HSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses

Molecular Therapy

Volumn 3, Issue 5, 2001, Pages 746-756

  Spencer, Brian ^a   Agarwala, Seema ^b   Gentry, Laura ^b   Brandt, Curtis R ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

bFGF; Electronetinogram; FGF2; HSV vectors; Neuroprotection; PC12 cells; Retinal degeneration

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; NERVE GROWTH FACTOR; RECOMBINANT FIBROBLAST GROWTH FACTOR; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENE INSERTION; GENE TARGETING; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS 1; HUMAN CYTOMEGALOVIRUS; IN VITRO STUDY; LIGHT EXPOSURE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PROMOTER REGION; RAT; RETINA; RETINA DEGENERATION; VIRUS ATTENUATION; VIRUS GENE;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 5;

EID: 0034986756     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0307     Document Type: Article

References (73)

1. Biological roles of fibroblast growth factor-2
2. Secretion of GDNF by glial cells does not account for the neurotrophic effect of bFGF on dopamine neurons in vitro
3. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
4. Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary cultures
5. Basic fibroblast growth factor and brain-derived neurotrophic factor promote survival and neuronal circuit formation in organotypic hippocampal culture
6. Marked diversity in the action of growth factors on N-methyl-d-aspartate-induced neuronal degeneration
7. Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension
8. Fibroblast growth factors promote the survival of adult retinal ganglion cells after transection of the optic nerve
9. Long-term protection of axotomized neurons in the dorsal lateral geniculate nucleus in the rat following a single administration of basic fibroblast growth factor or ciliary neurotrophic factor
10. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo
11. Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciated nerve on neuron death in adult rat dorsal root ganglia
12. Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils
13. Dose-response comparison of recombinant human nerve growth factor and recombinant human basic fibroblast growth factor in the fimbria fornix model of acute cholinergic degeneration
14. Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease
15. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
16. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat
17. Basic fibroblast growth factor treatment delays age-related photoreceptor degeneration in Fischer 344 rats
18. Light induced retinal degeneration in albino mice and rats: Strain and species differences
19. Basic fibroblast growth factor protects photoreceptors from light-induced degeneration in albino rats
20. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from damaging effects of constant light
21. vit (vitiligo) mouse: A morphologic and electrophysiological study
22. Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats
23. Retinal dystrophy in the rat
24. Inherited retinal dystrophy in the rat
25. Hereditary degeneration of the rat retina
26. Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis
27. Unilateral degeneration of retina and optic nerve in Fischer-344 rats
28. Changes in retinal morphology and glucose utilization in aging albino rats
29. Age-related and light-associated retinal changes in Fischer rats
30. The influences of age, retinal topography, and gender on retinal degeneration in the Fischer 344 rat
31. Hyperthermia accelerates retinal light damage in rats
32. Light damage in the rat retina: Glial fibrillary acidic protein accumulates in Müller cells in correlation with photoreceptor damage
33. Possible mechanisms of photoreceptor damage by light in mammalian eyes
34. Lipid peroxidation and retinal degeneration
35. The role of antioxidants in the retinal and retinal pigment epithelium and the nature of prooxidant-induced damage
36. Transgenic rat models of inherited retinal degeneration caused by mutant opsin genes
37. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rat
38. Retinal functional change caused by adenoviral vector-mediated transfection of lacZ gene
39. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2
40. Herpes simplex virus-mediated gene delivery to the rodent visual system
41. The herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease
42. Herpes simplex virus stromal keratitis is not titer-dependent and does not correlate with neurovirulence
43. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
44. Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro
45. Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro
46. Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures
47. Mixed infection with herpes simplex virus type 1 generates recombinants with increased ocular and neurovirulence
48. An ocular renin-angiotensin system. Immunohistochemistry of angiotensinogen
49. The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion
50. Retinal damage by light in rats
51. Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene
52. Functional rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat
53. Apoptosis in neurodegenerative disorders
54. Neuronal apoptosis in acute necrotic insults: Why is this subject such a mess?
55. The neurite-promoting effect of fibroblast growth factor
56. The effect of fibroblast growth factor on PC12 cells
57. The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia
58. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus
59. The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells
60. Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein
61. Basic fibroblast growth factor fused to a signal peptide transforms cells
62. Quantitative export of FGF-2 occurs through an alternative, energy-dependent, non-ER/Golgi pathway
63. Basic fibroblast growth factor, a protein devoid of secretory sequence signal, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex
64. Herpes simplex virus mediated gene delivery to primate ocular tissues
65. The brain fibroblast growth factor (FGF) is localized to neurons
66. Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen
67. The components of the retinal action potential in mammals and their relation to the discharge in the optic nerve
68. Retinitis pigmentosa: Defined form a molecular point of view
69. Stepwise dismantling of adenovirus 2 during entry into cells
70. Immune privilege and immune regulation in the eye
71. Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: Characterization of an ICP6 deletion mutant
72. Herpes simplex virus type-1 ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: Isolation and characterization of an ICP6 lacZ insertion mutant
73. The impact of basic fibroblast growth on photoreceptor function and morphology