Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration

Gene Therapy

Volumn 10, Issue 6, 2003, Pages 523-527

  Schlichtenbrede, F C ^a   MacNeil, A ^a   Bainbridge, J W B ^a   Tschernutter, M ^a   Thrasher, A J ^b   Smith, A J ^a   Ali, R R ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CNTF; Gene therapy; Neuroprotection; rds mouse; Retinal degeneration; Viral vector

Indexed keywords

ADENOVIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR; NEURITE PROMOTING FACTOR; PERIPHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B WAVE; CELL LOSS; CLINICAL STUDY; CONTROLLED STUDY; DRUG EFFICACY; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENE REPLACEMENT THERAPY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEGENERATION; RETINA DYSTROPHY; VIRAL GENE DELIVERY SYSTEM; VISION; WILD TYPE;

ANIMALS; CELL SURVIVAL; CILIARY NEUROTROPHIC FACTOR; DEPENDOVIRUS; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; INJECTIONS; INTERMEDIATE FILAMENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; NERVE TISSUE PROTEINS; PHOTORECEPTORS, VERTEBRATE; RETINA; RETINAL DEGENERATION; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; ANIMALIA;

EID: 0037352472     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301929     Document Type: Article

References (19)

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