Immunological and aetiological aspects of macular degeneration

Progress in Retinal and Eye Research

Volumn 20, Issue 3, 2001, Pages 385-414

  Penfold, Philip L ^a   Madigan, Michele C ^a   Gillies, Mark C ^a   Provis, Jan M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; C REACTIVE PROTEIN; CALCITONIN GENE RELATED PEPTIDE; CD31 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GELATINASE A; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; L SELECTIN; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PADGEM PROTEIN; PLATELET DERIVED GROWTH FACTOR; SUBSTANCE P; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRIAMCINOLONE ACETONIDE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

BLOOD RETINA BARRIER; DRUSEN; HUMAN; IMMUNITY; INCIDENCE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA CONE; RETINA FOVEA; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; REVIEW; RISK FACTOR; SMOKING;

ANIMALS; HUMANS; IMMUNITY; MACULA LUTEA; MACULAR DEGENERATION;

EID: 0035077783     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1350-9462(00)00025-2     Document Type: Review

References (202)

1. Drusen in age-related macular degeneration: Pathogenesis, natural course and laser photocoagulation induced regression
2. Oxygen distribution in the macaque retina
3. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
4. Growth factor localization in choroidal neovascular membranes of age-related macular degeneration
5. Distribution of transforming growth factor - β isoforms in the mammalian retina
6. Age-related maculopathy: A model of drusen biogenesis
7. The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization
8. Localization of the Thy-1 antigen to the surfaces of rat retinal ganglion cells
9. Age-related macular degeneration
10. Relationship of drusen and abnormalities of the pigment epithelium to the prognosis of neovascualr macular degeneration: The Macular Photocoagualtion Study Group
11. Clinico-morphologic correlations of Drusen of Bruch's membrane
12. Induction of c-fos and c-jun mRNA expression by basic FGF in cultured rat Müller cells
13. Mechanisms of IL-10 production in human microglia-T cell interaction
14. Case-control study of the risk factors forage-related macular degeneration. France-DMLA Study Group
15. Exudative macular degeneration and intravitreal triamcinolone: 18 Month follow up
16. The effect of triamcinolone acetonide on a refined experimental model of proliferative vitreoretinopathy
17. Histologic localization of indocyanine green dye in aging primate and human ocular tissues with clinical angiographic correlation
18. Cytokine release from microglia: Differential inhibition by pentoxifylline and dexamethasone
19. An immunologic study on age-related macular degeneration
20. Immunocytochemical localization of basic fibroblast growth factor and glial fibrillary acidic protein after laser photocoagulation in the Royal College of Surgeons rat
21. The human mast cell
22. Ultrastructural studies of the blood-retinal barrier after exposure to interleukin-1 beta or tumor necrosis alpha
23. Topography of ganglion cells in human retina
24. Basal linear deposit and large drusen are specific for early age-related maculopathy
25. Human photoreceptor topography
26. Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal injection of triamcicnolone acetonide
27. Short-term visual outcome of exudative age-related macular degeneration treatment with intravitreal triamcinolone acetonide
28. Intravitreal Triamcinolone acetonide in exudative age-related macular degeneration
29. Granulomatous reaction to Bruch's membrane in Age-related macular degeneration
30. Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis
31. Role of LFA-1, ICAM-1, VLA-4 & VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro
32. Multiple control of inflammation by glucocorticoids
33. Modulation of the resistance of a human endothelial cell line by human retinal glia
34. Evidence of photoreceptor migration during early foveal development: A quantitative analysis of human fetal retinae
35. Ontogeny and cellular expression of MHC and leucocyte antigens in human retina
36. Development of microglial topography in human retina
37. Multinucleated giant cells in aquired immunodeficiency syndrome encephalopathy. Origin from endogenous microglia?
38. Transience of astrocytes in the newborn macaque monkey retina
39. Adhesion molecules are expressed in the human retina and choroid
40. Anti-retinal auotimmunity and circulating immune complexes in patients with retinal vasculitis
41. Cellular mechanisms of resolution of drusen after laser coagulation. An experimental study
42. The ultrastructure of drusen
43. Senile macular degeneration: Review of epidemiologic features
44. Age-related macular degeneration
45. Transforming growth factor βs in neurodegenerative disease
46. Comparison of clinical and experimental uveitis
47. Growth factors in age-related macular degeneration: Pathogenetic and therapeutic impications
48. Age-related macular degeneration and choroidal neovascularization
49. Senile macular degeneration: Clinical, histopathological and ultrastructural studies
50. Senile choroidal vascular patterns and drusen
51. Pathogenesis of disciform detachment of the neuroepithelium. III. Senile disciform macular degeneration
52. Drusen and disciform macular detachment and degeneration
53. Transmission electron microscopic study of a subretinal choroidal neovascular membrane due to age-related macular degeneration
54. Glial fibrillary acidic protein (GFAP): Modulation by growth factors and its implication in astrocyte differentiation
55. Differential cataractogenic potency of TGF-β1, β2 and β3 and their expression in the postnatal rat eye
56. Microglia, macrophages and the blood-brain barrier
57. Neovascularisation associated with posterior uveitis
58. Age-related macular degeneration histolpathologic studies
59. Senile macular degeneration: A histopathological study
60. Choroidal neovascularization
61. Evidence for the intrinsic innervation of retinal vessels: Anatomical substrate of autoregulation in the retina?
62. Foveolar choroidal blood flow in age-related macular degeneration
63. Antiretinal antibodies in serum of patients with age-related macular degeneration
64. Erkrankungen der macula lutea
65. Sequestration of basis fibroblast growth factor in the primate retinal interphotreceptor matrix
66. Zur anatomie der scheibenformigen degeneration der netzhaumitte
67. Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration
68. Investigations of antiretinal antibodies in pigmentary retinopathy and other retinal degenerations
69. Retinitis exsudativa bei Lymphogranulomatosis
70. Surgical extraction of subretinal pseudotumors in age-related macular degeneration. Clinical, morphologic and immunohistochemical results
71. The morphological development of the human fovea
72. Ocular neovascularization. The Krill memorial lecture
73. Experimental and clinical observations of the intraocular toxicity of commercial corticosteroid preparations
74. T cell activation by antigen-presenting cells from lung tissue digests: Suppression by endogenous macrophages
75. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration
76. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide
77. Corticosteroids and daunomycin in the prevention of experimental proliferative vitreoretinopathy induced by macrophages
78. Giant-cell reaction in surgically excised subretinal neovascular membrane
79. Hypertension, cardiovascular disease, and age-related macular degeneration
80. Regulation of retinal glial cell proliferation by antiproliferative molecules
81. Effects of intravitreal administration of steroids on experimental subretinal neovascularization in the subhuman primate
82. Morphologic observations on experimental subretinal neovascularization in the monkey
83. Thy-1 induced on rat endothelium regulates vascular permeability at sites of inflammation
84. Glia as mediators of steroid hormone action on the nervous system: An overview
85. Dexamethasone suppresses release of soluble TNF receptors by human monocytes concurrently with TNF-alpha suppression
86. Glucocorticoid modulation of human monocyte/macrophage function: Control of TNF-alpha secretion
87. Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4-, IL-10-, and TGF-beta-induced suppression of TNF-alpha release
88. FGF 2 uses PLC-[gamma]1 for cell proliferation and PI3-kinase for alteration of cell shape and cell proliferation in corneal endothelial cells
89. Giant cells in disciform macular degeneration of the human eye
90. Macrophages related to Bruch's membrane in age-related macular degeneration
91. Ultrastructure of surgically excised subfoveal neovascular membranes
92. The relationship of age-related maculopathy, cataract and glaucoma to visual acuity
93. Increased expression of angiogenic growth factors in age-related maculopathy
94. Oxygen tension regulates the expression of angiogenesis factor by macrophages
95. Short-term oral pentoxifylline use increases choroidal blood flow in patients with age-related macular degeneration
96. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
97. Clinicopatholgical correlation in exudative age related macular degeneration: Histological differentiation between classic and occult choroidal neovascularisation
98. Posterior sub-Tenon's steroid injections for the treatment of posterior ocular inflammation: Indications, efficacy and side effects
99. The role of the macrophage in wound repair: A study with hydrocortisone and antimacrophage serum
100. Basic fibroblast growth factor: A potential regulator of proliferation and intermediate filament expression in the retina
101. Macrophage responses to hypoxia: Relevance to disease mechanisms
102. Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae
103. A burst of differentiation in the outer posterior retina of the eleven-week human fetus: An ultrastructural study
104. Basal linear deposit in the human macula
105. Terminology of sub-RPE deposits: Do we all speak the same language
106. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration
107. Corticosteroids as an antiangiogenic agent for histoplasmosis-related subfoveal choroidal neovascularization
108. Production of interleukin-1 by microglia inresponse to substance P: Role for a non-classical NK-1 receptor
109. Argon laser lesions of the retina; occurrence and origin of macrophages
110. Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro
111. Symposium: Macular diseases. Pathogenesis
112. The lack of toxicity of intravitreally administered triamcinolone acetonide
113. The role of substance P in cytokine production by glial cells
114. Immunohistochemical demonstration of mineralocorticoid receptor in ocular tissues
115. "Smoking is a major cause of blindness" A new cigarette pack warning?
116. Prevalence of age-related maculopathy in Australia
117. Smoking and the incidence of age-related maculopathy lesions: The Blue Mountains Eye Study
118. Muller cell changes in human diabetic retinopathy
119. Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells
120. Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids
121. Central senile areolar choroidal atrophy
122. Macular degeneration and elevated serum ceruloplasmin
123. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes
124. The architecture of the choroidal vascular system in clinical ophthalmology
125. Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes
126. Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis
127. Choroiditis exsudativa under dem bilde der scheibenformigen entartung der netzhautmitte
128. Drusen in Bruch's membrane. Their significance for the pathogenesis and therapy of age-associated macular degeneration
129. Submacular neovascular membrane and focal granulomatous inflammation
130. Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria
131. Exudative macular degeneration and intravitreal triamcinolone. A pilot study
132. An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane
133. Senile macular degeneration: The involvement of immunocompetent cells
134. Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium
135. Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration
136. Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina
137. Age-related macular degeneration: Ultrastructural studies of the relationship of leucocytes to angiogenesis
138. Autoantibodies to retinal astrocytes associated with age-related macular degeneration
139. Human retinal microglia express phenotypic characteristics in common with dendritic antigen-presenting cells
140. Angiogenesis in normal human retinal development: The involvement of astrocytes and macrophages
141. Triamcinolone acetonide modulates the permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: Implications for macular degeneration
142. Increase in interphotoreceptor matrix gelatinase A (MMP-2) associated with age-related macular degeneration
143. Ganglion cell topography in human fetal retinae
144. Ontogeny of the primate fovea: A central issue in retinal development
145. Microglia in human retina: A heterogeneous population with distinct ontogenies
146. Development of the human retinal vasculature: Cellular relations and VEGF expression
147. Human retinal microglia: Expression of immune markers and relationship to the glia limitans
148. Astrocytes and blood vessels define the foveal rim during primate foveal development
149. Development of the Human Retina: Patterns of cell distribution and redistribution in the ganglion cell layer
150. Distribution of growth factors in subfoveal neovascular membranes in age-related macular degeneration and presumed ocular histoplasmosis syndrome
151. The Primate Retina
152. Macular edema in chronic Vogt-Koyanagi-Harada syndrome
153. The disciform response: An historical perspective
154. Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity
155. Aging and degeneration in the macular region: A clinicopathological study
156. New vessel formation beneath the retinal pigment epithelium in senile eyes
157. Drusen and their relationship to senile macular degeneration
158. Drusen patterns predisposing to geographic atrophy of the retinal pigment epithelium
159. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: A clinicopathological study
160. Ultrastructural features of surgically excised subretinal neovascular membranes in the ocular histoplasmosis syndrome
161. Immnohistochemical characterisation of surgically removed subfoveal fibrovascular membranes
162. Prognosis of patients with bilateral macular drusen
163. Smoking and age-related maculopathy. The Blue Mountains Eye Study
164. Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: The Blue Mountains Eye Study
165. Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes
166. Suppression of human monocyte tumour necrosis factor-alpha release by glucocorticoid therapy: Relationship to systemic monocytopaenia and cortisol suppression
167. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
168. Development of the retinal vasculture is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
169. Immunoregulatory mechanisms of the eye
170. Macrophages and angiogenesis
171. Growth factors and their receptors in the retina and pigment epithelium
172. Posterior sub-Tenon's triamcinolone injections in the treatment of uveitis
173. Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide
174. Ultrastructural features of surgically excised idiopathic subfoveal neovascular membranes
175. Adherence of neutrophils to cultured human microvascular endothelial cells stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p160,95 glycoprotein family
176. Serum levels of antioxidants and age-related macular degeneration
177. Experiments on visual cells by nature and man: In search of treatment for photoreceptor degeneration
178. Pathogenetic features of aging macular degeneration
179. Scanning electron microscopy of human drusen
180. Early stages of age-related macular degeneration: An immunofluorescence and electron microscopy study
181. Histologic features of the early stages of age-related macular degeneration: A statistical analysis
182. Is basal laminar deposit unique for age-related macular degeneration?
183. Pathogenesis of disciform degeneration of the macula
184. The prevalence of age-related maculopathy in the Rotterdam study
185. Immunohistochemical localization of blood-retinal barrier breakdown sites associated with post-surgical macular oedema
186. Activated human retinal microglia under pathological conditions
187. The long-term course of multifocal choroiditis (presumed ocular histoplasmosis)
188. Modification of vision by change in rheologic parameters in senile macular degeneration through membrane differential filtration-initial results of a randomized study
189. Multinucleated giant cells on Bruch's membrane late in recurrent retinal and subretinal hemorrhaging
190. The probable role of benign histoplasmosis in the etiology of granulomatous uveitis
191. Study of pathogenesis of age-related macular degeneration
192. Immunolocalization of transforming growth factor beta during wound repair in rat retina after laser photocoagulation
193. Occult choroidal neovascularization
194. A qualitative and quantitative analysis of the human fovea during development
195. Expression of major histocompatibility complex molecules in rodent retina. Immunohistochemical study
196. Neuropeptide expression in the human fetal hyaloid vasculature and vitreous