Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage

Journal of Neuroscience

Volumn 23, Issue 10, 2003, Pages 4164-4172

  Okoye, Godwin ^a   Zimmer, Joelle ^a   Sung, Jennifer ^a   Gehlbach, Peter ^a   Deering, Tye ^a   Nambu, Hiroyuki ^a   Hackett, Sean ^a   Melia, Michele ^a   Esumi, Noriko ^a   Zack, Donald J ^a   Campochiaro, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BDNF; Gene transfer; Inducible transgenics; Neurotrophic factors; Oxidative damage; Retinal degenerations

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DOXYCYCLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NERVE GROWTH FACTOR; OXYGEN; RHODOPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; ELECTRORETINOGRAM; GENE INDUCTION; GENE THERAPY; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA DEGENERATION; RETINA NERVE CELL; RETINA ROD; TRANSGENIC MOUSE; VISUAL IMPAIRMENT; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DEATH; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; HYPEROXIA; IMMUNOHISTOCHEMISTRY; INJURY; METABOLISM; MUTATION; PHYSIOLOGY; RAT; RETINA;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOXYCYCLINE; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HYPEROXIA; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE GROWTH FACTORS; OXYGEN; PHOTORECEPTORS; RATS; RETINA; RETINAL DEGENERATION; RHODOPSIN; RNA, MESSENGER;

EID: 0037704444     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-10-04164.2003     Document Type: Article

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