Mitochondrial regulation of apoptotic cell death

Toxicology Letters

Volumn 149, Issue 1-3, 2004, Pages 19-23

  Orrenius, Sten ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Cardiopipin; Caspase; Cytochrome c; Mitochondria; Toxicant

Indexed keywords

CALCIUM ION; CARDIOLIPIN; CASPASE; CYTOCHROME C; HEAT SHOCK PROTEIN; HEMOPROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; PHOSPHOLIPID; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; TOXIC SUBSTANCE;

APOPTOSIS; CELL CYCLE; CELL DEATH; CELL ORGANELLE; CELL PERMEABILIZATION; CONFERENCE PAPER; CYTOSOL; ENVIRONMENTAL FACTOR; ENZYME ACTIVATION; ENZYME ACTIVITY; MEDICAL RESEARCH; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TOXICITY; MITOCHONDRION; MOLECULAR EVOLUTION; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN SECRETION; REGULATORY MECHANISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CASPASES; ENVIRONMENTAL POLLUTANTS; HUMANS; MITOCHONDRIA;

INTRACISTERNAL A-PARTICLES;

EID: 1842767259     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.12.017     Document Type: Conference Paper

References (15)

1. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
2. 2+-independent mechanisms that are regulated by Bax. J. Biol. Chem. 276:2001;19066-19071.
3. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
4. Kamath A.B., Camacho I., Nagarkatti P.S., Nagarkatti M. Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity: increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity. Toxicol. Appl. Pharmacol. 160:1999;141-155.
5. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP dependent formation of Apaf-1/caspase-9 complex initiate an apoptotic protease cascade. Cell. 91:1997;479-489.
6. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:1998;481-490.
7. Nobel C.S., Kimland M., Lind B., Orrenius S., Slater A.F. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol. Chem. 270:1995;26202-26208.
8. Nobel C.S., Burgess D.H., Zhivotovsky B., Burkitt M.J., Orrenius S., Slater A.F. Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme. Chem. Res. Toxicol. 10:1997;636-643.
9. Ostrander D.B., Sparagna G.C., Amoscato A.A., McMillin J.B., Dowhan W. Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J. Biol. Chem. 276:2001;38061-38067.
10. Ott M., Robertson J.D., Gogvadze V., Zhivotovsky B., Orrenius S. Cytochrome c release from mitochondria proceeds by a two-step process. Proc. Natl. Acad. Sci. USA. 99:2002;1259-1263.
11. Petrosillo G., Ruggiero F.M., Pistolese M., Paradies G. Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in apoptosis. FEBS Lett. 509:2001;435-438.
12. Robertson J.D., Orrenius S. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit. Rev. Toxicol. 30:2000;609-627.
13. Stridh H., Fava E., Single B., Nicotera P., Orrenius S., Leist M. Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production. Chem. Res. Toxicol. 12:1999;874-882.
14. Szalai G., Krishnamurty R., Hajnoczky G. Apoptosis driven by IP3-linked mitochondrial calcium signals. EMBO J. 18:1999;6349-6361.
15. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic Bax and Bak: a requisite gateway to mitochondrial dysfunction and death. Science. 292:2001;727-730.