Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

Documenta Ophthalmologica

Volumn 106, Issue 1, 2003, Pages 89-98

  Lau, Dana ^a   Flannery, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Light damage; Neurotrophic factor; Retinal gene therapy

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; NEUROTROPHIC FACTOR;

ADENOVIRUS; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRORETINOGRAPHY; GENE; GENE OVEREXPRESSION; GENE TRANSFER; LIGHT DAMAGE; MALE; MORPHOMETRICS; NONHUMAN; PHOTORECEPTOR; PROTEIN EXPRESSION; RAT; RECOMBINANT GENE; RETINA; RETINA DEGENERATION; VIRAL GENE THERAPY;

ANIMALS; DEPENDOVIRUS; FIBROBLAST GROWTH FACTOR 2; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0037230914     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022481306146     Document Type: Conference Paper

References (20)

1. Noell WK, Walker VS, et al. Retinal damage by light in rats. Invest Ophthalmol 1966; 5(5): 450-73.
2. Faktorovich EG, Steinberg RH, et al. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 1992; 12(9): 3554-67.
3. LaVail MM, Unoki K, et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA 1992; 89(23): 11249-53.
4. Unoki K, LaVail MM. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest Ophthalmol Vis Sci 1994; 35(3): 907-15.
5. Masuda K, Watanabe I, et al. Functional rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat. Invest Ophthalmol Vis Sci 1995; 36(10): 2142-6.
6. LaVail MM, Yasumura D, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 1998; 39(3): 592-602.
7. Liu C, Peng M, et al. Preconditioning with bright light evokes a protective response against light damage in the rat retina. J Neurosci 1998; 18(4): 1337-44.
8. Ranchon I, Gorrand JM, et al. Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract. Invest Ophthalmol Vis Sci 1999; 40(6): 1191-9.
9. Wiegand RD, Giusto NM, et al. Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci 1983; 24(10): 1433-5.
10. Akpalaba CO, AC Oraedu, et al. Biochemical studies on the effects of continuous light on the albino rat retina. Exp Eye Res 1986; 42(1): 1-9.
11. Lisman J, Fain G. Support for the equivalent light hypothesis for RP. Nat Med 1995; 1(12): 1254-5.
12. Lau D, McGee LH, et al. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest Ophthalmol Vis Sci 2000; 41(11): 3622-33.
13. LaVail MM, Gorrin GM, Repaci MA, Thomas LA, Ginsberg HM. Genetic regulation of light damage to photoreceptors Invest Ophthalmol Vis Sci 1987; 28: 1043-8.
14. Flannery JG, Zolotukhin S, et al. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. Proc Nat Acad Sci USA 1997; 94(13): 6916-21.
15. McGee Sanftner LH, Abel H, et al. Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol Ther 2001; 4(6): 622-9.
16. McGee Sanftner LH, Rendahl KG, et al. Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina. Mol Ther 2001; 3(5 Pt 1): 688-96.
17. Bachoud-Levi AC, Deglon N, et al. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum Gene Ther 2000; 11(12): 1723-9.
18. Aebischer P, Schluep M, et al. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients [published erratum appears in Nat Med 1996; 2(9): 1041]. Nat Med 1996; 2(6): 696-9.
19. Mandel RJ, Spratt SK, et al. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci USA 1997; 94(25): 14083-8.
20. Bilang-Bleuel A, Revah F, et al. Intrastriatal injection of an adenoviral vector expressing glial-cell- line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci USA 1997; 94(16): 8818-23.