Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

Nature Genetics

Volumn 25, Issue 1, 2000, Pages 63-66

  Grimm, Christian ^a   Wenzel, Andreas ^a   Hafezi, Farhad ^a   Yu, Shirley ^b   Redmond, T Michael ^b   Remé, Charlotte E ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RHODOPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; MOUSE; NICK END LABELING; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA MACULA DEGENERATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; EYE PROTEINS; LIGHT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOTORECEPTORS, VERTEBRATE; PIGMENT EPITHELIUM OF EYE; PROTEINS; RETINAL DEGENERATION; RHODOPSIN; TRANSCRIPTION FACTOR AP-1;

ANIMALIA;

EID: 0034105724     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/75614     Document Type: Article

References (29)

1. Reme, C.E., Grimm, C., Hafezi, F., Marti, A. & Wenzel, A. Apoptotic cell death in retinal degenerations. Prog. Retin. Eye Res. 17, 443-464 (1998).
2. Simons, K. Artificial light and early-life exposure in age-related macular degeneration and in cataractogenic phototoxicity. Arch. Ophthalmol. 111, 297-298 (1993).
3. Cruickshanks, K.J., Klein, R. & Klein, B.E. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch. Ophthalmol. 111, 514-518 (1993).
4. Cideciyan, A.V. et al. Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man. Proc. Natl Acad. Sci. USA 95, 7103-7108 (1998).
5. Taylor, H.R. et al. Visible light and risk of age-related macular degeneration. Trans. Am. Ophthalmol. Soc. 88, 163-173 (1990).
6. Naash, M.L. et al. Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin. Invest. Ophthalmol. Vis. Sci. 37, 775-782 (1996).
7. LaVail, M.M., Gorrin, G.M., Yasumura, D. & Matthes, M.T. Increased susceptibility to constant light in nr and pcd mice with inherited retinal degenerations. Invest. Ophthalmol. Vis. Sci. 40, 1020-1024 (1999).
8. Hanna, N. et al. Light induces peroxidation in retina by activating prostaglandin G/H synthase. Free Radic. Biol. Med. 23, 885-897 (1997).
9. Chen, E. Inhibition of cytochrome oxidase and blue-light damage in rat retina. Graefes Arch. Clin. Exp. Ophthalmol. 231, 416-423 (1993).
10. Williams, T.P. & Howell, W.L. Action spectrum of retinal light-damage in albino rats. Invest. Ophthalmol. Vis. Sci. 24, 285-287 (1983).
11. Hao, W. & Fong, H.K. Blue and ultraviolet light-absorbing opsin from the retinal pigment epithelium. Biochemistry 35, 6251-6256 (1996).
12. Redmond, T.M. et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nature Genet. 20, 344-351 (1998).
13. Humphries, M.M. et al. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nature Genet. 15, 216-219 (1997).
14. Hafezi, F. et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nature Med. 3, 346-349 (1997).
15. Wenzel, A. et al., c-fos controls the 'private pathway' of light-induced apoptosis of retinal photoreceptors. J. Neurosci. 20, 81-88 (2000).
16. Hafezi, F., Marti, A., Grimm, C., Wenzel, A. & Remé, C.E. Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors. Vision Res. 39, 2511-2518 (1999).
17. Nir, I. & Agarwal, N. Diurnal expression of c-fos in the mouse retina. Brain Res. Mol. Brain Res. 19, 47-54 (1993).
18. Mohand Said, S. et al. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc. Natl Acad. Sci. USA 95, 8357-8362 (1998).
19. Li, A., Lane, W.S., Johnson, L.V., Chader, G.J. & Tombran-Tink, J. Neuron-specific enolase: a neuronal survival factor in the retinal extracellular matrix? J. Neurosci. 15, 385-393 (1995).
20. Streichert, L.C., Birnbach, C.D. & Reh, T.A. A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in vitro model of retinitis pigmentosa. J. Neurobiol. 39, 475-490 (1999).
21. Gaur, V.P., Liu, Y. & Turner, J.E. RPE conditioned medium stimulates photoreceptor cell survival, neurite outgrowth and differentiation in vitro. Exp. Eye Res. 54, 645-659 (1992).
22. Campochiaro, P.A. et al. Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor. J. Neurosci. 16, 1679-1688 (1996).
23. Pang, J., Seko, Y., Tokoro, T., Ichinose, S. & Yamamoto, H. Observation of ultrastructural changes in cultured retinal pigment epithelium following exposure to blue light. Graefes Arch. Clin. Exp. Ophthalmol. 236, 696-701 (1998).
24. LaVail, M.M., Gorrin, G.M. & Repaci, M.A. Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice. Curr. Eye Res. 6, 825-834 (1987).
25. Organisciak, D.T., Li, M., Darrow, R.M. & Farber, D.B. Photoreceptor cell damage by light in young Royal College of Surgeons rats. Curr. Eye Res. 19, 188-196 (1999).
26. Sanyal, S. & Hawkins, R.K. Development and degeneration of retina in rds mutant mice: effects of light on the rate of degeneration in albino and pigmented homozygous and heterozygous mutant and normal mice. Vision Res. 26, 1177-1185 (1986).
27. Chen, C.K. et al. Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc. Natl Acad. Sci. USA 96, 3718-3722 (1999).
28. Chen, J., Simon, M.I., Matthes, M.T., Yasumura, D. & LaVail, M.M. Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness). Invest. Ophthalmol. Vis. Sci. 40, 2978-2982 (1999).
29. Weng, J. et al. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98, 13-23 (1999).