232 1994 167 175
106. I. Kaldi, M. Dittmar, P. Pierce, and R.E. Anderson L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats Exp. Eye Res. 76 2003 453 461
107. T. Kano, T. Abe, H. Tomita, T. Sakata, S. Ishiguro, and M. Tamai Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene Invest. Ophthalmol. Vis. Sci. 43 2002 3744 3753
108. M. Karin, and L. Chang AP-1 - glucocorticoid receptor crosstalk taken to a higher level J. Endocrinol. 169 2001 447 451
109. N. Katai, T. Kikuchi, H. Shibuki, S. Kuroiwa, J. Arai, T. Kurokawa, and N. Yoshimura Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats Invest. Ophthalmol. Vis. Sci. 40 1999 1802 1807
110. S.H. Kaufmann, and M.O. Hengartner Programmed cell death alive and well in the new millennium Trends Cell Biol. 11 2001 526 534
111. C. Keller, C. Grimm, A. Wenzel, F. Hafezi, and C. Reme Protective effect of halothane anesthesia on retinal light damage inhibition of metabolic rhodopsin regeneration Invest. Ophthalmol. Vis. Sci. 42 2001 476 480
112. U. Kellner, H. Tillack, and A.B. Renner Hereditary retinochoroidal dystrophies. Part 1 Pathogenesis, diagnosis, therapy and patient counselling Ophthalmologe 101 2004 307 319 quiz 320
113. J.F. Kerr, A.H. Wyllie, and A.R. Currie Apoptosis a basic biological phenomenon with wide-ranging implications in tissue kinetics Br. J. Cancer 26 1972 239 257
114. D. Kessel, Y. Luo, P. Mathieu, and J.J. Reiners Jr. Determinants of the apoptotic response to lysosomal photodamage Photochem. Photobiol. 71 2000 196 200
115. J. Kim, V.M. Dalton, K.P. Eggerton, S.V. Scott, and D.J. Klionsky Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways Mol. Biol. Cell 10 1999 1337 1351
116. D.H. Kim, J.A. Kim, J.S. Choi, and C.K. Joo Activation of caspase-3 during degeneration of the outer nuclear layer in the rd mouse retina Ophthalmic Res. 34 2002 150 157
117. Kim, S.R., Fishkin, N., Kong J., Nakanishi K., Allikmets R., Sparrow J.R., 2004. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc. Natl. Acad. Sci. USA 10.1073/pnas.0403499101 [doi].
118. J.A. Klein, C.M. Longo-Guess, M.P. Rossmann, K.L. Seburn, R.E. Hurd, W.N. Frankel, R.T. Bronson, and S.L. Ackerman The harlequin mouse mutation downregulates apoptosis-inducing factor Nature 419 2002 367 374
119. D.J. Klionsky, and S.D. Emr Autophagy as a regulated pathway of cellular degradation Science 290 2000 1717 1721
120. N. Kueng-Hitz, C. Grimm, N. Lansel, F. Hafezi, L. He, D.A. Fox, C.E. Reme, G. Niemeyer, and A. Wenzel The retina of c-fos-/- mice electrophysiologic, morphologic and biochemical aspects Invest. Ophthalmol. Vis. Sci. 41 2000 909 916
121. T.D. Lamb, and E.N. Pugh Jr. Dark adaptation and the retinoid cycle of vision Prog. Retin. Eye Res. 23 2004 307 380
122. D. Lau, and J. Flannery Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration Doc. Ophthalmol. 106 2003 89 98
123. D. Lau, L.H. McGee, S. Zhou, K.G. Rendahl, W.C. Manning, J.A. Escobedo, and J.G. Flannery Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2 Invest. Ophthalmol. Vis. Sci. 41 2000 3622 3633
124. M.M. LaVail, D. Yasumura, M.T. Matthes, C. Lau-Villacorta, K. Unoki, C.H. Sung, and R.H. Steinberg Protection of mouse photoreceptors by survival factors in retinal degenerations Invest. Ophthalmol. Vis. Sci. 39 1998 592 602
125. J.M. Lawrence, D.J. Keegan, E.M. Muir, P.J. Coffey, J.H. Rogers, M.J. Wilby, J.W. Fawcett, and R.D. Lund Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats Invest. Ophthalmol. Vis. Sci. 45 2004 267 274
126. A. Lemarie, D. Lagadic-Gossmann, C. Morzadec, N. Allain, O. Fardel, and L. Vernhet Cadmium induces caspase-independent apoptosis in liver Hep3B cells role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor Free Radic. Biol. Med. 36 2004 1517 1531
127. Leveillard, T., Mohand-Said, S., Lorentz, O., Hicks, D., Fintz A.C., Clerin, E., Simonutti, M., Forster, V., Cavusoglu, N., Chalmel, F., Dolle, P., Poch, O., Lambrou, G., Sahel, J.A., 2004. Identification and characterization of rod-derived cone viability factor. Nat. Genet.
128. P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489
129. L.Y. Li, X. Luo, and X. Wang Endonuclease G is an apoptotic DNase when released from mitochondria Nature 412 2001 95 99
130. F. Li, W. Cao, and R.E. Anderson Alleviation of constant-light-induced photoreceptor degeneration by adaptation of adult albino rat to bright cyclic light Invest. Ophthalmol. Vis. Sci. 44 2003 4968 4975
131. M.O. Li, M.R. Sarkisian, W.Z. Mehal, P. Rakic, and R.A. Flavell Phosphatidylserine receptor is required for clearance of apoptotic cells Science 302 2003 1560 1563
132. F.Q. Liang, T.S. Aleman, N.S. Dejneka, L. Dudus, K.J. Fisher, A.M. Maguire, S.G. Jacobson, and J. Bennett Long-term protection of retinal structure but not function using RAAV. CNTF in animal models of retinitis pigmentosa Mol. Ther. 4 2001 461 472
133. F.Q. Liang, T.S. Aleman, CideciyanA.V. ZaixinYang, S.G. Jacobson, and J. Bennett Melatonin delays photoreceptor degeneration in the rds/rds mouse Neuroreport 12 2001 1011 1014
134. F.Q. Liang, N.S. Dejneka, D.R. Cohen, N.V. Krasnoperova, J. Lem, A.M. Maguire, L. Dudus, K.J. Fisher, and J. Bennett AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse Mol. Ther. 3 2001 241 248
135. X.H. Liang, S. Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh, and B. Levine Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 402 1999 672 676
136. C. Liu, M. Peng, A.M. Laties, and R. Wen Preconditioning with bright light evokes a protective response against light damage in the rat retina J. Neurosci. 18 1998 1337 1344
137. C. Liu, Y. Li, M. Peng, A.M. Laties, and R. Wen Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration J. Neurosci. 19 1999 4778 4785
138. Z. Liu, C. Sun, E.T. Olejniczak, R.P. Meadows, S.F. Betz, T. Oost, J. Herrmann, J.C. Wu, and S.W. Fesik Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain Nature 408 2000 1004 1008
139. R.A. Lockshin, and Z. Zakeri Caspase-independent cell deaths Curr. Opin. Cell Biol. 14 2002 727 733
140. J.L. Louie, R.J. Kapphahn, and D.A. Ferrington Proteasome function and protein oxidation in the aged retina Exp. Eye Res. 75 2002 271 284
141. S. Machida, P. Chaudhry, T. Shinohara, D.P. Singh, V.N. Reddy, L.T. Chylack Jr., P.A. Sieving, and R.A. Bush Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats Invest. Ophthalmol. Vis. Sci. 42 2001 1087 1095
142. G. Marino, J.A. Uria, X.S. Puente, V. Quesada, J. Bordallo, and C. Lopez-Otin Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy J. Biol. Chem. 278 2003 3671 3678 Epub 2002 Nov 3621
143. L.M. Martins, I. Iaccarino, T. Tenev, S. Gschmeissner, N.F. Totty, N.R. Lemoine, J. Savopoulos, C.W. Gray, C.L. Creasy, C. Dingwall, and J. Downward The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif J. Biol. Chem. 277 2002 439 444
144. M.P. Mattson Apoptosis in neurodegenerative disorders Nat. Rev. Mol. Cell Biol. 1 2000 120 129
145. L.H. McGee Sanftner, H. Abel, W.W. Hauswirth, and J.G. Flannery Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa Mol. Ther. 4 2001 622 629
146. B. McMahon, S. Mitchell, H.R. Brady, and C. Godson Lipoxins revelations on resolution Trends Pharmacol. Sci. 22 2001 391 395
147. M.D. Miramar, P. Costantini, L. Ravagnan, L.M. Saraiva, D. Haouzi, G. Brothers, J.M. Penninger, M.L. Peleato, G. Kroemer, and S.A. Susin NADH oxidase activity of mitochondrial apoptosis-inducing factor J. Biol. Chem. 276 2001 16391 16398
148. K. Miyasaka, R. Hanayama, M. Tanaka, and S. Nagata Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells Eur. J. Immunol. 34 2004 1414 1422
149. M. Miyazaki, Y. Ikeda, Y. Yonemitsu, Y. Goto, T. Sakamoto, T. Tabata, Y. Ueda, M. Hasegawa, S. Tobimatsu, T. Ishibashi, and K. Sueishi Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats Gene Ther. 10 2003 1503 1511
150. N. Mizushima, Y. Ohsumi, and T. Yoshimori Autophagosome formation in mammalian cells Cell Struct. Funct. 27 2002 421 429
151. M.I. Naash, M.R. Al-Ubaidi, and R.E. Anderson Light exposure induces ubiquitin conjugation and degradation activities in the rat retina Invest. Ophthalmol. Vis. Sci. 38 1997 2344 2354
152. S. Nagata Apoptotic DNA fragmentation Exp. Cell Res. 256 2000 12 18
153. M. Neuner-Jehle, L.V. Berghe, S. Bonnel, Y. Uteza, F. Benmeziane, J.S. Rouillot, D. Marchant, A. Kobetz, J.L. Dufier, M. Menasche, and M. Abitbol Ocular cell transfection with the human basic fibroblast growth factor gene delays photoreceptor cell degeneration in RCS rats Hum. Gene Ther. 11 2000 1875 1890
154. I. Nir, C. Liu, and R. Wen Light treatment enhances photoreceptor survival in dystrophic retinas of Royal College of Surgeons rats Invest. Ophthalmol. Vis. Sci. 40 1999 2383 2390
155. I. Nir, W. Kedzierski, J. Chen, and G.H. Travis Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice J. Neurosci. 20 2000 2150 2154
156. I. Nir, J.M. Harrison, C. Liu, and R. Wen Extended photoreceptor viability by light stress in the RCS rats but not in the opsin P23H mutant rats Invest. Ophthalmol. Vis. Sci. 42 2001 842 849
157. W.K. Noell, V.S. Walker, B.S. Kang, and S. Berman Retinal damage by light in rats Invest. Ophthalmol. 5 1966 450 473
158. M. Obin, B.Y. Lee, G. Meinke, A. Bohm, R.H. Lee, R. Gaudet, J.A. Hopp, V.Y. Arshavsky, B.M. Willardson, and A. Taylor Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin J. Biol. Chem. 277 2002 44566 44575 Epub 42002 Sep 44564
159. G. Okoye, J. Zimmer, J. Sung, P. Gehlbach, T. Deering, H. Nambu, S. Hackett, M. Melia, N. Esumi, D.J. Zack, and P.A. Campochiaro Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage J. Neurosci. 23 2003 4164 4172
160. D.T. Organisciak, R.A. Darrow, L. Barsalou, R.M. Darrow, and L.A. Lininger Light-induced damage in the retina differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation Photochem. Photobiol. 70 1999 261 268
161. D.T. Organisciak, R.M. Darrow, L. Barsalou, R.K. Kutty, and B. Wiggert Circadian-dependent retinal light damage in rats Invest. Ophthalmol. Vis. Sci. 41 2000 3694 3701
162. D.T. Organisciak, R.M. Darrow, L. Barsalou, R.K. Kutty, and B. Wiggert Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations Invest. Ophthalmol. Vis. Sci. 44 2003 486 492
163. S. Orrenius Mitochondrial regulation of apoptotic cell death Toxicol. Lett. 149 2004 19 23
164. J.Z. Parrish, C. Yang, B. Shen, and D. Xue CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation Embo. J. 22 2003 3451 3460
165. B.S. Pawlyk, T. Li, M.S. Scimeca, M.A. Sandberg, and E.L. Berson Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse Invest. Ophthalmol. Vis. Sci. 43 2002 1912 1915
166. S.E. Pearce-Kelling, T.S. Aleman, A. Nickle, A.M. Laties, G.D. Aguirre, S.G. Jacobson, and G.M. Acland Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa Mol. Vis. 7 2001 42 47
167. P.L. Penfold, M.C. Madigan, M.C. Gillies, and J.M. Provis Immunological and aetiological aspects of macular degeneration Prog. Retin. Eye Res. 20 2001 385 414
168. C.M. Pickart, and R.E. Cohen Proteasomes and their kin proteases in the machine age Nat. Rev. Mol. Cell Biol. 5 2004 177 187
169. A.A. Pieper, A. Verma, J. Zhang, and S.H. Snyder Poly (ADP-ribose) polymerase, nitric oxide and cell death Trends Pharmacol. Sci. 20 1999 171 181
170. C. Portera-Cailliau, C.H. Sung, J. Nathans, and R. Adler Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa Proc. Natl. Acad. Sci. USA 91 1994 974 978
171. C. Portera-Cailliau, C.H. Sung, J. Nathans, and R. Adler Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa Proc. Natl. Acad. Sci. USA 91 1994 974 978
172. X. Qu, J. Yu, G. Bhagat, N. Furuya, H. Hibshoosh, A. Troxel, J. Rosen, E.L. Eskelinen, N. Mizushima, Y. Ohsumi, G. Cattoretti, and B. Levine Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene J. Clin. Invest. 112 2003 1809 1820
173. R.A. Radu, N.L. Mata, S. Nusinowitz, X. Liu, P.A. Sieving, and G.H. Travis Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration Proc. Natl. Acad. Sci. USA 100 2003 4742 4747
174. R.A. Radu, N.L. Mata, A. Bagla, and G.H. Travis Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration Proc. Natl. Acad. Sci. USA 101 2004 5928 5933
175. I. Ranchon, J.M. Gorrand, J. Cluzel, M.T. Droy-Lefaix, and M. Doly Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract Invest. Ophthalmol. Vis. Sci. 40 1999 1191 1199
176. I. Ranchon, S. Chen, K. Alvarez, and R.E. Anderson Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage Invest. Ophthalmol. Vis. Sci. 42 2001 1375 1379
177. I. Ranchon, M.M. LaVail, Y. Kotake, and R.E. Anderson Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration J. Neurosci. 23 2003 6050 6057
178. D.S. Read, M.A. McCall, and R.G. Gregg Absence of voltage-dependent calcium channels delays photoreceptor degeneration in rd mice Exp. Eye Res. 75 2002 415 420
179. T.M. Redmond, S. Yu, E. Lee, D. Bok, D. Hamasaki, N. Chen, P. Goletz, J.X. Ma, R.K. Crouch, and K. Pfeifer Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle Nat. Genet. 20 1998 344 351
180. J.J. Reinboth, K. Gautschi, M. Clausen, and C.E. Reme Lipid mediators in the rat retina light exposure and trauma elicit leukotriene B4 release in vitro Curr. Eye Res. 14 1995 1001 1008
181. J.J. Reinboth, M. Clausen, and C.E. Reme Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro Exp. Eye Res. 63 1996 277 284
182. C. Reme, A. Wirz-Justice, A. Rhyner, and S. Hofmann Circadian rhythm in the light response of rat retinal disk-shedding and autophagy Brain Res. 369 1986 356 360
183. C.E. Reme, A. Wirz-Justice, and M. Terman The visual input stage of the mammalian circadian pacemaking system. I. Is there a clock in the mammalian eye? J. Biol. Rhythms 6 1991 5 29
184. C.E. Reme, C. Grimm, F. Hafezi, A. Marti, and A. Wenzel Apoptotic cell death in retinal degenerations Prog. Retin. Eye Res. 17 1998 443 464
185. C.E. Reme, F. Hafezi, A. Marti, K. Munz, and J.J. Reinboth Light damage to retina and retinal pigment epithelium T.J. Wolfensberger The Retinal Pigment Epithelium. Function and Disease 1998 Oxford: Oxford University Press New York 563 586
186. C.E. Reme, U. Wolfrum, C. Imsand, F. Hafezi, and T.P. Williams Photoreceptor autophagy effects of light history on number and opsin content of degradative vacuoles Invest. Ophthalmol. Vis. Sci. 40 1999 2398 2404
187. C.E. Reme, C. Grimm, F. Hafezi, A. Wenzel, and T.P. Williams Apoptosis in the retina the silent death of vision News Physiol. Sci. 15 2000 120 124
188. C.E. Reme, C. Grimm, F. Hafezi, H.P. Iseli, and A. Wenzel Why study rod cell death in retinal degenerations and how? Doc. Ophthalmol. 106 2003 25 29
189. Reme, C.E., Grimm, C., Simon, M.I., Wenzel, A., 2003b. Effects of blue- and green light in arresting/rhodopsinkinase double knock out (Arr-/-/RK-/-) mice. Invest Ophthalmol Vis Sci 43: ARVO E-Abstract 5132.
190. K.A. Rich, Y. Zhan, and J.C. Blanks Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse J. Neurobiol. 32 1997 593 612
191. B. Rohrer, M.T. Matthes, M.M. LaVail, and L.F. Reichardt Lack of p75 receptor does not protect photoreceptors from light-induced cell death Exp. Eye Res. 76 2003 125 129
192. J.C. Saari, G.G. Garwin, J.P. Van Hooser, and K. Palczewski Reduction of all-trans-retinal limits regeneration of visual pigment in mice Vis. Res. 38 1998 1325 1333
193. J.C. Saari, M. Nawrot, B.N. Kennedy, G.G. Garwin, J.B. Hurley, J. Huang, D.E. Possin, and J.W. Crabb Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation Neuron 29 2001 739 748
194. M. Sato, H. Ohguro, I. Ohguro, K. Mamiya, Y. Takano, H. Yamazaki, T. Metoki, Y. Miyagawa, F. Ishikawa, and M. Nakazawa Study of pharmacological effects of nilvadipine on RCS rat retinal degeneration by microarray analysis Biochem. Biophys. Res. Commun. 306 2003 826 831
195. J. Savill, I. Dransfield, C. Gregory, and C. Haslett A blast from the past clearance of apoptotic cells regulates immune responses Nat. Rev. Immunol. 2 2002 965 975
196. R.A. Schlegel, and P. Williamson Phosphatidylserine, a death knell Cell Death Differ. 8 2001 551 563
197. F.C. Schlichtenbrede, A. MacNeil, J.W. Bainbridge, M. Tschernutter, A.J. Thrasher, A.J. Smith, and R.R. Ali Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration Gene Ther. 10 2003 523 527
198. F. Schutt, S. Davies, J. Kopitz, F.G. Holz, and M.E. Boulton Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin Invest. Ophthalmol. Vis. Sci. 41 2000 2303 2308
199. F. Shang, and A. Taylor Function of the ubiquitin proteolytic pathway in the eye Exp. Eye Res. 78 2004 1 14
200. Sharma, A.K., Rohrer, B., 2004. Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line. J. Biol. Chem.
201. J.C. Sharpe, D. Arnoult, and R.J. Youle Control of mitochondrial permeability by Bcl-2 family members Biochim. Biophys. Acta 1644 2004 107 113
202. T. Shinohara, D.P. Singh, and N. Fatma LEDGF, a survival factor, activates stress-related genes Prog. Retin. Eye Res. 21 2002 341 358
203. T. Shintani, N. Mizushima, Y. Ogawa, A. Matsuura, T. Noda, and Y. Ohsumi Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast Embo. J. 18 1999 5234 5241
204. P.A. Sieving, P. Chaudhry, M. Kondo, M. Provenzano, D. Wu, T.J. Carlson, R.A. Bush, and D.A. Thompson Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy Proc. Natl. Acad. Sci. USA 98 2001 1835 1840
205. G. Silvestri Age-related macular degeneration genetics and implications for detection and treatment Mol. Med. Today 3 1997 84 91
206. J.R. Sparrow, J. Zhou, S. Ben-Shabat, H. Vollmer, Y. Itagaki, and K. Nakanishi Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE Invest. Ophthalmol. Vis. Sci. 43 2002 1222 1227
207. S. Specht, M. Leffak, R.M. Darrow, and D.T. Organisciak Damage to rat retinal DNA induced in vivo by visible light Photochem. Photobiol. 69 1999 91 98
208. S. Specht, D.T. Organisciak, R.M. Darrow, and M. Leffak Continuing damage to rat retinal DNA during darkness following light exposure Photochem. Photobiol. 71 2000 559 566
209. B. Spencer, S. Agarwala, L. Gentry, and C.R. Brandt HSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses Mol. Ther. 3 2001 746 756
210. S. Sperandio, I. de Belle, and D.E. Bredesen An alternative, nonapoptotic form of programmed cell death Proc. Natl. Acad. Sci. USA 97 2000 14376 14381
211. V. Stoka, B. Turk, S.L. Schendel, T.H. Kim, T. Cirman, S.J. Snipas, L.M. Ellerby, D. Bredesen, H. Freeze, M. Abrahamson, D. Bromme, S. Krajewski, J.C. Reed, X.M. Yin, V. Turk, and G.S. Salvesen Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route J. Biol. Chem. 276 2001 3149 3157
212. A. Strasser, L. O'Connor, and V.M. Dixit Apoptosis signaling Annu. Rev. Biochem. 69 2000 217 245
213. T. Sugawara, P.A. Sieving, P.M. Iuvone, and R.A. Bush The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat Invest. Ophthalmol. Vis. Sci. 39 1998 2458 2465
214. H. Sun, and J. Nathans ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro. Implications for retinal disease J. Biol. Chem. 276 2001 11766 11774
215. X.M. Sun, M. Butterworth, M. MacFarlane, W. Dubiel, A. Ciechanover, and G.M. Cohen Caspase activation inhibits proteasome function during apoptosis Mol. Cell 14 2004 81 93
216. S.A. Susin, H.K. Lorenzo, N. Zamzami, I. Marzo, B.E. Snow, G.M. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D.R. Goodlett, R. Aebersold, D.P. Siderovski, J.M. Penninger, and G. Kroemer Molecular characterization of mitochondrial apoptosis-inducing factor Nature 397 1999 441 446
217. M. Suter, C. Reme, C. Grimm, A. Wenzel, M. Jaattela, P. Esser, N. Kociok, M. Leist, and C. Richter Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells J. Biol. Chem. 275 2000 39625 39630
218. Y. Suzuki, Y. Imai, H. Nakayama, K. Takahashi, K. Takio, and R. Takahashi A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death Mol. Cell 8 2001 613 621
219. P. Syntichaki, and N. Tavernarakis The biochemistry of neuronal necrosis rogue biology? Nat. Rev. Neurosci. 4 2003 672 684
220. Y. Takano, H. Ohguro, M. Dezawa, H. Ishikawa, H. Yamazaki, I. Ohguro, K. Mamiya, T. Metoki, F. Ishikawa, and M. Nakazawa Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse Biochem. Biophys. Res. Commun. 313 2004 1015 1022
221. I. Tanida, N. Mizushima, M. Kiyooka, M. Ohsumi, T. Ueno, Y. Ohsumi, and E. Kominami Apg7p/Cvt2p a novel protein-activating enzyme essential for autophagy Mol. Biol. Cell 10 1999 1367 1379
222. M. Tanito, H. Masutani, H. Nakamura, A. Ohira, and J. Yodoi Cytoprotective effect of thioredoxin against retinal photic injury in mice Invest. Ophthalmol. Vis. Sci. 43 2002 1162 1167
223. M. Tanito, H. Masutani, H. Nakamura, S. Oka, A. Ohira, and J. Yodoi Attenuation of retinal photooxidative damage in thioredoxin transgenic mice Neurosci. Lett. 326 2002 142 146
224. W. Tao, R. Wen, M.B. Goddard, S.D. Sherman, P.J. O'Rourke, P.F. Stabila, W.J. Bell, B.J. Dean, K.A. Kauper, V.A. Budz, W.G. Tsiaras, G.M. Acland, S. Pearce-Kelling, A.M. Laties, and G.D. Aguirre Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa Invest. Ophthalmol. Vis. Sci. 43 2002 3292 3298
225. D. Terwel, and W. van de Berg c-Jun/AP-1 (N) directed antibodies cross-react with "apoptosis-specific protein" which marks an autophagic process during neuronal apoptosis Neuroscience 96 2000 445 446
226. M.J. Thomenius, and C.W. Distelhorst Bcl-2 on the endoplasmic reticulum protecting the mitochondria from a distance J. Cell Sci. 116 2003 4493 4499
227. S.C. Tomany, K.J. Cruickshanks, R. Klein, B.E. Klein, and M.D. Knudtson Sunlight and the 10-year incidence of age-related maculopathy the Beaver Dam Eye Study Arch. Ophthalmol. 122 2004 750 757
228. J. Tombran-Tink, and C.J. Barnstable PEDF a multifaceted neurotrophic factor Nat. Rev. Neurosci. 4 2003 628 636
229. S.H. Tsang, J. Chen, H. Kjeldbye, W.S. Li, M.I. Simon, P. Gouras, and S.P. Goff Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene Invest. Ophthalmol. Vis. Sci. 38 1997 943 950
230. Y. Uteza, J.S. Rouillot, A. Kobetz, D. Marchant, S. Pecqueur, E. Arnaud, H. Prats, J. Honiger, J.L. Dufier, M. Abitbol, and M. Neuner-Jehle Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats Proc. Natl. Acad. Sci. USA 96 1999 3126 3131
231. G. van Loo, P. Schotte, M. van Gurp, H. Demol, B. Hoorelbeke, K. Gevaert, I. Rodriguez, A. Ruiz-Carrillo, J. Vandekerckhove, W. Declercq, R. Beyaert, and P. Vandenabeele Endonuclease G a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation Cell Death Differ. 8 2001 1136 1142
232. S. van Soest, A. Westerveld, P.T. de Jong, E.M. Bleeker-Wagemakers, and A.A. Bergen Retinitis pigmentosa defined from a molecular point of view Surv. Ophthalmol. 43 1999 321 334
233. D. Vercammen, G. Brouckaert, G. Denecker, M. Van de Craen, W. Declercq, W. Fiers, and P. Vandenabeele Dual signaling of the Fas receptor initiation of both apoptotic and necrotic cell death pathways J. Exp. Med. 188 1998 919 930
234. A.M. Verhagen, P.G. Ekert, M. Pakusch, J. Silke, L.M. Connolly, G.E. Reid, R.L. Moritz, R.J. Simpson, and D.L. Vaux Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins Cell 102 2000 43 53
235. Vision research conference, 2003. Retinal cell rescue: stem cells, remodelling, neuroprotection, apoptosis and replacement of retinal neurons. Proceedings of the 6th Annual Vision Research Conference. Ft. Lauderdale, Florida, USA. May 3-4.
236. X. Wang, C. Yang, J. Chai, Y. Shi, and D. Xue Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans Science 298 2002 1587 1592
237. A. Wenzel, C. Grimm, A. Marti, N. Kueng-Hitz, F. Hafezi, G. Niemeyer, and C.E. Reme c-fos controls the "private pathway" of light-induced apoptosis of retinal photoreceptors J. Neurosci. 20 2000 81 88
238. A. Wenzel, C. Grimm, M.W. Seeliger, G. Jaissle, F. Hafezi, R. Kretschmer, E. Zrenner, and C.E. Reme Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor Invest. Ophthalmol. Vis. Sci. 42 2001 1653 1659
239. A. Wenzel, C.E. Reme, T.P. Williams, F. Hafezi, and C. Grimm The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration J. Neurosci. 21 2001 53 58
240. A. Wenzel, H.P. Iseli, A. Fleischmann, F. Hafezi, C. Grimm, E.F. Wagner, and C.E. Reme Fra-1 substitutes for c-Fos in AP-1-mediated signal transduction in retinal apoptosis J. Neurochem. 80 2002 1089 1094
241. A. Wenzel, C. Grimm, M. Samardzija, and C.E. Reme The genetic modifier Rpe65Leu(450) effect on light damage susceptibility in c-Fos-deficient mice Invest. Ophthalmol. Vis. Sci. 44 2003 2798 2802
242. C. Wojcik Regulation of apoptosis by the ubiquitin and proteasome pathway J. Cell Mol. Med. 6 2002 25 48
243. S.C. Wright, Q.S. Wei, J. Zhong, H. Zheng, D.H. Kinder, and J.W. Larrick Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation J. Exp. Med. 180 1994 2113 2123
244. J. Wu, A. Gorman, X. Zhou, C. Sandra, and E. Chen Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure Invest. Ophthalmol. Vis. Sci. 43 2002 3349 3354
245. T. Wu, S.K. Chiang, F.Y. Chau, and M.O. Tso Light-induced photoreceptor degeneration may involve the NF kappa B/caspase-1 pathway in vivo Brain Res. 967 2003 19 26
246. A.H. Wyllie, and P. Golstein More than one way to go Proc. Natl. Acad. Sci. USA 98 2001 11 13
247. L. Xue, G.C. Fletcher, and A.M. Tolkovsky Autophagy is activated by apoptotic signalling in sympathetic neurons an alternative mechanism of death execution Mol. Cell Neurosci. 14 1999 180 198
248. H. Yamazaki, H. Ohguro, T. Maeda, I. Maruyama, Y. Takano, T. Metoki, M. Nakazawa, H. Sawada, and M. Dezawa Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist Invest. Ophthalmol. Vis. Sci. 43 2002 919 926
249. J.H. Yang, S.F. Basinger, R.L. Gross, and S.M. Wu Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport Invest. Ophthalmol. Vis. Sci. 44 2003 1312 1319
250. H. Ye, C. Cande, N.C. Stephanou, S. Jiang, S. Gurbuxani, N. Larochette, E. Daugas, C. Garrido, G. Kroemer, and H. Wu DNA binding is required for the apoptogenic action of apoptosis inducing factor Nat. Struct. Biol. 9 2002 680 684
251. K. Yoshizawa, K. Kiuchi, H. Nambu, J. Yang, H. Senzaki, Y. Kiyozuka, N. Shikata, and A. Tsubura Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene Graefes Arch. Clin. Exp. Ophthalmol. 240 2002 214 219
252. S.W. Yu, H. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, G.G. Poirier, T.M. Dawson, and V.L. Dawson Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor Science 297 2002 259 263
253. Z. Yue, S. Jin, C. Yang, A.J. Levine, and N. Heintz Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor Proc. Natl. Acad. Sci. USA 100 2003 15077 15082
254. C.J. Zeiss, J. Neal, and E.A. Johnson Caspase-3 in postnatal retinal development and degeneration Invest. Ophthalmol. Vis. Sci. 45 2004 964 970
255. E. Zrenner "Retinal implants" - replacement of retinal functions by technical implants a feasible way to replace vision?] Ophthalmologe 98 2001 353 356