Involvement of oxidative mechanisms in blue-light-Induced damage to A2e-laden RPE

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 4, 2002, Pages 1222-1227

  Sparrow, Janet R ^a   Zhou, Jilin ^a   Ben Shabat, Shimon ^a   Vollmer, Heidi ^a   Itagaki, Yasuhiro ^a   Nakanishi, Koji ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN;

ARTICLE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ILLUMINATION; LIGHT EXPOSURE; OXIDATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA INJURY;

APOPTOSIS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA DAMAGE; HUMANS; LIGHT; OXIDATION-REDUCTION; OXYGEN; PIGMENT EPITHELIUM OF EYE; PYRIDINIUM COMPOUNDS; RETINOIDS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 0036205219     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Solar radiation and age-related macular degeneration
2. A2e, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture
3. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells
4. Photodamage to human RPE cells by A2-E a retinoid component of lipofuscin
5. The involvement of the retinal pigment epithelium
6. Basic mechanisms underlying the production of photochemical lesions in the mammalian retina
7. Histologic analysis of photochemical lesions produced in rhesus retina by short-wavelength light
8. Blue-lightinduced dysfunction of the blood-retinal barrier at the pigment epithelium in albino versus pigmented rabbits
9. Temporal sequences of changes in rat retina after UV-A and blue light exposure
10. The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina
11. Blue light-induced apoptosis of A2E- containing RPE involvement of caspase-3 and protection by Bcl-2
12. Blue light-induced reactivity of retinal age pigment: In vitro generation of oxygen-reactive species
13. Photophysical studies on human retinal lipofuscin
14. The photochemistry of human retinal lipofuscin as studied by EPR
15. Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media
16. The photoreactivity of the retinal age pigment lipofuscin
17. Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro
18. Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase
19. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion
20. Role of ground and excited singlet state oxygen in the red light-induced stimulation of Escherichia coli cell growth
21. Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization
22. BPD-MA-mediated photosensitization in vitro and in vivo: Cellular adhesion and betal integrin expression in ovarian cancer cells
23. UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen
24. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein
25. 780 Nm low power diode laser irradiation stimulates proliferation of keratinocyte cultures: Involvement of reactive oxygen species
26. Effects of hematoporphyrin derivative and light on Y79 retinoblastoma cells in vitro
27. On the involvement of singlet oxygen in mutation induction by 8-methoxypsoralen and UVA irradiation in Escherichia coli K-12
28. Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5
29. Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium (VI) is mediated through oxidative stress but does not affect cytotoxicity
30. Antioxidant defenses of cultured gastric cells against oxygen metabolites: Role of GSH redox cycle and endogenous catalase
31. 2 or ultraviolet B light
32. Complement activation following reoxygenation of hypoxic human endothelial cells: Role of intracellular reactive oxygen species, NF-kappaB and new protein synthesis
33. Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells
34. Free radical production in hypoxic pulmonary artery smooth muscle cells
35. Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium
36. Quenching of singlet oxygen by aliphatic amines
37. Protection against retinal light damage by natural, synthetic antioxidants
38. Effects of repeated photic exposures on the monkey macula
39. Light effects on the retina
40. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects
41. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope
42. Aging human RPE: Morphometric analysis of macular, equatorial, and peripheral cells
43. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium
44. The relationships of age changes in retinal pigment epithelium and Bruch's membrane