Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 6, 2002, Pages 1912-1915

  Pawlyk, Basil S ^a   Li, Tiansen ^a   Scimeca, Michael S ^a   Sandberg, Michael A ^a   Berson, Eliot L ^a  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; DARK ADAPTATION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; ELECTRORETINOGRAPHY; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE STRAIN; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RANDOMIZATION; RETINA CELL; RETINA CONE; RETINA DEGENERATION; RETINA ROD; TISSUE SECTION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CELL COUNT; DARK ADAPTATION; DILTIAZEM; ELECTRORETINOGRAPHY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C3H; PHOTIC STIMULATION; PHOTORECEPTORS, VERTEBRATE; RETINITIS PIGMENTOSA; RHODOPSIN;

EID: 0036268005     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase
2. Mutation spectrum of the gene encoding the β-subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa
3. Recessive mutations in the gene encoding the β-subunit of rod phosphodiesterase in patients with retinitis pigmentosa
4. Visual excitation and recovery
5. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and 1-cis-diltiazem
6. Induction by cyclic GMP of a cationic conductance in plasma membrane of retinal rod outer segment
7. Light-suppressible, cyclic GMP-sensitive conductance in the plasma membrane of a truncated rod outer segment
8. Cyclic guanosine monophosphate elevation in degenerating photoreceptor cells of the C3H mouse retina
9. Cyclic GMP accumulation causes degeneration of photoreceptor cells: Simulation of an inherited disease
10. Current status of calcium channel blockers in patients with cardiovascular disease
11. Cyclic GMP directly regulates a cationic conductance in membranes of bovine rods by a cooperative mechanism
12. Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
13. Relationship of oscillatory potential amplitude to a wave slope over a range of flash luminances in normal subjects
14. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for x-linked retinitis pigmentosa (RP3)
15. Properties of the mouse cone-mediated electroretinogram during light adaptation
16. Monoclonal antibodies to rhodopsin and other proteins of rod outer segments
17. A sequence upstream of the mouse blue visual pigment gene directs blue cone-specific transgene expression in mouse retinas
18. Protection of mouse photoreceptors by survival factors in retinal degenerations
19. Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcdl canine model of retinitis pigmentosa
20. The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro23His rat